Abstract：
OBJECTIVE:To determine what percentage of inoperable oesophageal and oesophagogastric malignancies could be successfully intubated for palliation, and to compare Atkinson and Celestin tubes. DESIGN:A consecutive series of 210 patients who had been referred for palliation underwent endoscopy and intubation with the Nottingham introducer. PATIENTS:One hundred and nineteen men and 91 women aged 31-91 (mean age 71) years with inoperable malignant obstruction of the oesophagus or gastro-oesophageal junction were studied. One hundred and five tumours were in the lower third of the oesophagus, 78 in the middle third, 25 in the upper third and seven in the gastric fundus. Four tracheo-oesophageal fistulae resulting from bronchial carcinomas were also successfully intubated. MAJOR OUTCOME MEASURE: Eighty-nine per cent of gastro-oesophageal malignancies were successfully intubated using 120 Atkinson and 67 Celestin tubes. RESULTS:Eleven patients (5.2%) suffered oesophageal perforations during intubation, of whom six died. Nine of the perforations occurred in the first 100 patients treated but only two (2.3%) in the subsequent 87. Seven patients (3.7%) developed aspiration pneumonia, of whom five died. The mean survival time after intubation was 4.5 months (range 0.5-20 months), and 74% of patients required no further procedure. During follow-up, five (4.2%) Atkinson tubes displaced upwards, compared with 12 (17.9%) Celestin tubes (P < 0.01). Eighteen (9.6%) patients had recurrent dysphagia as a result of bolus obstruction and 11 (5.9%) had tumour overgrowth of the tube. CONCLUSION:Palliative intubation of malignant dysphagia is possible in approximately 90% of patients. The mortality associated with the procedure is low (5%) and effective relief of symptoms is achieved, with 74% of patients requiring no further treatment.
journal_name
Eur J Gastroenterol Hepatoljournal_title
European journal of gastroenterology & hepatologyauthors
Wilton A,Smith PMsubject
Has Abstractpub_date
1995-06-01 00:00:00pages
559-62issue
6eissn
0954-691Xissn
1473-5687journal_volume
7pub_type
杂志文章abstract：:Hepatocellular carcinoma (HCC) is a major worldwide health problem and the most common cause of cancer induced mortality. This review article examines the natural history of HCC and the known risk factors, as well as evaluating the current methods of detection of HCC and their impact on patient survival. ...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,评审
doi：
更新日期：1996-09-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to evaluate information provided on pregnancy, personal decision making, disease course, and outcome of pregnancy from a patient's perspective in a population of patients with inflammatory bowel disease (IBD) attending two general hospitals. PATIENTS AND METHODS:A questionnaire w...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,多中心研究
doi：10.1097/MEG.0000000000001117
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVES:The intestinal microbiota plays an important role in intestinal health. After colonic diversion from the fecal stream, luminal nutrients for bacteria are expected to be depleted, inducing changes in microbial composition. In this study, we describe microbial changes in the healthy colon following surgical fe...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000001330
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Metal stents offer superior biliary drainage in patients with malignant bile duct obstruction, with fewer episodes of stent occlusion compared with polyethylene stents. Metal stent patency has only been studied over limited time periods in such patients with malignant disease. OBJECTIVE:To assess the long-t...
journal_title：European journal of gastroenterology & hepatology
pub_type： 临床试验,杂志文章
doi：10.1097/00042737-199802000-00008
更新日期：1998-02-01 00:00:00
abstract：OBJECTIVES:Technical feasibility and safety of portal vein (PV) and superior mesenteric vein (SMV) resection during pancreaticoduodenectomy (PD) for cancer has been confirmed, but oncological benefits remain unclear. The present study aimed to explore the long-term outcomes of PD with PV/SMV resection and proven histol...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000001266
更新日期：2018-12-01 00:00:00
abstract：:Here we report two cases of inverted hyperplastic polyps of the colon. The first patient showed three inverted hyperplastic polyps in the ascending colon, one of which was associated with adenoma. We immunostained this adenoma-associated polyp using anti-beta-catenin antibody and found accumulation of beta-catenin in ...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-200401000-00016
更新日期：2004-01-01 00:00:00
abstract：:In this review, the role of chemotherapy in the palliative treatment of advanced gastrointestinal cancer is discussed. Emphasis is placed on chemotherapy-related problems, current chemo-therapy options, and new developments. ...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,评审
doi：10.1097/00042737-200012040-00004
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:Liver biopsy is considered as the gold standard for assessing nonalcoholic fatty liver disease (NAFLD) histologic lesions in patients with morbid obesity. The aim of this study was to determine the diagnostic utility of noninvasive markers of fibrosis (FibroTest), steatosis (SteatoTest), and steatohepatitis ...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0b013e3283464111
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVES:Hepatitis C virus (HCV) is the major cause of cryoglobulinemia. Direct-acting antivirals (DAAs) have markedly changed the therapeutic outcomes in the treatment of patients with HCV. We evaluate the efficacy, safety, immunological, and clinical response of different DAA regimens in HCV-cryoglobulinemia. PATI...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000001239
更新日期：2018-10-01 00:00:00
abstract：AIM:Many researchers consider portal thrombosis (PT) as a contraindication to transjugular intrahepatic portosystemic shunt (TIPS). The aim of this retrospective study was to compare the feasibility and long-term prognosis of TIPS in cirrhotic patients, with and without, complete PT. PATIENTS AND METHODS:Four hundred ...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0b013e328338d995
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND:As life expectancy rises worldwide and the prevalence of gallstones increases with age, the number of very elderly patients requiring treatment for gallstone diseases is increasing. The aim of this study was to compare the results of cholecystectomy in patients 80 years or older according to different clinic...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0b013e32835b7124
更新日期：2013-03-01 00:00:00
abstract：OBJECTIVES:To determine the efficacy of a three times daily (t.i.d.) versus a twice daily (b.i.d.) regimen of combination amoxycillin and metronidazole and famotidine in the eradication of Helicobacter pylori and the influence of metronidazole resistance on the outcome of treatment. PATIENTS:Patients selected had uneq...
journal_title：European journal of gastroenterology & hepatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00042737-199711000-00012
更新日期：1997-11-01 00:00:00
abstract：OBJECTIVE:Although antimony electrodes are by far the most popular for performing oesophageal pH monitoring, there are few data comparing the accuracy of glass and antimony electrodes. Therefore, we tested the accuracy of both electrodes in the prediction of oesophagitis. METHOD:pH monitoring using a glass electrode a...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-200412000-00015
更新日期：2004-11-01 00:00:00
abstract：OBJECTIVE:Bowel distension by insufflated air causes abdominal discomfort after colonoscopy. Carbon dioxide (CO2) instead of air insufflation during colonoscopy can reduce postprocedural discomfort in diagnostic and screening cases. Discomfort after colonoscopy and CO2 insufflation have never been studied in inflammato...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,随机对照试验
doi：10.1097/MEG.0000000000000791
更新日期：2017-03-01 00:00:00
abstract：:The role of smoking in the pathogenesis of gastrooesophageal reflux disease has been controversial since the early 1970s when Stanciu reported the two to be 92% epidemiologically associated (a study subsequently challenged by inconsistencies in the observational data). Mechanistically, reflux disease is caused by exce...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,评审
doi：10.1097/00042737-200012080-00002
更新日期：2000-08-01 00:00:00
abstract：BACKGROUND:Deoxycholic acid and other secondary bile acids have long been considered tumour promoters in the colon. However, their effect on cell migration, known to play an important role in colon carcinogenesis, has not been studied so far. OBJECTIVE:To investigate the possible effects of deoxycholic acid on colon c...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-200108000-00012
更新日期：2001-08-01 00:00:00
abstract：BACKGROUND:Diabetes mellitus can occur after acute pancreatitis (AP), but there are currently no tools for evaluating the risk of developing diabetes after an attack of AP. The aim of the study was to develop a nomogram for prediction of new-onset diabetes mellitus after the first attack of AP. PATIENTS AND METHODS:We...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000001307
更新日期：2019-03-01 00:00:00
abstract：OBJECTIVES:The activation of hepatic stellate cells (HSC) is considered the most important event in hepatic fibrogenesis. The precise mechanism of this process is unknown in autoimmune hepatitis (AIH), and more evidence is needed on the evolution of fibrosis. The aim of this study was to assess these aspects in childre...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0b013e328326cab6
更新日期：2010-03-01 00:00:00
abstract：:Oesophageal stenting for palliation of malignant obstruction with self-expanding metallic stents is undoubtedly well established. Numerous studies have proven it to be safe and easy to perform with good clinical outcomes. However, stenting of the upper oesophagus is still regarded with apprehension, with many endoscop...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0b013e3283496543
更新日期：2011-10-01 00:00:00
abstract：INTRODUCTION:The aim of this study is to present the contrast enhanced magnetic resonance angiography findings of hepatic venous outflow obstruction in patients in whom surgery had been performed for hepatic hydatidosis. No patient history of parasitic hepatic venous invasion or earlier hepatic venous outflow obstructi...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0b013e328305b9f3
更新日期：2009-07-01 00:00:00
abstract：:Interferon therapy is the cornerstone of chronic hepatitis C treatment. Side effects of interferon include possible triggering or exacerbation of immune diseases in consequence of immunomodulatory effects. We describe the unique case, in which pyoderma gangrenosum and exacerbation of psoriasis were developed 8 weeks a...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0b013e32816e070b
更新日期：2007-09-01 00:00:00
abstract：:Primary squamous cell carcinoma of the stomach is extremely rare. To date, only 80 cases have been reported. A 65-year-old man with complaints of epigastric pain and cachexia for the past year is presented. He had a tumour with infiltration of the corpus and antrum of the stomach. The tumour was unresectable, and the ...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,评审
doi：10.1097/01.meg.0000050011.68425.82
更新日期：2003-03-01 00:00:00
abstract：OBJECTIVES:To identify risk factors of carcinoma of the extrahepatic biliary tract in men. METHODS:Newly diagnosed and histologically confirmed patients, 35-70 years old, were interviewed between 1995 and 1997 in Denmark, Sweden, France, Germany and Italy. Population controls were frequency-matched by age and region. ...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章,多中心研究
doi：10.1097/01.meg.0000243876.79325.a1
更新日期：2007-08-01 00:00:00
abstract：OBJECTIVES:The hybrid allele of the carboxyl ester lipase gene (CEL-HYB1) is a genetic risk factor for chronic pancreatitis (CP) although the mechanism promoting disease development is largely unknown. Here, we aimed to clinically describe subjects carrying the CEL-HYB1 allele and to elucidate why the protein product i...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000001963
更新日期：2020-10-16 00:00:00
abstract：OBJECTIVES:At present, all colonic polyps are removed and sent for histopathological evaluation, resulting in laboratory and reporting costs. Recent American Society for Gastrointestinal Endoscopy (ASGE) guidelines have set standards for in-vivo diagnosis in place of conventional histopathology, and all future technolo...
journal_title：European journal of gastroenterology & hepatology
pub_type： 临床试验,杂志文章
doi：10.1097/MEG.0b013e328349e276
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:Early detection and treatment is important for the management of colorectal cancer (CRC). AIM:To assess patient and doctor delay and their determinants. METHODS:A retrospective observational study in a primary care setting concerning 197 patients with CRC. The time between initial symptoms and the onset of...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0b013e32834c4839
更新日期：2011-11-01 00:00:00
abstract：OBJECTIVE:We have previously identified that primary human hepatocellular carcinoma (HCC) is associated with altered guanine nucleotide regulatory protein (G-protein) expression concomitant with decreased adenylyl cyclase (AC) and increased mitogen activated protein kinase (MAPK) activity in vivo. This study aims to ad...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/00042737-199912000-00009
更新日期：1999-12-01 00:00:00
abstract：OBJECTIVE:Recent studies have suggested that endotoxin-induced cytokines play an important role in nonalcoholic fatty liver disease (NAFLD). Rifaximin is a nonabsorbable antibiotic that might act on Gram-negative bacteria, thereby inhibiting endotoxin proinflammatory cytokine production in patients with NAFLD. Our aim ...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000000348
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:Pancreatic enzyme preparations are a life-saving substitution for a pivotal physiological function of the entire organism that is impaired in chronic pancreatitis, cystic fibrosis and other diseases with exocrine pancreatic insufficiency. Pancreatic enzyme preparations, generically called pancreatin, are not...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0b013e328328f414
更新日期：2009-09-01 00:00:00
abstract：OBJECTIVE:Previous studies have found a differential expression of microRNAs (miRNAs) in the blood of patients with Crohn's disease (CD) compared with healthy controls. The aim of this study was to identify circulating miRNAs expressed in CD and assess their performance as biomarkers in patients with clinically suspect...
journal_title：European journal of gastroenterology & hepatology
pub_type： 杂志文章
doi：10.1097/MEG.0000000000000430
更新日期：2015-09-01 00:00:00
