Mechanisms of chlorophyllin anticarcinogenesis against aflatoxin B1: complex formation with the carcinogen.

abstract：:Jay Amin hydroxamic acid (JAHA; N8-ferrocenylN1-hydroxy-octanediamide) is a ferrocene-containing analogue of the histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA). JAHA's cytotoxic activity on MDA-MB231 triple negative breast cancer (TNBC) cells at 72 h has been previously demonstrated with ...

journal_title：Chemical research in toxicology

authors： Librizzi M,Caradonna F,Cruciata I,Dębski J,Sansook S,Dadlez M,Spencer J,Luparello C

更新日期：2017-12-18 00:00:00

abstract：:The development of a unique bioassay for cytotoxicity analysis of coal fly ash (CFA) particulate matter (PM) and its potential application for air quality monitoring is described. Using human cell lines, A549 and SK-MES-1, as live probes on microelectrode-embedded 96-well sensors, impedance changes over time are measu...

journal_title：Chemical research in toxicology

authors： Moe B,Yuan C,Li J,Du H,Gabos S,Le XC,Li XF

更新日期：2016-06-20 00:00:00

abstract：:The regulation of cellular stress responses to electrophiles and oxidants is mediated by the transcription factor NF-E2-related factor 2 (Nrf2), which, in turn, is regulated by CUL-E3 (CUL3) ligase-mediated ubiquitylation. The Kelch-like ECH-associated protein 1 (Keap1) serves as an adapter between CUL3 and Nrf2. We u...

journal_title：Chemical research in toxicology

authors： Rachakonda G,Xiong Y,Sekhar KR,Stamer SL,Liebler DC,Freeman ML

更新日期：2008-03-01 00:00:00

abstract：:While characterizing natural antiinflammatory substances in human placental blood, we discovered a factor that affected human neutrophils and their adherence. Rigorous chemical and stereochemical analyses revealed this factor to be the well-known alkaloid, colchicine. When samples from individual patients were analyze...

journal_title：Chemical research in toxicology

authors： Petty HR,Fernando M,Kindzelskii AL,Zarewych BN,Ksebati MB,Hryhorczuk LM,Mobashery S

更新日期：2001-09-01 00:00:00

abstract：:Diastereomeric 8,5'-cyclopurine 2'-deoxynucleosides, containing a covalent bond between the deoxyribose and the purine base, are induced in DNA by ionizing radiation. They are suspected to play a role in the etiology of neurodegeneration in xeroderma pigmentosum patients. If not repaired, the S-8,5'-cyclo-2'-deoxyguan...

journal_title：Chemical research in toxicology

authors： Huang H,Das RS,Basu AK,Stone MP

更新日期：2012-02-20 00:00:00

abstract：:All pesticides must go through a rigorous risk assessment process in order to show that they are safe for use.With respect to dermal risk assessment for re-entry workers, the absorption value applied to predict systemic dose from this external exposure is obtained by testing liquid forms of the pesticide in vivo and/o...

journal_title：Chemical research in toxicology

authors： Clarke JF,Cordery SF,Morgan NA,Knowles PK,Guy RH

更新日期：2015-02-16 00:00:00

abstract：:Bezafibrate is a hypolipidemic drug that belongs to the group of peroxisome proliferators because it binds to peroxisome proliferator-activated receptors type alpha (PPARs). Peroxisome proliferators produce a myriad of extraperoxisomal effects, which are not necessarily dependent on their interaction with PPARs. An in...

journal_title：Chemical research in toxicology

authors： Scatena R,Bottoni P,Vincenzoni F,Messana I,Martorana GE,Nocca G,De Sole P,Maggiano N,Castagnola M,Giardina B

更新日期：2003-11-01 00:00:00

abstract：:DNA molecules utilize adenine, thymine, cytosine, and guanine for coding genetic information. In addition to these four canonical nucleobases, DNA molecules also contain a variety of modified nucleobases that can control and regulate gene expression and chromosome structure. Elucidating the functions of DNA modificati...

journal_title：Chemical research in toxicology

authors： Yuan BF

更新日期：2020-03-16 00:00:00

abstract：:1,N6-ethenoadenine (εA) is a mutagenic lesion and biomarker observed in numerous cancerous tissues. Two pathways are responsible for its repair: base excision repair (BER) and direct reversal repair (DRR). Alkyladenine DNA glycosylase (AAG) is the primary enzyme that excises εA in BER, generating stable intermediates ...

journal_title：Chemical research in toxicology

authors： Caffrey PJ,Kher R,Bian K,Li D,Delaney S

更新日期：2020-07-20 00:00:00

abstract：:The cytotoxicity of Al(2)O(3) nanoparticles (NP) at very low exposure levels (1 μg/mL and less) to a dominant bacterial isolate from freshwater (lake water), Bacillus licheniformis, was examined. Sterile lake water was directly used as a test medium or matrix to simulate the freshwater environment. Exposure to 1 μg/mL...

journal_title：Chemical research in toxicology

authors： Pakrashi S,Dalai S,Sabat D,Singh S,Chandrasekaran N,Mukherjee A

更新日期：2011-11-21 00:00:00

abstract：:Mouse cytochrome P450 2A5 (CYP2A5) is upregulated in various pathophysiological liver diseases and induced by structurally variable hepatotoxic chemicals. A putative common feature for all of these conditions is altered cellular redox status. Nuclear factor erythroid 2-like 2 (Nrf2) is a transcription factor that is p...

journal_title：Chemical research in toxicology

authors： Lämsä V,Levonen AL,Leinonen H,Ylä-Herttuala S,Yamamoto M,Hakkola J

更新日期：2010-05-17 00:00:00

abstract：:Successful early attrition of potential problematic compounds is of great importance in the pharmaceutical industry. The lead compound in a recent project targeting neuropathic pain was susceptible to metabolic bioactivation, which produced reactive metabolites and showed covalent binding to protein. Therefore, as a p...

journal_title：Chemical research in toxicology

authors： Lenz EM,Martin S,Schmidt R,Morin PE,Smith R,Weston DJ,Bayrakdarian M

更新日期：2014-06-16 00:00:00

abstract：:The conjugation of reactive drug metabolites to GSH is considered an important detoxification mechanism that can be spontaneous and/or mediated by glutathione S-transferases (GSTs). In case GSTs play an important role in GSH conjugation, genetically determined deficiencies in GSTs may be a risk factor for adverse drug...

journal_title：Chemical research in toxicology

authors： Dragovic S,Boerma JS,van Bergen L,Vermeulen NP,Commandeur JN

更新日期：2010-09-20 00:00:00

abstract：:While considerable effort has been expended on determining the health effects of exposure to typical urban concentrations of O3, little is known about the chemical events responsible for toxicity. Phospholipids containing unsaturated fatty acids in the cell membranes of lung cells are likely reaction sites for inhaled...

journal_title：Chemical research in toxicology

authors： Santrock J,Gorski RA,O'Gara JF

更新日期：1992-01-01 00:00:00

abstract：:The .CCl3 radical generated during the metabolism of CCl4 is readily spin trapped in vivo and in vitro by phenyl N-tert-butylnitrone (PBN) to form the stable PBN/.CCl3 radical adduct, which can then be extracted into organic solvents and detected by ESR spectroscopy. We have used this technique to examine the proposed...

journal_title：Chemical research in toxicology

authors： Hanna PM,Kadiiska MB,Jordan SJ,Mason RP

更新日期：1993-09-01 00:00:00

abstract：:Exposure to the tobacco-related nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine is carcinogenic to humans. Metabolic activation of NNK leads to the formation of DNA adducts, which play a critical role in NNK carcinogenesis. Adducts specific to NNK result from covalent linkag...

journal_title：Chemical research in toxicology

authors： Sturla SJ,Scott J,Lao Y,Hecht SS,Villalta PW

更新日期：2005-06-01 00:00:00

abstract：:The pharmacodynamics of rat hepatic cytochrome P450 2B (P450 2B) induction by phenobarbital (PB) and two structural congeners, dl-5-ethyl-5-phenylhydantoin (EPH) and dl-5-ethyl-5-phenyloxazolidinedione (EPO), were investigated. The in vivo induction of P450 2B was probed in F344/NCr rats by measuring immunoreactive he...

journal_title：Chemical research in toxicology

authors： Nims RW,Sinclair PR,Sinclair JF,Thomas PE,Jones CR,Mellini DW,Syi JL,Lubet RA

更新日期：1993-03-01 00:00:00

abstract：:Antineoplastic therapy with anthracyclines like doxorubicin (DOX) and daunorubicin (DNR) is limited by the possible development of a dose-related cardiomyopathy. Secondary alcohol metabolites like doxorubicinol (DOXol) and daunorubicinol (DNRol), formed by cytoplasmic two-electron reductases, have been implicated as p...

journal_title：Chemical research in toxicology

authors： Silvestrini A,Meucci E,Vitali A,Giardina B,Mordente A

更新日期：2006-11-01 00:00:00

abstract：:1-{4-[(4-Phenyl-5-trifluoromethyl-2-thienyl)methoxy]benzyl}azetidine-3-carboxylic acid (MRL-A) is a potent sphingosine-1-phosphate-1 receptor agonist, with potential application as an immunosuppressant in organ transplantation or for the treatment of autoimmune diseases. When administered orally to rats, radiolabeled ...

journal_title：Chemical research in toxicology

authors： Aloysius H,Tong VW,Yabut J,Bradley SA,Shang J,Zou Y,Tschirret-Guth RA

更新日期：2012-07-16 00:00:00

abstract：:The importance of adsorption, distribution, metabolism, excretion, and toxicity (ADMET) analysis is expected to grow substantially due to recent failures in detecting severe toxicity issues of new chemical entities during preclinical/clinical development. Traditionally, safety risk assessment studies for humans have b...

journal_title：Chemical research in toxicology

authors： Goracci L,Valeri A,Sciabola S,Aleo MD,Moritz W,Lichtenberg J,Cruciani G

更新日期：2020-01-21 00:00:00

abstract：:2'-Deoxyoxanosine (dOxo) is a novel DNA lesion produced from dGuo by reaction with nitrous acid or nitric oxide [Suzuki, T., Yamaoka, R., Nishi, M., Ide, H., and Makino, K. (1996) J. Am. Chem. Soc. 118, 2515-2516]. We investigated the reaction of dOxo with glycine (Gly) under physiological conditions. When 5 mM dOxo w...

journal_title：Chemical research in toxicology

authors： Suzuki T,Yamada M,Ide H,Kanaori K,Tajima K,Morii T,Makino K

更新日期：2000-04-01 00:00:00

abstract：:Nuclei from human lymphoblast cells grown in culture were treated with [7-14C]-(+/-)-r-7,t-8-dihydroxy-t-9,t-10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene (anti-BPDE), and the nucleosomal core histones were isolated for adduct studies by cryogenic fluorescence line narrowing spectroscopy. The four core histones H2A, H2B...

journal_title：Chemical research in toxicology

authors： SooHoo CK,Singh K,Skipper PL,Tannenbaum SR,Dasari RR

更新日期：1994-03-01 00:00:00

abstract：:The metabolic pathway of tetrodotoxin (TTX), a powerful and specific voltage-gated sodium channel blocker, has not been well-clarified either in TTX-poisoned patients or in puffer fish. 4-S-CysteinylTTX (4-CysTTX) was isolated from the liver of the puffer fish, Fugu pardalis, as the first adduct of TTX with thiol. The...

journal_title：Chemical research in toxicology

authors： Yotsu-Yamashita M,Goto A,Nakagawa T

更新日期：2005-05-01 00:00:00

abstract：:To reveal the roles of Y family DNA polymerases in the mutagenesis induced by oxidatively damaged DNA precursors, 2-hydroxy-dATP (2-OH-dATP) and 8-hydroxy-dGTP (8-OH-dGTP) were introduced into Escherichia coli strains deficient in the Y family polymerases, DNA polymerase IV (pol IV, encoded by the dinB gene) and DNA p...

journal_title：Chemical research in toxicology

authors： Satou K,Yamada M,Nohmi T,Harashima H,Kamiya H

更新日期：2005-08-01 00:00:00

abstract：:A new method was developed to quantify the levels of 1,3-butadiene (BD), butadiene monoxide (BDO), and butadiene diepoxide (BDO2) in blood. The method was based on vacuum distillation of tissues followed by analysis of the distillates using multidimensional GC/MS. Metabolites isolated from blood by vacuum distillation...

journal_title：Chemical research in toxicology

authors： Bechtold WE,Strunk MR,Thornton-Manning JR,Henderson RF

更新日期：1995-03-01 00:00:00

abstract：:Arsenic is a human carcinogen, causing skin, bladder, and lung cancers. Although arsenic in drinking water affects millions of people worldwide, the mechanism(s) of action by which arsenic causes cancers is not known. Arsenic probably exerts some toxic effects by binding with proteins. However, few experimental data a...

journal_title：Chemical research in toxicology

authors： Jiang G,Gong Z,Li XF,Cullen WR,Le XC

更新日期：2003-07-01 00:00:00

abstract：:Sugars and sugar degradation products react in vivo readily with proteins (glycation) resulting in the formation of a heterogeneous group of reaction products, which are called advanced glycation end products (AGEs). AGEs notably change the structure and function of proteins so that extended protein-AGE formation is l...

journal_title：Chemical research in toxicology

authors： Schneider M,Thoss G,Hübner-Parajsz C,Kientsch-Engel R,Stahl P,Pischetsrieder M

更新日期：2004-10-01 00:00:00

abstract：:The Salmonella typhimurium (TA100) mutagenic compound, mucochloric acid [3,4-dichloro-5-hydroxy-2(5H)-furanone (MCA)], was inactivated by in vitro N-acetylcysteine (NAC). The reaction of MCA with NAC at pH7 was second order and gave products 4, 5, and 6a that resulted from the displacement of chlorine from C-3 or C-4 ...

journal_title：Chemical research in toxicology

authors： LaLonde RT,Xie S

更新日期：1992-09-01 00:00:00

abstract：:Nanoparticles can reach the blood and cause inflammation, suggesting that nanoparticles-endothelial cells interactions may be pathogenically relevant. We evaluated the effect of titanium dioxide nanoparticles (TiO₂) on proliferation, death, and responses related with inflammatory processes such as monocytic adhesion a...

journal_title：Chemical research in toxicology

authors： Montiel-Dávalos A,Ventura-Gallegos JL,Alfaro-Moreno E,Soria-Castro E,García-Latorre E,Cabañas-Moreno JG,del Pilar Ramos-Godinez M,López-Marure R

更新日期：2012-04-16 00:00:00

abstract：:Derivatives of methyl 3-(1-methyl-5-(1-methyl-5-(propylcarbamoyl)-1H-pyrrol-3-ylcarbamoyl)-1H-pyrrol-3-ylamino)-3-oxopropane-1-sulfonate (1), a peptide-based DNA minor groove binding methylating agent, were synthesized and characterized. In all cases, the N-terminus was appended with an O-methyl sulfonate ester, while...

journal_title：Chemical research in toxicology

authors： Iyer P,Srinivasan A,Singh SK,Mascara GP,Zayitova S,Sidone B,Fouquerel E,Svilar D,Sobol RW,Bobola MS,Silber JR,Gold B

更新日期：2013-01-18 00:00:00