Fetal fracture healing in a lamb model.

Abstract:

:A large animal model to assess fetal fracture repair and the ability to close excisional bony defects is presented. Incisional and excisional ulnar fractures were made in 14 midgestation fetal lambs, harvested at serial time points, and subjected to high-resolution low-kilovolt magnification radiographs, magnetic resonance imaging scans, and histologic analysis. Fetal fracture healing was characterized by early closure of excisional defects and rapid fracture healing with minimal or no soft-tissue inflammation or callus formation. Magnetic resonance imaging scans of the fractures revealed a characteristic pattern compatible with the histologic findings, namely, minimal inflammation in soft tissue adjacent to the fracture site. Histologic and magnification radiographic findings indicated that complete bony repair occurred within 21 days in incisional defects and within 40 days in excisional defects. In both cases, healed fetal bone resembled normal bone matrix. Excisional defects, including periosteum, of greater than three times the width of the bony cortex closed rapidly with virtually normal-appearing bony matrix and with minimal or no callus formation.

journal_name

Plast Reconstr Surg

authors

Longaker MT,Moelleken BR,Cheng JC,Jennings RW,Adzick NS,Mintorovich J,Levinsohn DG,Gordon L,Harrison MR,Simmons DJ

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

161-71; discussion 172-3

issue

2

eissn

0032-1052

issn

1529-4242

journal_volume

90

pub_type

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