Iloprost improves survival of ischemic experimental skin flaps.

Abstract:

:The ability of the prostacyclin analogue iloprost to improve survival of ischemic experimental skin flaps was investigated. Unilateral island skin flaps based on the superficial inferior epigastric vessels were raised in 70 rats and subjected to varying lengths of primary ischemia. The flaps were divided into the following four groups: group I, no perfusion washout; group II, postischemic washout with lactated Ringer's solution; group III, postischemic washout with urokinase; and group IV, postischemic washout with iloprost. Flap survival rates for group IV were significantly higher than all other groups (p < 0.05). The primary ischemia time at which 50% of the flaps failed was 8.9 hours for group I, 9.5 hours for group II, 13.3 hours for group III, and 15.3 hours for group IV. This is the first study to investigate the effect of iloprost on skin flap survival. Iloprost was found to be significantly more effective than urokinase in salvaging ischemic experimental skin flaps.

journal_name

Ann Plast Surg

authors

Senderoff DM,Israeli D,Zhang WX,Urken ML,Weinberg H

doi

10.1097/00000637-199405000-00009

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

490-5

issue

5

eissn

0148-7043

issn

1536-3708

journal_volume

32

pub_type

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