Safety and efficacy of nebulized lignocaine in patients with cancer and breathlessness.

Abstract:

:Although anecdotal reports suggest nebulized lignocaine may help breathlessness in patients with cancer this has not been examined formally. We report a pilot study comparing nebulized lignocaine 100 mg and 200 mg with saline in six patients with cancer who were breathless at rest. Nebulized lignocaine was well tolerated apart from mild bronchoconstriction in two patients after the 200 mg dose and the unpleasant taste; serum concentrations were below levels at which toxicity has been reported. The effort of breathing (measured on a visual analogue scale) did not differ between treatments, whereas the distress of breathing was less after saline than after either dose of lignocaine. These findings do not support the reported benefits of nebulized lignocaine.

journal_name

Palliat Med

journal_title

Palliative medicine

authors

Wilcock A,Corcoran R,Tattersfield AE

doi

10.1177/026921639400800106

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

35-8

issue

1

eissn

0269-2163

issn

1477-030X

journal_volume

8

pub_type

杂志文章
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