Abstract：
:In order to assess the role of collagens I and IV during the angiogenic process associated with bleomycin-induced pulmonary fibrosis in rat, in situ hybridization and immunocytochemical studies were carried out. An increased expression of collagen IV was observed before an enhanced expression of collagen I after intratracheal instillation of bleomycin. Deposits of both collagen types were detected on the 21st day after treatment with bleomycin, surrounding the new blood vessels formed during the fibrotic process. At this time, the presence of new lymphatic vessels was associated uniquely with deposition of collagen I. These observations lead us to conclude that, at least during pulmonary fibrosis, lymphangiogenesis takes place after blood angiogenesis.
journal_name
Lymphologyjournal_title
Lymphologyauthors
Teles-Grilo ML,Leite-Almeida H,Martins dos Santos J,Oliveira C,Boaventura P,Grande NRsubject
Has Abstractpub_date
2005-09-01 00:00:00pages
130-5issue
3eissn
0024-7766issn
2522-7963journal_volume
38pub_type
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