Abstract：
:The current literature suggests that atypical (benign atypia or class II) Papanicolaou smears occur at a frequency of 1.6-5.4% and are associated with a substantial rate of underlying cervical dysplasia. However, we noted that our rate of atypia exceeded these figures, particularly in our clinic population. To quantify this observation, 1107 consecutive Papanicolaou smears from the clinic population were audited prospectively and compared with 262 consecutive Papanicolaou smears performed contemporaneously in private patients served by the same laboratory. The rate of histologic dysplasia underlying this diagnosis was assessed by analyzing the results of 101 consecutive colposcopic examinations performed subsequently on clinic patients evaluated for persistently atypical cytology (atypical index smear followed by repeat cytology scheduled 2-4 months later). The prevalence of atypia in the clinic population was 321 of 1107 (29%; 95% confidence interval [CI] 26-32%), a rate 2.3 times that of the private patients (33 of 262, 13%) (P less than .001). Eighteen of 101 clinic patients with persistent atypia had dysplasia (18%; 95% CI 11-25%), and 25 of 101 (25%; 95% CI 17-33%) had human papillomavirus infection, both documented by the histology of directed cervical biopsies. Cervical intraepithelial neoplasia grade II or higher was present in three of these 18 women (17%; 95% CI 6-39%). We conclude that some populations have atypical cervical cytology at a frequency much greater than that reported previously. Furthermore, the pathology underlying this diagnosis is considerable and warrants evaluation. The optimal management of atypical cervical cytology in such populations is problematic.
journal_name
Obstet Gynecoljournal_title
Obstetrics and gynecologyauthors
Pearlstone AC,Grigsby PW,Mutch DGsubject
Has Abstractpub_date
1992-08-01 00:00:00pages
191-5issue
2eissn
0029-7844issn
1873-233Xjournal_volume
80pub_type
杂志文章abstract：OBJECTIVE:To determine if bacteria are capable of producing phosphatidylglycerol in amniotic fluid (AF) and the number of colony forming units (CFU) of bacteria necessary to produce this result. METHODS:Eleven species of bacteria and one species of yeast, common to the female genital tract and implicated in chorioamni...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0029-7844(95)00032-m
更新日期：1995-05-01 00:00:00
abstract：:The relationship between placental and peripheral concentrations of pregnancy-associated plasma protein A (PAPP-A) was investigated, using specific radioimmunoassay techniques. At term, placental concentrations of PAPP-A were significantly lower in diabetic pregnancies; 1.9 +/- 0.2 micrograms/mg (mean +/- SE) placenta...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/00006250-198609000-00019
更新日期：1986-09-01 00:00:00
abstract：:Adverse outcomes, preventable or otherwise, are a reality of medical care. Most importantly, adverse events affect patients, but they also affect health care practitioners. Disclosing information about adverse events has benefits for the patient and the physician and, ideally, strengthens the patient-physician relatio...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000001813
更新日期：2016-12-01 00:00:00
abstract：:The 15-methyl analog of prostaglandin F2 alpha (15-ME-PGF2 alpha), administered in a 3-mg dose via a single vaginal suppository and supplemented at 24 hours by intramuscular injection(s) of 250 micrograms, successfully induced abortion in 80 of 81 patients in the midtrimester of pregnancy. The mean abortion time was 1...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1981-07-01 00:00:00
abstract：:The prognostic significance of residual endometrial carcinoma in the hysterectomy specimen after preoperative radiotherapy is controversial. Sixty-two patients with stage II endometrial carcinoma were treated with a standardized program of preoperative radiotherapy, followed in six weeks by an extrafascial hysterectom...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1987-12-01 00:00:00
abstract：BACKGROUND:Intravascular fetal transfusion is an important therapeutic advance but is associated with several complications. Regression of an umbilical artery associated with transfusion is rare. CASE:A case of red blood cell alloimmunization managed by serial transfusions was complicated by functional loss of an umbi...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(98)00502-x
更新日期：1999-05-01 00:00:00
abstract：OBJECTIVE:To develop a curriculum for residents in obstetrics and gynecology that also provides training in family medicine. METHODS:We designed a 5-year curriculum with 36 months of obstetrics and gynecology, 12 of which are as chief resident, with a 4-month rotation through family medicine to meet the primary care r...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1999-08-01 00:00:00
abstract：OBJECTIVE:To evaluate postpartum blood loss in women with treated intrahepatic cholestasis of pregnancy. METHODS:In a retrospective case-control study, 15,083 deliveries including 348 women with intrahepatic cholestasis of pregnancy (2.3%) were analyzed from 2004 to 2014. To adjust for differences in baseline characte...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000001693
更新日期：2016-11-01 00:00:00
abstract：OBJECTIVE:To use a number of methods to control for confounding and selection bias to examine the association between lymphadenectomy and survival in a large cohort of women with endometrial cancer. METHODS:A retrospective cohort study using the National Cancer Data Base was performed to identify women with endometrio...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000001194
更新日期：2016-01-01 00:00:00
abstract：:This study reports serum levels of relaxin in normal and special-interest pregnancies using an homologous radioimmunoassay for human relaxin. The mean levels in uncomplicated antenatal patients were lower than those reported in studies using heterologous assays, but the trend in serum levels was similar. Serum levels ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1987-04-01 00:00:00
abstract：:Fifteen women weighing more than 250 pounds (113.6 kg) underwent laparoscopy. The open technique was used in two patients electively because of repeated pelvic laparotomies through periumbilical incisions. Of the remainder, four had used the closed technique and in nine it was necessary to adopt an open technique. Use...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1987-03-01 00:00:00
abstract：OBJECTIVE:To estimate whether the time interval between cervical conization and subsequent pregnancy is associated with risk of preterm birth. METHODS:Our study is a case control study nested in a retrospective cohort. Women who underwent colposcopic biopsy or conization with loop electrosurgical excision procedure, l...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/01.AOG.0000251497.55065.74
更新日期：2007-02-01 00:00:00
abstract：:Although cryosurgery is regularly used for treatment of cervical intraepithelial neoplasia (CIN), there are few data concerning freeze technique and attendant extension of the cryolesion. This study evaluated how to create cryolesions extensive enough to eradicate the CIN lesion completely. The way the extension of th...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1990-02-01 00:00:00
abstract：:Tubal reanastomosis was performed in 32 patients using microsurgical techniques. In 25 women, occlusion was due to prior sterilization. A splint was not used during or after repair. Intrauterine pregnancy occurred in 21 (84%) and fetal loss in 6% of 17 potentially viable pregnancies. The mean midluteal serum progester...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1981-05-01 00:00:00
abstract：:This study attempted to elucidate the etiology of cervical cancer by examining its association with a number of factors in a relatively unselected group of women. In 1963, a cytologic screening program was undertaken in Washington County, Maryland. The irrigation smear method was used. The final study group of 4341...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1966-10-01 00:00:00
abstract：OBJECTIVE:To examine the relationship between an obstetrician's delivery volume and a patient's risk for cesarean delivery. METHODS:This retrospective cohort study examined patient-level and obstetrician-level data between 2000 and 2012 at a large academic hospital. All laboring patients who delivered viable, liveborn...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000000473
更新日期：2014-10-01 00:00:00
abstract：:To evaluate the effects of maternal magnesium sulfate treatment on neonatal magnesium and calcium homeostasis, the authors studied 23 term neonates whose mothers had received intravenous magnesium sulfate for pre-eclampsia and compared them with 14 control neonates. Total and ionized calcium, magnesium, phosphorus, an...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1980-11-01 00:00:00
abstract：:The histologic diagnoses of premalignant and malignant lesions of the cervix obtained by examining the colposcopically directed biopsy material from 643 patients were compared with those of the surgical material subsequently obtained. The procedures during which samples were acquired included hysterectomy (370), cervi...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1981-08-01 00:00:00
abstract：:Ultrasonic surgical aspiration is a useful technique for safe and accurate tissue removal. This study was conducted to evaluate its role in noninvasive vulvar disease. From December 1988 to March 1990, 27 patients underwent ultrasonic surgery; nine patients had vulvar intraepithelial neoplasia (VIN) and 18 had condylo...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1991-04-01 00:00:00
abstract：:This month we focus on current research in human papillomavirus-related lower anogenital tract disease prevention and screening. Dr. Boardman discusses four recent publications, which are concluded with a "bottom line" that is the take-home message. The complete reference for each can be found in on this page, along w...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000001081
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVE:To review facility-based maternal deaths at a tertiary-level center in Johannesburg, South Africa, during a 5-year period (2003 to 2007) and to investigate the proportion of deaths attributable to human immunodeficiency virus (HIV), the etiology of deaths, and the effects of antiretroviral treatment introduce...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0b013e3181af33e6
更新日期：2009-08-01 00:00:00
abstract：OBJECTIVE:To estimate the detection rate of abnormalities by transvaginal ultrasound in early pregnancy. METHODS:We prospectively analyzed records of 3592 sequential pregnant women at 10-16 weeks' (singleton) gestation (mean 13 weeks and 2 days). After exclusion of 114 women, there were 3478 women in the study. Each w...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(00)00951-0
更新日期：2000-09-01 00:00:00
abstract：BACKGROUND:A pregnancy with Gorham disease (massive osteolysis syndrome) is described. To our knowledge, this is the first reported case of a pregnancy associated with this disease. CASE:A 25-year-old woman was seen for pre-conception counseling with the diagnosis of Gorham disease. Before pregnancy, magnetic resonanc...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1993-05-01 00:00:00
abstract：:Karyotypes of chorionic villi have been said to be less accurate than karyotypes of amniocytes. Karyotypic differences between placental and fetal tissue and maternal-cell contamination could potentially complicate clinical management. We compared cytogenetic results obtained by chorionic villus sampling and amniotic ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1989-11-01 00:00:00
abstract：:A case of endometrioid carcinoma arising in endometriosis of the fallopian tube is described. One case of tubal endometrioid carcinoma has been reported previously, but the entity has not hitherto been recognized among primary fallopian tube tumors. The clinical presentations, histopathology, and pathogenesis of this ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1978-07-01 00:00:00
abstract：OBJECTIVE:To evaluate whether there is an increased risk of cesarean delivery in women who delay childbearing into their later reproductive years, using a well-defined cohort and controlling for difference in baseline susceptibility such as complications of pregnancy and labor. METHODS:The current study included all w...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1993-02-01 00:00:00
abstract：OBJECTIVES:To estimate the number of women who will have symptomatic pelvic floor disorders in the United States from 2010 to 2050. METHODS:We used population projections from the U.S. Census Bureau from 2010 to 2050 and published age-specific prevalence estimates for bothersome, symptomatic pelvic floor disorders (ur...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0b013e3181c2ce96
更新日期：2009-12-01 00:00:00
abstract：OBJECTIVE:To estimate the incidence of endocervical dysplasia in women with cervical cytology of atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial lesion (SIL) who have a satisfactory and normal colposcopic examination. METHODS:An electronic colposcopy database was revi...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(00)00821-8
更新日期：2000-06-01 00:00:00
abstract：:Variations of urethral pressure were registered with microtransducers in 427 gynecologic patients with lower urinary tract symptoms during urethrocystometry. Urethral instability (variation of urethral pressure greater than 15 cm of water) was found in 16.4% of patients. The comparison of the urinary symptoms and the ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：:A preliminary report is made of 11 patients of childbearing age treated for symptomatic uterine prolapse by a suspension technic employing straps of external oblique aponeurosis according to the method of Williams and Richardson. In a relatively short period of follow-up, the operative results have been excellent in a...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1967-08-01 00:00:00
