Abstract:
:A hypothesis, and supporting evidence, is presented for the sudden infant death syndrome (SIDS). Our model is as follows. Fetal hemoglobin levels are abnormally elevated in SIDS infants, which contributes to a state of chronic hypoxia. Chronic hypoxia produces pronounced depressive effects on the respiratory system during slow wave sleep (a state of normal respiratory depression). These depressive effects are particularly manifest during that period of development in which slow wave sleep begins to occupy a very large percentage of total sleep time in infants -2-4 mo of age. A downward spiral is initiated in slow wave sleep such that hypoxia-induced decreases in ventilation produce more extreme hypoxia leading to further respiratory depression and ultimately death due to a cessation of respiration.
journal_name
Neurosci Biobehav Revjournal_title
Neuroscience and biobehavioral reviewsauthors
Vertes RP,Perry GWdoi
10.1016/s0149-7634(05)80014-4subject
Has Abstractpub_date
1993-10-01 00:00:00pages
305-12issue
3eissn
0149-7634issn
1873-7528pii
S0149-7634(05)80014-4journal_volume
17pub_type
杂志文章,评审abstract::The neurovisceral integration (NVI) model was originally proposed to account for observed relationships between peripheral physiology, cognitive performance, and emotional/physical health. This model has also garnered a considerable amount of empirical support, largely from studies examining cardiac vagal control. How...
journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
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更新日期:2017-04-01 00:00:00
abstract::Down syndrome (DS) is the most common genetic intellectual disability, caused by the triplication of the human chromosome 21 (HSA21). Although this would theoretically lead to a 1.5 fold increase in gene transcription, transcript levels of many genes significantly deviate. Surprisingly, the underlying cause of this ge...
journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
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journal_title:Neuroscience and biobehavioral reviews
pub_type: 杂志文章,评审
doi:10.1016/j.neubiorev.2017.09.008
更新日期:2017-12-01 00:00:00