Sudden infant death syndrome: a theory.

Abstract:

:A hypothesis, and supporting evidence, is presented for the sudden infant death syndrome (SIDS). Our model is as follows. Fetal hemoglobin levels are abnormally elevated in SIDS infants, which contributes to a state of chronic hypoxia. Chronic hypoxia produces pronounced depressive effects on the respiratory system during slow wave sleep (a state of normal respiratory depression). These depressive effects are particularly manifest during that period of development in which slow wave sleep begins to occupy a very large percentage of total sleep time in infants -2-4 mo of age. A downward spiral is initiated in slow wave sleep such that hypoxia-induced decreases in ventilation produce more extreme hypoxia leading to further respiratory depression and ultimately death due to a cessation of respiration.

journal_name

Neurosci Biobehav Rev

authors

Vertes RP,Perry GW

doi

10.1016/s0149-7634(05)80014-4

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

305-12

issue

3

eissn

0149-7634

issn

1873-7528

pii

S0149-7634(05)80014-4

journal_volume

17

pub_type

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