当前位置： SCI文献检索 > EUROPEAN JOURNAL OF ENDOCRINOLOGY期刊下所有文献 > Three-month sustained-release triptorelin (11.25 mg) in the treatment of central precocious puberty.

Three-month sustained-release triptorelin (11.25 mg) in the treatment of central precocious puberty.

Abstract：

OBJECTIVE:Depot GnRH agonists are commonly used in the treatment of central precocious puberty (CPP). The triptorelin 11.25 mg 3-month depot, currently used in adult indications, had not previously been evaluated in CPP. DESIGN:This was a multicenter, open-label, 12 month trial conducted in 64 CPP children (54 girls and 10 boys), treated quarterly. METHODS:Children with a clinical onset of pubertal development before the age of 8 years (girls) or 9 years (boys), pubertal response of LH to GnRH > or = 7 IU/l, advanced bone age > 1 year, enlarged uterus (> or = 36 mm) and testosterone level > or = 0.5 ng/ml (boys), were included. Suppression of gonadotropic activation, as determined from serum LH, FSH, estradiol or testosterone, and pubertal signs were assessed at Months 3, 6 and 12. RESULTS:GnRH-stimulated peak LH < or = 3 IU/l, the main efficacy criterion, was met in 53 out of 62 (85%), 60 out of 62 (97%) and 56 out of 59 (95%) of the children at Months 3, 6 and 12 respectively. Serum FSH and sex steroids were also significantly reduced, while pubertal development regressed in most patients. Mean residual triptorelin levels were stable from Month 3 through to Month 12. The triptorelin 3-month depot was well tolerated. Severe injection pain was experienced in only one instance. Five girls experienced mild-to-moderate or severe (one girl) withdrawal bleeding. CONCLUSIONS:The triptorelin 3-month depot efficiently suppresses the pituitary-gonadal axis and pubertal development in children with CPP. This formulation allows a 3-fold reduction, over the once-a-month depot, in the number of i.m. injections required each year.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Carel JC,Blumberg J,Seymour C,Adamsbaum C,Lahlou N,Triptorelin 3-month CPP Study Group.

doi

10.1530/eje.1.02056

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

119-24

issue

1

eissn

0804-4643

issn

1479-683X

pii

154/1/119

journal_volume

154

pub_type

临床试验,杂志文章,多中心研究

相关文献

EUROPEAN JOURNAL OF ENDOCRINOLOGY文献大全
  • Expression of nitric oxide synthase III in human thyroid follicular cells: evidence for increased expression in hyperthyroidism.

    abstract：:Nitric oxide mediates a wide array of cellular functions in many tissues. It is generated by three known isoforms of nitric oxide synthases (NOS). Recently, the endothelial isoform, NOSIII, was shown to be abundantly expressed in the rat thyroid gland and its expression increased in goitrous glands. In this study, we ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1360649

    authors： Colin IM,Kopp P,Zbären J,Häberli A,Grizzle WE,Jameson JL

    更新日期：1997-06-01 00:00:00

  • Higher free thyroxine levels are associated with all-cause mortality in euthyroid older men: the Health In Men Study.

    abstract：OBJECTIVE:Thyroid dysfunction predicts poorer health outcomes, but the relationship between thyroid hormone levels within the reference range and mortality in older adults remains unclear. In this study, we examined the associations between the concentrations of free thyroxine (FT4) and TSH and all-cause mortality in o...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-13-0306

    authors： Yeap BB,Alfonso H,Hankey GJ,Flicker L,Golledge J,Norman PE,Chubb SA

    更新日期：2013-09-12 00:00:00

  • 17 beta-estradiol stimulates a rapid Ca2+ influx in LNCaP human prostate cancer cells.

    abstract：:Prostate growth is known to be controlled by steroids such as androgens and estradiol. For this reason steroids (estradiol, adrenal androgens) or steroid inhibitors are commonly used as palliative treatments for prostate carcinoma. In view of the pivotal role played by Ca2+ ions in cell proliferation, we decided to in...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1350367

    authors： Audy MC,Vacher P,Duly B

    更新日期：1996-09-01 00:00:00

  • Clinical and molecular analysis of three families with autosomal dominant neurohypophyseal diabetes insipidus associated with a novel and recurrent mutations in the vasopressin-neurophysin II gene.

    abstract：OBJECTIVE:To test further the hypothesis that autosomal dominant neurohypophyseal diabetes insipidus (adFNDI) is caused by heterozygous mutations in the vasopressin-neurophysin II (AVP-NPII) gene that exert a dominant negative effect by producing a precursor that misfolds, accumulates and eventually destroys the neuros...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1460649

    authors： Rutishauser J,Kopp P,Gaskill MB,Kotlar TJ,Robertson GL

    更新日期：2002-05-01 00:00:00

  • Androgen receptor gene GGN repeat length and reproductive characteristics in young Swedish men.

    abstract：BACKGROUND:The human androgen receptor (AR) gene contains two polymorphisms of CAG and GGN repeats respectively. The GGN repeat function is still largely unknown and to date there are no in vivo data on this segment with respect to the general population. METHODS:We investigated the impact of CAG and GGN repeats on ma...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.02204

    authors： Lundin KB,Giwercman YL,Rylander L,Hagmar L,Giwercman A

    更新日期：2006-08-01 00:00:00

  • Acute changes in endocrine and fluid balance markers during high-intensity, steady-state, and prolonged endurance running: unexpected increases in oxytocin and brain natriuretic peptide during exercise.

    abstract：:Maintenance of fluid homeostasis during periods of heightened physical stress can be best evaluated in humans using exercise as a model. Although it is well established that arginine vasopressin (AVP), aldosterone and atrial natriuretic peptide (ANP) are the principle hormones regulating fluid balance at rest, the pot...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-08-0064

    authors： Hew-Butler T,Noakes TD,Soldin SJ,Verbalis JG

    更新日期：2008-12-01 00:00:00

  • Associations between subcutaneous fat density and systemic inflammation differ by HIV serostatus and are independent of fat quantity.

    abstract：Objectives:Adipose tissue (AT) density measurement may provide information about AT quality among people living with HIV. We assessed AT density and evaluated relationships between AT density and immunometabolic biomarker concentrations in men with HIV. Design:Cross-sectional analysis of men enrolled in the Multicente...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,多中心研究

    doi：10.1530/EJE-19-0296

    authors： Lake JE,Debroy P,Ng D,Erlandson KM,Kingsley LA,Palella FJ,Budoff MJ,Post WS,Brown TT

    更新日期：2019-10-01 00:00:00

  • Discriminating between virilizing ovary tumors and ovary hyperthecosis in postmenopausal women: clinical data, hormonal profiles and image studies.

    abstract：BACKGROUND:The presence of virilizing signs associated with high serum androgen levels in postmenopausal women is rare. Virilizing ovarian tumors (VOTs) and ovarian stromal hyperthecosis (OH) are the most common etiologies in virilized postmenopausal women. The differential diagnosis between these two conditions is oft...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-17-0111

    authors： Yance VRV,Marcondes JAM,Rocha MP,Barcellos CRG,Dantas WS,Avila AFA,Baroni RH,Carvalho FM,Hayashida SAY,Mendonca BB,Domenice S

    更新日期：2017-07-01 00:00:00

  • Serum free insulin-like growth factor-I in growth hormone-deficient adults before and after growth hormone replacement.

    abstract：:The objective of the present study was to compare fasting levels of free IGF-I in serum from patients with adult onset growth hormone deficiency (GHD) and from healthy volunteers, and to examine the effect of GH replacement therapy in GHD on serum free IGF-I. Free IGF-I was measured using separation of free IGF-I by u...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1530/eje.0.1370132

    authors： Skjaerbaek C,Vahl N,Frystyk J,Hansen TB,Jørgensen JO,Hagen C,Christiansen JS,Orskov H

    更新日期：1997-08-01 00:00:00

  • Effect of supplemental vitamin D and calcium on serum sclerostin levels.

    abstract：OBJECTIVE:Serum sclerostin levels have been reported to be inversely associated with serum 25OHD levels, but the effect of vitamin D and calcium supplementation on serum sclerostin levels is unknown. This study was carried out to determine whether vitamin D and calcium supplementation altered serum sclerostin levels in...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1530/EJE-13-0862

    authors： Dawson-Hughes B,Harris SS,Ceglia L,Palermo NJ

    更新日期：2014-03-13 00:00:00

  • Changes in the prevalence of hypothyroidism: the HUNT Study in Norway.

    abstract：OBJECTIVE:Untreated hypothyroidism is common in iodine-replete areas. Frequent thyroid function testing and use of levothyroxine treatment for subclinical hypothyroidism suggest that the prevalence may have decreased. Therefore, in this study, we examined changes in the prevalence of hypothyroidism in a Norwegian count...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-13-0459

    authors： Asvold BO,Vatten LJ,Bjøro T

    更新日期：2013-10-01 00:00:00

  • PRE-TERM BIRTH IN WOMEN EXPOSED TO CUSHING'S DISEASE: THE BABY-CUSH STUDY.

    abstract：:Design Hypercortisolism during pregnancy is a risk factor for prematurity. Long-term exposure to hypercortisolism may lead to permanent comorbidities, such as hypertension or diabetes, even after remission. Our aim was to determine whether women with a history of Cushing's disease (and being eu-, hypo- or hypercortiso...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-20-1224

    authors： Hochman C,Cristante J,Geslot A,Salenave S,Sonnet E,Briet C,Bachelot A,Chevalier N,Gilly O,Brue T,Hadjadj S,Kerlan V,Chanson P,Vezzosi D,Chabre O,Drui DD,Castinetti FF

    更新日期：2021-01-01 00:00:00

  • Age and stress as determinants of the severity of hyperthyroidism caused by Graves' disease in newly diagnosed patients.

    abstract：OBJECTIVE:The evidence that stress may provoke Graves' hyperthyroidism in genetically susceptible subjects is substantial. Whether exposure to stress is related to the severity of thyrotoxicosis has not been studied. Advancing age is associated with not only less severe Graves' hyperthyroidism but also self-reported st...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,多中心研究

    doi：10.1530/EJE-08-0573

    authors： Vos XG,Smit N,Endert E,Brosschot JF,Tijssen JG,Wiersinga WM

    更新日期：2009-02-01 00:00:00

  • Modulating effect of human growth hormone on tumour necrosis factor-alpha and interleukin-1beta.

    abstract：:We measured serum tumour necrosis factor-alpha (TNF-alpha) as well as interleukin-1betta (IL-1beta) and GH concentrations in 15 children with isolated growth hormone deficiency (GHD), age range 5.1-13.9 years, before and 4 and 24h after the first GH injection (0.1 IU/kg s.c.). No differences were found in basal concen...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1380640

    authors： Bozzola M,De Amici M,Zecca M,Schimpff RM,Rapaport R

    更新日期：1998-06-01 00:00:00

  • Early post-transplantation hypophosphatemia is associated with elevated FGF-23 levels.

    abstract：BACKGROUND:We examined the hypothesis that high FGF-23 levels early after transplantation contribute to the onset of hypophosphatemia, independently of parathyroid hormone (PTH) and other factors regulating phosphate metabolism. METHODS:We measured serum phosphate levels (sPi), renal tubular reabsorption of Pi (TmPi/G...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-10-1150

    authors： Trombetti A,Richert L,Hadaya K,Graf JD,Herrmann FR,Ferrari SL,Martin PY,Rizzoli R

    更新日期：2011-05-01 00:00:00

  • Some studies on the natural history of Graves' orbitopathy: increase in orbital fat is a rather late phenomenon.

    abstract：AIM:To describe volumes of orbital fat (FV) and extraocular muscles (MV) in Graves' orbitopathy (GO) as a function of the duration of GO. PATIENTS:i) Cross-sectional survey among 95 consecutive patients with untreated GO who had been referred to the combined thyroid-eye clinics of our university hospital. ii) Longitud...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-14-1140

    authors： Potgieser PW,Wiersinga WM,Regensburg NI,Mourits MP

    更新日期：2015-08-01 00:00:00

  • Simplified and improved fluid deprivation test for diagnosing diabetes insipidus.

    abstract：Objective:The challenge of finding patients with the rare conditon of diabetes insipidus in need of vasopressin treatment is demanding. The guidelines for performing the fluid deprivation test and interpreting the results are abundant. We evaluated the discriminative capacity of the fluid deprivation test in patients w...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-20-0759

    authors： Sjöström A,Bartuseviciene I,Höybye C

    更新日期：2021-01-01 00:00:00

  • Abiraterone acetate treatment lowers 11-oxygenated androgens.

    abstract：Context:The human adrenal is the dominant source of androgens in castration-resistant prostate cancer (CRPC) and classic 21-hydroxylase deficiency (21OHD). Abiraterone, derived from the prodrug abiraterone acetate (AA), inhibits the activity of cytochrome P450 17-hydroxylase/17,20-lyase (CYP17A1), the enzyme required f...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-19-0905

    authors： Wright C,O'Day P,Alyamani M,Sharifi N,Auchus RJ

    更新日期：2020-04-01 00:00:00

  • Testosterone prevents protein loss via the hepatic urea cycle in human.

    abstract：CONTEXT:The urea cycle is a rate-limiting step for amino acid nitrogen elimination. The rate of urea synthesis is a true indicator of whole-body protein catabolism. Testosterone reduces protein and nitrogen loss. The effect of testosterone on hepatic urea synthesis in humans has not been studied. OBJECTIVE:To determin...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-16-0868

    authors： Lam T,Poljak A,McLean M,Bahl N,Ho KKY,Birzniece V

    更新日期：2017-04-01 00:00:00

  • Effects of growth hormone overproduction on grip strength of transgenic mice.

    abstract：:Growth hormone (GH) is used by athletes like bodybuilders to increase muscle strength and weight gain. On the other hand, chronic hypersecretion of GH in active acromegaly may result in outwardly hypertrophied but functionally weaker muscles. As a model for studying long-term effects of GH on muscle strength, we analy...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1330735

    authors： Wolf E,Wanke R,Schenck E,Hermanns W,Brem G

    更新日期：1995-12-01 00:00:00

  • Increased levels of serum osteoprotegerin in hypothyroid patients and its normalization with restoration of normal thyroid function.

    abstract：:Hypothyroidism is associated with increased morbidity from cardiovascular disease, and an increase in serum osteoprotegerin (OPG) has recently been reported to be associated with the severity of coronary heart disease and cardiovascular mortality. The present study was designed to examine whether hypothyroidism causes...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.01870

    authors： Nagasaki T,Inaba M,Jono S,Hiura Y,Tahara H,Shirakawa K,Onoda N,Ishikawa T,Ishimura E,Nishizawa Y

    更新日期：2005-03-01 00:00:00

  • Regressive liver adenomatosis following androgenic progestin therapy withdrawal: a case report with a 10-year follow-up and a molecular analysis.

    abstract：OBJECTIVE:The relationship between sex hormones and hepatocellular adenoma development is well established. On the contrary, their contribution to liver adenomatosis (LA) development is still a debatable issue. Recently, inactivating mutations of hepatocyte nuclear factor-1alpha (HNF-1alpha) transcription factor gene o...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-07-0020

    authors： Svrcek M,Jeannot E,Arrivé L,Poupon R,Fromont G,Fléjou JF,Zucman-Rossi J,Bouchard P,Wendum D

    更新日期：2007-06-01 00:00:00

  • Abnormal carotid arterial wall dynamics in symptom-free hypopituitary adults.

    abstract：OBJECTIVE:Although vascular mortality is increased in hypopituitary adults on routine replacement, there are limited data on the atherosclerotic process during life in these patients. Measurement of arterial stiffness may provide an index of early vascular changes that predispose to the development of major vascular ac...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1360157

    authors： Markussis V,Beshyah SA,Fisher C,Parker KH,Nicolaides AN,Johnston DG

    更新日期：1997-02-01 00:00:00

  • Diabetes care in pediatric refugees from Africa or Middle East: experiences from Germany and Austria based on real-world data from the DPV registry.

    abstract：Objective:With increasing migration to Europe, diabetes diagnosis and treatment of refugees became challenging. To describe the current experience with pediatric refugees in Germany and Austria. Design and Methods:43,137 patients (<21 years) with type 1 diabetes from the diabetes patient follow-up registry (DPV) were ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-18-0898

    authors： Prinz N,Konrad K,Brack C,Hahn E,Herbst A,Icks A,Grulich-Henn J,Jorch N,Kastendieck C,Mönkemöller K,Razum O,Steigleder-Schweiger C,Witsch M,Holl RW

    更新日期：2019-07-01 00:00:00

  • MECHANISMS IN ENDOCRINOLOGY: Anorexia nervosa and endocrinology: a clinical update.

    abstract：:Anorexia nervosa is a syndrome, that is collections of symptoms, which is not defined by its etiology. The severe cases are intractable. The syndrome is associated with multiple, profound endocrine alterations which may be adaptive, reactive or etiologic. Adaptive changes potentially may be inappropriate in clinical s...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-18-0596

    authors： Støving RK

    更新日期：2019-01-01 00:00:00

  • Tumor necrosis factor-alpha decreases thyrotropin-induced 5'-deiodinase activity in FRTL-5 thyroid cells.

    abstract：:Tumor necrosis factor-alpha (TNF-alpha) exerts various effects on many cell types. Acute administration of TNF-alpha to rats decrease hepatic 5'-deiodinase activity (5'D-I) and TNF-alpha has been implicated in the pathogenesis of the low triiodothyronine syndrome in non-thyroidal illness in humans. The thyroid, liver ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1300502

    authors： Ongphiphadhanakul B,Fang SL,Tang KT,Patwardhan NA,Braverman LE

    更新日期：1994-05-01 00:00:00

  • Successful treatment of residual pituitary adenoma in persistent acromegaly following localisation by 11C-methionine PET co-registered with MRI.

    abstract：OBJECTIVE:To determine if functional imaging using 11C-methionine positron emission tomography co-registered with 3D gradient echo MRI (Met-PET/MRI), can identify sites of residual active tumour in treated acromegaly, and discriminate these from post-treatment change, to allow further targeted treatment. DESIGN/METHOD...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-16-0639

    authors： Koulouri O,Kandasamy N,Hoole AC,Gillett D,Heard S,Powlson AS,O'Donovan DG,Annamalai AK,Simpson HL,Akker SA,Aylwin SJ,Brooke A,Buch H,Levy MJ,Martin N,Morris D,Parkinson C,Tysome JR,Santarius T,Donnelly N,Buscombe

    更新日期：2016-11-01 00:00:00

  • Anionic iodotyrosine residues are required for iodothyronine synthesis.

    abstract：:Biosynthesis of iodothyronines in thyroglobulin occurs by oxidative coupling of two iodotyrosine residues catalyzed by thyroperoxidase. To study the mechanism of iodothyronine formation, iodine-free thyroglobulin was non-enzymatically iodinated and after removal of non-incorporated iodide, incubated with lactoperoxida...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1380227

    authors： de Vijlder JJ,den Hartog MT

    更新日期：1998-02-01 00:00:00

  • A thyroxine absorption test followed by weekly thyroxine administration: a method to assess non-adherence to treatment.

    abstract：OBJECTIVE:For patients who remain hypothyroid despite the administration of what would seem adequate doses of levothyroxine (L-T4), the underlying cause can be difficult to determine. The possibility of a biological cause should first be explored; however, in the majority of cases, poor adherence to medication is likel...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-12-1035

    authors： Walker JN,Shillo P,Ibbotson V,Vincent A,Karavitaki N,Weetman AP,Wass JA,Allahabadia A

    更新日期：2013-05-10 00:00:00

  • Effect of insulin and growth hormone on the synthesis of radiolabelled proteoglycans from cultured human arterial smooth-muscle cells.

    abstract：:The present study focuses on the pathogenesis of increased frequency of large-vessel disease in diabetes. The diabetic arterial wall displays characteristic alterations of the extracellular matrix secreted by arterial smooth-muscle cells. The effects of insulin and growth hormone on the synthesis of sulphate-labelled ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1340326

    authors： Thøgersen VB,Heickendorff L,Ledet T

    更新日期：1996-03-01 00:00:00