Transcription factor NF-kappaB: a sensor for smoke and stress signals.

abstract：:Cardiomyocytes in the adult mammal retain little or none of their developmental capacity for hyperplastic growth. As a consequence of this differentiated, nonproliferative phenotype, cardiomyocyte loss due to injury or disease is irreversible. Therapeutic intervention in end-stage diseased hearts is currently limited ...

journal_title：Annals of the New York Academy of Sciences

authors： Soonpaa MH,Daud AI,Koh GY,Klug MG,Kim KK,Wang H,Field LJ

更新日期：1995-03-27 00:00:00

abstract：:The gene encoding thermostable alanine recemase from Bacillus stearothermophilus was cloned and expressed in E. coli. The enzyme was purified to homogeneity from cell extracts of E. coli carrying a plasmid designated pICR4. The alanine racemase gene sequenced was found to contain an open reading frame of 1158 nucleoti...

journal_title：Annals of the New York Academy of Sciences

authors： Soda K,Tanizawa K

更新日期：1990-01-01 00:00:00

abstract：:The adrenergic system has long been known to be activated in a situation of stress and thus during opiate withdrawal. A method for detoxification that decreases the stimulation of the sympathetic nervous system will prevent changes of catecholamine levels. Some of such methods have been developed. One of them uses dir...

journal_title：Annals of the New York Academy of Sciences

authors： Macedo TR,Relvas J,Fontes Ribeiro CA,Pacheco F,Morgadinho MT,Pinto CM,Gomes PC,Ventura M,Henriques V,Nunes SV,Ruis GR,Ramalheira C,Boto I,Vale LL

更新日期：2000-09-01 00:00:00

abstract：:Departing from the functional parallelism that undoubtedly exists between the nervous and immune system, we suggest that the latter also counts with means for information exchange that may result in a mutual influence of immune processes between nearby individuals. Our concept relies on a molecular interface that is c...

journal_title：Annals of the New York Academy of Sciences

authors： Martín PI,Sánchez PA,Rewald E

更新日期：2009-09-01 00:00:00

abstract：:Lateral interaction of c-erbB family receptors resulting in dimer formation is the key event initiating signal transduction. Consequently cross-activation and intracellular signaling is triggered with immediate impact on cell proliferation, migration, cell survival, and differentiation. In order to elucidate the conne...

journal_title：Annals of the New York Academy of Sciences

authors： Diermeier-Daucher S,Hasmann M,Brockhoff G

更新日期：2008-01-01 00:00:00

abstract：:Research examining brain development during adolescence is escalating rapidly along multiple dimensions, as illustrated by the remarkable diversity of trans-disciplinary work shown in this symposium. Ontogenetic transitions characteristics of adolescence are common among mammalian species. Although no other species de...

journal_title：Annals of the New York Academy of Sciences

authors： Spear LP

更新日期：2004-06-01 00:00:00

abstract：:Female mosquitoes gorge on vertebrate blood, a rich nutrient source for developing eggs, but gorging meals increase the risk of predation. Mosquitoes are quick to reduce the flight payload with a potent diuresis. Diuretic peptides of the insect kinin family induce a tenfold reduction in the paracellular resistance of ...

journal_title：Annals of the New York Academy of Sciences

authors： Beyenbach KW

更新日期：2012-07-01 00:00:00

abstract：:Exposure to phosphine (PH3 ), a common grain fumigant, is characterized by diverse nonspecific symptoms and a high mortality rate. Although PH3 poisoning is thought to target oxidative respiration, the exact mechanism of action remains largely unknown, resulting in limited treatment options. In our study, the effects ...

journal_title：Annals of the New York Academy of Sciences

authors： Tuet WY,Racine MC,Jennings L,Pierce SA,Tressler J,McCranor BJ,Wong B

更新日期：2020-11-01 00:00:00

abstract：:Enhanced levels of plasminogen activator inhibitor-1 (PAI-1) are considered to be a risk factor for pathological conditions associated with hypoxia or hyperinsulinemia. The expression of the PAI-1 gene is increased by insulin in different cells, although, the molecular mechanisms behind insulin-induced PAI-1 expressio...

journal_title：Annals of the New York Academy of Sciences

authors： Dimova EY,Kietzmann T

更新日期：2006-12-01 00:00:00

abstract：:Venous thromboembolic events, such as pulmonary embolism, deep venous thrombosis, and portal vein thrombosis, have been observed in adult thalassemia patients, mainly in beta-thalassemia intermedia. The clinical findings are consistent with the observation of several alterations that indicate a state of activation of ...

journal_title：Annals of the New York Academy of Sciences

authors： Cappellini MD,Grespi E,Cassinerio E,Bignamini D,Fiorelli G

更新日期：2005-01-01 00:00:00

abstract：:Recent findings indicate that complement activation--involving specifically C3 and C5--contributes to antiphospholipid (aPL)-mediated thrombosis. Two complement effector pathways are initiated by the cleavage of C5, C5a and C5b, which leads to the formation of the C5b-9 membrane attack complex. To delineate and distin...

journal_title：Annals of the New York Academy of Sciences

authors： Romay-Penabad Z,Liu XX,Montiel-Manzano G,Papalardo De Martínez E,Pierangeli SS

更新日期：2007-06-01 00:00:00

abstract：:Cytokines are powerful mediators of biologic responses in the CNS and may contribute to cellular injury in pathophysiologic states. In order to better understand the actions of cytokines in the intact mammalian CNS, a transgenic approach was employed that targeted the expression of different cytokines to astrocytes in...

journal_title：Annals of the New York Academy of Sciences

authors： Campbell IL

更新日期：1998-05-01 00:00:00

abstract：:To date, the precise etiology of inflammatory bowel disease (IBD) remains largely unknown; however, it is well accepted that IBD results from a dysregulated mucosal immune response to environmental factors in genetically susceptible hosts. The primary defect, in at least a subpopulation of IBD patients, may be due to ...

journal_title：Annals of the New York Academy of Sciences

authors： Reuter BK,Pizarro TT

更新日期：2009-05-01 00:00:00

abstract：:In this historical treatise two biological-system theories, formulated in the 1920s and 1930s, are roughly sketched. The first part discusses the concept of a thermodynamically open system, as coined by the Russian pathologist Ervin Bauer (1890-1942). Like Bertalanffy, Bauer wanted to prove the specificity of the biol...

journal_title：Annals of the New York Academy of Sciences

authors： Brauckmann S

更新日期：2000-01-01 00:00:00

abstract：:Overt aggression in its various forms is the most prevalent symptom presenting to pediatric mental health providers, regardless of setting. It is a behavior with a heterogeneous etiology and requires a comprehensive approach to evaluation and treatment. Evaluation of the aggressive child must assess medical, neurologi...

journal_title：Annals of the New York Academy of Sciences

authors： Connor DF,Steingard RJ

更新日期：1996-09-20 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) and plasma exchange (PLEX) are used to treat myasthenia gravis (MG) but with little trial evidence. While a class I study provided evidence for the efficacy of IVIG treatment, the empirical support for PLEX has been less convincing until recently. In a randomized controlled single-mas...

journal_title：Annals of the New York Academy of Sciences

authors： Bril V,Barnett-Tapia C,Barth D,Katzberg HD

更新日期：2012-12-01 00:00:00

abstract：:In the current study, we examined the effects of minocycline on the osteopenia of ovariectomized (OVX) aged rats using the marrow ablation model. This injury induces rapid bone formation followed by bone resorption in the marrow cavity. Old female rats were randomly divided into five groups: sham, OVX, OVX + minocycli...

journal_title：Annals of the New York Academy of Sciences

authors： Williams S,Barnes J,Wakisaka A,Ogasa H,Liang CT

更新日期：1999-06-30 00:00:00

abstract：:The role of the potent proinflammatory cytokine IL-1 in disease could clinically be investigated with the development of the IL-1 blocking agent anakinra (Kineret), a recombinant IL-1 receptor antagonist. It was first tested in patients with sepsis without much benefit but was later FDA approved for the treatment of p...

journal_title：Annals of the New York Academy of Sciences

authors： Goldbach-Mansky R

更新日期：2009-12-01 00:00:00

abstract：:The purpose of this study was to determine the seroprevalence against Bartonella henselae and Bartonella quintana among a risk group, patients with HIV infection, and to identify the epidemiological factors involved. Our data indicate that the prevalence of Bartonella infection among HIV-infected patients is much grea...

journal_title：Annals of the New York Academy of Sciences

authors： Pape M,Kollaras P,Mandraveli K,Tsona A,Metallidis S,Nikolaidis P,Alexiou-Daniel S

更新日期：2005-12-01 00:00:00

abstract：:We have shown that the medial preoptic area (MPO) in the hypothalamus is a major site where interferon (IFN)-alpha acts to induce suppression of splenic natural killer (NK) cell activity through an activation of sympathetic nervous system (SNS) in rats. Here, we discuss the hypothalamic mechanisms of the cytokine acti...

journal_title：Annals of the New York Academy of Sciences

authors： Katafuchi T,Duan S,Take S,Yoshimura M

更新日期：2009-02-01 00:00:00

abstract：:MRI is a robust technology that allows for superior contrast of muscles, tissues, and bones within the body, which enables visualization of soft tissue pathology that cannot be seen with CT or plain film radiography. In order to appreciate the subtle (and sometimes not so subtle) intricacies of MRI, one must have a ba...

journal_title：Annals of the New York Academy of Sciences

authors： Khanna S,Crues JV 3rd

更新日期：2009-02-01 00:00:00

abstract：:The natural tetrapeptide acetyl-ser-asp-lys-pro (AcSDKP) is formed in vivo by enzymatic cleavage of the N terminus of thymosin beta4 by prolyl oligopeptidase (POP). Recently, AcSDKP was shown to promote angiogenesis. Because of the critical role of neovascularization in cancer development, the levels of AcSDKP and POP...

journal_title：Annals of the New York Academy of Sciences

authors： Liu JM,Garcia-Alvarez MC,Bignon J,Kusinski M,Kuzdak K,Riches A,Wdzieczak-Bakala J

更新日期：2010-04-01 00:00:00

abstract：:During food shortage, organisms activate defense mechanisms to maximize their chance of survival. At least in part, these responses are triggered by changes in hormonal status and neural status during starvation. The hypothalamus is organized as a collection of distinct autonomously active nuclei and is considered to ...

journal_title：Annals of the New York Academy of Sciences

authors： Chiba T,Fujita S,Kubota H,Inoue D,Mizuno A,Komatsu T,Yamaza H,Higami Y,Shimokawa I

更新日期：2007-11-01 00:00:00

abstract：:This article reviews the implementation processes for interventions that integrate nutrition and psychosocial stimulation for children under 5 years of age in low- and middle-income countries. We examine the content of these programs, the delivery strategy, intensity and duration, personnel training and supervision, c...

journal_title：Annals of the New York Academy of Sciences

authors： Yousafzai AK,Aboud F

更新日期：2014-01-01 00:00:00

abstract：:Antisense oligonucleotides (AON) are being developed for a wide array of therapeutic applications. Significant improvements in their serum stability, target affinity, and safety profile have been achieved with the development of chemically modified oligonucleotides. Here, we compared 2'-deoxy-2'-fluoro-beta-D-arabinon...

journal_title：Annals of the New York Academy of Sciences

authors： Ferrari N,Bergeron D,Tedeschi AL,Mangos MM,Paquet L,Renzi PM,Damha MJ

更新日期：2006-10-01 00:00:00

abstract：:Sarcopenia is the involuntary loss of skeletal muscle mass and strength that occurs with aging, resulting in physical frailty. One potential explanation for sarcopenia is the failure of muscle to regenerate after damage, some of which may be due to changes in the function of satellite cells. Recent studies have identi...

journal_title：Annals of the New York Academy of Sciences

authors： Machida S,Narusawa M

更新日期：2006-05-01 00:00:00

abstract：:Obesity is a phenotype resulting from a series of causative factors with a variable risk of complications. Etiologic diversity requires personalized prevention and treatment. Imaging procedures offer the potential to investigate the interplay between organs and pathways underlying energy intake and consumption in an i...

journal_title：Annals of the New York Academy of Sciences

authors： Iozzo P

更新日期：2015-09-01 00:00:00

abstract：:Our recent studies in non-human primates have identified and characterized cerebro-ponto-cerebellar pathways involved in the control of vergence eye movements. Specifically, within the deep cerebellar nuclei and nucleus reticularis tegmenti pontis, we have identified neurons that are related to either the near respons...

journal_title：Annals of the New York Academy of Sciences

authors： Gamlin PD

更新日期：2002-04-01 00:00:00

abstract：:Researchers in Utrecht, the Netherlands have studied the effects of different factors, such as oral contraceptives (OCs), on sex hormone binding globulin (SHBG) levels in blood. The SHBG levels in women who continuously used OCs consisting only of .05 mg of ethinyl estradiol (EE2) rose as high as 260% + or - 25% of t...

journal_title：Annals of the New York Academy of Sciences

authors： Thijssen JH

更新日期：1988-01-01 00:00:00

abstract：:The primary objective of this review is to suggest a major role of cytogenetic pathology in the genesis of both the neoplastic phenotype and the senescent phenotype of aging mammalian organisms. It is hypothesized that allelic variation at a number of genetic loci that have the potential to modulate various types of c...

journal_title：Annals of the New York Academy of Sciences

authors： Martin GM

更新日期：1991-01-01 00:00:00