Treatment of colon cancer based on biochemical modulation of fluoropyrimidines by hydroxyurea.

Abstract:

:Preclinical studies have indicated that hydroxyurea leads to enhancement of 5-fluorouracil (5-FU) activity when given after 5-FU. This is presumably due to hydroxyurea's actions resulting in maintaining low levels of deoxyuridine monophosphate pools. The combination of hydroxyurea and 5-FU has been tested in several inconclusive clinical trials in patients with advanced colorectal cancer. However, pharmacodynamic studies have been lacking, and the schedules tested have not usually tried to follow preclinical findings. With the current renewed interest in 5-FU, a role for hydroxyurea as part of its biochemical modulation is worthy of further study.

journal_name

Semin Oncol

journal_title

Seminars in oncology

authors

Muggia FM,Moran RG

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

90-3

issue

3 Suppl 9

eissn

0093-7754

issn

1532-8708

pii

0093-7754(92)90135-N

journal_volume

19

pub_type

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