Abstract：
:The levels of carcinoembryonic antigen (CEA) and the activities of creatine kinase isoenzyme BB (CK-BB) were assessed in 84 patients with primary lung carcinoma and in 20 patients with nonmalignant lung diseases. The level of CEA was measured by the immunoenzymatic method using monoclonal antibodies (Abbott). The activity of CK-BB was assayed using a commercial kit (Boehringer Manheim, Monotest CK-NAC aktiviert). Increased levels of CEA were observed in 62% of patients, mostly in patients with nonsmall cell lung carcinoma (NSCLC), while enhanced activities of CK-BB were found in 39%, first of all in patients with small cell lung carcinoma (SCLC). A relationship was found between enhanced levels of CEA or CK-BB and the degree of carcinoma advance. The increased values of studied markers seem to indicate the limited possibility of surgical treatment and they are also important in prognosis after the resection of lung tissue.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Nikliński J,Furman M,Laudański J,Pałynyczko Z,Welk Msubject
Has Abstractpub_date
1991-01-01 00:00:00pages
129-35issue
2eissn
0028-2685issn
1338-4317journal_volume
38pub_type
杂志文章相关文献
NEOPLASMA文献大全abstract：:Many reports indicate that glutathione and enzymes cooperating with it are important in neoplastic processes. Glutathione (GSH) concentrations and glutathione S-transferase (GSH STr) and glutathione peroxidase (GSH-Px) activities were determined in breast cancer tissue and adjacent healthy tissues, as well as in blood...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:Functional microRNA (miRNA) molecules are transported in extracellular vesicles among tumor cells and cells of the immune system. Macrophages as integral components of tumor microenvironment are known as potential contributors to tumor growth and progression. We searched for studies which could provide a direct link b...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2017_311
更新日期：2017-01-01 00:00:00
abstract：:The incidence of malignant tumors in children is not as high as that in adults, though in Cuba and other countries they are the most frequent causes of death in this age group. Data of the fourth triennial of the Registro Nacional del Cáncer (Cuban Cancer Registry) in the period 1973-1975 are presented. In the age gro...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Serum concentration of alpha1-proteinase inhibitor (alpha1-PI) was determined by nephelometric method in forty seven patients with liver cirrhosis (LC) and fifteen patients with hepatocellular carcinoma (HCC). Our data show an increase in the concentration of alpha1-PI in the group with decompensated LC by 17% and in ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:Increasing evidences have proved that circular RNAs (circRNAs), identified as a specific kind of non-coding RNAs, play a potential critical role in tumorigenesis including prostate cancer. However, the function of circRNAs in human prostate cancer remain largely unknown. In this study, we demonstrated that the express...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2019_190213N116
更新日期：2020-01-01 00:00:00
abstract：:Out of different nucleosides and deoxynucleosides testes for their ability to block the phosphorylation of labeled 5-aza-2'-deoxycytidine in the presence of ATP and the cell-free extract from mouse spleen only deoxycytidine and cytosine arabinoside depressed the reaction significantly. With the same system the phospha...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Sixty-five patients with Stage I and II endometrial carcinoma were investigated. After a short-time follow-up (17-24 months) significant differences in frequency of relapses were observed between patients with tumors containing low amounts of estrogen receptor (ER less than 60 fmol/mg DNA) in the nuclear pellet, and t...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Presented study aimed to prepare A10 aptamer-modified poly (D,L-lactic-co-glycolic acid) (PLGA) nanoparticles loaded with triplex forming oligonucleotides(TFO) for targeted prostate cancer therapy. We first synthesized a PLGA-PEG-Apt copolymer. The PLGA-PEG-Apt nanoparticles (NP-Apt) were loaded with TFO using double ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2016_410
更新日期：2016-01-01 00:00:00
abstract：:A coordination complex cis-dichlorodiamminedihydroxoplatinum (IV) (oxoplatinum) was first synthesized in the USSR by Chugaev and Khlopin in 1927 [3]. Its marked antitumor properties were revealed by one of the authors of this article at the All-Union Cancer Research Center of the Academy of Medical Sciences of the USS...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:The possible association between cigarette smoking and the risk of benign breast disease (BBD) was assessed in a case-control study conducted in Gdańsk, Poland, between 1990 and 1994. The study compared 160 women with newly diagnosed BBD admitted to the Gdańsk Cancer Outpatients Clinic and 160 controls, women from out...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:The response of different stages of spermatogenesis to heat have been assessed by scoring the cell types in testis tubules at 14, 28 and 35 days after treatment. Deficiencies in spermatids at these times can be related back to the stage that the precursor would have been in 14 and 28 days earlier. On the 35th day the ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Hippurate had antitumor effects both in vitro and in vivo by killing dose-dependently the cells derived from Skalsky lymphoma, Németh-Kellner lymphoma, L-asparaginase sensitive 6C3HED Gardner lymphoma, and LP-2 plasmacytoma. There was no significant difference between the effect of hippurate and its maternal compound ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:KLF6 is a key cell cycle regulator that is downregulated in several kinds of human cancers, including gastric cancer. The IVS1 -27G/A polymorphism of KLF6 has been investigated, which can influence susceptibility to gastric cancer and disease outcome. In order to investigate whether the IVS1 -27G/A polymorphism of KLF...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:The authors have studied the influence of primary, methylcholanthrene-induced tumor on T and B lymphocytes of spleen, thymus, draining lymph nodes and peripheral blood of rats. Differences in weight of tumors were found to correlate with changes in proportionality of T and B lymphocytes of followed organs. Small tumor...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:The treatment of locally advanced head and neck cancer (LAHNC) requires a multimodality approach. Radiotherapy with combination of chemotherapy are demonstrated to be effective, however, the treatment intensification leads to increased toxicity at the same time. The implementation of three-dimensional conformal radiot...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2018_181209N941
更新日期：2019-06-19 00:00:00
abstract：:Regional lymph nodes in 80 cases of gastric and 70 cases of breast cancer have been examined and the reactive types have been correlated to the survival periods of the patients. In both groups of patients, a prognostically favorable sign was the detection of lymphocytic predominance combined with sinus histiocytosis, ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:Granulocyte colony-stimulating factor (G-CSF) was found to exert antitumor activity against murine MmB16 melanoma when administered intratumorally. However, subcutaneous administration of this cytokine at a site distant from the growing tumor did not show any antitumor effects. G-CSF did not influence the proliferativ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:In 41 patients with Hodgkin's disease nitroblue tetrazolium (NBT) dye reduction with resting and stimulated granulocytes, before, in the course and after chemotherapy was examined. Twofold decrease of the capability of NBT reduction test with stimulated granulocytes was found, whereas with resting granulocytes only sl...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Antisera against tumor-associated and organ-specific antigens of human mammary glands, as well as mammary carcinoma patient sera were used in cross-reactions with the test-system for a nucleoid antigen of Hep-2 retravirus. None of the antigens, revealed in mammary carcinomas and human milk seems to be either viral str...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:Zinc finger protein 139(ZNF139), a member of zinc finger protein family, is a transcription factor. Our previous research showed ZNF139 was overexpressed in gastric cancer cells. The purpose of present study is to explore impact and mechanism of ZNF139 on metastasis by regulating invasive ability of gastric cancer cel...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2014_037
更新日期：2014-01-01 00:00:00
abstract：:Serial cytogenetic characteristics of four lymphoblastoid cell lines derived from the peripheral blood of four patients with acute leukemia are presented, including G and C banding techniques and the analysis of sister chromatid exchanges by means of FPG technique. One of these lines turned into predominantly diploid ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:Polymorphisms in tobacco carcinogen metabolizing enzymes may generate interindividual variations towards the risk of developing prostate cancer. One of these enzymes is microsomal epoxide hydrolase (EPHX1) which metabolizes polycyclic aromatic hydrocarbons, or PAH, carcinogens found in cigarette smoke. The activity of...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2012_010
更新日期：2012-01-01 00:00:00
abstract：:Modulatory effects of dopamine (DA) on hematotoxicity and antitumor efficacy of cyclophosphamide (CY) were studied in Swiss mice bearing transplantable Ehrlich ascites carcinoma (EAC). DA was administered i.p. at a dose of 50 mg/kg/day for 5 consecutive days beginning day 3 after tumor transplantation. CY (200 mg/kg i...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Cancer cells share numerous characteristics with pluripotent stem cells which develop normally, contributing to the tumor cell plasticity. So we investigated the effect of human embryonic germ cells (hEGCs) on SKOV3 cells. We examined the efficacy of hEGCs through coculturing SKOV3 with hEGCs, detecting tunel apoptosi...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2009_01_13
更新日期：2009-01-01 00:00:00
abstract：:Transplacental effect of benzo(a)pyrene was studied in organ cultures of embryonic lung tissue explanted from mouse donors injected by the carcinogen. Hyperplastic alteration of epithelium, followed by adenomatous changes were seen in embryonic lung tissue cultures from donor mice injected by benzo(a)pyrene. No altera...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:The expression of cytokeratins 7, 8, 14, 18, 19 and vimentin was examined in 100 cases of ductal invasive breast carcinomas. While the predominantly diffuse immunohistological positivity of simple epithelia cytokeratins 7 (in 93), 8 (in 100), 18 (in 100) and 19 (in 97) cases represents a constant feature of these tumo...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:To explore how Tim-3 is expressed and how its expression influences invasion and metastasis of colorectal cancer (CRC) cells. A total of 188 CRC patients were prospectively collected for this study. Meanwhile, 135 normal controls were incorporated during the same period. Intestinal samples of the CRC radical cancerous...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2017_112
更新日期：2017-01-01 00:00:00
abstract：:Bladder cancer remains a very challenging disease to treat with the high rates of recurrence and progression associated with current therapies. Although the association between bladder cancer pathology and circRNAs remains undetermined, circRNAs signatures may be useful as prognostic and predictive factors and clinica...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2019_190107N25
更新日期：2019-06-03 00:00:00
abstract：:Positron emission tomography (PET) is a new diagnostic method recently widely used in oncology. It is applied to distinguish benign and malign tumors, to diagnose relaps or posttherapeutic changes. PET is also complementary method to the standard used methods such as CT or NMR. Now it is used even as the predict facto...
journal_title：Neoplasma
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：:Breast cancer is one of the leading causes of cancer death in women. The Notch family of proteins plays crucial roles in determining cell fates such as proliferation, differentiation and apoptosis. A role for Notch signaling in human breast cancer has been suggested by the development of adenocarcinomas in the murine ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
