The future of hospital economic health.

abstract：OBJECTIVES:Maintenance of mean arterial pressure>65 mm Hg has been associated with improved clinical outcomes in many studies of critically ill patients. Current guidelines for the management of septic shock and guidelines for managing other critical illnesses suggest intra-arterial blood pressure measurement is prefer...

journal_title：Critical care medicine

authors： Chatterjee A,DePriest K,Blair R,Bowton D,Chin R

更新日期：2010-12-01 00:00:00

abstract：CONTEXT:Reducing aspiration of gastric contents by placing mechanically ventilated patients in a semirecumbent position has been associated with lower incidences of ventilator-associated pneumonia (VAP). The feasibility and efficacy of this intervention in a larger patient population, however, are unknown. OBJECTIVE:A...

journal_title：Critical care medicine

authors： van Nieuwenhoven CA,Vandenbroucke-Grauls C,van Tiel FH,Joore HC,van Schijndel RJ,van der Tweel I,Ramsay G,Bonten MJ

更新日期：2006-02-01 00:00:00

abstract：:Pentoxifylline has been shown to increase red blood cell malleability, thus increasing capillary blood flow in a number of disease states. The present study was undertaken to determine whether pentoxifylline might improve tissue oxygenation after anesthesia and during an operation in rats. Rats were anesthetized and d...

journal_title：Critical care medicine

authors： Soliman MH,O'Neal K,Waxman K

更新日期：1987-02-01 00:00:00

abstract：OBJECTIVE:To study the effect of early and continuous venovenous hemofiltration (CVVH) on the plasma concentrations of several humoral mediators of inflammation and subsequent organ dysfunction in septic patients. DESIGN:Randomized, controlled trial. SETTING:Intensive care unit of a tertiary hospital. PATIENTS:Twent...

journal_title：Critical care medicine

authors： Cole L,Bellomo R,Hart G,Journois D,Davenport P,Tipping P,Ronco C

更新日期：2002-01-01 00:00:00

abstract：:The Simplified Acute Physiology Score (SAPS), the Acute Physiology and Chronic Health Evaluation II (APACHE II), the Acute Physiology Score (APS), and the Coronary Prognostic Index (CPI), calculated within the first 24 h of ICU admission, were compared in 76 patients with acute myocardial infarction (AMI). Sixteen (21...

journal_title：Critical care medicine

authors： Moreau R,Soupison T,Vauquelin P,Derrida S,Beaucour H,Sicot C

更新日期：1989-05-01 00:00:00

abstract：:We found that altering aspirating flow rate (ASR) and sample tubing length (STL) affected the response time and capnogram of 2 different side-stream capnometers. Increased flow rate shortened rise time, transit time, and total delay time (TDT), whereas increased STL increased transit and TDTs but not rise time. Increa...

journal_title：Critical care medicine

authors： Schena J,Thompson J,Crone RK

更新日期：1984-08-01 00:00:00

abstract：OBJECTIVE:Therapeutic hypothermia has been used to attenuate the effects of traumatic brain injuries. However, the required degree of hypothermia, length of its use, and its timing are uncertain. We undertook a comprehensive meta-analysis to quantify benefits of hypothermia therapy for traumatic brain injuries in adult...

journal_title：Critical care medicine

authors： Crompton EM,Lubomirova I,Cotlarciuc I,Han TS,Sharma SD,Sharma P

更新日期：2017-04-01 00:00:00

abstract：:Cardiac arrest is most commonly encountered as the end result of severe derangements in metabolic homeostasis. These derangements may include toxic, ischemic, or electrophysiological causes of circulatory and/or respiratory arrests. Occasionally, mechanical obstruction or impediment to circulation may cause cardiac ar...

journal_title：Critical care medicine

authors： Ewer MS,Ali MK,Frazier OH

更新日期：1982-03-01 00:00:00

abstract：:The resolution time of pneumothorax in neonates requiring tube thoracotomy is not known. We found that 28%, 50%, and 83% of 54 pneumothoraces in 40 neonates resolved within 24, 96, and 168 h of tube thoracotomy, respectively. Pneumothoraces that persisted beyond 168 h were in infants requiring ventilatory assistance. ...

journal_title：Critical care medicine

authors： Bhatia J,Mathew OP

更新日期：1985-05-01 00:00:00

abstract：:Varying concentrations of lipopolysaccharide (LPS) and mannan suspensions were mixed with either saline or plasma from normal volunteers, heated to 100 degrees C for 10 min, and then subjected to the limulus amebocyte lysate test (LAL). A positive LAL in saline required minimum LPS and mannan concentrations of 10(-11)...

journal_title：Critical care medicine

authors： Hosotsubo KK,Takezawa J,Nishijima MK,Takahashi H,Shimada Y,Yoshiya I

更新日期：1985-12-01 00:00:00

abstract：OBJECTIVES:To determine how many multicenter, randomized controlled trials have been published that assess mortality as a primary outcome in the adult intensive care unit population, and to evaluate their methodologic quality. DATA SOURCE:A sensitive search strategy for randomized controlled trials was conducted in th...

journal_title：Critical care medicine

authors： Ospina-Tascón GA,Büchele GL,Vincent JL

更新日期：2008-04-01 00:00:00

abstract：:Hypophosphatemia may occur in Reye's syndrome. We retrospectively studied 42 patients with Reye's syndrome to determine the frequency and degree of hypophosphatemia, to identify possible causes, and to determine whether hypophosphatemia was related to the severity of disease or mortality. Nineteen (46%) patients were ...

journal_title：Critical care medicine

authors： Carroll JL,Kanter RK

更新日期：1985-06-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that therapeutic hypercapnia enhances the proinflammatory responses to endotoxemia in the lung and spleen of rats. DESIGN:Prospective randomized study. SETTINGS:Hospital research institute. SUBJECTS:Forty-eight adult male rats. INTERVENTIONS:Rats were randomly assigned for a 24-hr p...

journal_title：Critical care medicine

authors： Norozian FM,Leoncio M,Torbati D,Meyer K,Raszynski A,Totapally BR

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVES:To evaluate the ability of central venous-to-arterial carbon dioxide pressure difference, central venous oxygen saturation, and the combination of these two parameters to detect extubation failure in critically ill patients. DESIGN:Multicentric, prospective, observational study. SETTING:Three ICUs. PATIEN...

journal_title：Critical care medicine

authors： Mallat J,Baghdadi FA,Mohammad U,Lemyze M,Temime J,Tronchon L,Thevenin D,Fischer MO

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVES:The Accreditation Council for Graduate Medical Education recently released new standards for supervision and duty hours for residency programs. These new standards, which will affect over 100,000 residents, take effect in July 2011. In response to these new guidelines, the Society of Critical Care Medicine c...

journal_title：Critical care medicine

authors： Pastores SM,O'Connor MF,Kleinpell RM,Napolitano L,Ward N,Bailey H,Mollenkopf FP Jr,Coopersmith CM

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:To compare the responses of noninvasively measured tissue oxygen saturation (StO2) and calculated muscle oxygen tension (PmO2) to standard hemodynamic variables for early detection of imminent hemodynamic instability during progressive central hypovolemia in humans. DESIGN:Prospective study. SETTING:Researc...

journal_title：Critical care medicine

authors： Soller BR,Ryan KL,Rickards CA,Cooke WH,Yang Y,Soyemi OO,Crookes BA,Heard SO,Convertino VA

更新日期：2008-01-01 00:00:00

abstract：:To evaluate the effect of meconium on pulmonary surface tension properties, the mechanics of 30 excised, separated canine pulmonary lobes were studied. Meconia were blended in normal saline to produce solutions of 10% and 20%. Solutions were filtered to remove large particles and instilled endobronchially into the can...

journal_title：Critical care medicine

authors： Chen CT,Toung TJ,Rogers MC

更新日期：1985-04-01 00:00:00

abstract：OBJECTIVE:The use of corticosteroids in patients with sepsis or septic shock has been controversial for many decades. Clinical studies have reported beneficial, as well as negative results. We conducted a meta-analysis to assess the clinical evidence and to evaluate treatment effects in specific subgroups of patients. ...

journal_title：Critical care medicine

authors： Lefering R,Neugebauer EA

更新日期：1995-07-01 00:00:00

abstract：OBJECTIVE:The pathogenesis of acute gastric stress ulceration in the seriously ill is uncertain, and any role of Helicobacter pylori infection is unknown. We aimed to assess the relationship between H. pylori serological status and stress ulceration in seriously ill patients, as well as H. pylori serological status in ...

journal_title：Critical care medicine

authors： Robertson MS,Cade JF,Clancy RL

更新日期：1999-07-01 00:00:00

abstract：:Gastric mucosal damage occurs in critically ill patients in intensive care units and develops in the setting of severe physiologic stress. Within 24 hrs of admission to the intensive care unit, 75% to 100% of critically ill patients demonstrate evidence of stress-related mucosal disease. Stress ulcers present a risk o...

journal_title：Critical care medicine

authors： Fennerty MB

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to examine whether anandamide, an endogenous cannabinoid receptor ligand, is involved in the pathogenesis of septic encephalopathy. DESIGN:Prospective, controlled study. SUBJECTS:Male Wistar rats (7 wks old) were randomly divided into four groups as follows: group 1, control (...

journal_title：Critical care medicine

authors： Kadoi Y,Hinohara H,Kunimoto F,Saito S,Goto F

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:To investigate the interaction and involvement of hydrogen sulfide and transient receptor potential vanilloid type 1 in the pathogenesis of sepsis. Hydrogen sulfide has been demonstrated to be involved in many inflammatory states including sepsis. Its contribution in neurogenic inflammation has been suggested...

journal_title：Critical care medicine

authors： Ang SF,Moochhala SM,Bhatia M

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:Pathogens that cause pneumonia may be treated in a targeted fashion by antibiotics, but if this therapy fails, then treatment involves only nonspecific supportive measures, independent of the inciting infection. The purpose of this study was to determine whether host response is similar after disparate infect...

journal_title：Critical care medicine

authors： McConnell KW,McDunn JE,Clark AT,Dunne WM,Dixon DJ,Turnbull IR,Dipasco PJ,Osberghaus WF,Sherman B,Martin JR,Walter MJ,Cobb JP,Buchman TG,Hotchkiss RS,Coopersmith CM

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVES:Sepsis-associated changes of the arachidonic acid metabolism and the utility of arachidonic acid metabolites for the diagnosis of sepsis have been poorly investigated so far. Therefore, the primary objective of our study was to screen for differentially regulated arachidonic acid metabolites in septic patien...

journal_title：Critical care medicine

authors： Bruegel M,Ludwig U,Kleinhempel A,Petros S,Kortz L,Ceglarek U,Holdt LM,Thiery J,Fiedler GM

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVES:To explore the relationship between timing of continuous renal replacement therapy commencement and clinical outcomes in critically ill patients with acute kidney injury. The primary outcomes were all-cause mortality at 28 and 90 days. DESIGN:Nested observational cohort study using data from the Randomized ...

journal_title：Critical care medicine

authors： Jun M,Bellomo R,Cass A,Gallagher M,Lo S,Lee J,Randomized Evaluation of Normal Versus Augmented Level of Replacement Therapy (RENAL) Study Investigators.

更新日期：2014-08-01 00:00:00

abstract：:The hemodynamic response to a dopamine HCl infusion (10 microgram/kg per min) was measured in 25 adult patients with severe sepsis: there were 6 patients with circulatory hyperdynamic states, 9 patients with myocardial failure, and 10 with hypovolemia. Each patient also had acute respiratory failure. Changes of intrap...

journal_title：Critical care medicine

authors： Jardin F,Gurdjian F,Desfonds P,Margairaz A

更新日期：1979-06-01 00:00:00

abstract：OBJECTIVES:Although discussing a prognosis is a duty of physicians caring for critically ill patients, little is known about surrogate decision-makers' beliefs about physicians' ability to prognosticate. We sought to determine: 1) surrogates' beliefs about whether physicians can accurately prognosticate for critically ...

journal_title：Critical care medicine

authors： Zier LS,Burack JH,Micco G,Chipman AK,Frank JA,Luce JM,White DB

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVES:The results from the recent Targeted Temperature Management trial raised the question whether cooling or merely the avoidance of fever mediates better neurologic outcome in resuscitated patients. As temperature per se is a major determinant of cardiac function, we characterized the effects of hyperthermia (4...

journal_title：Critical care medicine

authors： Alogna A,Manninger M,Schwarzl M,Zirngast B,Steendijk P,Verderber J,Zweiker D,Maechler H,Pieske BM,Post H

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:Although the development of ventilator-associated pneumonia (VAP) is assumed to increase costs of intensive care unit stay, it is unknown whether prevention of VAP by means of oropharyngeal decontamination is cost-effective. Because of wide ranges of individual patient costs, crude cost comparisons did not sh...

journal_title：Critical care medicine

authors： van Nieuwenhoven CA,Buskens E,Bergmans DC,van Tiel FH,Ramsay G,Bonten MJ

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVES:Extracorporeal membrane oxygenation is used to stabilize severe cardiocirculatory and/or respiratory failure. However, extracorporeal membrane oxygenation is associated with a coagulopathy characterized by thromboembolic and hemorrhagic complications. This study aimed to characterize the pathomechanism of th...

journal_title：Critical care medicine

authors： Granja T,Hohenstein K,Schüssel P,Fischer C,Prüfer T,Schibilsky D,Wendel HP,Jaschonek K,Serna-Higuita L,Schlensak C,Häberle H,Rosenberger P,Straub A

更新日期：2020-05-01 00:00:00