Effect of reproductive compensation and the desire to have male offspring on the incidence of a sex-linked lethal disease.

Abstract:

:The effects of reproductive compensation on an X-linked recessive lethal are examined. Complete compensation without regard to the sex of the offspring increases the incidence of female carriers by a factor of 1.5, and of affected males by 1.33. However, if families reproduce until they have a healthy male offspring, the incidence of the X-linked lethal can be increased two or three orders of magnitude. Even only 1% of the population reproducing until a male is born can inflate the incidence of the disease by an order of magnitude, provided this pattern of family planning is culturally inherited. Similarly, reproducing until there is at least one child of each sex increases the incidence of an X-linked lethal. The impact of these types of sex-biased family planning on the fraction of new mutants among affect males is discussed.

journal_name

Am J Hum Genet

authors

Templeton AR,Yokoyama S

subject

Has Abstract

pub_date

1980-07-01 00:00:00

pages

575-81

issue

4

eissn

0002-9297

issn

1537-6605

journal_volume

32

pub_type

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