Abstract:
:A case of fulminant hepatic failure leading to death in a patient receiving DTIC for metastatic melanoma is presented. Autopsy revealed widespread centrilobular necrosis secondary to a veno-occlusive process. There was no evidence of a similar process in other organs, and common causes of similar pathology were ruled out. It is likely that in this patient the hepatic failure was due to DTIC alone. Similar cases have been reported in patients receiving other chemotherapeutic agents. Physicians using these drugs should be aware of this side-effect of therapy, since it is often fatal.
journal_name
Cancerjournal_title
Cancerauthors
Asbury RF,Rosenthal SN,Descalzi ME,Ratcliffe RL,Arseneau JCdoi
10.1002/1097-0142(19800515)45:10<2670::aid-cncr282subject
Has Abstractpub_date
1980-05-15 00:00:00pages
2670-4issue
10eissn
0008-543Xissn
1097-0142journal_volume
45pub_type
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