Abstract:
:Mitochondrial transcription factor B (mtTFB), an essential component in regulating the expression of mitochondrial DNA-encoded genes in both yeast and humans, is a dimethyladenosine methyltransferase (DMT) that has acquired a secondary role in mitochondrial transcription. So far, mtTFB has only been well studied in Opisthokonta (metazoan animals and fungi). Here we investigate the phylogenetic distribution of mtTFB homologs throughout the domain Eucarya, documenting the first examples of this protein outside of the opisthokonts. Surprisingly, we identified putative mtTFB homologs only in amoebozoan protists and trypanosomatids. Phylogenetic analysis together with conservation of intron positions in amoebozoan and human genes supports the grouping of the putative mtTFB homologs as a distinct clade. Phylogenetic analysis further demonstrates that the mtTFB is most likely derived from the DMT of the mitochondrial endosymbiont.
journal_name
Mol Biol Evoljournal_title
Molecular biology and evolutionauthors
Shutt TE,Gray MWdoi
10.1093/molbev/msk001subject
Has Abstractpub_date
2006-06-01 00:00:00pages
1169-79issue
6eissn
0737-4038issn
1537-1719pii
msk001journal_volume
23pub_type
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pub_type: 杂志文章
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