Abstract:
:Five patients received leukapheresis therapy for Sézary syndrome. All patients had erythroderma, lymphocytic band infiltration of the skin, and a normal white blood cell count with an absolute Sézary cell count of more than 1,000/mm3. Improvement in 3 to 6 months occurred, usually with the addition of a combined regimen of prednisone and low-dose chlorambucil therapy. One patient had sustained improvement with repeated leukapheresis for more than 2 years. The two patients who showed a major response were the youngest patients, who had normal karyotypes, normal delayed-hypersensitivity skin tests, and a quantitative response of the Sézary cells and the T and B cells to leukapheresis. These preliminary results suggest that there may be selected patients for whom leukapheresis is useful therapy and that it is possible to perform the procedure safely in patients with normal white blood cell counts.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Pineda AA,Winkelmann RKdoi
10.1016/s0190-9622(81)70114-2subject
Has Abstractpub_date
1981-11-01 00:00:00pages
544-9issue
5eissn
0190-9622issn
1097-6787pii
S0190-9622(81)70114-2journal_volume
5pub_type
杂志文章abstract:BACKGROUND:Access to dermatologists is low among Medicaid-insured patients. Higher clinic nonattendance among Medicaid-insured patients might affect provider decisions to accept these patients. OBJECTIVE:To determine the effect of different scheduling policies on the attendance among children seen at a pediatric derma...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2019.02.018
更新日期:2019-08-01 00:00:00
abstract::This review begins with a classification of adverse drug reactions and a summary of those features that distinguish allergic from toxic and idiosyncratic reactions. Factors that influence the risk of developing drug allergy are then reviewed, followed by a discussion of the known and suspected immunologic mechanisms r...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/s0190-9622(82)70073-8
更新日期:1982-05-01 00:00:00
abstract:BACKGROUND:Safety profiles of systemic biologic agents for the treatment of psoriasis and psoriatic arthritis (PsA) encompass a wide spectrum of adverse events. To date, no uniform evidence-based guidelines exist regarding screening and monitoring patients who are undergoing biologic therapy. OBJECTIVE:We sought to id...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.jaad.2015.06.004
更新日期:2015-09-01 00:00:00
abstract::Two cases of semicircular lipoatrophy and one of annular lipoatrophy are presented. The reasons why semicircular lipoatrophy, annular lipoatrophy, and annular atrophy of the ankles seem to be different clinical entities are discussed. ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/s0190-9622(89)70053-0
更新日期:1989-03-01 00:00:00
abstract::We report a patient with a vesiculopustular eruption with features distinct from typical subcorneal pustular dermatosis. Clinically, well-formed pustular lesions, which were flowerlike in appearance, were present. Histopathologically, early vesicular lesions showed intraepidermal bullae containing numerous neutrophils...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/0190-9622(90)70125-2
更新日期:1990-05-01 00:00:00
abstract::Retiform hemangioendothelioma is a rare low-grade angiosarcoma of the skin. It shares some clinical characteristics with Kaposi's sarcoma, a tumor with known human herpesvirus 8 (HHV-8) association. We report a case of retiform hemangioendothelioma in which we detected HHV-8 DNA sequences. ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/S0190-9622(00)90143-9
更新日期:2000-02-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/0190-9622(91)70117-k
更新日期:1991-05-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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更新日期:2009-05-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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更新日期:2009-10-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(88)70214-5
更新日期:1988-10-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
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更新日期:2007-11-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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更新日期:1993-05-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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更新日期:2020-11-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1067/mjd.2002.109255
更新日期:2002-08-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1067/mjd.2001.116340
更新日期:2001-11-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(97)70043-4
更新日期:1997-05-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2015.04.008
更新日期:2015-07-01 00:00:00
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更新日期:2012-10-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,随机对照试验
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更新日期:2019-01-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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更新日期:2004-09-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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更新日期:2019-04-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1067/mjd.2001.115966
更新日期:2001-08-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.jaad.2005.04.013
更新日期:2005-07-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(98)70076-3
更新日期:1998-08-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
abstract::We present the identification and characterization of two patients with xeroderma pigmentosum (XP) and squamous cell carcinoma of the tongue. Dermal fibroblasts from two black siblings with XP were shown to be hypersensitive to ultraviolet (UV) light measured by colony-forming ability. UV-induced unscheduled deoxyribo...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(85)70072-2
更新日期:1985-03-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(88)70059-6
更新日期:1988-02-01 00:00:00
abstract::Clinical trials for systemic psoriasis therapy typically enroll healthy patients and exclude patients with cardiovascular disease, latent tuberculosis, liver disease, histories of malignancies, viral infections, children, and pregnant or breast-feeding women. Physicians often require guidance for optimum management of...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2009.03.017
更新日期:2009-07-01 00:00:00