Pancreatic polypeptide in acute pancreatitis and small-bowel infarction in dogs.

Abstract:

:Serum and urine concentrations of pancreatic polypeptide (PP) were measured during experimental acute hemorrhagic pancreatitis and small-bowel infarction in dogs. The mean serum PP concentration in animals with pancreatitis increased markedly after 1 hr and remained elevated, while the mean serum PP concentration in the animals with infarction showed a late trend to increase. The urine PP concentration in pancreatitis increased nonsignificantly, whereas, during bowel infarction, there was no increase. In the infarction group, PP clearance correlated with the serum PP concentration. During pancreatitis, PP was cleared independently of the serum PP concentration. The results suggest that during acute hemorrhagic pancreatitis there is an acute release of PP related to immediate cell injury in the pancreas. The high serum concentration of PP may lead to an override of the normal renal handling of PP. In small-bowel infarction there may be a delayed mode of PP release.

journal_name

Dig Dis Sci

authors

Pappas TN,Yovos JG,Ellison EC,O'Dorisio TM,Cataland S,Pace WG,Carey LC

doi

10.1007/BF01314764

subject

Has Abstract

pub_date

1981-11-01 00:00:00

pages

1013-8

issue

11

eissn

0163-2116

issn

1573-2568

journal_volume

26

pub_type

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