Immunological effects of toluene diisocyanate exposure on painters.

Abstract:

:Among the painters handling polyurethane varnish in two furniture manufacturing factories with high toluene diisocyanate (TDI) exposure (0.79 mg/m3 and 0.31 mg/m3), 26.3% and 15% subjects, respectively displayed asthmatic symptoms, lung function loss, and an increment in mast cell degranulation percentage specific to TDI. Some cases of TDI-linked contact dermatitis were also found among them, being elucidated by positive patch testing to TDI. However, the previous abnormalities could not be verified among the painters from another factory with TDI concentration below the TLV of it (0.11 mg/m3). It was concluded that both pulmonary hypersensitivity and contact sensitization to TDI had occurred in some of the painters included in this study, and that the immunologic effects of TDI was concentration dependent.

authors

Huang J,Wang XP,Chen BM,Ueda A,Aoyama K,Matsushita T

doi

10.1007/BF01183884

subject

Has Abstract

pub_date

1991-11-01 00:00:00

pages

607-11

issue

4

eissn

0090-4341

issn

1432-0703

journal_volume

21

pub_type

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