当前位置： SCI文献检索 > RADIOLOGY期刊下所有文献 > Dynamic CT measurement of pulmonary enhancement in piglets with experimental acute respiratory distress syndrome.

Dynamic CT measurement of pulmonary enhancement in piglets with experimental acute respiratory distress syndrome.

Abstract：

PURPOSE:To investigate whether analysis of a washout curve of contrast material obtained with serial computed tomography (CT) enables differentiation between hydrostatic pulmonary edema and pulmonary edema caused by increased capillary permeability. MATERIALS AND METHODS:The institutional committee on animal experiments approved this study, which was performed in accordance with designated guidelines. Chest CT was performed in 12 piglets after induction of anesthesia and start of mechanical ventilation. Dynamic CT was performed before and after induction of hydrostatic edema (n = 5) or oleic acid-induced increased vascular permeability edema (n = 7). Scans were obtained over 240 seconds during inspiratory breath holding at a single representative subcarinal level in the lungs. This anatomic level was kept constant and included areas of normal ventilation before and after induction of pulmonary edema and areas of ground-glass opacity and consolidation after induction of pulmonary edema. Measured lung attenuation in the regions of interest was normalized to that before contrast material injection and plotted as a function of time. Statistical analysis was performed by using two-way analysis of variance with repeated measures. RESULTS:In general, before induction of pulmonary edema, attenuation of normally aerated lung areas did not increase after the initial peak of enhancement during the first pass of contrast material. In animals with hydrostatic edema, no attenuation changes in areas of ground-glass opacity were observed after the initial peak. Conversely, lung attenuation increased continuously in animals with oleic acid-induced high-permeability pulmonary edema (P = .002). After induction of lung edema, pulmonary enhancement measured in lung regions with normal ventilation or consolidation did not change in either group. Pulmonary fluid accumulation 90 minutes after induction of edema did not significantly differ between groups. CONCLUSION:Dynamic contrast-material enhanced CT can help differentiate between permeability and hydrostatic lung edema in an animal model.

journal_name

Radiology

journal_title

Radiology

authors

Schueller-Weidekamm C,Wassermann E,Redl H,Prokop M,Zimpfer M,Herold C,Germann P,Ullrich R

doi

10.1148/radiol.2392042177

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

398-405

issue

eissn

0033-8419

issn

1527-1315

pii

239/2/398

journal_volume

239

pub_type

杂志文章

在线工具

Dynamic CT measurement of pulmonary enhancement in piglets with experimental acute respiratory distress syndrome.