A comparison of collagen synthesis by different categories of human chondrosarcoma in organ culture.

Abstract:

:Accurate diagnosis of the degree of malignancy of individual chondrosarcomas is a difficult problem for the orthopedist. To determine whether certain biochemical and metabolic parameters might provide a useful supplement to roentgenologic and histologic evaluations, 19 human chondrosarcomas were analyzed for DNA and collagen content, and for 3H-proline incorporation into 3H-hydroxyproline and total protein. When these values were compared by estimated tumor grade (benign, low, or high) and by tissue type (hyaline, fibrous, myxoid, or mixed), collagen content, synthesis, and total protein synthesis appeared to vary inversely with apparent degree of malignancy, suggesting that different levels of transformation may be represented in these tumors. These measurements may provide a useful adjunct to histologic and roentgenologic evaluations to more accurately predict the degree of malignancy and the tendency of individual tumors to metastasize.

journal_name

Clin Orthop Relat Res

authors

Miller DR,Mankin HJ

subject

Has Abstract

pub_date

1982-08-01 00:00:00

pages

252-7

issue

168

eissn

0009-921X

issn

1528-1132

pub_type

杂志文章
  • Preoperative hip to ankle radiographs in total knee arthroplasty.

    abstract::Whether a preoperative long leg radiograph taken with the patient standing helps the surgeon reproduce a normal mechanical axis after total knee arthroplasty is unknown. The purpose of the current study was to evaluate whether a preoperative long leg radiograph helps to restore normal limb alignment after total knee a...

    journal_title:Clinical orthopaedics and related research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00003086-200211000-00032

    authors: McGrory JE,Trousdale RT,Pagnano MW,Nigbur M

    更新日期:2002-11-01 00:00:00

  • Effect of component fixation method on osteolysis in total knee arthroplasty.

    abstract::Eighty-three total knee arthroplasties done at a single university hospital were reviewed specifically to examine the presence of lysis. Components that were radiographically loose were excluded. The incidence of lysis varied significantly with the method of component fixation. The highest incidence of lysis (30%) was...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Ezzet KA,Garcia R,Barrack RL

    更新日期:1995-12-01 00:00:00

  • Can Genipin-coated Sutures Deliver a Collagen Crosslinking Agent to Improve Suture Pullout in Degenerated Tendon? An Ex Vivo Animal Study.

    abstract:BACKGROUND:The suture-tendon interface is often the weakest link in tendon-to-tendon or tendon-to-bone repair. Genipin is an exogenous collagen crosslink agent derived from the gardenia fruit that can enhance suture force to failure of the tendon-suture interface. Viable methods for intraoperative clinical delivery of ...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1007/s11999.0000000000000247

    authors: Camenzind RS,Tondelli TO,Götschi T,Holenstein C,Snedeker JG

    更新日期:2018-05-01 00:00:00

  • Case report: reconstruction of the distal tibia with porous tantalum spacer after resection for giant cell tumor.

    abstract::Treatment options for giant cell tumors of the distal tibia include curettage and cement packing, curettage and bone grafting, or resection and reconstruction for aggressive tumors. Curettage of aggressive tumors often leads to severe bone loss requiring reconstruction. Allograft and autograft may be effective options...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1007/s11999-009-1097-y

    authors: Economopoulos K,Barker L,Beauchamp C,Claridge R

    更新日期:2010-06-01 00:00:00

  • Mechanism for superior subluxation of the glenohumeral joint in fibrodysplasia ossificans progressiva.

    abstract::Progressive heterotopic ossification leads to ankylosis of the major joints in patients who have fibrodysplasia ossificans progressiva. Joint subluxation has not been recognized widely in patients with this disease. The clinical records and radiographs of 79 patients with fibrodysplasia ossificans progressiva were rev...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Sawyer JR,Klimkiewicz JJ,Iannotti JP,Rocke DM

    更新日期:1998-01-01 00:00:00

  • Medial unicompartmental arthroplasty. A survival study of the Oxford meniscal knee.

    abstract::One hundred twenty-one knees with medial compartment osteoarthrosis were treated by unicompartmental arthroplasty with the Oxford Knee. The strict selection criteria were (1) the presence of a functioning anterior cruciate ligament, (2) fully correctable deformity, and (3) full thickness of articular cartilage in the ...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Carr A,Keyes G,Miller R,O'Connor J,Goodfellow J

    更新日期:1993-10-01 00:00:00

  • Persistent structural disease is the most common cause of repeat hip preservation surgery.

    abstract:BACKGROUND:Hip preservation surgery has become more commonplace, yet when it fails, it is unclear why it does so. Understanding failed procedures should lead to improved surgical results. QUESTIONS/PURPOSES:The purposes of this study were to (1) characterize patients undergoing hip preservation surgery after prior pro...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s11999-013-3218-x

    authors: Clohisy JC,Nepple JJ,Larson CM,Zaltz I,Millis M,Academic Network of Conservation Hip Outcome Research (ANCHOR) Members.

    更新日期:2013-12-01 00:00:00

  • Clinical pathway for hip fractures in the elderly: the Hospital for Joint Diseases experience.

    abstract::Hip fractures are common injuries in the elderly and are associated with considerable morbidity and mortality. Although technical advances in the treatment of the elderly have resulted in improved fracture fixation and surgical outcomes, clinical pathways have been developed to further improve patient outcome while sh...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1097/01.blo.0000132266.59787.d2

    authors: Koval KJ,Chen AL,Aharonoff GB,Egol KA,Zuckerman JD

    更新日期:2004-08-01 00:00:00

  • Operative neurological complications resulting from thoracic and lumbar spine internal fixation.

    abstract::Of 2023 patients treated for acute spinal injuries, 729 sustained acute injuries in thoracic and lumbar regions; 295 surgically treated patients were reviewed for evidence of postoperative neurological complications. Of the 295 patients, 150 were intraoperatively monitored using somatosensory-evoked potentials (SSEP)....

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Meyer PR Jr,Cotler HB,Gireesan GT

    更新日期:1988-12-01 00:00:00

  • Lengthened callus activated by axial shortening. Histological and cytomorphometrical analysis.

    abstract::The tibiae of rabbits were lengthened by 10 mm in 2 weeks, then approximately one half of the limbs were shortened by 2 mm in 3 days, and left for 3 days. Histological and cytomorphometrical findings of the calluses in both groups were compared. In the shortened callus, marked histologic changes were observed in the c...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Hamanishi C,Yoshii T,Totani Y,Tanaka S

    更新日期:1994-10-01 00:00:00

  • Hospital for special surgery. A brief review of its development and current position.

    abstract::On May 1, 1999, the Hospital for Special Surgery was 136 years old. To present a history that does adequate justice to the many people, who have been or still are involved in the making of it, is an impossible task. Nevertheless, this document is important because the hospital, first under the name of Ruptured and Cri...

    journal_title:Clinical orthopaedics and related research

    pub_type: 历史文章,杂志文章

    doi:

    authors: Wilson PD Jr,Levine DB

    更新日期:2000-05-01 00:00:00

  • Experimental meniscal lesions reconstructed with a carbon fiber-polyurethane-poly(L-lactide) graft.

    abstract::Reconstructive procedures were investigated in meniscal lesions in 14 dogs. Large wedge-shaped lesions were repaired with a graft containing carbon fibers and an organic polymer, prepared from physical mixtures of poly(L-lactide) and a segmented polyurethane. Four and eight weeks postoperation, arthroscopy was perform...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Veth RP,Jansen HW,Leenslag JW,Pennings AJ,Hartel RM,Nielsen HK

    更新日期:1986-01-01 00:00:00

  • Cryptococcal bone disease: a manifestation of disseminated cryptococcosis.

    abstract::In three patients with cryptococcal bone infection, skeletal involvement was sometimes occult, localized (offering a clinically accessible area for the diagnosis of disseminated) or part of a disseminated disease. Cryptococcal bone infection may clinically imitate neoplastic disease. Cryptococcal antigen determination...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Fialk MA,Marcove RC,Armstrong D

    更新日期:1981-07-01 00:00:00

  • The study of Maquet dome high tibial osteotomy. Arthroscopic-assisted analysis.

    abstract::A review of 118 Maquet valgus high tibial osteotomies, secured with Charnley's external compression fixator, included 110 cases of primary osteoarthritis, six cases of osteonecrosis, and two cases of traumatic arthritis. Preoperatively, the mechanical axis of alignment showed varus deformity with an average of 9.6 deg...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Hsu RW

    更新日期:1989-06-01 00:00:00

  • C-reactive protein (CRP) levels after elective orthopedic surgery.

    abstract::The levels of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were determined by serial measurements after four types of uncomplicated elective orthopedic surgery. The type of operations chosen for this study were total hip arthroplasty (primary, n = 109; and revisions caused by aseptic loosening, n ...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Larsson S,Thelander U,Friberg S

    更新日期:1992-02-01 00:00:00

  • Nonunion of intertrochanteric fractures of the femur following open reduction and internal fixation. Results of second attempts to gain union.

    abstract::A retrospective review was performed on 20 patients treated at the authors' hospital between 1961 and 1981 with noninfected nonunions following primary open reduction and internal fixation (ORIF) of intertrochanteric femoral fractures. All patients were available for follow-up examination. Each patient was interviewed...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Mariani EM,Rand JA

    更新日期:1987-05-01 00:00:00

  • Conversion of Hemiarthroplasty to THA Carries an Increased Risk of Reoperation Compared With Primary and Revision THA.

    abstract:BACKGROUND:There is limited information on the complications and costs of conversion THA after hemiarthroplasty for femoral neck fractures. Previous studies have found that patients undergoing conversion THA experience higher risk complications, but it has been difficult to quantify the risk because of small sample siz...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1097/CORR.0000000000000702

    authors: Hernandez NM,Fruth KM,Larson DR,Kremers HM,Sierra RJ

    更新日期:2019-06-01 00:00:00

  • Alumina heads minimize wear and femoral osteolysis progression after isolated simple acetabular revision.

    abstract:BACKGROUND:Patients with THA requiring cup revision for acetabular osteolysis may have a stable stem component without loosening. However, it is unclear whether isolated cup revision halts femoral osteolysis progression. QUESTION/PURPOSES:We asked (1) whether and to what degree osteolysis progresses after isolated ace...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1007/s11999-012-2363-y

    authors: Hernigou P,Dupuy N,Pidet O,Homma Y,Flouzat Lachaniette CH

    更新日期:2012-11-01 00:00:00

  • Innovations in design and technology. The story of hip arthroplasty.

    abstract::The current study reviews the early history of surgeon-initiated trial and error development in hip joint arthroplasty and the subsequent methodological evolution to proper criteria for hypothesis testing using bioengineers and other research scientists. The interplay and relationships to industry, universities, scien...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Amstutz HC

    更新日期:2000-09-01 00:00:00

  • High early failure rate after cementless hip replacement in the octogenarian.

    abstract:BACKGROUND:Use of cementless hip replacements is increasing in many countries, but the best method for fixation for octogenarian patients remains unknown. QUESTIONS/PURPOSES:We studied how fixation method (cemented, cementless, hybrid) affects the survival of primary hip replacements and mortality in patients 80 years...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1007/s11999-014-3641-7

    authors: Jämsen E,Eskelinen A,Peltola M,Mäkelä K

    更新日期:2014-09-01 00:00:00

  • Mechanisms of metastasis.

    abstract::The mechanism by which a malignant tumor cell establishes a metastatic foci is a complex process requiring the successful completion of a series of steps. If any step cannot be completed, the entire process fails. The tumor cell must separate from the primary tumor, gain access to an efferent channel (lymphatic or vas...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Springfield DS

    更新日期:1982-09-01 00:00:00

  • The John Charnley Award. Natural history of thromboembolic disease after total hip arthroplasty.

    abstract::In 1079 consecutive patients undergoing total hip arthroplasty between 1984 and 1992, complications of thromboembolic disease and related anticoagulation were reviewed for 6 months after hospital discharge, including cost data. Of 347 patients having venograms, 78 (22.5%) had positive results and 269 (77.5%) had negat...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Pellegrini VD Jr,Clement D,Lush-Ehmann C,Keller GS,Evarts CM

    更新日期:1996-12-01 00:00:00

  • Osteoporosis and bone density measurement methods.

    abstract::Recent technologic advances in bone mineral densitometry have resulted in increasingly precise and accurate methods of estimating bone mineral density. Dual-photon absorptiometry has been made obsolete by the introduction of dual-energy radiography, a development that is likely to result in more widespread use of dens...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章,评审

    doi:

    authors: Ostlere SJ,Gold RH

    更新日期:1991-10-01 00:00:00

  • Isolated all-polyethylene patellar revisions for metal-backed patellar failure.

    abstract:UNLABELLED:The outcome of isolated patellar component revisions after metal-backed patellar failure is variable with satisfactory results reported from 78% to 100%. To supplement information in the literature we determined the failure rate and the functional outcome based on the Knee Society clinical and roentgenograph...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1007/s11999-008-0414-1

    authors: Garcia RM,Kraay MJ,Goldberg VM

    更新日期:2008-11-01 00:00:00

  • Management of thumb duplication.

    abstract::Radial polydactyly, a common congenital problem, most often occurs as thumb duplication. It appears in pentadactylous, polydactylous, and hypoplastic hands and is simulated by complex syndactyly. Classically, there are three categories for radial polydactyly: severe hypoplasia, partial duplication, and total duplicati...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章,评审

    doi:

    authors: Dobyns JH,Lipscomb PR,Cooney WP

    更新日期:1985-05-01 00:00:00

  • Erythrocyte sedimentation rate and heterotopic bone formation after cemented total hip arthroplasty.

    abstract::The erythrocyte sedimentation rate (ESR) was analyzed in 176 patients treated with cemented total hip arthroplasty (THA) for primary osteoarthritis and correlated with the degree of heterotopic bone formation (HBF) one year after the THA. Ninety patients were treated with indomethacin in the first six postoperative we...

    journal_title:Clinical orthopaedics and related research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Kjaersgaard-Andersen P,Schmidt SA,Pedersen NW,Kristensen SS,Pedersen P

    更新日期:1989-11-01 00:00:00

  • Periosteal Fiber Transection During Periosteal Procedures Is Crucial to Accelerate Growth in the Rabbit Model.

    abstract:BACKGROUND:Disruption of the periosteum has been used to explain overgrowth after long bone fractures. Clinically, various periosteal procedures have been reported to accelerate growth with varied results. Differences between procedures and study populations, in these prior studies, make drawing conclusions regarding t...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1007/s11999-015-4646-6

    authors: Halanski MA,Yildirim T,Chaudhary R,Chin MS,Leiferman E

    更新日期:2016-04-01 00:00:00

  • Improvement in comfort and function after cuff repair without acromioplasty.

    abstract::The repair of full thickness rotator cuff tears traditionally has included acromioplasty and coracoacromial ligament section. Acromioplasty can be complicated by deltoid detachment, compromise of the deltoid lever arm, anterosuperior instability, and adhesions of the rotator cuff tendons under the bleeding cancellous ...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章,评审

    doi:10.1097/00003086-200109000-00017

    authors: Goldberg BA,Lippitt SB,Matsen FA 3rd

    更新日期:2001-09-01 00:00:00

  • Is a cementless dual mobility socket in primary THA a reasonable option?

    abstract:BACKGROUND:Dislocation after THA continues to be relatively common. Dual mobility sockets have been associated with low dislocation rates, but it remains unclear whether their use in primary THA would not introduce additional complications. QUESTIONS/PURPOSES:We therefore asked whether a current cementless dual mobili...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1007/s11999-012-2395-3

    authors: Hamadouche M,Arnould H,Bouxin B

    更新日期:2012-11-01 00:00:00

  • The current status of material used for depot delivery of drugs.

    abstract::The ideal local antibiotic delivery system has not been created. Antibiotic-laden bone cement has become the gold standard in the treatment of infected orthopaedic implants and there are confirmatory laboratory and clinical data that support the use of these materials. Heat-stable antibiotics elute from antibiotic-lad...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章,评审

    doi:10.1097/01.blo.0000143741.92384.18

    authors: Nelson CL

    更新日期:2004-10-01 00:00:00