Abstract:
:The notion of nanotechnology has evolved since its inception as a fantastic conceptual idea to its current position as a mainstream research initiative with broad applications among all divisions of science. In the first part of this series, we reviewed the structures and principles that comprise the main body of knowledge of nanoscience and nanotechnology. In the second part, we discussed applications of nanotechnology to the emerging field of nanomedicine, with specific attention on medical diagnostics and imaging. This article further explores the applications of nanotechnology to nanomedicine. Specific attention is given to developments in therapeutic modalities, including advanced drug delivery systems and targeted nanotherapy, which will form the basis for the treatment arm of mature nanomedicine. A variety of modalities are discussed, including polymeric nanoparticles, micelles, liposomes, dendrimers, fullerenes, hydrogels, nanoshells, and smart surfaces. Applications of nanotechnology to nanosurgery and nanoneurosurgery are presented. Femtosecond laser systems, nanoneedles, and nanotweezers are presented as technologies that are operational at the nanoscale level and have the potential to revolutionize the practice of neurosurgery in a profound and momentous way.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Leary SP,Liu CY,Apuzzo MLdoi
10.1227/01.NEU.0000217016.79256.16subject
Has Abstractpub_date
2006-06-01 00:00:00pages
1009-26; discussion 1009-26issue
6eissn
0148-396Xissn
1524-4040pii
00006123-200606000-00001journal_volume
58pub_type
杂志文章,评审相关文献
NEUROSURGERY文献大全abstract::We report the metastasis of a rectal carcinoid to the dura mater of the posterior fossa. The clinical presentation was unusual because of a 10-year latent period between resection of the primary rectal tumor and symptoms and signs of the posterior fossa metastasis; the radiological findings were atypical of a metastas...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-197910000-00017
更新日期:1979-10-01 00:00:00
abstract::The techniques for the treatment of intracranial arteriovenous fistulae include angiographic balloon occlusion of the fistula as well as direct surgical attack. Regardless of the method, the occurrence of severe hyperemia caused by a lack of autoregulation after obliteration of the fistula remains a significant concer...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199410000-00033
更新日期:1994-10-01 00:00:00
abstract::Intracranial cartilaginous tumors are unusual lesions, of which myxoid chondrosarcoma is the rarest. We describe this tumor arising from the falx in a 28-year-old woman treated at recurrence with a second operation and a radiation implant. The behavior of classic chondrosarcoma and mesenchymal chondrosarcoma is also r...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199208000-00021
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Posttraumatic syringomyelia affects approximately 28% of spinal cord injury patients, and current treatments are often ineffective. The pathogenesis of this condition remains poorly understood. Previous reports have focused on pathways and mechanisms of fluid inflow; however, disturbances of fluid outflow me...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e31825927d6
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:To develop a new saccular aneurysm model in vitro using elastase to study aneurysm initiation, growth, and rupture and to create a new in vivo aneurysm model to test endovascular therapies. METHODS:Seventeen common carotid arteries excised from freshly killed pigs and sheep were treated with seven different ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199707000-00034
更新日期:1997-07-01 00:00:00
abstract::A newly designed cottonoid is fixed to the tip of the suction device by the negative pressure. It is especially useful during microsurgical procedures in areas crowded with neurovascular elements. The advantage of pressure-mounted cottonoids lies in the protection provided to the brain and neurovascular elements durin...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-198212000-00010
更新日期:1982-12-01 00:00:00
abstract:BACKGROUND:Intracranial aneurysm rupture prediction is poor, with only a few risk factors for rupture identified and used in clinical practice. OBJECTIVE:To provide an overview of all the risk factors (including genetic, molecular, morphological, and hemodynamic factors) that have potential for use in clinical practic...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyx238
更新日期:2018-04-01 00:00:00
abstract::Tumor necrosis factor-alpha (TNF-alpha), a cytokine produced by astrocytes in vivo and in vitro, was tested for its effects on two malignant astrocytoma cell lines (A-172, U-87). Both lines were immunoreactive for glial fibrillary acidic protein, vimentin, Class I antigens, and interleukin-6. The lines differed in the...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199301000-00013
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:Carotid-cavernous fistulae are uncommon but well-documented sequelae of craniofacial trauma. A rare subset may arise from the posterior communicating artery instead of from the carotid artery proper. The presentation is similar to that of carotid-cavernous fistulae, with ocular pain, chemosis, and proptosis b...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000043817.55770.f8
更新日期:2003-02-01 00:00:00
abstract::A case of ulnar neuropathy at the elbow produced by spontaneous intraneural hemorrhage in a patient with acquired immunodeficiency syndrome and thrombocytopenia is reported. Intraneural hemorrhage in patients with bleeding disorders occurs infrequently. It consists of acute intrafascicular bleeding, presumably produci...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199102000-00019
更新日期:1991-02-01 00:00:00
abstract:OBJECTIVE:We evaluated somatosensory and motor interhemispheric integration in four patients who underwent transection of different portions of the anterior corpus callosum (CC) for removal of an intraventricular cyst. The study goal was to relate their performances to the topographical organization of the CC. METHODS...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000163089.31657.08
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Two patients with vertebrobasilar dolichoectasia sustained massive fatal subarachnoid hemorrhage from rupture of the basilar artery wall. Hemorrhage from this entity is not widely known to occur during its natural history and may be exacerbated by systemic anticoagulation. CLINICAL PRESENTATIO...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199802000-00108
更新日期:1998-02-01 00:00:00
abstract::We describe a case of spondylotic lumbar spinal stenosis in an infirm elderly patient successfully treated with multilevel laminotomies. This procedure is less stressful to patients than a full laminectomy. In a selected subgroup of patients with "hourglass" spondylotic stenosis, it may provide adequate decompression....
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198807000-00021
更新日期:1988-07-01 00:00:00
abstract::Oligodendrogliomas occur primarily in the cerebral hemispheres of adults. A rare case of an oligodendroglioma in the cerebellum of a child is presented. The tendency for oligodendroglioma to metastasize through the cerebrospinal fluid (CSF) is reviewed and emphasized. A recommendation for CSF cytology and possible spi...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198005000-00010
更新日期:1980-05-01 00:00:00
abstract::In this retrospective, consecutive series of 128 elderly patients (over 65 years of age) with histologically proven Grade 4 astrocytomas, 88 patients underwent stereotactic biopsy and 40 patients underwent stereotactic volumetric resection of the mass lesion defined by contrast enhancement on computed tomography. Ther...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:To search for correlations between specific anatomic, geometric, and morphological properties of the trigeminal nerve and the success of radiosurgical treatment and elimination of facial hypesthesia as a complication. METHODS:Forty-six patients with at least 6 months of follow-up after CyberKnife (Accuray, I...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000340795.87734.70
更新日期:2009-02-01 00:00:00
abstract::With the advent of more sensitive diagnostic techniques, we are encountering an increasing number of young patients harboring cerebral astrocytoma. The great danger in such patients is that the astrocytoma cells will undergo dedifferentiation to a higher state of malignancy. An essential question is whether the use of...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198706000-00028
更新日期:1987-06-01 00:00:00
abstract::The object of this investigation was to study the effects of dimethyl sulfoxide (DMSO) upon the evolution of cerebral infarction. Twenty adult cats anesthetized lightly with ketamine hydrochloride underwent right middle cerebral artery occlusion for 6 hours. Ten cats were not treated and 10 cats received DMSO (2.5 g/k...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198107000-00006
更新日期:1981-07-01 00:00:00
abstract:OBJECTIVE:Cerebral syphilitic gummata are rare manifestations of tertiary, meningovascular syphilis. No extensive characterization of these lesions has been published recently, and only a few small reviews containing imaging findings have been published to date. To better characterize cerebral gummata, we present a cas...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/01.NEU.0000337079.12137.89
更新日期:2009-03-01 00:00:00
abstract::External ventricular drainage (EVD) was used before and after posterior fossa operations in 62 children and adolescents. In all cases, the removal of the tumor (midline in 47 and laternal in 15) was attempted; total removal was achieved in 41. The overall mortality was 6.5% (4 patients). Only 25% of the survivors need...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract:OBJECTIVE:During the past 15 years, the concept of dysembryoplastic neuroepithelial tumors has continued to evolve. We present an interesting case of dysembryoplastic neuroepithelial tumor that showed rapid growth during a short period of time. CLINICAL PRESENTATION:A 9-year-old boy had been experiencing intractable c...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000245621.62721.79
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:The posterior meningeal artery (PMA) normally arises from the vertebral artery; however, its origin varies considerably as the result of its embryological development. This gains clinical significance when associated with vascular pathology. CLINICAL PRESENTATION:A 65-year-old man presented to his local hosp...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000325256.72308.AF
更新日期:2008-09-01 00:00:00
abstract::Dural arteriovenous fistulas are abnormal connections of dural arteries to dural veins or venous sinuses originating from within the dural leaflets. They are usually located near or within the wall of a dural venous sinus that is frequently obstructed or stenosed. The dural fistula sac is contained within the dural le...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/NEU.0000000000000228
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Cavernous malformations can present in children with a sporadic course of repeated hemorrhage and enlargement, but they are rarely aggressive, infiltrative, or multilobar. We present the case of a young boy with a complex cavernous malformation that evolved during the course of a decade to enco...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000137277.08281.48
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:Intraoperative detection of residual tumor tissue in glioma surgery remains an important challenge because the extent of tumor removal is related to the prognosis of the disease. Multiphoton excited fluorescence tomography of living tissues provides high-resolution structural and photochemical imaging at a su...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000204885.45644.22
更新日期:2006-04-01 00:00:00
abstract::A 23-year-old pregnant woman presented with sudden diplopia, ataxia, hemiparesis, and headache secondary to a brain stem hemorrhage. Magnetic resonance imaging (MRI) revealed a hematoma associated with a probable cavernous hemangioma of the rostral brain stem. In this report, we discuss the MRI findings leading to the...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198810000-00015
更新日期:1988-10-01 00:00:00
abstract:OBJECTIVE:This study assessed the neuropsychological outcome of patients after surgical treatment for third ventricle brain tumors. Neuropsychological consequences of surgical intervention can have a major impact on patients' quality of life and therefore have important implications for treatment planning. METHODS:A r...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000333775.81563.91
更新日期:2008-06-01 00:00:00
abstract::Fifty-one surgical decompressions without nerve transposition for ulnar neuropathy were performed in 46 patients. All of the patients were men with an average age of 59 years at the time of surgery. The follow-up range was between 5 and 32 months (average, 17.8 months). The disease involved the nondominant arm in 24 p...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199011000-00007
更新日期:1990-11-01 00:00:00
abstract::Intraoperative monitoring with electroencephalography and the use of brain protection with steroids, phenytoin, mannitol, and pentobarbital or etomidate were evaluated in 15 patients undergoing operation for an aneurysm of the upper basilar artery. One patient harbored a basilar trunk aneurysm, 1 an aneurysm of the pr...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-198912000-00008
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND:While multiple new larger-bore aspiration catheters have been introduced for stroke thrombectomy, sizeable cohort outcome studies are lacking along with meaningful comparative studies to evaluate whether they represent a clinically relevant improvement compared to predecessors. OBJECTIVE:To evaluate compara...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyaa498
更新日期:2020-12-28 00:00:00