Abstract:
:We recently introduced a novel method for estimating selection pressures on proteins, termed "volatility," which requires only a single genome sequence. Some criticisms that have been levied against this approach are valid, but many others are based on misconceptions of volatility, or they apply equally to comparative methods of estimating selection. Here, we introduce a simple regression technique for estimating selection pressures on all proteins in a genome, on the basis of limited comparative data. The regression technique does not depend on an underlying population-genetic mechanism. This new approach to estimating selection across a genome should be more powerful and more widely applicable than volatility itself.
journal_name
Mol Biol Evoljournal_title
Molecular biology and evolutionauthors
Plotkin JB,Dushoff J,Desai MM,Fraser HBdoi
10.1093/molbev/msl021subject
Has Abstractpub_date
2006-08-01 00:00:00pages
1457-9issue
8eissn
0737-4038issn
1537-1719pii
msl021journal_volume
23pub_type
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