Techniques used in studies of age-related DNA methylation changes.

abstract：:Biologics are playing an increasingly significant role in the practice of modern medicine and surgery in general and orthopedics in particular. Cell-based approaches are among the most important and widely used modalities in orthopedic biologics, with mesenchymal stem cells and other multi/pluripotent cells undergoing...

journal_title：Annals of the New York Academy of Sciences

authors： Lebaschi A,Nakagawa Y,Wada S,Cong GT,Rodeo SA

更新日期：2017-12-01 00:00:00

abstract：:Human alpha 2-antiplasmin (alpha 2AP) is the primary inhibitor of plasmin-mediated fibrinolysis and is an efficient substrate of activated factor XIII (FXIIIa). Among 452 amino acid residues in alpha 2AP, Gln2 is believed to be the sole FXIIIa-reactive site that participates in crosslinking alpha 2AP to fibrin. We stu...

journal_title：Annals of the New York Academy of Sciences

authors： Lee KN,Lee CS,Tae WC,Jackson KW,Christiansen VJ,McKee PA

更新日期：2001-01-01 00:00:00

abstract：:Successful introduction of nucleic acids into mammalian neurons has revolutionized the analyses of gene regulation and cellular function. Various methods, including viral infection, have been developed to introduce plasmid DNA into primary neuronal cultures. However, transfection of primary cultures of neurons using t...

journal_title：Annals of the New York Academy of Sciences

authors： Anji A,Shaik KA,Kumari M

更新日期：2003-05-01 00:00:00

abstract：:Regional climate modeling bridges the gap between the coarse resolution of current global climate models and the regional-to-local scales, where the impacts of climate change are of primary interest. Here, we present a review of the added value of the regional climate modeling approach within the scope of paleoclimate...

journal_title：Annals of the New York Academy of Sciences

authors： Ludwig P,Gómez-Navarro JJ,Pinto JG,Raible CC,Wagner S,Zorita E

更新日期：2019-01-01 00:00:00

abstract：:We report a case of latent autoimmune diabetes in adults (LADA), also known as slowly progressive type 1 diabetes (SPT1D), followed up for changes, including reactivity to the GAD65 antibody epitope for the 9-year period from impaired glucose tolerance (IGT) to the insulin-dependent stage (IDDM). This 69-year-old male...

journal_title：Annals of the New York Academy of Sciences

authors： Maruyama T,Koyama A,Hampe CS

更新日期：2008-12-01 00:00:00

abstract：:Carbon nanotubes are considered to be one of the novel most attractive materials in nanotechnology. Because of their multiple industrial and biomedical applications, thorough studies on their toxicity and biocompatibility become a priority in order to prevent possible health risks. In this study the effects of multiwa...

journal_title：Annals of the New York Academy of Sciences

authors： De Nicola M,Nuccitelli S,Gattia DM,Traversa E,Magrini A,Bergamaschi A,Ghibelli L

更新日期：2009-08-01 00:00:00

abstract：:The discrepancy between dynamical mass measures of objects such as galaxies and the observed distribution of luminous matter in the universe is typically explained by invoking an unseen "dark matter" component. Dark matter must necessarily be nonbaryonic. We introduce a simple hypothesis to do away with the necessity ...

journal_title：Annals of the New York Academy of Sciences

authors： Kinney WH,Brisudova M

更新日期：2001-06-01 00:00:00

abstract：:Acute viral infection of humans induces virus-specific serum antibody production that often persists for decades. To better understand the nature of this long-term antiviral antibody response, we studied antiviral antibody production of mice acutely infected with lymphocytic choriomeningitis virus (LCMV). Although thi...

journal_title：Annals of the New York Academy of Sciences

authors： Slifka MK,Ahmed R

更新日期：1996-10-25 00:00:00

abstract：:On the basis of evidence just reviewed, the hormonal requirements during IVM of mammalian oocytes for fertilization and developmental competence may be summarized as follows: 1. Nuclear maturation occurs "spontaneously," without follicular factors or hormones, in all mammalian species. 2. Cumulus cells are necessary d...

journal_title：Annals of the New York Academy of Sciences

authors： Armstrong DT,Zhang X,Vanderhyden BC,Khamsi F

更新日期：1991-01-01 00:00:00

abstract：:This study investigates the complete genome sequences of the Nine Mile, K, and G isolates to improve our understanding of the unique virulence properties of C. burnetii and to provide important insight into the genome architecture and genetic diversity of this pathogen. ...

journal_title：Annals of the New York Academy of Sciences

authors： Beare PA,Porcella SF,Seshadri R,Samuel JE,Heinzen RA

更新日期：2005-12-01 00:00:00

abstract：:Modest changes in gene expression of three-fold or less might be expected after mild to moderate neurotoxic exposure to classes of compounds, such as the substituted amphetamines, or at time points that are weeks after more severe neurotoxic exposures. When many genes appear to change expression by less than two-fold,...

journal_title：Annals of the New York Academy of Sciences

authors： Delongchamp RR,Harris AJ,Bowyer JF

更新日期：2003-05-01 00:00:00

abstract：:The recent identification of lymphatic endothelial cell-specific markers and the generation of mouse models harboring mutations in many genes that encode those markers have enabled us to begin to elucidate the developmental steps that go toward establishing the lymphatic vasculature network. Understanding these basic ...

journal_title：Annals of the New York Academy of Sciences

authors： Oliver G,Srinivasan RS

更新日期：2008-01-01 00:00:00

abstract：:Investigation of blood-brain barrier permeability and metabolic processes, and their regulation by endogenous or exogenous factors, will be important for development of efficient and selective delivery of therapeutic agents to the central nervous system. Primary cultures of brain microvessel endothelial cells offer a ...

journal_title：Annals of the New York Academy of Sciences

authors： Audus KL,Borchardt RT

更新日期：1987-01-01 00:00:00

abstract：:First we remind general considerations concerning biodiversity on earth and particularly the loss of genetic biodiversity that seems irreversible whether its origin is directly or indirectly linked to human activities. Urgent and considerable efforts must be made from now on to cataloge, understand, preserve, and enha...

journal_title：Annals of the New York Academy of Sciences

authors： Maillard JC,Gonzalez JP

更新日期：2006-10-01 00:00:00

abstract：:Approximately 90% of all cancer deaths arise from metastasis formation. Hence, understanding the molecular mechanisms underlying tumor progression, local invasion, and the formation of tumor metastases represents one of the great challenges in exploratory cancer research. Recent experimental results indicate that chan...

journal_title：Annals of the New York Academy of Sciences

authors： Cavallaro U,Christofori G

更新日期：2004-04-01 00:00:00

abstract：:Social motor coordination (SMC) pertains to the timing of contingent movements during social interactions and is of high relevance for successful social and musical interactions. Semi-automated, objective methods are increasingly being used to analyze SMC, though it is unclear if these methods are feasible in naturali...

journal_title：Annals of the New York Academy of Sciences

authors： Pfeiffer R,Wallace M,Lense M

更新日期：2018-05-04 00:00:00

abstract：:The 65-kDa isoform of glutamic acid decarboxylase (GAD65) is a major autoantigen in type 1 diabetes, and most patients have serum antibodies reactive with conformational epitopes on the GAD65 molecule. The aims of this study were to prepare mutants of GAD65 to further localize the type 1 diabetes epitope in the region...

journal_title：Annals of the New York Academy of Sciences

authors： Myers MA,Fenalti G,Gray R,Scealy M,Tong JC,El-Kabbani O,Rowley MJ

更新日期：2003-11-01 00:00:00

abstract：:Increase in the dosage of cellular oncogenes by DNA amplification is a frequent genetic alteration of cancer cells. In neuroblastoma, amplification of the gene MYCN has been associated with aggressively growing cancers and is an indicator for poor prognosis. MYCN amplification is of predictive value in identifying pat...

journal_title：Annals of the New York Academy of Sciences

authors： Schwab M

更新日期：2002-06-01 00:00:00

abstract：:The definition of polycystic ovary syndrome in very young girls is complicated by the fact that many features typical of the syndrome can also be seen as physiological stages in the maturation of the hypothalamus-pituitary-ovarian axis. The role of reduced insulin sensitivity in the pathogenesis and evolution of the d...

journal_title：Annals of the New York Academy of Sciences

authors： Bruni V,Dei M,Nannini S,Balzi D,Nuvolone D

更新日期：2010-09-01 00:00:00

abstract：:Justice judgments are subjective by nature, and are influenced substantially by motivational processes. In the present contribution, two motives underlying justice judgments are examined: individualistic motives to evaluate solutions to social problems that benefit the self in material or immaterial ways as fair versu...

journal_title：Annals of the New York Academy of Sciences

authors： van Prooijen JW

更新日期：2013-09-01 00:00:00

abstract：:The effects on ex vivo LDL resistance to oxidation and biomarkers of in vivo oxidative stress in response to 3-month dietary vitamin E restriction to 25% of recommended intake and 2-month unrestricted dietary intake and supplementation with 800 IU/d were studied in 100 healthy, nonsmoking 20-75-year-old volunteers. Si...

journal_title：Annals of the New York Academy of Sciences

authors： Winklhofer-Roob BM,Meinitzer A,Maritschnegg M,Roob JM,Khoschsorur G,Ribalta J,Sundl I,Wuga S,Wonisch W,Tiran B,Rock E,VITAGE Study Group.

更新日期：2004-12-01 00:00:00

abstract：:"Module networks" are a framework to learn gene regulatory networks from expression data using a probabilistic model in which coregulated genes share the same parameters and conditional distributions. We present a method to infer ensembles of such networks and an averaging procedure to extract the statistically most s...

journal_title：Annals of the New York Academy of Sciences

authors： Michoel T,De Smet R,Joshi A,Marchal K,Van de Peer Y

更新日期：2009-03-01 00:00:00

abstract：:The four diseases discussed in this chapter (dracunculiasis, onchocerciasis, schistosomiasis, and trachoma) are among the officially designated "Neglected Tropical Diseases," and each is also both the result of and a contributor to the poverty of many rural populations. To various degrees, they all have adverse effect...

journal_title：Annals of the New York Academy of Sciences

authors： Hopkins DR,Richards FO Jr,Ruiz-Tiben E,Emerson P,Withers PC Jr

更新日期：2008-01-01 00:00:00

abstract：:One of the most studied effects of verbal working memory (WM) is the influence of the length of the words that compose the list to be remembered. This work aims to investigate the nature of musical WM by replicating the word length effect in the musical domain. Length and rate of presentation were manipulated in a rec...

journal_title：Annals of the New York Academy of Sciences

authors： Akiva-Kabiri L,Vecchi T,Granot R,Basso D,Schön D

更新日期：2009-07-01 00:00:00

abstract：:In this chapter, we examine the possibility that negative emotions contribute to the relationship between socioeconomic status (SES) and health. A model of the associations among SES, emotion, and health is presented first. We then review the evidence for this model, showing associations of SES with depression, hopele...

journal_title：Annals of the New York Academy of Sciences

authors： Gallo LC,Matthews KA

更新日期：1999-01-01 00:00:00

abstract：:A range of imidazoline derivatives are known to be effective stimulators of insulin secretion, and this response correlates with closure of ATP-sensitive potassium channels in the pancreatic beta-cell. However, mounting evidence indicates that potassium channel blockade may form only part of the mechanism by which imi...

journal_title：Annals of the New York Academy of Sciences

authors： Morgan NG,Chan SL,Mourtada M,Monks LK,Ramsden CA

更新日期：1999-06-21 00:00:00

abstract：:Spinal cord injury remains with limited natural recovery and only a few general ineffective treatment options. Recent publications have reported enhanced neurologic recovery with the use of methylprednisolone and GM-1 ganglioside. The results of the Maryland GM-1 Ganglioside Study reported a significant drug effect wi...

journal_title：Annals of the New York Academy of Sciences

authors： Geisler FH

更新日期：1998-06-19 00:00:00

abstract：:This paper summarizes the goals of this section and considers current knowledge about the association between hormonal changes that occur over pubertal development and the changes in behavior and brain function over the adolescent period. It reviews the cascade of neural and hormonal changes that occur with puberty; d...

journal_title：Annals of the New York Academy of Sciences

authors： Cameron JL

更新日期：2004-06-01 00:00:00

abstract：:The prevalence of taste loss over a discrete area of the tongue or palate is unknown; however, we have identified discrete losses in three etiological groups: head trauma, upper respiratory infection, and bulimia. We have now identified discrete losses in elderly subjects. To summarize, elderly subjects show elevated ...

journal_title：Annals of the New York Academy of Sciences

authors： Bartoshuk LM

更新日期：1989-01-01 00:00:00

abstract：:Studies of animals with spontaneous autoimmune diabetes have revealed that autoreactive T cells that mediate islet beta cell destruction can be manipulated by the administration of Th(2) cytokines. Using gene delivery to express the targeted protein, we can overcome the need for frequent administration of cytokines on...

journal_title：Annals of the New York Academy of Sciences

authors： Park L,Lee E,Lee S,Lim M,Hong H,Shin G,Park Y

更新日期：2008-12-01 00:00:00