Dialysis enhances renal epithelial proliferations.

Abstract:

:Study of 115 kidneys from 60 patients with chronic renal failure maintained by dialysis for two months to five years revealed an unexpected number and variety of epithelial proliferative processes, several types of which are hitherto unreported. Proliferative activity was defined either by the presence of epithelial structures in ectopic situations, continuity with existing structures being demonstrable by serial sections, or by mitotic figures, or by both. The tendency for renal carcinoma development may relate to these dialysis-related epithelial proliferations originating in both glomerular and tubular epithelia. Enhanced renal epithelial proliferative capacity in dialysis may be employable in the experimental study of renal regeneration and in the therapy of patients with preterminal renal disease.

journal_name

Arch Pathol Lab Med

authors

McManus JF,Hughson MD,Hennigar GR,Fitts CT,Rajagopalan PR,Williams AV

subject

Has Abstract

pub_date

1980-04-01 00:00:00

pages

192-5

issue

4

eissn

0003-9985

issn

1543-2165

journal_volume

104

pub_type

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