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Nutritional outcomes following pediatric intestinal transplantation.

Abstract：

BACKGROUND:This study sought to describe the long-term nutritional outcomes of children after intestinal transplant (SBT). METHODS:Between 1991 and March 2005, 30 children received 33 SBT at a single center. Eligibility criteria included patient and graft survival >6 months. Weight, height, albumin, prealbumin, zinc (Zn), and essential fatty acid (EFA) levels were reviewed retrospectively. RESULTS:The 19 patients who met inclusion criteria had a median age at SBT of 2.9 years. The majority of patients were male, Latino, transplanted for necrotizing enterocolitis and received combined liver-SBT. All patients were weaned off total parenteral nutrition to elemental formula at a mean of 39 days post-SBT. Seventeen of 19 patients were Zn deficient and four patients were EFA deficient post-SBT. CONCLUSIONS:Pre-SBT most subjects were significantly deficient in anthropometric and biochemical parameters. Post-SBT the mean Z score for weight and height improved significantly at year 1, then leveled off in year 2. Serum protein levels improved from pre-SBT, yet remained low-normal. Zn deficiency was seen frequently after SBT and is under investigation. Children who developed EFA deficiency were on the same formula, receiving inadequate EFA supplementation. Successful SBT was associated with growth and maintenance of serum nutritional parameters but not with significant catch-up growth.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Venick RS,Farmer DG,Saikali D,Gordon S,Colangelo J,Reyen L,McDiarmid SV,Vargas JH,Ament ME,Busuttil RW

doi

10.1016/j.transproceed.2006.05.051

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

1718-9

issue

6

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(06)00539-2

journal_volume

38

pub_type

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