Modification of human airway smooth muscle reactivity by drugs that interfere with arachidonic acid metabolism.

Abstract:

:Histamine-induced contractions of small airways from human lung were substantially augmented by the cyclo-oxygenase inhibitor, indomethacin, whereas the contraction of larger airways was not. Mixed cyclo-oxygenase/lipoxygenase inhibitors of arachidonic acid metabolism did not modify histamine-induced contractions of smooth muscle from either small or large airways but completely reversed the augmentation of histamine responses produced by indomethacin on the smaller airways. The SRS-A (slow reacting substance of anaphylaxis) antagonist, FPL55712, did not affect the augmentation of histamine-induced contractions by indomethacin.

journal_name

Br J Pharmacol

authors

Adcock JJ,Garland LG

doi

10.1111/j.1476-5381.1982.tb09333.x

subject

Has Abstract

pub_date

1982-12-01 00:00:00

pages

570-2

issue

4

eissn

0007-1188

issn

1476-5381

journal_volume

77

pub_type

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