Selective toxicity of 5-S-cysteinyldopa, a melanin precursor, to tumor cells in vitro and in vivo.

abstract：:Multifunctional cytokines play important and only partially defined roles in mammary tumor development and progression. Normal human mammary epithelia] cells (MECs) constitutively produce interleukin (IL) 6, IL8, and a nonsecreted form of tumor necrosis factor. MEC transformation by different oncogenes is frequently a...

journal_title：Cancer research

authors： Basolo F,Fiore L,Fontanini G,Conaldi PG,Calvo S,Falcone V,Toniolo A

更新日期：1996-07-01 00:00:00

abstract：:Despite the impressive results obtained in animal models, the clinical use of tumor necrosis factor-alpha (TNF) as an anticancer drug is limited by severe toxicity. We have shown previously that targeted delivery of TNF to aminopeptidase N (CD13), a marker of angiogenic vessels, improved the therapeutic index of this ...

journal_title：Cancer research

authors： Curnis F,Gasparri A,Sacchi A,Longhi R,Corti A

更新日期：2004-01-15 00:00:00

abstract：:The alkylating agent temozolomide, commonly used in the treatment of malignant glioma, causes cellular cytotoxicity by forming O(6)-methylguanine adducts. In this report, we investigated whether temozolomide alters the activity of the transcription factor nuclear factor-kappaB (NF-kappaB). Temozolomide inhibits basal ...

journal_title：Cancer research

authors： Yamini B,Yu X,Dolan ME,Wu MH,Darga TE,Kufe DW,Weichselbaum RR

更新日期：2007-07-15 00:00:00

abstract：:The immunobiology of Friend erythroleukemia virus (FLV) has been the focal point of much research into immunological control of leukemia. We have been studying a murine model in which a rapidly fatal FLV infection of DBA/2 mice is suppressed to a dormant state by treatment with statolon, a double stranded RNA extract ...

journal_title：Cancer research

authors： DiCicco LM,Truitt GA,Wheelock EF

更新日期：1986-01-01 00:00:00

abstract：:MEK inhibition is of interest in cancer drug development, but clinical activity in metastatic colorectal cancer (mCRC) has been limited. Preclinical studies demonstrated Wnt pathway overexpression in KRAS-mutant cell lines resistant to the MEK inhibitor, selumetinib. The combination of selumetinib and cyclosporin A, a...

journal_title：Cancer research

authors： Krishnamurthy A,Dasari A,Noonan AM,Mehnert JM,Lockhart AC,Leong S,Capasso A,Stein MN,Sanoff HK,Lee JJ,Hansen A,Malhotra U,Rippke S,Gustafson DL,Pitts TM,Ellison K,Davis SL,Messersmith WA,Eckhardt SG,Lieu CH

更新日期：2018-09-15 00:00:00

abstract：:Advanced prostate cancer commonly metastasizes to bone, but transit of malignant cells across the bone marrow endothelium (BMEC) remains a poorly understood step in metastasis. Prostate cancer cells roll on E-selectin(+) BMEC through E-selectin ligand-binding interactions under shear flow, and prostate cancer cells ex...

journal_title：Cancer research

authors： Barthel SR,Hays DL,Yazawa EM,Opperman M,Walley KC,Nimrichter L,Burdick MM,Gillard BM,Moser MT,Pantel K,Foster BA,Pienta KJ,Dimitroff CJ

更新日期：2013-01-15 00:00:00

abstract：:Inflammatory pathways may mediate preparation of the "metastatic soil" in the lungs. Some of these pathways--activation and/or the recruitment of certain inflammatory cells--might depend on vascular endothelial growth factor receptor 1 (VEGFR1) activity. Thus, blocking the activity of VEGFR1 (or the interaction with i...

journal_title：Cancer research

authors： Duda DG,Jain RK

更新日期：2010-07-15 00:00:00

abstract：:Pregnant C3HeB/FeJ mice were treated with ethylnitrosourea (ENU) on one of gestation Days 10, 13, or 15 to determine if ENU treatment at different stages of gestation would result in qualitative or quantitative differences in lung tumors induced in the offspring. Lung tumors were counted and measured 6 mo after treatm...

journal_title：Cancer research

authors： Branstetter DG,Stoner GD,Budd C,Conran PB,Goldblatt PJ

更新日期：1988-01-15 00:00:00

abstract：:Driver tyrosine kinase mutations are rare in sarcomas, and patterns of tyrosine phosphorylation are poorly understood. To better understand the signaling pathways active in sarcoma, we examined global tyrosine phosphorylation in sarcoma cell lines and human tumor samples. Anti-phosphotyrosine antibodies were used to p...

journal_title：Cancer research

authors： Bai Y,Li J,Fang B,Edwards A,Zhang G,Bui M,Eschrich S,Altiok S,Koomen J,Haura EB

更新日期：2012-05-15 00:00:00

abstract：:Clinically available taxanes represent one of the most promising class of antitumor agents, despite several problems with their solubility and toxicity. In an attempt to improve the pharmacological profile of taxanes, a new series of analogues was synthesized from 14beta-hydroxy-10-deacetylbaccatin III and tested in a...

journal_title：Cancer research

authors： Polizzi D,Pratesi G,Tortoreto M,Supino R,Riva A,Bombardelli E,Zunino F

更新日期：1999-03-01 00:00:00

abstract：:2'-Fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine (FIAC) is a potent selective inhibitor of the replication of herpes simplex virus types 1 and 2 (HSV-1, HSV-2), varicella zoster virus, and cytomegalovirus in cell culture systems. FIAC produces an unequivocal therapeutic effect in mice that have been inoculated with ...

journal_title：Cancer research

authors： Young CW,Schneider R,Leyland-Jones B,Armstrong D,Tan CT,Lopez C,Watanabe KA,Fox JJ,Philips FS

更新日期：1983-10-01 00:00:00

abstract：:Cellular immune competence was found to be impaired in previous studies of patients with malignant brain tumors. In patients with nonneural tumors, we recently found that serum levels of acute-phase proteins were related to immune status as well as to tumor extent. To determine whether the serum proteins in patients w...

journal_title：Cancer research

authors： Weiss JF,Morantz RA,Bradley WP,Chretien PB

更新日期：1979-02-01 00:00:00

abstract：:Docetaxel tolerance and antitumor efficacy could be enhanced if drug administration was adapted to circadian rhythms. This hypothesis was investigated in seven experiments involving a total of 626 male B6D2F1 mice, synchronized with an alternation of 12 h of light and 12 h of darkness (12:12), after i.v. administratio...

journal_title：Cancer research

authors： Tampellini M,Filipski E,Liu XH,Lemaigre G,Li XM,Vrignaud P,François E,Bissery MC,Lévi F

更新日期：1998-09-01 00:00:00

abstract：:We have applied Raman spectroscopy to analyze the chemical composition of microcalcifications occurring in benign and malignant lesions in the human breast. Microcalcifications were initially separated into two categories based on their Raman spectrum: type I, calcium oxalate dihydrate, and type II, calcium hydroxyapa...

journal_title：Cancer research

authors： Haka AS,Shafer-Peltier KE,Fitzmaurice M,Crowe J,Dasari RR,Feld MS

更新日期：2002-09-15 00:00:00

abstract：:One of the greatest challenges in developing therapeutic regimens is the inability to rapidly and objectively assess tumor response due to treatment. Moreover, tumor response to therapeutic intervention in many cases is transient, and progressive alterations within the tumor may mask the effectiveness of an initially ...

journal_title：Cancer research

authors： Lee KC,Hall DE,Hoff BA,Moffat BA,Sharma S,Chenevert TL,Meyer CR,Leopold WR,Johnson TD,Mazurchuk RV,Rehemtulla A,Ross BD

更新日期：2006-05-01 00:00:00

abstract：:Cultures of human mammary epithelial cells (HMECs) contain a subpopulation of variant cells with the capacity to propagate beyond an in vitro proliferation barrier. These variant HMECs, which contain hypermethylated and silenced p16(INK4a) (p16) promoters, eventually accumulate multiple chromosomal changes, many of wh...

journal_title：Cancer research

authors： Holst CR,Nuovo GJ,Esteller M,Chew K,Baylin SB,Herman JG,Tlsty TD

更新日期：2003-04-01 00:00:00

abstract：:The aim of this study was to determine whether buccal mucosa would provide an alternate source of tissue for human biomonitoring. Samples of clinically normal oral biopsies were excised, and buccal mucosa were scraped or brushed from patients while they were undergoing surgery for the excision of intra-oral squamous c...

journal_title：Cancer research

authors： Stone JG,Jones NJ,McGregor AD,Waters R

更新日期：1995-03-15 00:00:00

abstract：:The purpose of this study was to evaluate the efficacy of treatment with recombinant interleukin-2 (rIL-2) and lymphokine-activated killer cells in patients with advanced bladder cancer and to study the induced changes in the distribution of leukocyte subsets in blood and tumor. Nine patients with metastatic transitio...

journal_title：Cancer research

authors： Hermann GG,Geertsen PF,von der Maase H,Steven K,Andersen C,Hald T,Zeuthen J

更新日期：1992-02-01 00:00:00

abstract：:Cytogenetic analysis has indicated that deletion of chromosome 9p occurs in a significant number of non-small cell lung and mesothelioma tumors. Using paired oligonucleotide primers, we have undertaken an extensive analysis of 9p markers to determine homozygous and heterozygous loss of marker sequences. Homozygous los...

journal_title：Cancer research

authors： Mead LJ,Gillespie MT,Irving LB,Campbell LJ

更新日期：1994-05-01 00:00:00

abstract：:The effect of the potent angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (TNP-470), a semisynthetic analogue of fumagillin, on tumor growth and metastasis was studied using rodent tumors. Injection of TNP-470 s.c. inhibited tumor growth in a dose-dependent manner, and the tumor sizes of B16BL6 melanoma, M5...

journal_title：Cancer research

authors： Yamaoka M,Yamamoto T,Masaki T,Ikeyama S,Sudo K,Fujita T

更新日期：1993-09-15 00:00:00

abstract：:The liver represents a major and frequently sole site of metastases for many types of cancer, particularly gastrointestinal cancers. We showed previously that coadministration of an engineered hepatic-targeting Listeria monocytogenes (LM) with a cancer vaccine enhanced the antitumor effect of vaccine-induced T cells s...

journal_title：Cancer research

authors： Yoshimura K,Laird LS,Chia CY,Meckel KF,Slansky JE,Thompson JM,Jain A,Pardoll DM,Schulick RD

更新日期：2007-10-15 00:00:00

abstract：:The nevoid basal cell carcinoma (Gorlin) syndrome (NBCCS) is an autosomal dominant disorder characterized by multiple developmental defects and cancer susceptibility. NBCCS is caused by mutations in the human homologue (PTCH) of the Drosophila patched gene, a developmental regulator implicated in signaling of hedgehog...

journal_title：Cancer research

authors： Vorechovský I,Undén AB,Sandstedt B,Toftgård R,Ståhle-Bäckdahl M

更新日期：1997-11-01 00:00:00

abstract：:In spite of preclinical efficacy and recent randomized, controlled studies with adenoviral vectors expressing herpes simplex virus-1 thymidine kinase (HSV1-TK) showing statistically significant increases in survival, most clinical trials using single therapies have failed to provide major therapeutic breakthroughs. Be...

journal_title：Cancer research

authors： Ali S,King GD,Curtin JF,Candolfi M,Xiong W,Liu C,Puntel M,Cheng Q,Prieto J,Ribas A,Kupiec-Weglinski J,van Rooijen N,Lassmann H,Lowenstein PR,Castro MG

更新日期：2005-08-15 00:00:00

abstract：:The retinoic acid receptor type beta (RAR beta) complementary DNA from a small cell tumor line was amplified, sequenced, and found to be homologous to the murine RAR beta 1. Seventeen lung tumor lines were analyzed. Five of seven small cell lung carcinoma lines expressed RAR beta 1, but only one other line (epidermoid...

journal_title：Cancer research

authors： Houle B,Pelletier M,Wu J,Goodyer C,Bradley WE

更新日期：1994-01-15 00:00:00

abstract：:Alpha-particle immunotherapy by targeted alpha-emitters or alpha-emitting isotope generators is a novel form of extraordinarily potent cancer therapy. A major impediment to the clinical use of targeted actinium-225 (225Ac) in vivo generators may be the radiotoxicity of the systemically released daughter radionuclides....

journal_title：Cancer research

authors： Jaggi JS,Kappel BJ,McDevitt MR,Sgouros G,Flombaum CD,Cabassa C,Scheinberg DA

更新日期：2005-06-01 00:00:00

abstract：:We have analyzed the Fas-mediated death pathway in a panel of 11 Epstein-Barr virus (EBV)-negative and 10 EBV-positive Burkitt's lymphoma (BL) cell lines. We show that the increased expression of Fas in EBV-positive cell lines is mediated via LMP-1. Four of the 21 BL cell lines are readily responsive to Fas-mediated c...

journal_title：Cancer research

authors： Gutiérrez MI,Cherney B,Hussain A,Mostowski H,Tosato G,Magrath I,Bhatia K

更新日期：1999-02-01 00:00:00

abstract：:The effect of an i.p. injection of glucose on the thermal response of murine tissues was studied. Animal tumors were early generation isotransplants of a spontaneous fibrosarcoma, FSa-II. Tumors were transplanted into the foot pad, and hyperthermia was given by immersing the foot into a constant-temperature water bath...

journal_title：Cancer research

authors： Urano M,Montoya V,Booth A

更新日期：1983-02-01 00:00:00

abstract：:A superinduction of the polyamine catabolic enzyme, spermidine/spermine N1-acetyltransferase (SSAT) accompanies the phenotype-specific cytotoxic response to a class of antitumor polyamine analogues in several important human solid tumor models. A highly specific antiserum against the human SSAT protein has been develo...

journal_title：Cancer research

authors： Casero RA Jr,Gabrielson EW,Pegg AE

更新日期：1994-08-01 00:00:00

abstract：:Human papillomavirus type 16 (HPV16) E7 is a viral oncoprotein that is believed to play a major role in cervical neoplasia. Anti-HPV16 E7 intracellular single-chain antibodies (scFvs) were constructed to down-regulate HPV16 E7 oncoprotein in HPV DNA-containing cell lines. In these studies, we transfected anti-E7 scFvs...

journal_title：Cancer research

authors： Wang-Johanning F,Gillespie GY,Grim J,Rancourt C,Alvarez RD,Siegal GP,Curiel DT

更新日期：1998-05-01 00:00:00

abstract：:Mutations in the NH(2)-terminal regulatory domain of the beta-catenin gene lead to aberrant stabilization and accumulation of the protein and increased TCF/LEF-dependent transcription. Although these mutations are common in some cancers, they are infrequent in prostate and breast cancer. We have found that metastatic ...

journal_title：Cancer research

authors： Rios-Doria J,Kuefer R,Ethier SP,Day ML

更新日期：2004-10-15 00:00:00