Increased lipid peroxidation in patients with non-alcoholic fatty liver disease and chronic hepatitis C as measured by the plasma level of 8-isoprostane.

Abstract:

BACKGROUND:Oxidative stress plays an important role in the pathogenesis of chronic liver diseases. The plasma level of 8-isoprostane, a product of lipid peroxidation, is a marker of oxidative stress in vivo. The aim of the present study was to clarify whether the degree of lipid peroxidation, as measured by the plasma level of 8-isoprostane, influences the progression of chronic liver diseases and hepatocarcinogenesis. METHODS:Plasma 8-isoprostane levels were investigated in 14 patients with non-alcoholic fatty liver disease (NAFLD), 75 with chronic hepatitis C (CH-C), 14 with cured CH-C, 14 with HCV-positive hepatocellular carcinoma (HCC-C) and 38 healthy volunteers. 8-Isoprostane was measured by enzyme immunoassay after affinity column purification. RESULTS:Plasma 8-isoprostane was significantly elevated in NAFLD (11.9 [3.8-56.8] pg/mL), CH-C (10.1 [4.2-134.5] pg/mL) as compared to controls (6.3 [3.6-11.1] pg/mL). Plasma 8-isoprostane values were positively correlated with body mass index in NAFLD (P < 0.05) and with total cholesterol in cured CH-C (P < 0.01). 8-Isoprostane levels were not significantly related to sex, age, biochemical data or iron metabolism markers in all liver diseases. In addition, after the administration of peg-interferon, the values of 8-isoprostane improved in almost all patients, reaching values of healthy subjects. CONCLUSIONS:8-Isoprostane values are elevated in patients with NAFLD and CH-C as compared to healthy controls. Oxidative stress caused by increased lipid peroxidation is involved in the pathogenesis of NAFLD and CH-C.

authors

Konishi M,Iwasa M,Araki J,Kobayashi Y,Katsuki A,Sumida Y,Nakagawa N,Kojima Y,Watanabe S,Adachi Y,Kaito M

doi

10.1111/j.1440-1746.2006.04420.x

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

1821-5

issue

12

eissn

0815-9319

issn

1440-1746

pii

JGH4420

journal_volume

21

pub_type

杂志文章
  • What is the clinical significance of stromal angiogenesis in Barrett's esophagus?

    abstract:BACKGROUND:Enriched blood vessels occur in the stroma of Barrett's esophagus and are related to the ease of tumor invasion in the early stage of the cancer. Hypoxia-inducible factor (HIF) is closely related with angiogenesis through expression of vascular endothelial growth factor. The aim of the present study was to d...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2008.05440.x

    authors: Moriyama N,Amano Y,Mishima Y,Okita K,Takahashi Y,Yuki T,Ishimura N,Ishihara S,Kinoshita Y

    更新日期:2008-12-01 00:00:00

  • Case report: acanthosis nigricans in association with primary biliary cirrhosis: resolution after liver transplantation.

    abstract::A case is described of a 58 year old Caucasian male with primary biliary cirrhosis (PBC) who first presented with acanthosis nigricans of both axillae, skin pigmentation, which was pronounced over the posterior surface of the neck, and generalized pruritus. Following orthotopic liver transplantation for progressive li...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1996.tb00025.x

    authors: Pham TH,Kaushik S,Lin BP,Jones DB

    更新日期:1996-11-01 00:00:00

  • Predicting the efficacy of proton pump inhibitors in patients with non-erosive reflux disease before therapy using dual-channel 24-h esophageal pH monitoring.

    abstract:BACKGROUND AND AIM:We aimed to determine whether reflux- and symptom-related parameters can predict the efficacy of proton pump inhibitors (PPI) in non-erosive reflux disease (NERD). METHODS:Twenty-seven NERD patients who had experienced heartburn more than once a week within the previous month were enrolled. Intraeso...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/j.1440-1746.2011.06975.x

    authors: Shimatani T,Sugimoto M,Nishino M,Adachi K,Furuta K,Ito M,Kurosawa S,Manabe N,Mannen K,Hongo M,Chiba T,Kinoshita Y,Acid-Related Symptom Research (ARS) Group.

    更新日期:2012-05-01 00:00:00

  • Repeating measurements by transient elastography in non-alcoholic fatty liver disease patients with high liver stiffness.

    abstract:BACKGROUND AND AIM:The Baveno VI Consensus recommends repeating examination in patients with high liver stiffness measurement (LSM) by transient elastography to reduce false-positive diagnosis of advanced liver disease. We tested whether repeating transient elastography can increase the overall diagnostic accuracy. ME...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14311

    authors: Chow JC,Wong GL,Chan AW,Shu SS,Chan CK,Leung JK,Choi PC,Chim AM,Chan HL,Wong VW

    更新日期:2019-01-01 00:00:00

  • Reutilization of accessories in gastrointestinal endoscopic practice.

    abstract::The key issues that determine the decision between reusable versus disposable accessories are cost and functionality. In most health-care systems the availability and dissemination of endoscopic services relates directly to the resources (i.e. budget) of that system. Given the limitations of health-care budgets, acces...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1440-1746.2000.02272.x

    authors: Haber G

    更新日期:2000-10-01 00:00:00

  • Clinical features and outcomes of cirrhosis due to non-alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C.

    abstract:BACKGROUND AND AIM:Ethnic differences in non-alcoholic steatohepatitis (NASH) are well-documented, but there has been no study on the prognosis of Japanese NASH patients with cirrhosis. Accordingly, we compared cirrhotic NASH with liver cirrhosis caused by chronic hepatitis C (LC-C) to clarify its clinical features and...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2008.05640.x

    authors: Yatsuji S,Hashimoto E,Tobari M,Taniai M,Tokushige K,Shiratori K

    更新日期:2009-02-01 00:00:00

  • Validation of an extension of the international non-invasive criteria for the diagnosis of hepatocellular carcinoma to the characterization of macroscopic portal vein thrombosis.

    abstract:BACKGROUND AND AIM:We aimed to validate the non-invasive criteria for the characterization of portal vein thrombosis (PVT) in patients with cirrhosis and hepatocellular carcinoma (HCC). In a prospective study, we examined the impact of arterial hypervascularity, as established by the European Association for the Study ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2010.06564.x

    authors: Sorrentino P,Tarantino L,D'Angelo S,Terracciano L,Ferbo U,Bracigliano A,Panico L,De Chiara G,Lepore M,De Stefano N,Fiorentino F,Vecchione R

    更新日期:2011-04-01 00:00:00

  • Utility and limitations of noninvasive fibrosis markers for predicting prognosis in biopsy-proven Japanese non-alcoholic fatty liver disease patients.

    abstract:BACKGROUND AND AIM:The fibrosis stage of non-alcoholic fatty liver disease (NAFLD) is closely associated with long-term prognosis, including liver-related mortality. However, it is not yet clear whether noninvasive fibrosis markers can predict the incidence of non-liver-related complications in Japanese NAFLD. In this ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14448

    authors: Ito T,Ishigami M,Ishizu Y,Kuzuya T,Honda T,Hayashi K,Nishimura D,Toyoda H,Kumada T,Goto H,Hirooka Y

    更新日期:2019-01-01 00:00:00

  • Effects of lipopolysaccharide on platelet-derived growth factor isoform and receptor expression in cultured rat common bile duct fibroblasts and cholangiocytes.

    abstract:BACKGROUND AND AIM:Little is known about the role of platelet-derived growth factor (PDGF) in biliary fibrosis in the setting of bacterial colonization of the biliary tree. We therefore sought to investigate whether exposure to bacterial lipopolysaccharide (LPS) alters PDGF isoform and receptor expression in cultured r...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2008.05729.x

    authors: Kim TH,Moon JH,Savard CE,Kuver R,Lee SP

    更新日期:2009-07-01 00:00:00

  • Oral manifestations in patients with familial adenomatous polyposis: A systematic review and meta-analysis.

    abstract:BACKGROUND AND AIM:The oral manifestations of familial adenomatous polyposis (FAP) have been reported in the recent literature. Therefore, there has been growing interest in the characterization of the dento-osseous anomalies because they may precede colorectal cancer and may be used as a diagnostic marker. This system...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/jgh.13149

    authors: Almeida FT,Pachêco-Pereira C,Porporatti AL,Flores-Mir C,Leite AF,De Luca Canto G,Guerra EN

    更新日期:2016-03-01 00:00:00

  • Serum hyaluronic acid reflects the effect of interferon treatment on hepatic fibrosis in patients with chronic hepatitis C.

    abstract::Changes in serum hyaluronic acid (HA) in 35 patients treated with interferon (IFN) were studied and the histological change in fibrosis was analysed. Serum HA levels and hepatitis C virus (HCV) RNA were followed from the start of therapy to 12 months after completion of treatment. Histological changes in pre- and post...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1996.tb00308.x

    authors: Yamada M,Fukuda Y,Koyama Y,Nakano I,Urano F,Katano Y,Hayakawa T

    更新日期:1996-07-01 00:00:00

  • Case report: Colonic duplication: a rare cause of obstruction.

    abstract::Complete duplication of the entire large bowel with partial ileal involvement is very rare and diagnosis can often be difficult as illustrated by this case report. We also review the other clinical associations of this rare condition and briefly discuss the embryology of duplications of the gastrointestinal tract. ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.1999.01951.x

    authors: Jimenez SG,Oliver MR,Stokes KB,Morreau PN,Chow CW

    更新日期:1999-09-01 00:00:00

  • Significance of RCAS1 antigen in hepatocellular, cholangiocellular and pancreatic carcinomas.

    abstract::Since receptor-binding cancer antigen expressed on SiSo cells (RCAS1) was first reported as a tumor-associated antigen of gynecologic cancer, its function and practical value as a tumor marker have been investigated in various types of carcinomas. Basic research has indicated that RCAS1 expression in cancer cells cont...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.2005.03840.x

    authors: Enjoji M,Nakashima M,Yamaguchi K,Kotoh K,Nakamuta M

    更新日期:2005-08-01 00:00:00

  • Circulating Th17 cells frequency is associated with the disease progression in HBV infected patients.

    abstract:BACKGROUND AND AIMS:Th17 cells have been shown to mediate host defensive mechanisms in various infections, but their role in HBV infection in humans has not been well characterized. In this study, we analyzed the frequency and cytokines secretion of circulating Th17 cells in HBV infected patients with different statuse...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2009.06154.x

    authors: Wu W,Li J,Chen F,Zhu H,Peng G,Chen Z

    更新日期:2010-04-01 00:00:00

  • Complications and diagnostic difficulties arising from biliary self-expanding metal stent insertion before definitive histological diagnosis.

    abstract:BACKGROUND:Self-expanding metal bile duct stents provide good palliation for inoperable malignant disease. However, problems may arise if metal stents are inserted before definitive histological diagnosis. The aim of this study was to evaluate the outcome of such patients. METHODS:A retrospective case note review was ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2006.04562.x

    authors: Ayaru L,Kurzawinski TR,Shankar A,Webster GJ,Hatfield AR,Pereira SP

    更新日期:2008-02-01 00:00:00

  • Attitudes and knowledge of colorectal cancer and screening in Hong Kong: a population-based study.

    abstract:BACKGROUND:Colorectal cancer (CRC) ranks third of all cancer mortalities in Hong Kong. CRC screening can reduce mortality. However, participation in the CRC screening program depends on the knowledge and attitude of the population. The aim of this study is to investigate the knowledge and attitude towards CRC screening...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2005.04000.x

    authors: Wong BC,Chan AO,Wong WM,Hui WM,Kung HF,Lam SK

    更新日期:2006-01-01 00:00:00

  • A prospective randomized double blind trial comparing prednisolone and 4-aminosalicylic acid enemas in acute distal ulcerative colitis.

    abstract::A prospective double blind and randomized study was conducted to compare 4-aminosalicylic acid (4-ASA) and prednisolone-21-phosphate enemas in inducing remission in patients with acute distal ulcerative colitis. Patients with ulcerative colitis distal to the splenic flexure as assessed by flexible colonoscopy, barium ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1440-1746.1992.tb00957.x

    authors: Sharma MP,Duphare HV,Dasarathy S

    更新日期:1992-03-01 00:00:00

  • The preliminary experimental and clinical study of the relationship between the pigment gallstone and intestinal mucosal barrier.

    abstract:AIMS:To investigate the relations between the formation of pigment gallstone and the function of the intestinal mucosal barrier, as well as the underlying mechanism. METHODS:Eighty guinea pigs were randomly divided into three groups in which they were respectively given normal diet, gallstone-causing diet, and gallsto...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2009.05842.x

    authors: Su Y,Wu S,Fan Y,Jin J,Zhang Z

    更新日期:2009-08-01 00:00:00

  • Noninvasive evaluation of hepatic fibrosis in hepatitis C virus-infected patients using ethoxybenzyl-magnetic resonance imaging.

    abstract:BACKGROUND AND AIMS:Liver biopsy is the gold standard test to determine the grade of fibrosis, but there are associated problems. Because gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid is secreted partially in hepatocytes and bile, it is possible that ethoxybenzyl-magnetic resonance imaging (EOB-MRI) corre...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12181

    authors: Nojiri S,Kusakabe A,Fujiwara K,Shinkai N,Matsuura K,Iio E,Miyaki T,Joh T

    更新日期:2013-06-01 00:00:00

  • Acute pancreatitis associated with biliary disease in children.

    abstract:BACKGROUND AND AIMS:Biliary disease is one of the most common causes of acute pancreatitis in adults; however, this cause and outcome in children have rarely been described in the literature. Therefore, the present study was conducted to evaluate the role of biliary disease as a cause of acute pancreatitis in children....

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2003.03080.x

    authors: Choi BH,Lim YJ,Yoon CH,Kim EA,Park YS,Kim KM

    更新日期:2003-08-01 00:00:00

  • Achalasia of the oesophagus: treatments with pneumatic dilatation.

    abstract::A series of 51 patients with achalasia of the oesophagus treated by pneumatic dilatation between 1980 and 1988 is reported. Treatment was assessed as effective (no or minimal dysphagia) in 78% of patients, followed for a mean of 30 months. Thirty-four patients required only one dilatation and only two patients had mor...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1990.tb01125.x

    authors: Prewett EJ,Desmond PV,Breen KJ

    更新日期:1990-11-01 00:00:00

  • Quality of meta-analyses in major leading gastroenterology and hepatology journals: A systematic review.

    abstract:BACKGROUND AND AIM:To appraise the current reporting methodological quality of meta-analyses in five leading gastroenterology and hepatology journals, and to identify the variables associated with the reporting quality. METHODS:We systematically searched the literature of meta-analyses in Gastroenterology, Gut, Hepato...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/jgh.13591

    authors: Liu P,Qiu Y,Qian Y,Chen X,Wang Y,Cui J,Zhai X

    更新日期:2017-01-01 00:00:00

  • Immunohistochemical study of microvessel density, CD44 (standard form), p53 protein and c-erbB2 in gallbladder carcinoma.

    abstract:BACKGROUND:The purpose of the present study was to investigate microvessel density (MVD), and the expression of CD44 adhesion molecule, p53 protein and c-erbB2 in gallbladder carcinoma, and their relation to histological grade and tumor invasiveness. METHODS:Immunohistochemical staining with antibodies against factor ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2004.03357.x

    authors: Kalekou H,Miliaras D

    更新日期:2004-07-01 00:00:00

  • Clinical significance of SEN-virus on interferon response in chronic hepatitis C patients.

    abstract:BACKGROUND AND AIM:A novel virus, SEN-virus (SENV), was recently discovered. It has been reported as a candidate for a non-A-E hepatitis virus. However, much is still unknown about the clinical significance of SENV. The aim of the present study was to clarify the clinical significance of SENV in patients coinfected wit...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2003.02946.x

    authors: Lin JG,Goto T,Nakane K,Miura K,Mikami K,Ohshima S,Yoneyama K,Watanabe S

    更新日期:2003-10-01 00:00:00

  • Effects of washout following indomethacin administration on electrical field stimulation-induced isolated rat gastric fundus strip contractions.

    abstract:BACKGROUND AND AIM:Although gastric hypermotility is one of the mechanisms proposed to explain the ulcerogenic action of indomethacin, the drug has shown relaxatory effects on isolated longitudinal and transverse rat gastric fundus. To explain the above discrepancy, the aim of this study was to investigate the effects ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2007.04860.x

    authors: Keshavarz M,Afshin S,Djahanguiri B

    更新日期:2007-09-01 00:00:00

  • Pegylated alpha-interferon-2a plus ribavirin compared with pegylated alpha-interferon-2b plus ribavirin for initial treatment of chronic hepatitis C virus: prospective, non-randomized study.

    abstract:BACKGROUND AND AIM:We assessed whether the two regimens of pegylated alpha-interferon-2b (PEG-IFN-alpha2b) plus ribavirin and pegylated alpha-interferon-2a (PEG-IFN-alpha2a) plus ribavirin showed differences in terms of sustained virological response, withdrawal due to side-effects and dose adjustment requirements in t...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2008.05397.x

    authors: Escudero A,Rodríguez F,Serra MA,Del Olmo JA,Montes F,Rodrigo JM

    更新日期:2008-06-01 00:00:00

  • Effects of insulin-like growth factors-IR and -IIR antisense gene transfection on the biological behaviors of SMMC-7721 human hepatoma cells.

    abstract:BACKGROUND AND AIMS:Insulin-like growth factors (IGFs) are closely related to hepatocellular carcinoma growth. The study aim was to investigate the effects of IGF-IR and IGF-IIR antisense gene transfection on the biological behaviors of SMMC-7721 human hepatoma cells. METHODS:7721-IGF-IR-AS cells (human hepatoma SMMC-...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2003.02961.x

    authors: Yang JM,Chen WS,Liu ZP,Luo YH,Liu WW

    更新日期:2003-03-01 00:00:00

  • Changes in the first line Helicobacter pylori eradication rates using the triple therapy-a multicenter study in the Tokyo metropolitan area (Tokyo Helicobacter pylori study group).

    abstract:BACKGROUND AND AIM:Helicobacter pylori (H. pylori) infection is a strong risk factor for the development of gastric cancer. In 2013, the Japanese government approved H. pylori eradication therapy in patients with chronic gastritis as well as peptic ulcer. However, the continuing decline in eradication rates for first-l...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12796

    authors: Kawai T,Takahashi S,Suzuki H,Sasaki H,Nagahara A,Asaoka D,Matsuhisa T,Masaoaka T,Nishizawa T,Suzuki M,Ito M,Kurihara N,Omata F,Mizuno S,Torii A,Kawakami K,Ohkusa T,Tokunaga K,Mine T,Sakaki N

    更新日期:2014-12-01 00:00:00

  • Real-time polymerase chain reaction quantification of specific butyrate-producing bacteria, Desulfovibrio and Enterococcus faecalis in the feces of patients with colorectal cancer.

    abstract:BACKGROUND AND AIM:Bacterial metabolites produced in the bowel are potentially related to the genesis of colorectal cancer. Butyrate is protective against cancer, whereas hydrogen sulfide and oxygen free radicals can be toxic to the epithelium. The present study was designed to quantitate Eubacterium rectale, Faecaliba...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2008.05490.x

    authors: Balamurugan R,Rajendiran E,George S,Samuel GV,Ramakrishna BS

    更新日期:2008-08-01 00:00:00

  • Safety and efficacy of elbasvir/grazoprevir in Asian participants with hepatitis C virus genotypes 1 and 4 infection.

    abstract:BACKGROUND AND AIM:Estimates suggest that in Asia, more than 31 million individuals have hepatitis C virus infection. The present analysis was conducted to assess the efficacy and safety of elbasvir/grazoprevir in Asian participants enrolled in the elbasvir/grazoprevir phase 2/3 clinical trials. METHODS:This is an int...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14636

    authors: Wei L,Kumada H,Perumalswami PV,Tanwandee T,Cheng W,Heo J,Cheng PN,Hwang P,Mu SM,Zhao XM,Asante-Appiah E,Caro L,Hanna GJ,Robertson MN,Haber BA,Talwani R

    更新日期:2019-09-01 00:00:00