Abstract:
:From knowledge of the optical parameters of experimental animal eyes and radiometric parameters of the light source, it is possible to provide accurate retinal irradiances (dose rates). Examples are given for the rat, cat, monkey and other animals of interest. Fluorescent lamps and incandescent lamp radiances are provided and from them, retinal irradiances are given. These levels are compared with daylight exposure conditions. It is explained that small animal eyes received the highest light levels at the retina.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Sliney DHdoi
10.3109/02713688408997199subject
Has Abstractpub_date
1984-01-01 00:00:00pages
175-9issue
1eissn
0271-3683issn
1460-2202journal_volume
3pub_type
杂志文章abstract:PURPOSE:Increases in matrix proteins, such as type I collagen and fibronectin, are observed with aging in the retinal pigment epithelium (RPE) basement membrane. However, little is known about altered gene expression profiles of RPE associated with increases in matrix proteins. We investigated changes in gene expressio...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680701604749
更新日期:2007-10-01 00:00:00
abstract:PURPOSE:Most studies of cell growth of the RPE employ cultures which have been previously passaged, but here we investigated freshly-explanted RPE cells, which may have been growth-quiescent for years, within the eye to determine whether co-culture affects initial outgrowth in primary culture. METHODS:Bovine or human ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.9.891.5051
更新日期:1997-09-01 00:00:00
abstract:PURPOSE:To examine the effects of external modulation of epithelial-mesenchymal interaction on conjunctival epithelial cell differentiation characteristics. METHODS:Keratin K4 and laminin beta2 chain protein localization was examined in an organotypic model which facilitates the comparison of differentiation character...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.18.1.28.5394
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:To investigate the relationship between meibomian gland dysfunction (MGD) and incomplete blinking caused by cranial nerve seven (CN VII) palsy. METHODS:A prospective case series of 60 consecutive patients with unilateral CN VII palsy was evaluated for MGD. According to the House-Brackmann scale, patients were ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1007211
更新日期:2016-01-01 00:00:00
abstract::Loteprednol etabonate (LE) is a new corticosteroid based on the "soft drug" concept. Contact lens-associated giant papillary conjunctivitis (GPC) was studied as a model for the anti-inflammatory effect of LE. Patients with bilateral GPC were enrolled in a multicenter, randomized, double-masked, placebo-controlled, par...
journal_title:Current eye research
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.3109/02713689308999455
更新日期:1993-04-01 00:00:00
abstract:PURPOSE:To determine the plasma levels of the sulfur-containing amino-acids homocysteine, cysteine, cysteinylglycine, glutamylcysteine, glutathione, and taurine in patients with central retinal vein occlusion (CRVO) and in healthy subjects and to ascertain whether there are statistically significant differences between...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713681003698863
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVES:To evaluate the suitablity of commercially available moisture retention eyewear for treating evaporative dry eye. METHODS:Eleven patients with evaporative dry eyes were prescibed moisture retention eyewear for 3 months in addition to regular lubricant eye drops. Frequency and severity of dry eye symptoms, c...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.932389
更新日期:2015-05-01 00:00:00
abstract:PURPOSE:Membrane-associated mucins are important components of the ocular tear film. Our objective was to characterize the expression of membrane-associated mucins MUC1, MUC4, and MUC16 in healthy cornea, healthy conjunctiva, fibrovascular tissue (pannus) covering the corneal surface in limbal stem cell deficiency (LSC...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680802699408
更新日期:2009-03-01 00:00:00
abstract::The initial rapid fall in tear film fluorescence after instilling a 1 microliter drop of fluorophore could be a result of stimulated tear flow or of distribution of the dye throughout the tear fluid present in the conjunctival sac. An attempt was made to decide this by comparing the fall in fluorescence of two differe...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689509033526
更新日期:1995-04-01 00:00:00
abstract:PURPOSE:Several previous studies have shown that glycoconjugates of extracellular matrix, cell membrane and nucleus play an important role in the mediation of cell proliferation, migration and differentiation. Lens epithelial cells and lens fiber cells show regional differences with regard to these parameters. If glyco...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.6.527.5083
更新日期:1997-06-01 00:00:00
abstract::Blood and lymphatic vessel proliferation into the cornea occurs after severe trauma. Whilst the events early in blood vessel growth are reasonably understood, little is known of the early events in lymphangiogenesis. In this study, a model for proliferating lymphatic vessels using tritiated-thymidine autoradiography a...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688909013898
更新日期:1989-01-01 00:00:00
abstract:PURPOSE:The aim of this study is to determine age-related morphological changes in the corneal subbasal nerve plexus (SNP) in two inbred mouse strains. MATERIALS AND METHODS:The corneal SNP was investigated by in vivo confocal laser scanning microscopy (CLSM) in 0.5-, 1-, 1.5-, and 2-year-old C57BL/6J mice and in 0.5-...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1088952
更新日期:2016-08-01 00:00:00
abstract::The variation of central corneal thickness with age was measured weekly at 10am by ultrasound pachometry in 10 normal (5 to 19 weeks of age) and 10 alloxan-induced diabetic (9 to 19 weeks of age) rabbits. The diurnal variation of corneal thickness was also measured at 2 hour intervals for a period of 24 hours on both ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008999611
更新日期:1990-05-01 00:00:00
abstract::The present study was aimed to demonstrate that cytochrome P-450 was induced by drug administration in particular tissues in the eye. Phenobarbital was used as an inducer. We showed immunohistochemically that cytochrome P-450 was induced in the cornea, conjunctiva and ciliary epithelium of rabbits after four days of i...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688709034854
更新日期:1987-07-01 00:00:00
abstract:PURPOSE:To investigate the multifocal electroretinogram (mfERG) and subjective function in early age-related maculopathy (ARM). METHODS:Seventeen subjects with early ARM with visual acuity (VA) of 6/12 or better and 20 age-matched control subjects were examined. We assessed mfERGs, high and low contrast distance VA, n...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680490516198
更新日期:2004-10-01 00:00:00
abstract:PURPOSE:To investigate the association of nailfold capillaroscopy, heart rate variability (HRV), and clinical characteristics of glaucoma with the plasma matrix metalloproteinase-9 (MMP-9) level in normal-tension glaucoma (NTG). MATERIALS AND METHODS:We conducted a prospective, cross-sectional study on 25 patients wit...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.971937
更新日期:2015-01-01 00:00:00
abstract::Retinal degeneration is a leading cause of untreatable blindness in the industrialised world. It is typically irreversible and there are few curative treatments available. The use of stem cells to generate new retinal neurons for transplantation purposes has received significant interest in recent years and is beginni...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1669665
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:To study retinal neovascularization (RNV) inhibition by intravitreal injections (IVs) of ranibizumab, sTie2 fusion protein (sTie2-Fc), and a combined therapy in an oxygen-induced retinopathy (OIR) model. MATERIALS AND METHODS:An OIR mouse model was used to simulate RNV in retinopathy of prematurity (ROP); and ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1484144
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:To study changes in the morphometric characteristics of the whole brain visual-related cortex in various stages of primary open angle glaucoma (POAG) in vivo. MATERIALS AND METHODS:Thirty POAG patients (nine early stage cases and 21 advanced-late stage cases) and 30 gender-, education-, and age-matched healthy...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.683506
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:To demonstrate spectroscopic retinal oximetry measurements on arteries and veins in swine using intravitreal illumination. Retinal arterial and venous saturations are measured for a range of inspired O2 levels after pars plana vitrectomy. METHODS:Pars plana vitrectomy and intravitreal manipulations were perfor...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680600760493
更新日期:2006-07-01 00:00:00
abstract:PURPOSE:This study was undertaken in order to investigate whether the production of vasodilatory prostaglandins is increased in the retinal vasculature of the diabetic rat. METHODS:Diabetes was induced in male Sprague-Dawley rats using streptozotocin. Diabetic rats were left uncontrolled for 3-4 weeks or were treated ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.18.2.79.5386
更新日期:1999-02-01 00:00:00
abstract::The morphology and postnatal ontogeny of the major pathway for aqueous outflow in the canine eye has been examined. Normal canine chamber angles of the Beagle at one day, one through ten weeks, three, four and six months, and one and two years of age were used. Angle tissue was prepared and examined by standard techni...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409000791
更新日期:1984-06-01 00:00:00
abstract:PURPOSE:To evaluate choroidal thickness (CT) and retinal morphological changes in eyes with neovascular age-related macular degeneration (nAMD) following ranibizumab or aflibercept intravitreal treatment. MATERIALS AND METHODS:This was a prospective, observational, comparative study where 76 eyes of 76 consecutive pat...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2017.1405045
更新日期:2018-03-01 00:00:00
abstract::The effects of light damage were studied in four inbred strains of albino rats, Fischer (F344), Lewis (L), Wistar (W), and Buffalo (BUF). Thirty-five-day-old rats (3 from each strain) were kept in cyclic light for two weeks, after which they were exposed to constant fluorescent light (180-190 foot-candles, 490-580 nm)...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008999576
更新日期:1990-08-01 00:00:00
abstract::Intraocular synthesis of IgG antibodies against HSV (herpes simplex virus), CMV (cytomegalovirus) and VZV (varicella zoster virus) is considered as an indirect proof of uveoretinal infection. Paired serum and aqueous samples obtained from 16 patients with retinitis associated with AIDS, 3 patients with ARN, 8 patients...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008999412
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:The present study was conducted to develop and characterize a functional primary culture of pigmented rabbit conjunctival epithelial cells on permeable support exhibiting tight barrier properties. METHODS:Conjunctival epithelial cells were isolated by 0.2% protease treatment, cultured at 0.5-1.8 x 10(6) cells/...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689608995151
更新日期:1996-12-01 00:00:00
abstract:PURPOSE:Nitric oxide production can cause either apoptotic or necrotic cell death through oxidative stress. We aimed to investigate the nitrite oxide metabolites (NOx) and nitrite levels in the aqueous humor of rabbit eyes after different methods of corneal collagen cross-linking (CXL). MATERIALS AND METHODS:Twenty-fo...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2016.1139726
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:Both HSV-1 and HSV-2 express LAT during viral latency. Previous studies indicated that deletion of either LAT impairs viral reactivation from latency, but that the HSV-1 LAT confers the ability to reactivate efficiently from trigeminal ganglia onto HSV-2. We sought to determine whether the HSV-2 LAT could funct...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.26.3.219.14896
更新日期:2003-03-01 00:00:00
abstract:PURPOSE:To investigate the effects of pyrrolidine dithiocarbamate (PDTC), a nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) inhibitor, on the expression of matrix metalloproteinases (MMP) and MMP-mediated apoptosis in retinal ganglion cells (RGCs) following the transection of the optic nerve (ON) in ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2011.606591
更新日期:2011-11-01 00:00:00
abstract::The content of rhodopsin in the eyes of 15 donors (30 eyes) was determined. Both retinal and pigment epithelial fractions were collected from each globe, extracted using 1% CTAB, and the rhodopsin difference spectrum of each fraction was obtained separately. The total amount of rhodopsin, obtained by summing the amoun...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689009003477
更新日期:1990-12-01 00:00:00