Antagonism of substance P induced facilitation of central neuronal activity by 2,4-dinitrophenol and depressant agents.

abstract：:Microglial inflammation, involved in the occurrence and development of sepsis-associated encephalopathy, exhibits upregulation of proinflammatory cytokine and proinflammatory enzyme expression, leading to inflammation-induced neuronal cell apoptosis. TIR domain containing adaptor molecule-2 (TICAM-2) participates in l...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhao Y,Yang X,Meng F,Li W

更新日期：2020-11-01 00:00:00

abstract：:In this study, we examined the effect of hydrogen peroxide on the accumulation of various mRNAs encoding heat shock proteins (hsps) and proto-oncogenes in Xenopus A6 kidney epithelial cells. Hydrogen peroxide treatment enhanced the accumulation of hsp90, hsp70, hsp30, c-jun, c-fos, and actin mRNAs with distinct tempor...

journal_title：Canadian journal of physiology and pharmacology

authors： Muller M,Gauley J,Heikkila JJ

更新日期：2004-07-01 00:00:00

abstract：:The precise neurobiological mechanisms of tramadol abuse underlying the cognitive function are still unknown. The aim of the present study was to examine the possible effects of intra-CA1 injections of N-methyl-d-aspartate (NMDA), a glutamate NMDA receptor (NMDAR) agonist, and d,l-2-amino-5-phosphonopentanoic acid (DL...

journal_title：Canadian journal of physiology and pharmacology

authors： Jafari-Sabet M,Mofidi H,Attarian-Khosroshahi MS

更新日期：2018-01-01 00:00:00

abstract：:We previously reported that calpain, the Ca2+-sensitive cysteine protease, gets involved in atherogenesis. This study aimed to investigate the effects of calpain inhibitor I (CAI, 5 mg/kg per day) with or without NG-nitro-l-arginine-methyl ester (l-NAME) (100 mg/kg per day), the inhibitor of nitric oxide synthase (NOS...

journal_title：Canadian journal of physiology and pharmacology

authors： Yu L,Yin M,Yang X,Lu M,Tang F,Wang H

更新日期：2018-01-01 00:00:00

abstract：:We recently reported that the two-chain form of human high molecular weight kininogen (HKa) inhibits angiogenesis by inducing endothelial cell apoptosis (Zhang et al. 2000). This property appears to be primarily conferred by HKa domain 5 (HKa D5). In this manuscript, we further characterize the activity of these polyp...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang JC,Qi X,Juarez J,Plunkett M,Donaté F,Sakthivel R,Mazar AP,McCrae KR

更新日期：2002-02-01 00:00:00

abstract：:There is general agreement about potentiation in dose-response studies, characterized by a left shift of the dose-response curve of A by a fixed dose of B when B is causing no effect by itself (simple situation). When B causes an effect similar to A (complex situation) by binding to different molecular sites, we propo...

journal_title：Canadian journal of physiology and pharmacology

authors： Pöch G,Reiffenstein RJ,Köck P,Pancheva SN

更新日期：1995-11-01 00:00:00

abstract：:Investigation of the relationship of diet to blood lipids and atherosclerosis has dominated the field of lipid nutritional biochemistry for the past 25 years. Although this subject has consumed considerable time, effort, and research funds, it has also proved beneficial to other areas of lipid biochemistry by attracti...

journal_title：Canadian journal of physiology and pharmacology

authors： Walker BL

更新日期：1983-03-01 00:00:00

abstract：:Androgens have been reported to stimulate progesterone production by granulosa cells of several species, and to act synergistically with FSH in stimulation of progesterone accumulation by rat granulosa cells. Studies were undertaken to examine the effect of androgens on FSH-stimulated progesterone production in cultur...

journal_title：Canadian journal of physiology and pharmacology

authors： Evans G,Lischinsky A,Daniel SA,Armstrong DT

更新日期：1984-07-01 00:00:00

abstract：:Spironolactone is a diuretic steroid which is capable of blocking the binding of aldosterone to its cytosol receptor at the distal convoluted tubule. In addition, it has been shown that spironolactone is a strong inhibitor of steroidogenesis. More recently, new aldosterone antagonists have been discovered. Some of the...

journal_title：Canadian journal of physiology and pharmacology

authors： Netchitailo P,Perroteau I,Delarue C,Leboulenger F,Capron MH,Vaudry H

更新日期：1983-01-01 00:00:00

abstract：:Most cardiac diseases are associated with fibrosis. Calcineurin (CaN) is regulated by Ca(2+)/calmodulin (CaM). The CaN-NFAT (nuclear factor of activated T cell) pathway is involved in the process of cardiac diseases, such as cardiac hypertrophy, but its effect on myocardial fibrosis remains unclear. The present study ...

journal_title：Canadian journal of physiology and pharmacology

authors： Chen QQ,Zhang W,Chen XF,Bao YJ,Wang J,Zhu WZ

更新日期：2012-12-01 00:00:00

abstract：:This year, 2011, the Department of Pharmacology at the University of Alberta celebrated its 50th anniversary. This timeframe covers nearly the entire history of Cys-loop pentameric ligand-gated ion channel (pLGIC) research. In this review we consider how major technological advancements affected our current understand...

journal_title：Canadian journal of physiology and pharmacology

authors： Kozuska JL,Paulsen IM

更新日期：2012-06-01 00:00:00

abstract：:The effect of ionizing radiation on jejunal blood flow was investigated in rats receiving whole-body exposure to 10 Gy gamma-radiation. Irradiation resulted in increased myeloperoxidase activity, indicative of neutrophil infiltration, and prostaglandin E2 synthesis by 2 h post-irradiation, but had no effect on leukotr...

journal_title：Canadian journal of physiology and pharmacology

authors： MacNaughton WK,Prud'homme-Lalonde L

更新日期：1995-06-01 00:00:00

abstract：:Muscle pain and poor sleep commonly occur together. Whether pain induces poor sleep or vice versa is difficult to know. Muscle pain is also observed in the presence of some types of dyskinesia or movement disorders. The interaction between sleep, movement disorders, and some musculoskeletal pain appears to be complex ...

journal_title：Canadian journal of physiology and pharmacology

authors： Lavigne GJ,Velly-Miguel AM,Montplaisir J

更新日期：1991-05-01 00:00:00

abstract：:Premature weaning of rats to high carbohydrate diets causes a variety of short- and long-term changes in lipid metabolism, but the mechanisms involved are unclear. It is likely that interaction of diet with certain emerging hormonal control patterns during weaning might condition metabolic control and (or) subsequent ...

journal_title：Canadian journal of physiology and pharmacology

authors： Angel JF,Back DW

更新日期：1985-05-01 00:00:00

abstract：:The long noncoding RNA (lncRNA) GAS5 has been found to act as a decoy for the glucocorticoid receptor (GR), thus implicating GAS5 as a potential regulator of glucocorticoid sensitivity and resistance. Airway smooth muscle (ASM) cells and airway epithelial cells (AEC) play an important role in the pathogenesis and pers...

journal_title：Canadian journal of physiology and pharmacology

authors： Keenan CR,Schuliga MJ,Stewart AG

更新日期：2015-03-01 00:00:00

abstract：:The activity of the lipolytic system of the obese hyperglycemic mouse was assessed after treatment with physiological doses of thyroxin (T4). The treatment significantly increased fatty acid mobilization in response to adrenaline over the levels observed in the control mice under all conditions studied. The activities...

journal_title：Canadian journal of physiology and pharmacology

authors： Bégin-Heick N,Heick HM

更新日期：1977-12-01 00:00:00

abstract：:The effects of lithium chloride on ornithine decarboxylase (ODC) activity were compared in the adrenal and kidney of control (saline treated) and prolactin-treated rats. ODC activity was decreased in kidney of both groups of animals, the magnitude of the effect of lithium in the hormone-treated group varying with the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Strümpfer A,Hsiao J,Peng T,Richards J

更新日期：1992-09-01 00:00:00

abstract：:Airway smooth muscle (ASM) contraction controls the airway caliber. Airway narrowing is exaggerated in obstructive lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD). The mechanism by which ASM tone is dysregulated in disease is not clearly understood. Recent research on ion channels, parti...

journal_title：Canadian journal of physiology and pharmacology

authors： Jha A,Sharma P,Anaparti V,Ryu MH,Halayko AJ

更新日期：2015-03-01 00:00:00

abstract：:Calcium antagonists may reduce propensity to ventricular fibrillation, by altering the balance between coronary blood flow and metabolic demand, and thus may substantially prolong time to occurrence of fibrillations. This delay in the onset of fibrillation should be sufficient to prevent sudden death in the case of tr...

journal_title：Canadian journal of physiology and pharmacology

authors： Timour Q,Aupetit JF,Freysz M,Frassati D,Faucon G

更新日期：1996-12-01 00:00:00

abstract：:Small, sinusoidal length changes were superimposed on isometric contractions of fast- and slow-twitch mouse muscles, which were stimulated maximally via their nerves. Stiffness increased with increasing frequency of sinusoidal stimulation, but the relative time course of force and stiffness changes during twitch, teta...

journal_title：Canadian journal of physiology and pharmacology

authors： Stein RB,Gordon T

更新日期：1986-09-01 00:00:00

abstract：:The effects of a vasopressin (AVP) pressor antagonist, d(CH2)5Tyr(Me)AVP, on mean arterial pressure (MAP), total peripheral resistance (TPR), cardiac output (CO), and the distribution of CO were investigated by the microsphere technique in three groups of pentobarbital anesthetized rats: intact (I), saralasin pretreat...

journal_title：Canadian journal of physiology and pharmacology

authors： Tabrizchi R,King KA,Pang CC

更新日期：1986-08-01 00:00:00

abstract：:The aim of this study was to investigate the possible effects of captopril as a promoter in modulating the oxidant-antioxidant balance in rats with type 1 diabetes, and the influence of protein kinase C (PKC) pathways in the production of reactive oxygen species (ROS) induced by bradykinin in type 1 diabetic rats. Thi...

journal_title：Canadian journal of physiology and pharmacology

authors： Rodrigues de Araujo G,Granato de Faria K,Lima WG,Pádua Bda C,Rossoni JV Jr,Souza AA,Chianca-Júnior D,Silva ME,Pedrosa ML,Chaves MM,Costa DC

更新日期：2011-12-01 00:00:00

abstract：:Epinephrine caused hyperglycemia in part by increasing gluconeogenesis. However, the mechanism of its gluconeogenic effects has not been studied in ruminants. This study was undertaken to examine the effect of epinephrine on the net hepatic uptake of selected glucose precursors in sheep. The major abdominal blood vess...

journal_title：Canadian journal of physiology and pharmacology

authors： Brockman RP

更新日期：1991-04-01 00:00:00

abstract：:Acetylcholine (ACh) is an important regulator of intestinal epithelial ion transport via muscarinic or nicotinic ACh receptors. Previous studies emphasize the role of the M3 muscarinic receptor subtype in mediating the effects of cholinergic agonists on intestinal ion transport. With the prevalence of mouse models to ...

journal_title：Canadian journal of physiology and pharmacology

authors： Hirota CL,McKay DM

更新日期：2006-11-01 00:00:00

abstract：:Blood pressure fluctuates continuously throughout life and autoregulation is the primary mechanism that isolates the kidney from this fluctuation. Compared with Wistar rats, Brown Norway (B-N) rats display impaired renal myogenic autoregulation when blood pressure fluctuation is increased. They also are very susceptib...

journal_title：Canadian journal of physiology and pharmacology

authors： Wang X,Cupples WA

更新日期：2001-03-01 00:00:00

abstract：:Microiontophoretic applications of ibotenate, an amino acid analogue of glutamate, evoked biphasic responses from single dorsal horn interneurones of the cat spinal cord, i.e., an initial increase in the firing rate followed by a sustained depression of spontaneous firing. A reduced cell sensitivity to excitatory amin...

journal_title：Canadian journal of physiology and pharmacology

authors： MacDonald JF,Nistri A

更新日期：1977-08-01 00:00:00

abstract：:The sarco(endo)plasmic reticulum calcium ATPase (SERCA) is responsible for transporting calcium (Ca(2+)) from the cytosol into the lumen of the sarcoplasmic reticulum (SR) following muscular contraction. The Ca(2+) sequestering activity of SERCA facilitates muscular relaxation in both cardiac and skeletal muscle. Ther...

journal_title：Canadian journal of physiology and pharmacology

authors： Stammers AN,Susser SE,Hamm NC,Hlynsky MW,Kimber DE,Kehler DS,Duhamel TA

更新日期：2015-10-01 00:00:00

abstract：:Cumulative data suggest the significant role of the renin-angiotensin system in the development of the pathological consequences of diabetes mellitus (DM). Newly synthesized AT2 receptor agonists gained importance as a target for creating new antihypertensives. The aim of the present work was to study the effects of p...

journal_title：Canadian journal of physiology and pharmacology

authors： Pechlivanova D,Petrov K,Grozdanov P,Nenchovska Z,Tchekalarova J,Stoynev A

更新日期：2018-05-01 00:00:00

abstract：:Alterations of the ionic constituents of solutions perfused through the tissue of the posterior hypothalamic region in conscious cats elicited changes in body temperatures. Increasing the (Ca2+) to (Na+) ratio of the perfusion solution elicited falls in body temperature which were accompanied by changes in posture and...

journal_title：Canadian journal of physiology and pharmacology

authors： Jones DL,Veale WL,Cooper KE

更新日期：1978-08-01 00:00:00

abstract：:The postprandial release of immunoreactive insulin, glucagon, gastrin, somatostatin, pancreatic polypeptide (PP), and gastric inhibitory polypeptide (GIP) was studied in parallel with the absorption of sugars and amino acids in conscious pigs. Six pigs fitted with permanent catheters in the portal vein and arterial bl...

journal_title：Canadian journal of physiology and pharmacology

authors： Rérat A,Chayvialle JA,Kandé J,Vaissade P,Vaugelade P,Bourrier T

更新日期：1985-12-01 00:00:00