Late complications after surgery in patients with neuroblastoma.


PURPOSE:The purpose of this study was 2-fold: to study the complications of neuroblastoma treatment and to establish surgical guidelines. MATERIALS AND METHODS:The medical records of 92 patients with neuroblastoma (stage 1 or 2, n = 33; stage 3, n = 21; stage 4, n = 31; stage 4S, n = 7) who had undergone surgery in our department between 1985 and 2001 were reviewed, with an emphasis on treatments and late complications. RESULTS:The disease-free survival rate was 98.3% (58/59) in infantile patients, whereas it was 36.4% (12/33) in advanced patients older than 1 year. The rate was improved up to greater than 50% after the introduction of intensive local therapy with intraoperative radiation (IOR). The treatment-associated morbidity rate was 15.0% in nonadvanced infantile patients, was 42.1% in advanced infantile patients, and was 33.3% in advanced older patients. In the advanced cases, renovascular problems were most frequently seen especially after IOR. Furthermore, pulmonary problems, cardiac problems, and second cancer were highlighted as fatal problems; thyroid dysfunction, vertebral deformity, and growth retardation were also noted. CONCLUSIONS:Higher incidences of late morbidity and treatment-associated mortality appeared to be more strongly related to disease stage rather than to patient age. Appropriate surgery and IOR with lower doses should be recommended as a surgical strategy for high-risk patients.


J Pediatr Surg


Kuroda T,Saeki M,Honna T,Kumagai M,Masaki H




Has Abstract


2006-12-01 00:00:00














  • Immunohistochemical assessment of the MIB-1 Labeling Index in human hepatoblastoma and its prognostic relevance.

    abstract:BACKGROUND/PURPOSE:The MIB-1 monoclonal antibody has been raised against recombinant parts of the Ki-67 antigen, which is a cell cycle-related nuclear protein that is elevated in late G1 and S phases. The aim of the study was to analyze the expression pattern of MIB-1 in hepatoblastoma and to assess whether it provides...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Ara T,Fukuzawa M,Oue T,Komoto Y,Kusafuka T,Imura K,Okada A

    更新日期:1997-12-01 00:00:00

  • Embryonal rhabdomyosarcoma of the lung arising in cystic adenomatoid malformation: case report and review of the literature.

    abstract::Rhabdomyosarcoma (RMS) of the lung is a very rare lesion, but the association with cystic adenomatoid malformation (CCAM) is unlikely to be a coincidence. Although the etiologic factors predisposing infants and children to pulmonary neoplasms are unknown, pulmonary developmental abnormalities may play a pathogenetic r...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,评审


    authors: d'Agostino S,Bonoldi E,Dante S,Meli S,Cappellari F,Musi L

    更新日期:1997-09-01 00:00:00

  • Portal vein thrombosis in children and adolescents: the low prevalence of hereditary thrombophilic disorders.

    abstract:PURPOSE:The aim of this study was to determine the frequency of thrombophilic disorders in children and adolescents with portal vein thrombosis (PVT) as well as assessing the hereditary character of this disorder. METHODS:A 2-year prospective study was carried out in pediatric PVT patients (n = 14), their parents (n =...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Pinto RB,Silveira TR,Bandinelli E,Röhsig L

    更新日期:2004-09-01 00:00:00

  • Laparoscopy improves outcomes for pediatric splenectomy.

    abstract:BACKGROUND:Pediatric laparoscopic splenectomy is a relatively new surgical procedure with a limited number of reports comparing its outcomes to that of the open procedure. The authors have minimized the invasiveness of our procedure by using only three ports and have described the technique as well as compared it with ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Curran TJ,Foley MI,Swanstrom LL,Campbell TJ

    更新日期:1998-10-01 00:00:00

  • Repeated mechanical lengthening of intestinal segments in a novel model.

    abstract:PURPOSE:Currently, animal models used for mechanical intestinal lengthening utilize a single lengthening procedure prior to analysis or restoration back into continuity. Here we developed a novel surgical model to examine the feasibility of repeated lengthening of intestinal segments. METHODS:A Roux-en-Y jejunojejunos...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Scott A,Sullins VF,Steinberger D,Rouch JD,Wagner JP,Chiang E,Lee SL,Wu BM,Dunn JC

    更新日期:2015-06-01 00:00:00

  • A proposal to preserve the ileocecal valve and right colon in total colonic aganglionosis.

    abstract::We report two cases of total colonic aganglionosis in which the ileocecal valve and right colon were preserved. The aganglionic ileal segment is removed leaving behind only a very short prececal remnant, which is anastomosed end-to-back to the remaining ileum. An ileal loop (of approximately 20 cm in length) is isolat...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Sauer H,Klos I

    更新日期:1989-05-01 00:00:00

  • Pediatric genital burns: a 15-year retrospective analysis of outcomes at a level 1 burn center.

    abstract:BACKGROUND/PURPOSE:Burns involving the genitalia and perineum are commonly seen in the context of extensive total body surface area (TBSA) burns and rarely as isolated injuries because of protection provided by the thighs and the abdomen. Genital burns usually result in extended hospital stays and are accompanied by se...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Klaassen Z,Go PH,Mansour EH,Marano MA,Petrone SJ,Houng AP,Chamberlain RS

    更新日期:2011-08-01 00:00:00

  • Acute acalculous cholecystitis as the initial presentation of primary Epstein-Barr virus infection.

    abstract::The case of a 13-year-old girl with primary Epstein-Barr virus (EBV) infection and concomitant cholestatic hepatitis, which initially presented as acute acalculous cholecystitis (AAC), is described. The diagnosis of AAC was documented by clinical and ultrasonographic criteria, whereas acute EBV infection was confirmed...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Prassouli A,Panagiotou J,Vakaki M,Giannatou I,Atilakos A,Garoufi A,Papaevangelou V

    更新日期:2007-01-01 00:00:00

  • Inhibiting hydrogen sulfide production in umbilical stem cells reduces their protective effects during experimental necrotizing enterocolitis.

    abstract:INTRODUCTION:Umbilical mesenchymal stem cells (USC) have been shown to reduce illness in animal models of necrotizing enterocolitis (NEC), possibly through the paracrine release of hydrogen sulfide (H2S). We hypothesized that animals treated with USCs with inhibited H2S synthesis would exhibit more severe disease. MET...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Drucker NA,Te Winkel JP,Shelley WC,Olson KR,Markel TA

    更新日期:2019-06-01 00:00:00

  • Anorectal anomalies associated with Kabuki make-up syndrome.

    abstract::A case report of a 3-year-old girl with Kabuki make-up syndrome (KMS) associated with anovestibular fistula is presented. To our knowledge, 62 patients with KMS have been reported in the literature, three of whom were described as having an anorectal anomaly. Including the present patient, all four KMS patients were f...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Matsumura M,Yamada R,Kitani Y,Nishi T,Yamamoto H,Oahama Y,Kuroki Y

    更新日期:1992-12-01 00:00:00

  • Hemodynamic significance of pediatric femur fractures.

    abstract:PURPOSE:To determine whether hemodynamically significant bleeding occurs after pediatric femur fractures. METHOD:A retrospective chart review was performed; demographic and injury data were collected for all patients with the diagnosis of femur fracture over a 30-month period at a level/ pediatric trauma center. Inclu...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Lynch JM,Gardner MJ,Gains B

    更新日期:1996-10-01 00:00:00

  • Ex vivo testing of a temperature- and pressure-controlled amnio-irrigator for fetoscopic surgery.

    abstract:BACKGROUND:Currently, amnioinfusion fluids used in operative fetoscopy usually are preheated to body temperature. As the complexity of procedures increases, purposed designed devices should be designed that allow control of pressure and temperature during amnioinfusion or amnioexchange. In the current study, a prototyp...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Bonati F,Perales A,Novak P,Barki G,Gratacós E,Nicolini U,Deprest JA

    更新日期:2002-01-01 00:00:00

  • Pelviureteric obstruction in infancy.

    abstract::Of 33 infants with pelviureteric obstruction, most presented in the first month of life with an abdominal mass and most were males. Half of these patients had bilateral renal pathology. The association between cystic dysplasia in the hydronephrotic kidney and contralateral cystic renal abnormality in patients with uni...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Robson WJ,Rudy SM,Johnston JH

    更新日期:1976-02-01 00:00:00

  • Prenatal magnetic resonance imaging enhances fetal diagnosis.

    abstract:BACKGROUND:Ultrasound (US) evaluation of some fetal anomalies provides limited information. Anatomic details that affect prognosis and selection for fetal therapy, such as liver herniation and pulmonary hypoplasia in congenital diaphragmatic hernia (CDH) and airway patency in giant neck masses, may be difficult to deli...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Quinn TM,Hubbard AM,Adzick NS

    更新日期:1998-04-01 00:00:00

  • Wide gap esophageal atresia: a new method to elongate the upper pouch.

    abstract::A new surgical method is presented for overbridging wide gap esophageal atresia. The method is based on the fact that the atretic upper pouch has an excellent longitudinal blood supply, and is two to three times wider than the lower pouch. Muco-muscular flap is created, which is anastomosed to the lower esophagus. ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Bar-Maor JA,Shoshany G,Sweed Y

    更新日期:1989-09-01 00:00:00

  • Transabdominal testicular descent is disrupted in mice with deletion of insulinlike factor 3 receptor.

    abstract:BACKGROUND:Several factors are implicated in transabdominal testicular descent, including insulinlike factor 3 (INSL3) hormone and Müllerian-inhibiting substance (MIS). A transgene insertional mutation found on chromosome 5 in the mouse, known as crsp, causes deletion of a transmembrane G protein-coupled receptor gene,...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Tomiyama H,Hutson JM,Truong A,Agoulnik AI

    更新日期:2003-12-01 00:00:00

  • Management of giant omphalocele by progressive external compression: case report.

    abstract::The management of giant omphalocele remains a major surgical challenge. A staged approach is mandatory to achieve an uncomplicated reduction. The case of a child conservatively and successfully treated by progressive external compression of the herniated organs and viscera using an elastic bandaging is described here....

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Belloli G,Battaglino F,Musi L

    更新日期:1996-12-01 00:00:00

  • Diagnosis of spontaneous perforation of the biliary tract in the newborn.

    abstract::This report is of a 2-month-old child with spontaneous perforation of the common bile duct diagnosed by 99m-Tc disofenin nuclear hepatobiliary imaging. Of the agents available, the radiopharmaceutical properties of this compound allow the most accurate, safe, high-resolution imaging of the hepatobiliary tree in the di...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Kolbe A,Beaver BL,Rosenbaum R,Hill JL

    更新日期:1986-12-01 00:00:00

  • Congenital peritoneal mesothelioma.

    abstract::Only three primary peritoneal mesotheliomas in children have been previously reported. We describe a 6-wk-old girl with a papillary peritoneal mesothelioma of low grade malignancy. This is probably a congenital mesothelioma and is the youngest patient reported to date. ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Silberstein MJ,Lewis JE,Blair JD,Graviss ER,Brodeur AE

    更新日期:1983-06-01 00:00:00

  • Protective effect of erythropoietin on torsion/detorsion injury in rat model.

    abstract:PURPOSE:The aim of the study is to investigate the effects of erythropoietin on torsion/detorsion injury in rats. METHODS:Forty rats were divided randomly into 5 groups: group I (sham, S), sham operation; group II (torsion/detorsion 1, T/D(1)), 3 hours ischemia and 1 hour reperfusion; group III (torsion/detorsion 2, T...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Bakan V,Ciralik H,Tolun FI,Atli Y,Mil A,Oztürk S

    更新日期:2009-10-01 00:00:00

  • Intraoperative cardiopulmonary resuscitation in the prone position.

    abstract::Cardiopulmonary resuscitation (CPR) occasionally is necessary in the operating-room setting. In such instances, it may be difficult to perform CPR if the patient is in the prone position. Although the supine position is optimal for CPR, it may not be feasible because of the risks of damage to craniospinal structures. ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Tobias JD,Mencio GA,Atwood R,Gurwitz GS

    更新日期:1994-12-01 00:00:00

  • The research on screening differentially expressed genes in Hirschsprung's disease by using Microarray.

    abstract:OBJECTIVE:To study the differential expression of genes between Hirschsprung's disease (HSCR) and normal tissue by using microarray for exploring the mechanism of HSCR development and establishing the gene expression profiles of HSCR. METHODS:Colon tissues (aganglionic and normal segments) of 4 patients with HSCR were...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Qin KW,Shi H,Zhang L,Liu PF,Cai WL,Wu KH,Zhu XC,Lan FF

    更新日期:2013-11-01 00:00:00

  • Intrathyroidal thymic tissue in children: Avoiding unnecessary surgery.

    abstract:BACKGROUND/PURPOSE:Intrathyroidal thymic tissue may be misinterpreted as a thyroid lesion in children, leading to invasive tests or resection. We sought to describe the characteristic imaging features of these lesions and to evaluate the safety of non-operative management. METHODS:A retrospective review of all patient...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Kay-Rivest E,Mascarella MA,Puligandla P,Emil S,Saint-Martin C,Nguyen LHP,Daniel SJ,Baird R

    更新日期:2018-05-01 00:00:00

  • A case of tracheal agenesis surviving without mechanical ventilation after external esophageal stenting.

    abstract::Tracheal agenesis is a rare and usually lethal congenital malformation of the forgut. Although some infants can be resuscitated with an intra-esophageal intubation temporarily, long-term airway management is difficult because of the collapsing airway. We report a long-term survivor with tracheal agenesis in whom a Gor...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Watanabe T,Okuyama H,Kubota A,Kawahara H,Hasegawa T,Ueno T,Saka R,Morishita Y

    更新日期:2008-10-01 00:00:00

  • Abdominal cutaneous nerve entrapment syndrome after blunt abdominal trauma in an 11-year-old girl.

    abstract::Chronic abdominal pain is a common complaint in children. Pain originating from the abdominal wall is often overlooked. Nevertheless, recognizing this type of pain prevents unnecessary examinations (Editorial: Abdominal wall tenderness test: could Carnett cut costs? Lancet. 1991, 337:1134). Abdominal cutaneous nerve e...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Ivens D,Wojciechowski M,Vaneerdeweg W,Vercauteren M,Ramet J

    更新日期:2008-05-01 00:00:00

  • Cystourethroscopy versus contrast studies in urogenital sinus and cloacal anomalies in children.

    abstract:BACKGROUND:Cloacal malformation is a spectrum of diseases affecting females, resulting in abnormal confluence of the urinary system, genital system, and/or gastrointestinal system. Proper reconstruction depends mainly on accurate preoperative illustration of the abnormal anatomy. Among the various modalities to delinea...

    journal_title:Journal of pediatric surgery

    pub_type: 临床试验,杂志文章


    authors: Ashour K,Shehata S,Osheba A

    更新日期:2018-02-01 00:00:00

  • Laparoscopic resection of a giant retroperitoneal T-shaped duplication of descending colon.

    abstract::The authors encountered an uncommon case of a retroperitoneal T-shaped duplication that presented with a communication with the descending colon, descending downward along the descending colon posterolaterally, passing through the sigmoid mesocolon and across the midline at the level of L5 to S1 vertebrae, ascending b...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,评审


    authors: Chang YT,Lee JY,Liao YM,Chiou SS

    更新日期:2008-02-01 00:00:00

  • An immunohistochemical study of neurofilament and microtubule-associated Tau protein in the enteric innervation in Hirschsprung's disease.

    abstract::The distribution and localization of neurofilament (NF) and microtubule-associated tau protein (Tau) in the colon from Hirschsprung's disease were examined by immunohistochemistry. Specimens of the normoganglionic, oligoganglionic, and aganglionic segments of colons from nine patients with Hirschsprung's disease were ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Deguchi E,Iwai N,Goto Y,Yanagihara J,Fushiki S

    更新日期:1993-07-01 00:00:00

  • Assessment and comparison of fecal continence in children following primary posterior sagittal anorectoplasty and abdominoperineal pull through for anorectal anomaly using clinical scoring and MRI.

    abstract:INTRODUCTION:We aimed to compare and contrast these main surgical procedures for ARM in terms of structural outcome through pelvic MRI & functional outcome through Kelly's scoring. MATERIAL AND METHOD:A prospective study was conducted from August 2011 to July 2013 including all the cases of ARM managed in single stage...

    journal_title:Journal of pediatric surgery

    pub_type: 临床试验,杂志文章


    authors: Gangopadhyay AN,Pandey V,Gupta DK,Sharma SP,Kumar V,Verma A

    更新日期:2016-03-01 00:00:00

  • Giant multilocular thymic cyst in an HIV-infected adolescent.

    abstract::A girl with vertically acquired HIV infection presented with a 6-month history of dyspnea and chest pain. Computed tomography of the thorax showed a heterogenous mass measuring 13 × 9 × 17 cm located in the anterior mediastinum. Complete surgical resection was accomplished with no complications. The final diagnosis wa...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Tamagno M,Bibas BJ,Bernardi F,Lian YC,Bammann RH,Fernandez A,Jatene FB

    更新日期:2011-09-01 00:00:00