Abstract:
:CD4+ T lymphocytes initiate and regulate both the specific and nonspecific effector mechanisms of allergic immune responses. The definition of immunogenic components within allergens has allowed the specificity of the T-cell repertoire to be examined, and the refinement of their molecular structure is now facilitating the mapping of functional epitopes. Nevertheless, the immunological mechanisms that distinguish between atopic and nonatopic states remain unclear; as knowledge of the complex network of cytokines in the regulation of immune responses unfolds, this problem may be resolved. Population genetics indicates that susceptibility to allergic disease is partly determined by products of the major histocompatibility gene complex. The use of molecular genetic probes and monoclonal T cells demonstrates the functional importance of both the HLA-DRAB1 and -DRAB3 gene products in T-cell recognition of allergen. Collectively, this information has made it possible to develop in vitro models examining the modulation of responsiveness to allergens.
journal_name
Annu Rev Immunoljournal_title
Annual review of immunologyauthors
O'Hehir RE,Garman RD,Greenstein JL,Lamb JRdoi
10.1146/annurev.iy.09.040191.000435subject
Has Abstractpub_date
1991-01-01 00:00:00pages
67-95eissn
0732-0582issn
1545-3278journal_volume
9pub_type
杂志文章,评审abstract::NF-kappa B is a ubiquitous transcription factor. Nevertheless, its properties seem to be most extensively exploited in cells of the immune system. Among these properties are NF-kappa B's rapid posttranslational activation in response to many pathogenic signals, its direct participation in cytoplasmic/nuclear signaling...
journal_title:Annual review of immunology
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更新日期:2010-01-01 00:00:00
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journal_title:Annual review of immunology
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更新日期:1995-01-01 00:00:00
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journal_title:Annual review of immunology
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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更新日期:1994-01-01 00:00:00
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journal_title:Annual review of immunology
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更新日期:1991-01-01 00:00:00
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更新日期:2013-01-01 00:00:00
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更新日期:2001-01-01 00:00:00
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更新日期:2014-01-01 00:00:00
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更新日期:2012-01-01 00:00:00
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