The role of the organ microenvironment in the biology and therapy of cancer metastasis.

Abstract:

:By the time of diagnosis, primary neoplasms are biologically heterogeneous and contain subpopulations of cells with different metastatic potentials. The pathogenesis of a metastasis consists of many sequential steps that must be completed to produce clinically relevant lesions. During any of these steps, tumor cells interact with host factors in the microenvironment that the tumor cells can usurp. Treatment of metastasis can be directed against tumor cells and/or microenvironmental factors that support tumor growth, such as tumor-associated blood vessels.

journal_name

J Cell Biochem

authors

Fidler IJ,Kim SJ,Langley RR

doi

10.1002/jcb.21148

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

927-36

issue

4

eissn

0730-2312

issn

1097-4644

journal_volume

101

pub_type

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