Changes in tissue concentration of prostaglandins during endochondral bone differentiation.

abstract：:Lysinuric protein intolerance (LPI; MIM 222700) is an autosomal recessive disorder characterized by defective transport of cationic amino acids lysine, arginine and ornithine. The defect is localized in the basolateral membrane of polar epithelial cells of the renal tubules and intestine. The SLC7A7 (solute carrier fa...

journal_title：Biochemical and biophysical research communications

authors： Toivonen M,Mykkänen J,Aula P,Simell O,Savontaus ML,Huoponen K

更新日期：2002-03-15 00:00:00

abstract：:The major active protein phosphatase present in a rabbit skeletal muscle extract is associated with the glycogen particle and migrates in sucrose density gradient centrifugation as a Mr = 70,000 protein and contains modulator activity. Addition of extra modulator protein causes a time- and concentration-dependent conv...

journal_title：Biochemical and biophysical research communications

authors： Vandenheede JR,Yang SD,Merlevede W

更新日期：1983-09-30 00:00:00

abstract：:The cell membrane and the nuclear membrane are two major barriers hindering the free movement of various macromolecules through animal cells. Nevertheless, some proteins can actively bypass these barriers by dint of intrinsic peptidic signals, so incorporation of these signals might improve the efficacy of artificial ...

journal_title：Biochemical and biophysical research communications

authors： Akuta T,Eguchi A,Okuyama H,Senda T,Inokuchi H,Suzuki Y,Nagoshi E,Mizuguchi H,Hayakawa T,Takeda K,Hasegawa M,Nakanishi M

更新日期：2002-10-04 00:00:00

abstract：:A peptide corresponding to the full-length proregion (amino acids 16-114) of human cathepsin K was expressed and purified from Escherichia coli. This recombinant propeptide was investigated for its ability to inhibit the activity of three cysteine proteinases: cathepsins K, L, and B. Kinetic studies showed the propept...

journal_title：Biochemical and biophysical research communications

authors： Billington CJ,Mason P,Magny MC,Mort JS

更新日期：2000-10-05 00:00:00

abstract：:In a number of cell lines responsive to basic fibroblast growth factor (bFGF), two major tyrosine phosphorylated proteins, of molecular weights around 120kDa and 90kDa, are precipitated along with the tyrosine phosphatase SHP2 from the lysates of stimulated cells. The docker protein Gab-1 represents at least part of t...

journal_title：Biochemical and biophysical research communications

authors： Ong SH,Lim YP,Low BC,Guy GR

更新日期：1997-09-08 00:00:00

abstract：:The control of cellular adhesion to extracellular matrix proteins is poorly understood. In the present analyses, we set out to test the hypothesis that high galectin-3 concentration on the cell surface downregulates cellular adhesion to the extracellular matrix proteins. Various tumor cell lines were briefly incubated...

journal_title：Biochemical and biophysical research communications

authors： Ochieng J,Leite-Browning ML,Warfield P

更新日期：1998-05-29 00:00:00

abstract：:An antifungal protein that inhibits the growth of filamentous fungal pathogens was isolated from Chinese cabbage (Brassica campestris L. ssp. pekinensis) by affinity chromatography on Affi-gel blue gel and ion exchange chromatography on CM-Sepharose. The N-terminal amino acid sequence of the protein was highly homolog...

journal_title：Biochemical and biophysical research communications

authors： Lee JR,Park SC,Kim JY,Lee SS,Park Y,Cheong GW,Hahm KS,Lee SY

更新日期：2007-02-16 00:00:00

abstract：:Nuclear orphan receptor TLX is an essential regulator of the growth of neural stem cells. However, its exact function in pancreatic islet cells is still unknown. In the present study, gene expression profiling analysis revealed that overexpression of TLX in beta cell line MIN6 causes suppression of 176 genes and upreg...

journal_title：Biochemical and biophysical research communications

authors： Shi X,Xiong X,Dai Z,Deng H,Sun L,Hu X,Zhou F,Xu Y

更新日期：2015-12-04 00:00:00

abstract：:Co3O4 nanoparticles (NPs) are one kind of the important nanomaterials that have the application potential in catalyst, electrochromic devices, sensors, etc. However, their biological effect remains to be detailed. In this study, we investigated the effect of the as-synthesized Co3O4 NPs (15-30 nm) on the growth of mam...

journal_title：Biochemical and biophysical research communications

authors： Wang H,Ren T,Zhu N,Yu Q,Li M

更新日期：2018-11-02 00:00:00

abstract：:Insulin gene was induced into differentiated hepatic cell line. These cells released immunoreactive insulin (IRI) of which molecular weight was greater than mature insulin. The secretion of IRI was responsive to glucose concentration and inhibited by glucose metabolism antagonist, 2-deoxy glucose (2-DOG). The mRNA of ...

journal_title：Biochemical and biophysical research communications

authors： Hayashi M,Taguchi M,Fujita T

更新日期：1997-04-17 00:00:00

abstract：:Spinal muscular atrophy (SMA) is caused by mutations within the survival motor neuron 1 (SMN1) gene. These mutations result in the reduction of survival motor neuron (SMN) protein expression and SMN complex in spinal motor neurons and other tissues. SMN protein has been used as a therapeutic biomarker in recent SMA cl...

journal_title：Biochemical and biophysical research communications

authors： Arakawa M,Arakawa R,Tatsumi S,Aoki R,Saito K,Nomoto A

更新日期：2014-10-24 00:00:00

abstract：:Epididymal fluid from rats rendered infertile by oral administration of ornidazole contains a protein CAP1 (contraception-associated protein 1) that is absent from epididymal fluid, but present on epididymal sperm, from fertile vehicle-treated rats. The gene for CAP1 has been isolated from a rat testis cDNA library an...

journal_title：Biochemical and biophysical research communications

authors： Wagenfeld A,Gromoll J,Cooper TG

更新日期：1998-10-20 00:00:00

abstract：:Two genes expressing 70 kDa heat shock proteins were identified in Cyprinus carpio. The sequence similarities and the intron-interrupted structure of the coding regions indicate that carp Hsc70-1 and Hsc70-2 belong to the Hsp70 cognate subfamily. The expressions of the two hsc70 genes were followed by semi-quantitativ...

journal_title：Biochemical and biophysical research communications

authors： Ali KS,Dorgai L,Abrahám M,Hermesz E

更新日期：2003-08-01 00:00:00

abstract：:A bioassay based on the measurement of thymidine incorporation into trichloroacetic acid-insoluble materials in erythroid cell suspensions from fetal calf liver was used as the assay for purification of two small peptides (erythrotropins I and II) from fetal calf intestine. The peptides were purified using reversed-ph...

journal_title：Biochemical and biophysical research communications

authors： Congote LF

更新日期：1983-09-15 00:00:00

abstract：:Dlx5 transcription factor plays important roles in osteoblast differentiation and its transcription is regulated by many osteogenic signals including BMP-2. Recent studies suggest that the function of Dlx5 is also regulated post-translationally by protein kinases such as p38 and CaMKII. Protein kinase A (PKA) is invol...

journal_title：Biochemical and biophysical research communications

authors： Han Y,Jin YH,Yum J,Jeong HM,Choi JK,Yeo CY,Lee KY

更新日期：2011-04-15 00:00:00

abstract：:Hammerhead ribozymes may be of great therapeutic importance, since they can, in theory, be developed to cleave any undesired target RNA. In order to design ribozymes which are stable against endogenous RNases, we incorporated 2'-acetamido-2'-deoxynucleosides in the catalytic core of a hammerhead ribozyme. The 2'-aceta...

journal_title：Biochemical and biophysical research communications

authors： Hendrix C,Mahieu M,Anné J,Van Calenbergh S,Van Aerschot A,Content J,Herdewijn P

更新日期：1995-05-05 00:00:00

abstract：:Genetic mutation is one of the causative factors for idiopathic progressive hearing loss. A patient with late-onset, moderate, and high-frequency hearing loss was found to have a novel, heterozygous KCNQ4 mutation, c.806_808delCCT, which led to a p.Ser260del located between S5 and the pore helix (PH). Molecular modeli...

journal_title：Biochemical and biophysical research communications

authors： Watabe T,Matsunaga T,Namba K,Mutai H,Inoue Y,Ogawa K

更新日期：2013-03-15 00:00:00

abstract：:Fluorescent ubiquitination-based cell cycle indicator (Fucci) technology utilizing the cell cycle-dependent proteolysis of ubiquitin oscillators enables visualization of cell cycle progression in living cells. The Fucci probe consists of two chimeric fluorescent proteins, FucciS/G2/M and FucciG1, which label the nucle...

journal_title：Biochemical and biophysical research communications

authors： Yo M,Sakaue-Sawano A,Noda S,Miyawaki A,Miyoshi H

更新日期：2015-01-30 00:00:00

abstract：:Legionella pneumophila is a flagellated pathogenic bacterium that causes atypical pneumonia called Legionnaires' disease. The flagellum plays a key role in the pathogenesis of L. pneumophila in the host. The protein FlgL forms a junction between the flagellar hook and filament and has been reported to elicit the host ...

journal_title：Biochemical and biophysical research communications

authors： Song WS,Hong HJ,Yoon SI

更新日期：2020-08-20 00:00:00

abstract：:Glycogen-storage disease type II (GSD II, acid maltase deficiency, Pompe's disease) is caused by defects in the lysosomal acid alpha-glucosidase (GAA) gene. Clinically, patients with the severe infantile form of GSD II have muscle weakness and cardiomyopathy eventually leading to death before the age of two years. Pat...

journal_title：Biochemical and biophysical research communications

authors： Nicolino M,Puech JP,Letourneur F,Fardeau M,Kahn A,Poenaru L

更新日期：1997-06-09 00:00:00

abstract：:Receptor activator of NF-κB ligand (RANKL) is a member of the TNF superfamily. RANKL increases endothelial permeability and induces angiogenesis, suggesting its critical roles in the vasculature. Despite the evidence implicating RANKL in vascular pathology, its role in ischemic retinopathy has not been previously repo...

journal_title：Biochemical and biophysical research communications

authors： Ock S,Park S,Lee J,Kim J

更新日期：2019-08-20 00:00:00

abstract：:The immunoglobulin G of a polyclonal antiserum (pIgG) from a patient with insulin resistance and hypoglycemia was tested for its ability to inhibit insulin binding and to affect the autophosphorylation of partially-purified insulin receptors extracted from rat liver membranes. pIgG, when added 4 hr prior to insulin, i...

journal_title：Biochemical and biophysical research communications

authors： Cordera R,Gherzi R,De Pirro R,Rossetti L,Freidenberg GR,Andraghetti G,Lauro R,Adezati L

更新日期：1985-11-15 00:00:00

abstract：:This study examined the actions of L-arginine, a putative precursor of endothelium-derived nitric oxide, and arginine analogs on endothelium-dependent relaxation of isolated rings of bovine pulmonary artery. L-Arginine did not consistently relax arterial rings unless rings were first rendered refractory to endothelium...

journal_title：Biochemical and biophysical research communications

authors： Gold ME,Wood KS,Buga GM,Byrns RE,Ignarro LJ

更新日期：1989-06-15 00:00:00

abstract：:To evaluate the immunomodulatory effects of histamine in vivo, we analyzed an experimental syngenic tumor model using a colon adenocarcinoma cell line, CT-26, in Balb/c mice. In this model, distinct tumor growth was observed around 6 days after inoculation. Daily administration of cimetidine (0.12 mg/kg/day) significa...

journal_title：Biochemical and biophysical research communications

authors： Takahashi K,Tanaka S,Ichikawa A

更新日期：2001-03-01 00:00:00

abstract：:Simultaneous incubation of bovine adrenal medullary plasma membranes (PM) with chromaffin granules (CG) resulted in the release of the soluble granular content. The molecular mechanism of this process was studied with several monoclonal antibodies (mAb) raised against different plasma membrane components. Specific inh...

journal_title：Biochemical and biophysical research communications

authors： Bohner K,Boons J,Gheuens J,Konings F,De Potter WP

更新日期：1985-12-31 00:00:00

abstract：:Anethole has been known to have chemopreventive activities as a suppressor of the incidence and multiplicity of both invasive and noninvasive carcinomas. The goal of this study was to understand the anti-metastatic effect of anethole through C-X-C chemokine receptor type 4 (CXCR4)/tumor suppressor phosphatase and tens...

journal_title：Biochemical and biophysical research communications

authors： Rhee YH,Chung PS,Kim SH,Ahn JC

更新日期：2014-05-16 00:00:00

abstract：:The ability of exogenous nitric oxide (NO) to induce apoptosis in macrophages was analyzed using NOC, a NO-releasing compound, as a source of NO. Exogenous NO was shown to induce apoptosis in a dose dependent manner. Quantitative analysis revealed that the amount of NO required to induce apoptosis in more than half of...

journal_title：Biochemical and biophysical research communications

authors： Shimaoka M,Iida T,Ohara A,Taenaka N,Mashimo T,Honda T,Yoshiya I

更新日期：1995-04-17 00:00:00

abstract：:Although the introduction of cyclosporine A (CyA) and FK506 for immunosuppressive therapy has dramatically enhanced the early survival of organ transplant recipients, administration of these immunosuppresants is correlated with high incidence of transplant arteriosclerosis. Transplant-associated arteriosclerosis is be...

journal_title：Biochemical and biophysical research communications

authors： Sata M,Walsh K

更新日期：1999-09-24 00:00:00

abstract：:Most studies characterizing H-ras have been conducted in constitutively expressing cell lines. To explore the early interaction between H-ras p21 and signal transduction systems we have utilized an NIH3T3 fibroblast line transfected with a steroid inducible MMTV H-ras vector. Exposure to dexamethasone resulted in tran...

journal_title：Biochemical and biophysical research communications

authors： Murphy SK,Lindberg JB,Prussack DA

更新日期：1994-12-15 00:00:00

abstract：:The expression of mouse CYP27B1 in Escherichia coli has been dramatically enhanced by coexpression of GroEL/ES. To reveal the enzymatic properties of CYP27B1, we measured its hydroxylation activity toward vitamin D3 and 1alpha-hydroxyvitamin D3 (1alpha(OH)D3) in addition to the physiological substrate 25(OH)D3. Surpri...

journal_title：Biochemical and biophysical research communications

authors： Uchida E,Kagawa N,Sakaki T,Urushino N,Sawada N,Kamakura M,Ohta M,Kato S,Inouye K

更新日期：2004-10-15 00:00:00