Iron metabolism in murine erythroleukaemic cells.

abstract：:Risk assessment for patients with sickle cell disease (SCD) remains challenging as it depends on an individual physician's experience and ability to integrate a variety of test results. We aimed to provide a new risk score that combines clinical, laboratory, and imaging data. In a prospective cohort of 600 adult patie...

journal_title：British journal of haematology

authors： Sachdev V,Tian X,Gu Y,Nichols J,Sidenko S,Li W,Beri A,Layne WA,Allen D,Wu CO,Thein SL

更新日期：2021-01-28 00:00:00

abstract：:The endothelial hybridoma (EAhy926) cell line was employed to clarify whether antiphospholipid antibodies (aPA) [lupus anticoagulant (LA), antiprothrombin antibody (aPT) and/or anticardiolipin antibody (aCL)] and anti-endothelial cell antibodies (AECA) are identical, and establish whether beta2-glycoprotein I (beta2-G...

journal_title：British journal of haematology

authors： Matsuda J,Gotoh M,Gohchi K,Kawasugi K,Tsukamoto M,Saitoh N

更新日期：1997-04-01 00:00:00

abstract：:Hydroxyurea (HU), an inhibitor of DNA synthesis, can also induce haemoglobinization in certain erythroid cell lines. In this study, we report that intracellular peroxides levels were increased in HU-treated murine erythroleukaemia (MEL) cells and that l-acetyl-N-cysteine (LNAC), a potent reducing reagent, had a signif...

journal_title：British journal of haematology

authors： Nagai T,Tarumoto T,Miyoshi T,Ohmine K,Muroi K,Komatsu N,Sassa S,Ozawa K

更新日期：2003-05-01 00:00:00

abstract：:Differentiation therapy using retinoic acids (RAs) or 1alpha25-dihydroxyvitamin D3 (D3) is an attractive alternative to chemotherapy in acute myeloid leukaemia (AML) and myelodysplastic syndromes (MDS). However, with the exception of RA therapy for acute promyelocytic leukaemia (APL), RAs and D3 are not potent enough ...

journal_title：British journal of haematology

authors： Fenton SL,Drayson MT,Hewison M,Vickers E,Brown G,Bunce CM

更新日期：1999-05-01 00:00:00

abstract：:Diamond Blackfan Anaemia (DBA) is a rare congenital pure red cell aplasia that may be associated with facio-skeletal developmental defects. The disease is caused by mutations in one of at least ten ribosomal proteins, which results in haploinsufficiency and an imbalance between the synthesis of rRNA and ribosomal prot...

journal_title：British journal of haematology

authors： Horos R,von Lindern M

更新日期：2012-12-01 00:00:00

abstract：:The aim of our study was to investigate whether haemophilia A patients with inversion of intron 22 are at high risk for non-inhibitory anti-FVIII antibodies development detected by ELISA. It is known that patients with severe forms of haemophilia A are more likely to develop anti-FVIII antibodies. The incidence of inh...

journal_title：British journal of haematology

authors： Vianello F,Radossi P,Tison T,Dazzi F,Tagariello G,Davoli PG,Girolami A

更新日期：1997-06-01 00:00:00

abstract：:Both atypical haemolytic uraemic syndrome (aHUS) and the HELLP syndrome (haemolytic anaemia, elevated liver enzymes, and low platelets) are thrombotic microangiopathies characterized by microvascular endothelial activation, cell injury and thrombosis. aHUS is a disease of complement dysregulation, specifically a gain ...

journal_title：British journal of haematology

authors： Fang CJ,Richards A,Liszewski MK,Kavanagh D,Atkinson JP

更新日期：2008-11-01 00:00:00

abstract：:Between January 1987 and January 1997, 69 eligible patients with acute myeloid leukaemia (AML) in either second (CR2) or third (CR3) complete remission (CR2 = 60, CR3 = 9) underwent 4-hydroperoxycyclophosphamide-purged autologous bone marrow transplantation (BMT) at the Johns Hopkins Oncology Center. The patients' med...

journal_title：British journal of haematology

authors： Smith BD,Jones RJ,Lee SM,Piantadosi S,Vala MS,Fuller D,Gore SD,Noga SJ,O'Donnell PV,Braine H,Vogelsang GB,Fuchs EJ,Flinn IW,Brodsky RA,Ambinder RF,Miller CB

更新日期：2002-06-01 00:00:00

abstract：:Dickkopf-1 (DKK1), expressed by myeloma cells, suppresses osteoblast function and plays a key role in bone disease in multiple myeloma. BHQ880, a human neutralizing IgG1 anti-DKK1 monoclonal antibody, is being investigated for its impact on multiple myeloma-related bone disease and as an agent with potential anti-myel...

journal_title：British journal of haematology

authors： Iyer SP,Beck JT,Stewart AK,Shah J,Kelly KR,Isaacs R,Bilic S,Sen S,Munshi NC

更新日期：2014-11-01 00:00:00

abstract：:We investigated the molecular basis of factor VII deficiency in a Japanese patient and identified a novel missense mutation in the signal sequence of the gene. Factor VII activity and antigen level measured in the patient were 10.7% and 11% of normal, respectively. All exons except 1B and the 5'-flanking region contai...

journal_title：British journal of haematology

authors： Ozawa T,Takikawa Y,Niiya K,Ejiri N,Suzuki K,Sato S,Sakuragawa N

更新日期：1998-04-01 00:00:00

abstract：:The Complement 1 trial investigated the efficacy and safety of ofatumumab + chlorambucil with chlorambucil monotherapy in patients with previously untreated chronic lymphocytic leukaemia (CLL). On long-term follow-up in the chemoimmunotherapy arm vs. the chemotherapy arm there was an estimated 12% (not significant) an...

journal_title：British journal of haematology

authors： Offner F,Robak T,Janssens A,Govind Babu K,Kloczko J,Grosicki S,Mayer J,Panagiotidis P,Schuh A,Pettitt A,Montillo M,Werner O,Vincent G,Khanna S,Hillmen P

更新日期：2020-09-01 00:00:00

abstract：:We attempted to identify the diagnostic markers and severity predictors of hepatic veno-occlusive disease (VOD) in 115 adult patients who were uniformly conditioned with busulphan and cyclophosphamide and who underwent allogeneic bone marrow transplantation (BMT). A diagnosis of VOD was made according to clinical crit...

journal_title：British journal of haematology

authors： Lee JH,Lee KH,Lee JH,Kim S,Seol M,Park CJ,Chi HS,Kang W,Kim ST,Kim WK,Lee JS

更新日期：2002-09-01 00:00:00

abstract：:A novel principle is proposed for a differential separation of live cells (such as leucocytes) from a main flow. A microfluidic device with planar insulated electrodes as the side walls of the channel was manufactured and tested. An array of insulated vertical conductor wires was inserted along the axis of the channel...

journal_title：British journal of haematology

authors： Popa C,Su B,Vadgama P,Cotter F

更新日期：2007-02-01 00:00:00

abstract：:In a randomized study that compared human leucocyte antigen-identical allogeneic granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood stem cell (PBSC) versus bone marrow (BM) transplantation, the expression of activation markers, CD23, CD25 and CD45RO by B cells, was compared in blood before and af...

journal_title：British journal of haematology

authors： Tayebi H,Lapierre V,Saas P,Lienard A,Sutton L,Milpied N,Attal M,Cahn JY,Kuentz M,Blaise D,Hervé P,Tiberghien P,Robinet E,Société Française de Greffe de Moelle et de Therapie Cellulaire.

更新日期：2001-09-01 00:00:00

abstract：:The alpha+ thalassaemias are the most common single gene disorders of humans, yet little is known about their haematological characteristics in childhood. Blood samples have been collected randomly from more than 2000 individuals in village communities in Vanuatu in the South West Pacific and analysed for alpha thalas...

journal_title：British journal of haematology

authors： Williams TN,Maitland K,Ganczakowski M,Peto TE,Clegg JB,Weatherall DJ,Bowden DK

更新日期：1996-11-01 00:00:00

abstract：:Establishing a precise diagnosis is essential in inborn haematological cytopenias to enable appropriate treatment decisions and avoid secondary organ damage. However, both diversity and phenotypic overlap of distinct disease entities may make the identification of underlying genetic aetiologies by classical Sanger seq...

journal_title：British journal of haematology

authors： Kager L,Jimenez Heredia R,Hirschmugl T,Dmytrus J,Krolo A,Müller H,Bock C,Zeitlhofer P,Dworzak M,Mann G,Holter W,Haas O,Boztug K

更新日期：2018-07-01 00:00:00

abstract：:The Hodgkin lymphomas are a family of unique lymphoma subtypes, in which the nature of the neoplastic cell was enigmatic for many years. Much of the mystery has been solved, with all forms now considered to be of B-cell origin, in most cases of germinal centre derivation. Today we recognize Hodgkin lymphoma as an epon...

journal_title：British journal of haematology

authors： Wang HW,Balakrishna JP,Pittaluga S,Jaffe ES

更新日期：2019-01-01 00:00:00

abstract：:The bleeding time in healthy volunteers was determined according to both the Ivy and the Simplate II techniques. A significantly longer bleeding time in people with blood group O than in people with non-O blood groups was demonstrated with both techniques. This difference could not be attributed to a difference in sex...

journal_title：British journal of haematology

authors： Caekebeke-Peerlinck KM,Koster T,Briët E

更新日期：1989-10-01 00:00:00

abstract：:Hereditary haemochromatosis (HH) is an autosomal recessive disorder characterized by excessive intestinal iron absorption resulting in increased pathological body iron stores. It is typically associated with homozygosity for the c.845G>A (p.C282Y) mutation in the HFE gene. However, other HFE alterations have been repo...

journal_title：British journal of haematology

authors： Silva B,Martins R,Proença D,Fleming R,Faustino P

更新日期：2012-08-01 00:00:00

abstract：:Myelofibrosis with myeloid metaplasia (MMM) is uniquely characterized by macroscopic bone marrow stromal changes that are believed to be both reactive and cytokine mediated. Furthermore, a prognostically detrimental increase in bone marrow angiogenesis has recently been demonstrated. These observations suggest a poten...

journal_title：British journal of haematology

authors： Elliott MA,Mesa RA,Li CY,Hook CC,Ansell SM,Levitt RM,Geyer SM,Tefferi A

更新日期：2002-05-01 00:00:00

abstract：:Iron is required for monocyte/macrophage differentiation of HL-60 leukaemia cells. Differentiation requires induction of the cyclin-dependent kinase inhibitor p21 (WAF1/CIP1), and cell cycle arrest at the G1/S checkpoint. With iron depletion, p21 induction and differentiation are blocked. To establish the roles of iro...

journal_title：British journal of haematology

authors： Kramer JL,Baltathakis I,Alcantara OS,Boldt DH

更新日期：2002-06-01 00:00:00

abstract：:In previously reported cases, congenital deficiency of coagulation factor XIII has been found to result from the absence of the enzymatically active A subunits. In the family reported here two members were found to be heterozygous for an unstable A subunit which, in the homozygous state, or in the heterozygous state w...

journal_title：British journal of haematology

authors： Castle S,Board PG,Anderson RA

更新日期：1981-06-01 00:00:00

abstract：:Reduced-intensity conditioning (RIC) regimens for allogeneic haematopoietic stem cell transplantation (SCT) have been shown to lead to engraftment of donor stem cells without the severe extra-haematological toxicities of traditional myeloablative transplants. Between December 1998 and December 2000, 76 patients underw...

journal_title：British journal of haematology

authors： Martino R,Caballero MD,Canals C,Simón JA,Solano C,Urbano-Ispízua A,Bargay J,Rayón C,Léon A,Sarrá J,Odriozola J,Conde JG,Sierra J,San Miguel J,ALLOPBSCT Subcommittee of the Spanish Group for Haematopoietic Transplantation (GET

更新日期：2001-12-01 00:00:00

abstract：:Patients belonging to four families with 'atypical elliptocytosis' have been investigated. Clinical, haematological, erythrokinetic and enzymatic characteristics as well as the effect of splenectomy are discussed. These studies appear to define the fundamental features of a particular disorder or a variety of heredita...

journal_title：British journal of haematology

authors： Torlontano G,Fioritoni G,Salvati AM

更新日期：1979-11-01 00:00:00

abstract：:Screening of the skeleton by plain radiography was compared to magnetic resonance imaging (MRI) of the lumbar spine in 41 patients with multiple myeloma. In the lumbar spine, myeloma lesions were detected in 15 patients with radiography and in 28 patients with MRI. Radiography of the lumbar spine was not positive in a...

journal_title：British journal of haematology

authors： Tertti R,Alanen A,Remes K

更新日期：1995-11-01 00:00:00

abstract：:Five out of nine adults (55%) with lymphoblastic disease developed severe avascular necrosis of bone (AVN) when treated with a Berlin-Frankfurt-Munster (BFM) ALL protocol similar to the current joint MRC-ECOG ALL trial (UKALL XII). The principal purpose of these intensified regimens is to improve long-term disease-fre...

journal_title：British journal of haematology

authors： Chan-Lam D,Prentice AG,Copplestone JA,Weston M,Williams M,Hutton CW

更新日期：1994-01-01 00:00:00

abstract：:Excessive bleeding represents a major complication of surgical interventions and its control is especially relevant in patients with Congenital Bleeding Disorders (CBD). In factor VII (FVII) deficiency, scanty data on surgery is available to guide treatment strategies. The STER (Seven Treatment Evaluation Registry) is...

journal_title：British journal of haematology

authors： Mariani G,Dolce A,Batorova A,Auerswald G,Schved JF,Siragusa S,Napolitano M,Knudsen JB,Ingerslev J,STER and the International Factor VII Deficiency Study Groups.

更新日期：2011-02-01 00:00:00

abstract：:The t(4;14) translocation is found in approximately 10% of myeloma patients and results in the deregulation of at least two genes, MMSET and fibroblast growth factor receptor 3 (FGFR3), with the formation of a fusion product between MMSET and the immunoglobulin heavy chain (IgH) locus and overexpression of FGFR3. We h...

journal_title：British journal of haematology

authors： Sibley K,Fenton JA,Dring AM,Ashcroft AJ,Rawstron AC,Morgan GJ

更新日期：2002-08-01 00:00:00

abstract：:In the positron emission tomography (PET) era, traditional prognostic factors may not apply for patients with relapsed/refractory (R/R) diffuse large B cell lymphoma (DLBCL) undergoing autologous stem cell transplantation (ASCT). Moreover, little is known about prognostic factors in patients transplanted for transform...

journal_title：British journal of haematology

authors： Armand P,Welch S,Kim HT,LaCasce AS,Jacobsen ED,Davids MS,Jacobson C,Fisher DC,Brown JR,Coughlin E,Freedman AS,Chen YB

更新日期：2013-03-01 00:00:00

abstract：:The combination of bortezomib and rituximab was evaluated in patients with mantle cell lymphoma (MCL), follicular lymphoma (FL) and Waldenström macroglobulinaemia (WM), in a Phase I and later, a randomized Phase II study. In the randomized study, 42 patients with recurrent/refractory disease received either: bortezomi...

journal_title：British journal of haematology

authors： Agathocleous A,Rohatiner A,Rule S,Hunter H,Kerr JP,Neeson SM,Matthews J,Strauss S,Montoto S,Johnson P,Radford J,Lister A

更新日期：2010-11-01 00:00:00