Involvement of cell-cell adhesion molecules in liver colonization by metastatic murine lymphoma/lymphosarcoma variants.

abstract：:The idea for this Special Issue originated from our recent review in Nature Reviews Clinical Oncology entitled "Does the mobilization of circulating tumour cells during cancer therapy cause metastasis?" Martin et al. (Nat Rev Clin Oncol 14:32-44, 2017). While preparing this review, it became evident that an overwhelmi...

journal_title：Clinical & experimental metastasis

authors： Martin OA,Anderson RL

更新日期：2018-04-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with poor prognosis, particularly for patients with metastatic disease. Treatment for oligometastatic presentation has been reported in recent literature, but the role of intraperitoneal chemotherapy for patients with peritoneal metastases (PM) remain...

journal_title：Clinical & experimental metastasis

authors： Brind'Amour A,Webb M,Parapini M,Sidéris L,Segedi M,Chung SW,Chartier-Plante S,Dubé P,Scudamore CH,Kim PTW

更新日期：2021-01-24 00:00:00

abstract：:Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer known. IBC carries a guarded prognosis primarily due to rapid onset of disease, typically within six months, and the propensity of tumor emboli to invade the dermal lymphatics and spread systemically. Although the clinical manif...

journal_title：Clinical & experimental metastasis

authors： van Golen KL,Bao LW,Pan Q,Miller FR,Wu ZF,Merajver SD

更新日期：2002-01-01 00:00:00

abstract：:Metastatic castrate resistant prostate cancer (mCRPC) is responsible for the majority of prostate cancer deaths with the median survival after diagnosis being 2 years. The metastatic lesions often arise in the skeleton, and current treatment options are primarily palliative. Using guidelines set forth by the National ...

journal_title：Clinical & experimental metastasis

authors： Gallaher J,Cook LM,Gupta S,Araujo A,Dhillon J,Park JY,Scott JG,Pow-Sang J,Basanta D,Lynch CC

更新日期：2014-12-01 00:00:00

abstract：:Hypermethylation of the promoter region of tumor suppressor genes is associated with carcinogenesis in lung cancer (LC). Endobronchial ultrasound with needle aspiration (EBUS-NA) is a semi-invasive method for obtaining cell blocks from lymph nodes, which can be used for epigenetic analyses. To establish the relationsh...

journal_title：Clinical & experimental metastasis

authors： Millares L,Serra M,Andreo F,Sanz-Santos J,Montón C,Grimau C,Gallego M,Setó L,Combalia N,Llatjos M,Escoda R,Castellà E,Monsó E

更新日期：2015-10-01 00:00:00

abstract：:Metastasis is the most devastating aspect of cancer and it is the main cause of morbidity and mortality in cancer patients. Tumor cell adhesion to the vascular endothelial cell lining is an important step in metastatic progression and is prompted by platelets. Mucin 1 is over-expressed and aberrantly glycosylated in m...

journal_title：Clinical & experimental metastasis

authors： Sudha T,Phillips P,Kanaan C,Linhardt RJ,Borsig L,Mousa SA

更新日期：2012-06-01 00:00:00

abstract：:Several lines of evidence indicate that sialosyl Le(a), tumor-associated carbohydrate antigen present on human colon carcinoma cells, is involved in formation of metastases. To study the role of this carbohydrate structure in development of metastases, we have used the clone of human colon carcinoma CX-1 cells transfe...

journal_title：Clinical & experimental metastasis

authors： Opolski A,Laskowska A,Madej J,Wietrzyk J,Kłopocki A,Radzikowski C,Ugorski M

更新日期：1998-11-01 00:00:00

abstract：:Tumor cell adhesion to the extracellular matrix (ECM) is closely linked with tumor cell invasion and metastasis. In this study, we demonstrate that low levels of adriamycin, a widely used anticancer drug, can inhibit the invasion of highly metastatic K1735-M2 mouse melanoma cells in vitro through a reconstituted basem...

journal_title：Clinical & experimental metastasis

authors： Repesh LA,Drake SR,Warner MC,Downing SW,Jyring R,Seftor EA,Hendrix MJ,McCarthy JB

更新日期：1993-01-01 00:00:00

abstract：:Considering recent findings that cyclooxygensase-2 (COX-2) is involved in the progression of colorectal carcinoma (CRC), the role of COX-2 in promoting invasion and angiogenesis was investigated by evaluating the relationship of COX-2 expression to various clinicopathological variables, including plasminogen activatin...

journal_title：Clinical & experimental metastasis

authors： Konno H,Baba M,Shoji T,Ohta M,Suzuki S,Nakamura S

更新日期：2002-01-01 00:00:00

abstract：:We have investigated the gelatinase profiles and invasiveness of clonal tumour sublines derived from a spontaneously arising mammary tumour in a Balb/cfC3H mouse. The 67NR. 66c14 and 4T1.2 sublines have low, intermediate and high metastatic potential respectively. In Boyden chamber studies, Matrigel invasion was seen ...

journal_title：Clinical & experimental metastasis

authors： Tester AM,Ruangpanit N,Anderson RL,Thompson EW

更新日期：2000-01-01 00:00:00

abstract：:Metastasis, responsible for most deaths from breast cancer (BC), is a multistep process leading to cancer cell spread. Extracellular matrix (ECM)-related adhesion and apoptosis resistance play pivotal role in metastasis. Ras suppressor-1 (RSU-1) localizes to cell-ECM adhesions and binds to pro-survival adhesion protei...

journal_title：Clinical & experimental metastasis

authors： Giotopoulou N,Valiakou V,Papanikolaou V,Dubos S,Athanassiou E,Tsezou A,Zacharia LC,Gkretsi V

更新日期：2015-03-01 00:00:00

abstract：:We studied the influence of 10 synthetic glycoamine analogs on colony formation in 0.3 and 0.9% agarose by metastatic human breast carcinoma (MDA-MB-435) and melanoma (TXM-13) cells. Nine synthetic analogs significantly inhibited the colony formation in 0.9% agarose of MDA-MB-435 human breast carcinoma cells; five com...

journal_title：Clinical & experimental metastasis

authors： Glinsky GV,Mossine VV,Price JE,Bielenberg D,Glinsky VV,Ananthaswamy HN,Feather MS

更新日期：1996-05-01 00:00:00

abstract：:Previous studies have shown that thrombospondin (TSP) is an adhesion factor for some human tumor cells. The previous studies have shown further that tumor cells which utilize TSP as an adhesion factor also synthesize it. This study continues the effort to understand how TSP production and expression are regulated in h...

journal_title：Clinical & experimental metastasis

authors： Varani J,Riser BL,Hughes LA,Carey TE,Fligiel SE,Dixit VM

更新日期：1989-05-01 00:00:00

abstract：:To study the tumor cell autonomous processes of metastasis, an in vivo tumor metastasis model is required that excludes the involvement of the innate immune system. For this purpose we used the established syngeneic MTLn3 cell - Fischer 344 tumor model. MTLn3 cells are efficiently eradicated by NK cells in vivo. Using...

journal_title：Clinical & experimental metastasis

authors： van Nimwegen MJ,Verkoeijen S,Kuppen PJ,Velthuis JH,van de Water B

更新日期：2007-01-01 00:00:00

abstract：:Cancer stem cells drive the metastatic cascade by undergoing epithelial to mesenchymal transition (EMT) and again mesenchymal to epithelial transition (MET). Using multiple breast cancer cell lines including cigarette smoke induced breast cancer cells and tumor derived primary cells from patient sample; we developed a...

journal_title：Clinical & experimental metastasis

authors： Siddharth S,Das S,Nayak A,Kundu CN

更新日期：2016-10-01 00:00:00

abstract：:The concurrent administration of Metrazol (60 mg/kg, i.v.) to anaesthetized rats enhances the cerebral penetration of the anticancer agent razoxane. Such an enhancement leads to an increase in the therapeutic efficacy of razoxane against intracerebrally sequestered L1210 leukaemia cells in mice. The combination of Met...

journal_title：Clinical & experimental metastasis

authors： Greig N,Newell D,Hellmann K

更新日期：1984-01-01 00:00:00

abstract：:Patients with small cell lung cancer (SCLC) are more likely to have synchronous brain metastasis (SBM) at the time of diagnosis than patients with any other extracranial primary malignancy. We sought to identify which factors predicted an increased risk of SBM in SCLC as well as which factors affected the prognosis of...

journal_title：Clinical & experimental metastasis

authors： Reddy SP,Dowell JE,Pan E

更新日期：2020-08-01 00:00:00

abstract：:An overview of colorectal cancer discussed (Philip Paty) the good outcome after primary management with local control in 90-95 % of colon and 85 % in rectal cancer patients with major progression to metastases and to death related to hematogenous dissemination. The major disease pathways include the APC, aneuploid pat...

journal_title：Clinical & experimental metastasis

authors： Wanebo HJ,LeGolvan M,Paty PB,Saha S,Zuber M,D'Angelica MI,Kemeny NE

更新日期：2012-10-01 00:00:00

abstract：:Tumor metastasis often confers poor prognosis for cancer patients due to lack of comprehensive strategy in dealing with cells growing in different environment. Current anticancer therapies have incomplete effectiveness because they were designed assuming metastatic tumors behave similarly in different organs. We hypot...

journal_title：Clinical & experimental metastasis

authors： Alsaggar M,Yao Q,Cai H,Liu D

更新日期：2016-02-01 00:00:00

abstract：:The present study assessed the effects of dietary fat on spontaneous metastasis of Lewis lung carcinoma in mice. Three-week old male C57BL/6 mice were fed the AIN-93G diet or a 45% fat diet (% kcal.) for 7 weeks before they were subcutaneously injected with 2.5 × 10⁵ viable carcinoma cells. The primary tumor was resec...

journal_title：Clinical & experimental metastasis

authors： Yan L,DeMars LC

更新日期：2010-12-01 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is one of few cancers with rising incidence in North America. The prognosis of ccRCC is variable and difficult to predict. Stratification of patients according to disease aggressiveness can significantly improve patient management. We investigated the expression of the S100A11 p...

journal_title：Clinical & experimental metastasis

authors： Gabril M,Girgis H,Scorilas A,Rotondo F,Wala S,Bjarnason GA,Ding Q,Evans A,Tawedrous E,Pasic M,Finelli A,Al-Haddad S,Yousef GM

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:One of the major clinical problems in breast cancer detection is the relatively high incidence of occult lymph node metastases undetectable by standard procedures. Since the ascertainment of breast cancer stage determines the following treatment, such a "hypo-diagnosis" leads to inadequate therapy, and hence...

journal_title：Clinical & experimental metastasis

authors： Afrimzon E,Deutsch A,Shafran Y,Zurgil N,Sandbank J,Pappo I,Deutsch M

更新日期：2008-01-01 00:00:00

abstract：:Organ-specific metastasis of tumour cells may result from selective invasion and growth or from selective host cell responses. The present study demonstrates how selective interactions with the host affect the metastatic pattern of two murine T cell hybridoma lines, derived from the BW 5147 thymoma. Upon intravenous i...

journal_title：Clinical & experimental metastasis

authors： Schmidt C,Verschueren H,Toussaint-Demylle D,van den Berg T,Kraal G,De Baetselier P

更新日期：1994-03-01 00:00:00

abstract：:We have previously isolated a series of MCF-7 human breast cancer cell variants which no longer require estrogen-supplementation for tumor growth in nude mice (Clarke et al. Proc Natl Acad Sci USA 86: 3649-3653, 1989). We now report that these hormone-independent and hormone-responsive variants (MIII, MCF7/LCC1) can i...

journal_title：Clinical & experimental metastasis

authors： Thompson EW,Brünner N,Torri J,Johnson MD,Boulay V,Wright A,Lippman ME,Steeg PS,Clarke R

更新日期：1993-01-01 00:00:00

abstract：:In this study the relationship between brain structure and brain metastases (BM) occurrence was analyzed. A model for predicting the time of BM onset in patients with non-small cell lung cancer (NSCLC) was proposed. Twenty patients were used to develop the model, whereas the remaining 69 were used for independent vali...

journal_title：Clinical & experimental metastasis

authors： Yin G,Li C,Chen H,Luo Y,Orlandini LC,Wang P,Lang J

更新日期：2017-02-01 00:00:00

abstract：:Insulin-like growth factor I receptor (IGF-IR) is critical to cell survival and growth and altered IGF-IR expression is found in many human cancers. However, its expression and potential role in gastric cancer development and progression has not been explored. The IGF-IR expression level was determined via immunohisto...

journal_title：Clinical & experimental metastasis

authors： Jiang Y,Wang L,Gong W,Wei D,Le X,Yao J,Ajani J,Abbruzzese JL,Huang S,Xie K

更新日期：2004-01-01 00:00:00

abstract：:The majority of patients recur after resection of colorectal liver metastases (CRLM). Patients with CRLM displaying a desmoplastic histopathological growth pattern (dHGP) have a better prognosis and lower probability of recurrence than patients with non-dHGP CRLM. The current study evaluates the impact of HGP type on ...

journal_title：Clinical & experimental metastasis

authors： Nierop PMH,Galjart B,Höppener DJ,van der Stok EP,Coebergh van den Braak RRJ,Vermeulen PB,Grünhagen DJ,Verhoef C

更新日期：2019-04-01 00:00:00

abstract：:Fischer 344/CRJ rats harbor a G633R substitution in dipeptidyl peptidase IV (DPP IV) that leads to retention and degradation of the mutant protein in the endoplasmic reticulum (Tsuji E, Misumi Y, Fujiwara T et al. Biochemistry 1992; 31 (47): 11921-7). However, when these rats were used as a 'protein knock-out' model i...

journal_title：Clinical & experimental metastasis

authors： Cheng HC,Abdel-Ghany M,Zhang S,Pauli BU

更新日期：1999-01-01 00:00:00

abstract：:Pulmonary metastasectomy (PM) is an accepted treatment modality in colorectal cancer (CRC) patients with pulmonary tumor spread. Positive intrathoracic lymph nodes at the time of PM are associated with a poor prognosis and 5-year survival rates of <20 %. Increased lymphangiogenesis in pulmonary metastases might repres...

journal_title：Clinical & experimental metastasis

authors： Schweiger T,Nikolowsky C,Graeter T,Seebacher G,Laufer J,Glueck O,Glogner C,Birner P,Lang G,Klepetko W,Ankersmit HJ,Hoetzenecker K

更新日期：2016-02-01 00:00:00

abstract：:Tumour endothelial markers (TEMs) are a newly discovered family of endothelial markers associated with tumour specific angiogenesis. This study sought to examine the levels of expression for TEMs in human breast cancer. Breast cancer tissues (n = 120) together with normal background tissues (n = 33) were obtained afte...

journal_title：Clinical & experimental metastasis

authors： Davies G,Cunnick GH,Mansel RE,Mason MD,Jiang WG

更新日期：2004-01-01 00:00:00