[Effects of iodine deficiency during intrauterine and early postnatal life on DNA synthesis in liver and brain of rats].

Abstract:

:Iodine deficiency during intrauterine and early postnatal life of the rat produces a transient decrease in the DNA content of brain and cerebellum, which is spontaneously recovered without replacement therapy. Results of the study revealed that DNA synthesis measured through thymidine-H3 incorporation to DNA, was increased at 21 days of life in liver, brain and cerebellum, indicative of a higher activity of DNA synthesis. This prolongation of the critical period of brain cell multiplication in iodine deficient rats, suggests, therefore, an alteration of brain maturation.

journal_name

Arch Latinoam Nutr

authors

Fábrega I,Mánquez M,Leiva L,Zvaighaft A,Muzzo S

subject

Has Abstract

pub_date

1984-06-01 00:00:00

pages

321-32

issue

2

eissn

0004-0622

issn

2309-5806

journal_volume

34

pub_type

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