Diuretic-induced magnesium losses.

abstract：:Alectinib (Alecensa(®)) is a second-generation, orally active, potent and highly selective inhibitor of anaplastic lymphoma kinase (ALK). Alectinib is approved for the treatment of ALK fusion-gene positive, unresectable, advanced or recurrent non-small cell lung cancer (NSCLC) in Japan, where it has been given orphan ...

journal_title：Drugs

authors： McKeage K

更新日期：2015-01-01 00:00:00

abstract：:A rapid, practical diagnostic scheme is the key to selecting proper candidates for treatment with bromocriptine. The evaluation centres around assays for prolactin and follicle stimulating hormone, polytomography and computerised axial tomography of the sella turcica and parasellar regions, and the ergot alkaloid, bro...

journal_title：Drugs

authors： March CM

更新日期：1979-05-01 00:00:00

abstract：:Chlamydia trachomatis infections are exceedingly prevalent, and can be associated with significant sequelae. The major infections are urethritis, cervicitis, salpingitis, and ocular infection. Chlamydial genital infections present as syndromes, where C. trachomatis is one of the causes of the syndrome. Because specifi...

journal_title：Drugs

authors： Bowie WR

更新日期：1984-05-01 00:00:00

abstract：:Cytotoxic chemotherapy plays a key role in the treatment of carcinoma for thousands of patients annually who either present with metastatic disease or relapse after surgical excision of apparently localised disease. Unfortunately, there is such a wide range of responsiveness to drug therapy within individual tumour ty...

journal_title：Drugs

authors： Sarosdy MF,Von Hoff DD

更新日期：1983-11-01 00:00:00

abstract：:Intravenous susoctocog alfa (Obizur(®)) is a recombinant, B-domain deleted, porcine sequence antihaemophilic factor VIII (FVIII) product that has recently been approved for the treatment of bleeding episodes in adults with acquired haemophilia A (AHA). Intravenous susoctocog alfa was an effective and generally well to...

journal_title：Drugs

authors： Burness CB,Scott LJ

更新日期：2016-05-01 00:00:00

abstract：:Rheumatoid arthritis is a disease of unknown aetiology characterised by persistent joint swelling, functional disability and increased mortality. No curative therapy exists at present but some therapeutic agents, commonly referred to as disease-modifying drugs, offer the potential for suppression of the inflammatory a...

journal_title：Drugs

authors： Jackson CG,Williams HJ

更新日期：1998-09-01 00:00:00

abstract：:The efficacy and safety of cefadroxil in the treatment of paediatric patients with a wide variety of infections were evaluated in a multicentre clinical trial. This study included 395 infants and children with Group A streptococcal pharyngitis, sinusitis, otitis media, bronchitis, pneumonia or bronchopneumonia, urinar...

journal_title：Drugs

authors： Puhakka H,Virolainen E

更新日期：1986-01-01 00:00:00

abstract：:The comprehensive treatment of schizophrenia requires the full resources of a clinical team that is able to offer treatment for the acute psychotic state in a hospital environment, and appropriate rehabilitation following resolution of the florid symptoms. Following a second or subsequent relapse, maintenance therapy ...

journal_title：Drugs

authors： Johnson DA

更新日期：1977-10-01 00:00:00

abstract：:The efficacy and tolerability of nimesulide were compared with those of paracetamol in a nonblind randomised study that recruited 110 children (64 males, 46 females; aged 3 to 6 years) with inflammation of the upper respiratory tract and fever. Nimesulide suspension (1.5 mg/kg 3 times daily) or paracetamol syrup (10 m...

journal_title：Drugs

authors： Polidori G,Titti G,Pieragostini P,Comito A,Scaricabarozzi I

更新日期：1993-01-01 00:00:00

abstract：:Suvorexant (Belsomra(®)), a first-in-class, orally active dual orexin-1 receptor and orexin-2 receptor antagonist, has been developed by Merck for the treatment of insomnia. Variations in the levels of the neuropeptides orexin A and orexin B have been linked to circadian rhythms and wakefulness. Orexin-producing neuro...

journal_title：Drugs

authors： Yang LP

更新日期：2014-10-01 00:00:00

abstract：:Nizatidine is an H2-receptor antagonist which in animal studies was more active on a weight-for-weight basis than cimetidine in inhibiting basal and stimulated gastric acid secretion. Similarly, studies in humans have confirmed that nizatidine is a potent inhibitor of basal, nocturnal and stimulated gastric acid secre...

journal_title：Drugs

authors： Price AH,Brogden RN

更新日期：1988-11-01 00:00:00

abstract：:A randomised multicentre double-blind study was conducted to compare the efficacy and safety of roxatidine acetate 75 mg twice daily and ranitidine 150 mg twice daily in 295 patients with endoscopically confirmed gastric ulcers. Substantial reductions in ulcer diameters and healing rates of 85.6 and 88.2% for roxatidi...

journal_title：Drugs

authors： Judmaier G

更新日期：1988-01-01 00:00:00

abstract：:204 individuals from a rural community were given a single dose of oxantel-pyrantel at 15mg/kg bodyweight and if still infected, 20mg/kg bodyweight, with cure rates of 100%, 53% and 71% for ascariasis, trichuriasis and hookworm infection, respectively. From an urban community, 124 patients were given the same drug eit...

journal_title：Drugs

authors： Cabrera BD,Sy FS

更新日期：1978-01-01 00:00:00

abstract：:Trigeminal neuralgia is a representative neuropathic facial pain condition, characterised by unilateral paroxysmal pain in the distribution territory of one or more divisions of the trigeminal nerve, triggered by innocuous stimuli. A subgroup of patients with trigeminal neuralgia [TN (previously defined as atypical TN...

journal_title：Drugs

authors： Di Stefano G,Truini A,Cruccu G

更新日期：2018-09-01 00:00:00

abstract：:Dapoxetine, a selective serotonin reuptake inhibitor, is the first oral pharmacological agent indicated for the treatment of men aged 18-64 years with premature ejaculation. In four randomized, double-blind, placebo-controlled, multicentre studies of 12-24 weeks' duration, oral dapoxetine 30 or 60 mg (administered as ...

journal_title：Drugs

authors： Hoy SM,Scott LJ

更新日期：2010-07-30 00:00:00

abstract：:Novo Nordisk has developed a subcutaneous formulation of semaglutide (Ozempic®), a modified human glucagon-like peptide-1 (GLP-1) analogue, for the treatment of type 2 diabetes mellitus. It has been developed using Novo Nordisk's proprietary protein-acylation technology, and is administered using an injection device. ...

journal_title：Drugs

authors： Dhillon S

更新日期：2018-02-01 00:00:00

abstract：:Resistance to the metabolic actions of insulin is thought to play a determining role in the aetiology of a great variety of disorders, including essential hypertension, accelerated atherosclerosis and cardiomyopathies. ACE inhibitors are recognised as being highly effective therapy for hypertension and cardiac insuffi...

journal_title：Drugs

authors： Bernobich E,de Angelis L,Lerin C,Bellini G

更新日期：2002-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is thought to be a chronic inflammatory disorder of the CNS. The past decade has seen the introduction of the new immunomodulatory drugs, interferon (IFN)-beta and glatiramer acetate, that have considerably improved the therapeutic options for this often disabling disease. The efficacy of these...

journal_title：Drugs

authors： Flachenecker P,Rieckmann P

更新日期：2003-01-01 00:00:00

abstract：:The incidence of adenocarcinoma of the pancreas has risen steadily over the past 4 decades. Since pancreatic cancer is diagnosed at an advanced stage, and because of the lack of effective therapies, the prognosis of such patients is extremely poor. Despite advances in our understanding of the molecular biology of panc...

journal_title：Drugs

authors： Rosenberg L

更新日期：2000-05-01 00:00:00

abstract：:Effective control of variceal rebleeding (secondary prophylaxis) or prevention of the initial bleeding (primary prophylaxis) are the main objectives of the treatment of portal hypertension. Endoscopic sclerotherapy is the treatment of choice for secondary prophylaxis, since it significantly decreases rebleeding and, t...

journal_title：Drugs

authors： Sarin SK

更新日期：1992-01-01 00:00:00

abstract：:Rapid progress has recently been encountered in pharmacologically treating the unborn baby. This unique area of drug therapy raises new methodological and ethical questions. This article is a systematic review of known modalities of fetal pharmacotherapy, and aims to highlight essential principles, difficulties and co...

journal_title：Drugs

authors： Koren G,Klinger G,Ohlsson A

更新日期：2002-01-01 00:00:00

abstract：:Health behaviors such as retention in HIV medical care and adherence to antiretroviral therapy (ART) pose major challenges to reducing new HIV infections, addressing health disparities, and improving health outcomes. Andersen's Behavioral Model of Health Service Use provides a conceptual framework for understanding ho...

journal_title：Drugs

authors： Holtzman CW,Brady KA,Yehia BR

更新日期：2015-04-01 00:00:00

abstract：:Drotrecogin alfa (activated), recombinant human activated protein C, inhibits coagulation and inflammation and promotes fibrinolysis in patients with severe sepsis. 850 patients with severe sepsis treated with intravenous drotrecogin alfa (activated) 24 microg/kg/h for 96 hours had a significantly greater reduction in...

journal_title：Drugs

authors： Lyseng-Williamson KA,Perry CM

更新日期：2002-01-01 00:00:00

abstract：:In a double-blind study, 40 patients scheduled for saphenectomy or inguinal hernioplasty were randomly assigned to treatment with nimesulide (200mg 3 times daily) or diclofenac (100mg 3 times daily) administered rectally. Therapy with either drug resulted in significantly less pain, oedema and hyperaemia, and resoluti...

journal_title：Drugs

authors： Ramella G,Costagli V,Vetere M,Capra C,Casella G,Sogni A,Scaricabarozzi I

更新日期：1993-01-01 00:00:00

abstract：:Hypertension is a major risk factor for coronary heart disease (CHD) and is the primary risk factor for stroke. Drug trials lowering blood pressure by pharmacological means have demonstrated impressive reduction in both fatal and nonfatal stroke (33 to 50%) that are virtually identical to the predicted stroke reductio...

journal_title：Drugs

authors： Grimm RH Jr,Flack JM,Byington R,Bond G,Brugger S

更新日期：1990-01-01 00:00:00

abstract：:Heparin remains the most effective antithrombotic drug. It acts by combining with plasma antithrombin, thereby accelerating the neurtalisation of thrombin and other acitvated coagulation factors. Full-dose intravenous heparin is indicated in all cases of pulmonary embolism and established deep venous thrombosis, unles...

journal_title：Drugs

authors： Deykin D

更新日期：1977-01-01 00:00:00

abstract：:Accumulating evidence suggests the involvement of estrogen in depression. Estrogen can modulate neurotransmitter turnover, enhancing the levels of serotonin and noradrenaline (norepinephrine), and it is involved in the regulation of serotonin receptor number and function. Across the female reproductive life, fluctuati...

journal_title：Drugs

authors： Ryan J,Ancelin ML

更新日期：2012-09-10 00:00:00

abstract：:Coronary artery disease and acute myocardial infarction still represent the leading cause of mortality in developed countries. Therefore, great efforts have been made in the last decades to improve reperfusion strategies and adjunctive antithrombotic therapies. In fact, despite optimal epicardial recanalisation, a lar...

journal_title：Drugs

authors： De Luca G,Savonitto S,van't Hof AW,Suryapranata H

更新日期：2015-07-01 00:00:00

abstract：:Mild to moderate hypertension still remains poorly controlled. This relates to multiple factors including low antihypertensive efficacy of single drug therapies reluctance of primary care physicians to modify/titrate initially chosen therapy to obtain target blood pressure, and poor compliance with medication. Several...

journal_title：Drugs

authors： Ruzicka M,Leenen FH

更新日期：2001-01-01 00:00:00

abstract：:The incidence of pulmonary embolism (PE) and venous thromboembolism (VTE) is higher in pregnant patients than in non-pregnant patients. The incidence of thrombosis in all pregnancies is reported to be between 0.05 and 1%, and an incidence as high as 3% may be present in women after caesarean section. Anticoagulant med...

journal_title：Drugs

authors： Laurent P,Dussarat GV,Bonal J,Jego C,Talard P,Bouchiat C,Cellarier G

更新日期：2002-01-01 00:00:00