Immunoreactive trypsin level in fetoscopically-obtained cord sera of second trimester fetuses.

Abstract:

:Immunoreactive trypsin (IRT) has been assayed in cord blood collection by fetoscopy from fetuses with estimated gestational ages of between 16-24 weeks. Eighty per cent of the specimens contained more than 5 ng/ml of IRT indicating pancreatic synthesis of trypsin by mid-term. A prenatal test for cystic fibrosis based on IRT estimation might be valid if the onset of pancreatic dysfunction associated with the disease also occurs at mid-trimester.

journal_name

Prenat Diagn

journal_title

Prenatal diagnosis

authors

Ryley HC,Rodeck CH

doi

10.1002/pd.1970040410

subject

Has Abstract

pub_date

1984-07-01 00:00:00

pages

303-6

issue

4

eissn

0197-3851

issn

1097-0223

journal_volume

4

pub_type

杂志文章
  • Unilateral congenital short femur: a case report.

    abstract::A case of congenital short femur in an otherwise healthy infant is described. Antenatal sonographic diagnosis was made at 26 weeks of gestation. The left femur was shorter than the right (ratio 0.82-0.85). In this case, the occurrence of congenital short femur was sporadic. The diagnosis was confirmed after delivery. ...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.1970100110

    authors: Ashkenazy M,Lurie S,Ben-Itzhak I,Appelman Z,Caspi B

    更新日期:1990-01-01 00:00:00

  • Normal and abnormal fetal cardiac anatomy.

    abstract::The heart is often perceived as a difficult organ to understand by ultrasound during fetal life. This is undoubtedly reflected in the low detection rate of cardiac abnormalities as compared to those of most other organ systems in the fetus. In this article we start by updating classical concepts of cardiac embryology,...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章,评审

    doi:10.1002/pd.1061

    authors: Cook AC,Yates RW,Anderson RH

    更新日期:2004-12-30 00:00:00

  • Prenatal detection of congenital heart disease in a low risk population undergoing first and second trimester screening.

    abstract:OBJECTIVES:The prenatal detection rate of congenital heart disease (CHD) is low compared with other fetal malformations. Our aim was to evaluate the prenatal detection of CHD in Eastern Denmark. METHODS:Fetuses and infants diagnosed with CHD in the period 01.01.2008-31.12.2010 were assessed regarding prenatal detectio...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.4525

    authors: Jørgensen DE,Vejlstrup N,Jørgensen C,Maroun LL,Steensberg J,Hessellund A,Jørgensen FS,Larsen T,Shalmi AC,Skibsted L,Zingenberg H,Ekelund C,Tabor A

    更新日期:2015-04-01 00:00:00

  • Chromosomal abnormalities associated with a single umbilical artery.

    abstract::A single umbilical artery was seen in 10 out of 117 cytogenetically abnormal pregnancies. The abnormal karyotypes found to be associated with a single umbilical artery were trisomy 18 (n = 5), monosomy X (n = 2), triploidy (n = 1), sex chromosome (47,XYY; n = 1) and translocation (46t(X,5)(q13p15);n = 1). With the exc...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.1970121118

    authors: Khong TY,George K

    更新日期:1992-11-01 00:00:00

  • Synchronization of amniotic fluid cells for high resolution cytogenetics.

    abstract::A high resolution technique was applied to amniotic fluid cells by synchronization. After inoculation, the cells were incubated for 30 h in the presence of either thymidine or 5-bromodeoxyuridine (BrdU). After removal of the blocking agent and addition of a low concentration of thymidine, the cells were incubated for ...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.1970090107

    authors: Qu J,Dallaire L,Lemieux N,Drouin R,Richer CL

    更新日期:1989-01-01 00:00:00

  • Psychological consequences of termination of pregnancy for fetal anomaly: similarities and differences between partners.

    abstract:OBJECTIVE:We examined the psychological responses to termination of pregnancy (TOP) for fetal anomaly from both men and women. The aim was to find risk factors for poor psychological outcome both for the individuals and for the couple. METHODS:A cross-sectional study was performed in 151 couples 2-7 years after TOP. W...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.1307

    authors: Korenromp MJ,Page-Christiaens GC,van den Bout J,Mulder EJ,Hunfeld JA,Bilardo CM,Offermans JP,Visser GH

    更新日期:2005-12-01 00:00:00

  • Changing trends in carrier screening for genetic disease in the United States.

    abstract::Genetic disease is the leading cause of infant death in the United States, accounting for approximately 20% of annual infant mortality. Advances in genomic medicine and technological platforms have made possible low cost, pan-ethnic expanded genetic screening that enables obstetric care providers to offer screening fo...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章,评审

    doi:10.1002/pd.4647

    authors: Nazareth SB,Lazarin GA,Goldberg JD

    更新日期:2015-10-01 00:00:00

  • First-trimester sonographic diagnosis of distal urethral atresia with megalourethra in VACTERL association.

    abstract::Congenital megalourethra is a rare disorder. We present an early case diagnosed in the first trimester. Prenatal ultrasound showed a megalourethra with a normal fetal bladder, hyperechogenic cystic right kidney and single umbilical artery. After termination of pregnancy, necropsy confirmed all sonographic findings and...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.328

    authors: Krapp M,Geipel A,Germer U,Krokowski M,Gembruch U

    更新日期:2002-05-01 00:00:00

  • Issues and concerns of couples presenting for preimplantation genetic diagnosis (PGD).

    abstract:BACKGROUND:The use of preimplantation genetic diagnosis (PGD) to select genetically 'normal' human embryos and to transfer them to the uterus of a woman has generated considerable controversy. Debate has occurred over the implications of PGD, sex selection, safety of embryonic manipulation and eugenics. This study eval...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.498

    authors: Katz MG,Fitzgerald L,Bankier A,Savulescu J,Cram DS

    更新日期:2002-12-01 00:00:00

  • Early prenatal diagnosis of Fanconi anaemia in a twin pregnancy, using DNA analysis.

    abstract::We present a case of prenatal diagnosis of Fanconi anaemia (FA) in a pair of twins at 14 weeks of gestation. The parents had previously had two children: a healthy boy and a boy with FA belonging to complementation group C (FAC). The FA patient is a compound heterozygote, carrying a 322delG and a IVS4+4A-->T mutation ...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0223(199604)16:4<345::AID-PD852

    authors: Kwee ML,Lo Ten Foe JR,Arwert F,Pals G,Madan K,Nieuwint A,In't Veld PA,Van der Horst AR,Van Vugt JM,Ten Kate LP

    更新日期:1996-04-01 00:00:00

  • Chorionic villus sampling and materno-fetal transfusions: an immunological pathogenesis of vascular disruptive syndromes?

    abstract::Experimental materno-embryonic transfusions with serum that is immunologically active against blood group antigens cause congenital malformations in the rat embryo. In view of the possible increased incidence of vascular disruptive syndromes after chorionic villus sampling (CVS), we investigated the occurrence of mate...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0223(199603)16:3<193::AID-PD827

    authors: Los FJ,Noomen P,Vermeij-Keers C,Gaillard JL,Brandenburg H,Jahoda MG,Luider TM

    更新日期:1996-03-01 00:00:00

  • Patient preferences for screening in the first trimester.

    abstract:OBJECTIVE:We theorized that a significant number of women would choose integrated screening (IS) over first trimester screening (FTS) and that demographic characteristics and baseline anxiety levels might predict which patients would choose each test. We also hypothesized that screening results might alter patients' fu...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.2158

    authors: Werner EF,Pastore LM,Karns LB,Ventura KA,Saller DN

    更新日期:2008-12-01 00:00:00

  • Prenatal diagnosis of autosomal dominant hereditary spastic paraplegia (SPG4) using direct mutation detection.

    abstract:OBJECTIVE:To present a report on prenatal diagnosis using direct SPG4 gene analysis in a family with autosomal dominant hereditary spastic paraplegia (AD-HSP). METHODS:Genetic linkage and haplotype analysis were previously carried out with chromosome 2p markers. DNA was obtained from affected individuals, the affected...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.875

    authors: Nielsen JE,Koefoed P,Kjaergaard S,Jensen LN,Nørremølle A,Hasholt L

    更新日期:2004-05-01 00:00:00

  • Increased fetal nuchal fold leading to prenatal diagnosis of ring chromosome 15.

    abstract::We report on the prenatal diagnosis of ring chromosome 15 in a fetus with increased nuchal fold and intrauterine growth restriction (IUGR). A 27-year-old woman gravida 2, para 1 had normal maternal serum screen tests in the early second trimester of the index pregnancy. Fetal nuchal fold thickening up to 8 mm was inci...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.168

    authors: Liu YH,Chang SD,Chen FP

    更新日期:2001-12-01 00:00:00

  • Second-trimester uterine artery Doppler, PlGF, sFlt-1, sEndoglin, and lipid-related markers for predicting preeclampsia in a high-risk population.

    abstract:OBJECTIVE:This study aimed to determine if screening for preeclampsia could be improved between 20 and 24 weeks of gestation by uterine artery Doppler (UAD), biomarkers and lipid-related markers. METHOD:Women at high risk of preeclampsia according to obstetric and medical characteristics and history were prospectively...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.4198

    authors: Diguisto C,Le Gouge A,Piver E,Giraudeau B,Perrotin F

    更新日期:2013-11-01 00:00:00

  • First-trimester combined screening for Down syndrome: prediction of low birth weight, small for gestational age and pre-term delivery in a cohort of non-selected women.

    abstract:OBJECTIVE:To establish the relationship between the first-trimester screening markers [pregnancy-associated plasma protein A (PAPP-A), free human chorionic gonadotrophin-beta (beta-hCG), nuchal translucency (NT)], the Down syndrome (DS) risk estimate, and the adverse outcomes such as low birth weight, small for gestati...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.1946

    authors: Pihl K,Sørensen TL,Nørgaard-Pedersen B,Larsen SO,Nguyen TH,Krebs L,Larsen T,Christiansen M

    更新日期:2008-03-01 00:00:00

  • Complex cardiac defect with hypoplastic right ventricle in a fetus with valproate exposure.

    abstract::We describe a fetus with a hypoplastic right ventricle detected by prenatal ultrasound examination. A possible causal relationship with prenatal valproate exposure is discussed. ...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.1098

    authors: ten Berg K,van Oppen AC,Nikkels PG,Gittenberger-de Groot AC,van der Voet GB,Brilstra EH,Lindhout D

    更新日期:2005-02-01 00:00:00

  • HLA-G positive trophoblastic cells in transcervical samples and their isolation and analysis by laser microdissection and QF-PCR.

    abstract:OBJECTIVE:To assess the frequency of cytotrophoblastic cells in endocervical samples collected by lavage at early stages of gestation using a specific anti-HLA-G McAb (G233). From a set of four selected samples, cells identified by immunostaining were collected by laser microdissection and then tested by quantitative f...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.511

    authors: Bulmer JN,Cioni R,Bussani C,Cirigliano V,Sole F,Costa C,Garcia P,Adinolfi M

    更新日期:2003-01-01 00:00:00

  • Detection of fetal structural abnormalities at the 11-14 week ultrasound scan.

    abstract::The aim of this study was to evaluate the detection of fetal structural abnormalities by the 11-14 week scan. 2853 pregnant women were submitted to a routine ultrasound scan between the 11th and 14th week and the fetal skull, brain, spine, abdominal wall, limbs, stomach and bladder were examined. Following the scans t...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.200

    authors: Carvalho MH,Brizot ML,Lopes LM,Chiba CH,Miyadahira S,Zugaib M

    更新日期:2002-01-01 00:00:00

  • Outcomes following the detection of fetal edema in early pregnancy prior to non-invasive prenatal testing.

    abstract:OBJECTIVE:To investigate the incidence of structural and chromosomal abnormalities in cases of fetal edema on early ultrasound prior to non-invasive prenatal testing (NIPT). METHODS:A retrospective study of women undergoing pre-NIPT ultrasound with fetal crown-rump length (CRL) of 28 to 44 mm was conducted at a tertia...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.5847

    authors: Ramkrishna J,Menezes M,Humnabadkar K,Tse C,Maxfield MJ,da Silva Costa F,Rolnik DL,Meagher S

    更新日期:2020-10-17 00:00:00

  • The risk of adverse pregnancy outcome among pregnancies with extremely low maternal PAPP-A.

    abstract:OBJECTIVE:The aim of the study was to analyze the risk of adverse pregnancy outcome in three subgroups with extremely low maternal pregnancy-associated plasma protein-A (PAPP-A), that is, <0.3 multiples of median (MoM) at the first trimester screening. METHOD:A cohort of 961 pregnancies with PAPP-A levels < 0.3 MoM at...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.4946

    authors: Kaijomaa M,Ulander VM,Hämäläinen E,Alfthan H,Markkanen H,Heinonen S,Stefanovic V

    更新日期:2016-12-01 00:00:00

  • Evaluation of long-term neurodevelopment in twin-twin transfusion syndrome after laser therapy.

    abstract:OBJECTIVE:The primary objective of our study was to evaluate the long-term neurodevelopment outcome after laser surgery for twin-twin transfusion syndrome (TTTS). The secondary objective was to identify perinatal prognostic factors associated with neurodevelopmental impairment. METHOD:This was a single-center cohort p...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.4950

    authors: Sananès N,Gabriele V,Weingertner AS,Ruano R,Sanz-Cortes M,Gaudineau A,Langer B,Nisand I,Akladios CY,Favre R

    更新日期:2016-12-01 00:00:00

  • Results of 12 years' combined maternal serum alpha-fetoprotein screening and ultrasound fetal monitoring for prenatal detection of fetal malformations in Havana City, Cuba.

    abstract::Progressively since 1982 and as part of a nationwide programme for the diagnosis and prevention of genetic diseases, maternal serum alpha-fetoprotein (MS-AFP) screening and ultrasound fetal monitoring has been implemented in all pregnant women in Cuba. In Havana City, 328,983 pregnant women underwent MS-AFP screening ...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0223(199704)17:4<301::aid-pd969

    authors: Rodríguez L,Sánchez R,Hernández J,Carrillo L,Oliva J,Heredero L

    更新日期:1997-04-01 00:00:00

  • Second-trimester prenatal screening for trisomy 21 using biochemical markers: a 7-year experience in one cytogenetic laboratory.

    abstract:BACKGROUND:Screening for trisomy 21 in the second trimester of pregnancy using biochemical markers is an established part of prenatal care in many developed countries. OBJECTIVE:The present study was aimed at determining the incidence of trisomy 21 and other chromosomal abnormalities in women undergoing prenatal chrom...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.1398

    authors: Marical H,Douet-Guilbert N,Bages K,Collet M,Le Bris MJ,Morel F,De Braekeleer M

    更新日期:2006-04-01 00:00:00

  • Differential patterns of prenatal ipsilateral and contralateral lung growth in cases of isolated left-sided congenital diaphragmatic hernia.

    abstract:OBJECTIVE:The aim of this research was to compare the impact of varying degrees of visceral herniation on the growth rates of the contralateral and ipsilateral fetal lungs in cases of isolated left-sided congenital diaphragmatic hernia (CDH). METHODS:Data were retrieved from 58 fetuses with isolated left-sided CDH und...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.4605

    authors: Phithakwatchara N,Coleman A,Peiro JL,Lee AE,Keswani SG,Kline-Fath B,Lim FY,Shaaban AF

    更新日期:2015-08-01 00:00:00

  • Measurement of nuchal translucency for prenatal screening of congenital heart defects: a population-based evaluation.

    abstract:OBJECTIVES:(1) Assess sensitivity of the measurement of nuchal translucency (NT), for the prenatal screening of congenital heart defect (CHD) on population-based data; (2) examine whether the sensitivity of NT varies for specific types of cardiac defects. METHODS:Using population-based data of the Paris Registry of Co...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.2883

    authors: Jouannic JM,Thieulin AC,Bonnet D,Houyel L,Lelong N,Goffinet F,Khoshnood B

    更新日期:2011-12-01 00:00:00

  • Development and targeted application of a rapid QF-PCR test for sex chromosome imbalance.

    abstract:OBJECTIVES:A QF-PCR test has been developed to diagnose sex chromosome imbalances in prenatal samples and has been applied to a diagnostic service. METHODS:The test uses a PCR multiplex with eight primer pairs: six X-chromosome polymorphic markers, including two markers from Xp (a region not included in previously pub...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.569

    authors: Donaghue C,Roberts A,Mann K,Ogilvie CM

    更新日期:2003-03-01 00:00:00

  • Fetal aqueductal stenosis: Prenatal diagnosis and intervention.

    abstract::Fetal severe central nervous system ventriculomegaly is associated with poor neurologic outcomes, usually driven by a primary malformation, deformation, or disruption of brain parenchyma. In utero shunting of excess cerebrospinal fluid (CSF) in hopes of improving neurologic outcomes was attempted in the 1980s but was ...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章,评审

    doi:10.1002/pd.5527

    authors: Emery SP,Narayanan S,Greene S

    更新日期:2020-01-01 00:00:00

  • Therapy with intravenous immunoglobulin G (ivIgG) during pregnancy for fetal alloimmune (HPA-1a(Zwa)) thrombocytopenic purpura.

    abstract::We have evaluated the effect of maternal intravenous immunoglobulin G (ivIgG) treatment on platelet counts in fetal alloimmune thrombocytopenia. Seven patients were studied. All of them were multiparous women who had been immunized against the HPA-1a antigen during previous pregnancies and had given birth to at least ...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0223(199606)16:6<495::AID-PD899

    authors: Giers G,Hoch J,Bauer H,Bald R,Kiefel V,Kroll H,Hansmann M,Hanfland P,Mueller-Eckhardt C,Scharf RE

    更新日期:1996-06-01 00:00:00

  • Ethnic variation of fetal nasal bone length between 11-14 weeks' gestation.

    abstract:OBJECTIVE:We sought to compare the fetal nasal bone length (FNBL) between different ethnic groups at 11-14 weeks' gestation. METHODS:FNBL and the FNBL/CRL ratio were measured in patients undergoing first trimester ultrasound for nuchal translucency (NT) and the ethnicity of the patient was recorded under four categori...

    journal_title:Prenatal diagnosis

    pub_type: 杂志文章

    doi:10.1002/pd.1195

    authors: Collado F,Bombard A,Li V,Julliard K,Aptekar L,Weiner Z

    更新日期:2005-08-01 00:00:00