Analysis of a familial 15p + polymorphism: exclusion of Y/15 translocation.

Abstract:

:A large 15p + chromosome with a whole heterochromatic short arm has been studied by means of different banding techniques in six of nine individuals of a family; a possible Y/15 translocation has been excluded. Furthermore a heteromorphic pair 9 has been observed in seven family members, representing a "possible" small partial inversion 9q12;p11 or a centromeric variation. The transmission of these variant chromosomes as well as of some h + acrocentric chromosomes over three generations could be demonstrated. By means of AgI-staining large intercellular variation of Ag-NORs of the variant acrocentrics has been observed in the family members studied. The unusual accumulation of these variant chromosomes had no phenotypic effects.

journal_name

Clin Genet

journal_title

Clinical genetics

authors

Werner W,Herrmann FH

doi

10.1111/j.1399-0004.1984.tb04368.x

subject

Has Abstract

pub_date

1984-09-01 00:00:00

pages

204-8

issue

3

eissn

0009-9163

issn

1399-0004

journal_volume

26

pub_type

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