Vascular endothelial growth factors: biology and current status of clinical applications in cardiovascular medicine.

abstract：:Fibromuscular dysplasia (FMD) involving the coronary arteries is an uncommon but important condition that can present as acute coronary syndrome, left ventricular dysfunction, or potentially sudden cardiac death. Although the classic angiographic "string of beads" that may be observed in renal artery FMD does not occu...

journal_title：Journal of the American College of Cardiology

authors： Michelis KC,Olin JW,Kadian-Dodov D,d'Escamard V,Kovacic JC

更新日期：2014-09-09 00:00:00

abstract：OBJECTIVES:The purpose of this study was to assess trends in endothelial coverage and recovery among leading polymer-based drug-eluting stents (DES). BACKGROUND:Autopsy studies of human U.S. Food and Drug Administration (FDA)-approved DES implanted coronary arteries suggest that complications of late stent thrombosis ...

journal_title：Journal of the American College of Cardiology

authors： Joner M,Nakazawa G,Finn AV,Quee SC,Coleman L,Acampado E,Wilson PS,Skorija K,Cheng Q,Xu X,Gold HK,Kolodgie FD,Virmani R

更新日期：2008-07-29 00:00:00

abstract：BACKGROUND:In the ISAR-CABG (Is Drug-Eluting-Stenting Associated with Improved Results in Coronary Artery Bypass Grafts?) trial, clinical outcomes at 1 year in patients undergoing treatment of saphenous vein graft lesions were superior with drug-eluting stents (DES) versus bare-metal stents. OBJECTIVES:The authors com...

journal_title：Journal of the American College of Cardiology

authors： Colleran R,Kufner S,Mehilli J,Rosenbeiger C,Schüpke S,Hoppmann P,Joner M,Mankerious N,Fusaro M,Cassese S,Abdel-Wahab M,Neumann FJ,Richardt G,Ibrahim T,Schunkert H,Laugwitz KL,Kastrati A,Byrne RA,ISAR-CABG Investigator

更新日期：2018-05-08 00:00:00

abstract：OBJECTIVES:The present study evaluates the impact of total cholesterol (TC) and its subfractions on coronary flow reserve (CFR), an index of the integrated function of the coronary circulation, in asymptomatic subjects. BACKGROUND:Endothelial dysfunction of the coronary microcirculation has been reported in asymptomat...

journal_title：Journal of the American College of Cardiology

authors： Kaufmann PA,Gnecchi-Ruscone T,Schäfers KP,Lüscher TF,Camici PG

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVES:The current study was designed to determine the effect of secular trend and referral bias on the natural history of idiopathic dilated cardiomyopathy. BACKGROUND:In a previous study of 104 patients with idiopathic dilated cardiomyopathy conducted in a referral population at the Mayo Clinic between 1960 and ...

journal_title：Journal of the American College of Cardiology

authors： Redfield MM,Gersh BJ,Bailey KR,Ballard DJ,Rodeheffer RJ

更新日期：1993-12-01 00:00:00

abstract：OBJECTIVES:The purpose of this research was to determine the levels of platelet, leukocyte, and endothelial activation and markers of cellular interactions in patients with venous thromboembolism (VTE). BACKGROUND:The details of interactions between endothelium, platelets, and leukocytes in VTE are not well understood...

journal_title：Journal of the American College of Cardiology

authors： Chirinos JA,Heresi GA,Velasquez H,Jy W,Jimenez JJ,Ahn E,Horstman LL,Soriano AO,Zambrano JP,Ahn YS

更新日期：2005-05-03 00:00:00

abstract：:The criteria proposed for the clinical diagnosis of Takayasu's disease (chronic inflammatory arteriopathy of unknown origin) were based on clinical and angiographic data from 108 Japanese patients: 96 with Takayasu's disease and 12 with another disease of the aorta. The criteria consist of one obligatory criterion (ag...

journal_title：Journal of the American College of Cardiology

authors： Ishikawa K

更新日期：1988-10-01 00:00:00

abstract：OBJECTIVES:This trial examined the relative clinical efficacy, angiographic outcomes, and safety of zotarolimus-eluting coronary stents (ZES) with a phosphorylcholine polymer versus sirolimus-eluting stents (SES). BACKGROUND:Whether a cobalt-based alloy stent coated with the novel antiproliferative agent, zotarolimus,...

journal_title：Journal of the American College of Cardiology

authors： Kandzari DE,Leon MB,Popma JJ,Fitzgerald PJ,O'Shaughnessy C,Ball MW,Turco M,Applegate RJ,Gurbel PA,Midei MG,Badre SS,Mauri L,Thompson KP,LeNarz LA,Kuntz RE,ENDEAVOR III Investigators.

更新日期：2006-12-19 00:00:00

abstract：OBJECTIVES:This study was undertaken to assess the hematologic, clinical, and biochemical response to intravenous iron in patients with chronic heart failure (CHF) and anemia. BACKGROUND:Anemia is common in patients with CHF and is associated with higher morbidity and mortality. The combination of erythropoietin (EPO)...

journal_title：Journal of the American College of Cardiology

authors： Bolger AP,Bartlett FR,Penston HS,O'Leary J,Pollock N,Kaprielian R,Chapman CM

更新日期：2006-09-19 00:00:00

abstract：OBJECTIVES:We designed a study to explore the effect of glycoprotein (GP) IIb/IIIa blockade on the atherosclerotic plaque and distal coronary vasculature. BACKGROUND:Platelet GP IIb/IIIa blockers have been proven to be beneficial in acute ischemic syndromes. This effect has also been attributed to the prevention of mi...

journal_title：Journal of the American College of Cardiology

authors： Marzilli M,Sambuceti G,Testa R,Fedele S

更新日期：2002-12-18 00:00:00

abstract：OBJECTIVES:In patients with atrial flutter (AFL) and postoperative right atrial incisional scars, we sought to assess if the use of additional ablative lesions that targeted all potential re-entrant circuits, regardless of the presenting type of flutter, would prevent long-term recurrence. BACKGROUND:Patients with AFL...

journal_title：Journal of the American College of Cardiology

authors： Verma A,Marrouche NF,Seshadri N,Schweikert RA,Bhargava M,Burkhardt JD,Kilicaslan F,Cummings J,Saliba W,Natale A

更新日期：2004-07-21 00:00:00

abstract：OBJECTIVES:This study was undertaken to test the hypothesis that lipoprotein(a) [Lp(a)] impairs endothelial function. BACKGROUND:Elevated Lp(a) plasma levels have been demonstrated to be associated with an increased risk of coronary heart disease. In atherosclerosis, endothelial dysfunction is known to be an early ind...

journal_title：Journal of the American College of Cardiology

authors： Schlaich MP,John S,Langenfeld MR,Lackner KJ,Schmitz G,Schmieder RE

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVES:This study evaluated technetium-99m (Tc-99m) teboroxime kinetics in postischemic and partially necrotic myocardium with complete and low flow reperfusion using an isolated perfused rat heart model. BACKGROUND:Technetium-99m teboroxime has been proposed for use in the early diagnosis of reperfusion after thr...

journal_title：Journal of the American College of Cardiology

authors： Beanlands RS,DeKemp RA,Harmsen E,Veinot JP,Hartman NG,Ruddy TD

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVES:A technique for terminating refractory ventricular fibrillation is described. BACKGROUND:Refractory ventricular fibrillation can occur in up to 0.1% of electrophysiologic studies. Animal studies have shown that rapid sequential shocks may reduce ventricular fibrillation threshold. METHODS:Five patients of ...

journal_title：Journal of the American College of Cardiology

authors： Hoch DH,Batsford WP,Greenberg SM,McPherson CM,Rosenfeld LE,Marieb M,Levine JH

更新日期：1994-04-01 00:00:00

abstract：OBJECTIVES:We sought to assess whether high dose estrogen treatment is associated with enhanced arterial reactivity in genetic males. BACKGROUND:Although estrogens have been shown to enhance arterial reactivity in women, and are thereby thought to confer cardiovascular benefit, the vascular effects of long-term estrog...

journal_title：Journal of the American College of Cardiology

authors： McCrohon JA,Walters WA,Robinson JT,McCredie RJ,Turner L,Adams MR,Handelsman DJ,Celermajer DS

更新日期：1997-06-01 00:00:00

abstract：:It has long been observed that heart failure (HF) is associated with measures of systemic inflammation. In recent years, there have been significant advancements in our understanding of how inflammation contributes to the pathogenesis and progression of HF. However, although numerous studies have validated the associa...

journal_title：Journal of the American College of Cardiology

authors： Murphy SP,Kakkar R,McCarthy CP,Januzzi JL Jr

更新日期：2020-03-24 00:00:00

abstract：OBJECTIVES:We sought to investigate the effect of cardiac medication on long-term mortality in patients with peripheral arterial disease (PAD). BACKGROUND:Peripheral arterial disease is associated with increased cardiovascular morbidity and mortality. Treatment guidelines recommend aggressive management of risk factor...

journal_title：Journal of the American College of Cardiology

authors： Feringa HH,van Waning VH,Bax JJ,Elhendy A,Boersma E,Schouten O,Galal W,Vidakovic RV,Tangelder MJ,Poldermans D

更新日期：2006-03-21 00:00:00

abstract：OBJECTIVES:We sought to study the prognostic utility of coronary artery calcium (CAC) in the elderly. BACKGROUND:The prognostic significance of CAC in the elderly is not well known. METHODS:All-cause mortality was assessed in 35,388 patients (3,570 were >or=70 years old at screening, and 50% were women) after a mean ...

journal_title：Journal of the American College of Cardiology

authors： Raggi P,Gongora MC,Gopal A,Callister TQ,Budoff M,Shaw LJ

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVES:We investigated whether statin therapy could be beneficial in patients with acute myocardial infarction (AMI) who have baseline low-density lipoprotein cholesterol (LDL-C) levels below 70 mg/dl. BACKGROUND:Intensive lipid-lowering therapy with a target LDL-C value <70 mg/dl is recommended in patients with v...

journal_title：Journal of the American College of Cardiology

authors： Lee KH,Jeong MH,Kim HM,Ahn Y,Kim JH,Chae SC,Kim YJ,Hur SH,Seong IW,Hong TJ,Choi DH,Cho MC,Kim CJ,Seung KB,Chung WS,Jang YS,Rha SW,Bae JH,Cho JG,Park SJ,KAMIR (Korea Acute Myocardial Infarction Registry) Investigat

更新日期：2011-10-11 00:00:00

abstract：OBJECTIVES:We proposed to examine the relation between angiographic morphologic characteristics and abrupt closure after coronary angioplasty and to develop an empirically based risk stratification system. BACKGROUND:Certain lesion morphologic characteristics are associated with higher rates of abrupt closure after co...

journal_title：Journal of the American College of Cardiology

authors： Tenaglia AN,Fortin DF,Califf RM,Frid DJ,Nelson CL,Gardner L,Miller M,Navetta FI,Smith JE,Tcheng JE

更新日期：1994-10-01 00:00:00

abstract：:Accurate quantification and timing of regional myocardial function allows early identification of dysfunction, and therefore becomes increasingly important for clinical risk assessment, patient management, and evaluation of therapeutic efficacy. For this purpose, the application of tissue Doppler echocardiography has ...

journal_title：Journal of the American College of Cardiology

authors： Götte MJ,Germans T,Rüssel IK,Zwanenburg JJ,Marcus JT,van Rossum AC,van Veldhuisen DJ

更新日期：2006-11-21 00:00:00

abstract：:Seventy-four patients with chronic stable mild angina, mild coronary artery disease (83% had one- or two-vessel disease) and normal left ventricular function were studied to measure the response of treadmill exercise performance and painful and silent ischemia in the ambulatory setting to randomly assigned treatment w...

journal_title：Journal of the American College of Cardiology

authors： Kawanishi DT,Reid CL,Morrison EC,Rahimtoola SH

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVES:This study sought to evaluate the relationship between brain natriuretic peptide (BNP), renal function, and the severity of congestive heart failure (CHF). BACKGROUND:Both BNP and renal function are prognostic predictors in CHF patients. METHODS:We measured the plasma BNP level in the aortic root and coron...

journal_title：Journal of the American College of Cardiology

authors： Tsutamoto T,Wada A,Sakai H,Ishikawa C,Tanaka T,Hayashi M,Fujii M,Yamamoto T,Dohke T,Ohnishi M,Takashima H,Kinoshita M,Horie M

更新日期：2006-02-07 00:00:00

abstract：BACKGROUND:Pulmonary vascular disease, pulmonary endothelial dysfunction, liver fibrosis, renal disease, and exercise intolerance are common in adults with Fontan physiology. Although the pathophysiologic mechanisms linking these phenomena have been studied, certain aspects are not well understood. OBJECTIVES:This stu...

journal_title：Journal of the American College of Cardiology

authors： Egbe AC,Miranda WR,Anderson JH,Borlaug BA

更新日期：2020-12-08 00:00:00

abstract：:In 26 consecutive cases with acquired immunodeficiency syndrome (AIDS) the main cardiac findings were Kaposi's sarcoma in 2 cases, microfocal myocardial abscess in 1, subendocardial infarct necrosis in 2, contraction band necrosis in 13, lymphocytic myocarditis in 9, intramyocardial lymphocytic infiltrates without myo...

journal_title：Journal of the American College of Cardiology

authors： Baroldi G,Corallo S,Moroni M,Repossini A,Mutinelli MR,Lazzarin A,Antonacci CM,Cristina S,Negri C

更新日期：1988-08-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to examine the effect of intracoronary radiation therapy (IRT) in diabetic patients with in-stent restenosis (ISR). BACKGROUND:Diabetic patients are at an increased risk for restenosis, repeat revascularization procedures and late mortality after percutaneous coronary intervent...

journal_title：Journal of the American College of Cardiology

authors： Gruberg L,Waksman R,Ajani AE,Kim HS,White RL,Pinnow EE,Satler LF,Pichard AD,Kent KM,Lindsay J Jr

更新日期：2002-06-19 00:00:00

abstract：OBJECTIVES:The goal of this study was to determine whether the World Trade Center (WTC) attack on September 11, 2001, had an effect on the occurrence of ventricular arrhythmias among patients with implantable cardioverter-defibrillators (ICDs) living in Florida. BACKGROUND:Increased frequencies of ICD therapies for ve...

journal_title：Journal of the American College of Cardiology

authors： Shedd OL,Sears SF Jr,Harvill JL,Arshad A,Conti JB,Steinberg JS,Curtis AB

更新日期：2004-09-15 00:00:00

abstract：OBJECTIVES:This prospective study examined types, frequency and time dependency of the electrophysiologic manifestation of the sinus node dysfunction after the Cox-maze III procedure--the technique of choice for the management of medically refractory atrial fibrillation-in patients with organic heart disease, chronic f...

journal_title：Journal of the American College of Cardiology

authors： Pasic M,Musci M,Siniawski H,Edelmann B,Tedoriya T,Hetzer R

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVES:We evaluated the potential vasodilator effects of transcutaneous low-frequency ultrasound (US) in human brachial arteries. BACKGROUND:Recent data show that transthoracic low-frequency US energy results in canine coronary artery vasodilation. METHODS:Brachial artery diameters were measured before and after ...

journal_title：Journal of the American College of Cardiology

authors： Iida K,Luo H,Hagisawa K,Akima T,Shah PK,Naqvi TZ,Siegel RJ

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVES:We sought to determine the effects of cardiac resynchronization therapy (CRT) in New York Heart Association (NYHA) functional class II heart failure (HF) and NYHA functional class I (American College of Cardiology/American Heart Association stage C) patients with previous HF symptoms. BACKGROUND:Cardiac res...

journal_title：Journal of the American College of Cardiology

authors： Linde C,Abraham WT,Gold MR,St John Sutton M,Ghio S,Daubert C,REVERSE (REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction) Study Group.

更新日期：2008-12-02 00:00:00