Effect of antineoplastic agents on gamma-interferon production in human peripheral blood mononuclear cells.

abstract：:The chemotherapeutic agent and vitamin A metabolite retinoic acid (RA) has been used to treat many tumor types. The effects of RA are mediated by a family of ligand-dependent transcription factors, the retinoic acid receptors (RAR) and the retinoid X receptors. Alterations in RAR expression have been implicated in tum...

journal_title：Cancer research

authors： Crowe DL

更新日期：1998-01-01 00:00:00

abstract：:Alkylating agents, such as temozolomide, are among the most effective cytotoxic agents used for malignant gliomas, but responses remain very poor. The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) plays an important role in cellular resistance to alkylating agents. IFN-beta can act as a drug sensiti...

journal_title：Cancer research

authors： Natsume A,Ishii D,Wakabayashi T,Tsuno T,Hatano H,Mizuno M,Yoshida J

更新日期：2005-09-01 00:00:00

abstract：:We compared L-phenylalanine mustard (L-PAM)-induced cytotoxicity and DNA cross-linking with and without a 42-h preincubation with the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO, 1 mM) in a human lymphoma cell line. The combination showed increased toxicity with a Do ratio of 1.6. L-PAM-induc...

journal_title：Cancer research

authors： Ducore JM,McNamara L

更新日期：1986-03-01 00:00:00

abstract：:The discovery of somatic mutations in EGFR and development of EGFR tyrosine kinase inhibitors (TKI) have revolutionized treatment for lung cancer. However, resistance to TKIs emerges in almost all patients and currently no effective treatment is available. Here, we show that β-catenin is essential for development of E...

journal_title：Cancer research

authors： Nakayama S,Sng N,Carretero J,Welner R,Hayashi Y,Yamamoto M,Tan AJ,Yamaguchi N,Yasuda H,Li D,Soejima K,Soo RA,Costa DB,Wong KK,Kobayashi SS

更新日期：2014-10-15 00:00:00

abstract：:Estrogen receptor (ER) agonists and antagonists elicit distinct responses in non-small cell lung cancer (NSCLC) cells. To determine how such responses are generated, the expression of ERalpha, ERbeta, and ER coregulators in human lung fibroblasts and human NSCLC cell lines was evaluated by immunoblot. Ligand-dependent...

journal_title：Cancer research

authors： Hershberger PA,Vasquez AC,Kanterewicz B,Land S,Siegfried JM,Nichols M

更新日期：2005-02-15 00:00:00

abstract：:In immunodeficient mice antitumor single-chain Fv (scFv) molecules penetrate tumors rapidly and have rapid serum clearance, leading to excellent tumor:normal organ ratios. However, the absolute quantity of scFv retained in the tumor is low due to rapid serum clearance and monovalent scFv binding. We previously demonst...

journal_title：Cancer research

authors： Nielsen UB,Adams GP,Weiner LM,Marks JD

更新日期：2000-11-15 00:00:00

abstract：:HER2/Neu/ERBB2 is a receptor tyrosine kinase overexpressed in approximately 20% of human breast tumors. Truncated or mutant isoforms that show increased oncogenicity compared with the wild-type receptor are found in many breast tumors. Here, we report that constitutively active ERBB2 sensitizes human breast epithelial...

journal_title：Cancer research

authors： Martín-Pérez R,Palacios C,Yerbes R,Cano-González A,Iglesias-Serret D,Gil J,Reginato MJ,López-Rivas A

更新日期：2014-03-15 00:00:00

abstract：:Chromosomal rearrangements involving receptor tyrosine kinases (RTK) are a clinically relevant oncogenic mechanism in human cancers. These chimeric oncoproteins often contain the C-terminal kinase domain of the RTK joined in cis to various N-terminal, nonkinase fusion partners. The functional role of the N-terminal fu...

journal_title：Cancer research

authors： Neel DS,Allegakoen DV,Olivas V,Mayekar MK,Hemmati G,Chatterjee N,Blakely CM,McCoach CE,Rotow JK,Le A,Karachaliou N,Rosell R,Riess JW,Nichols R,Doebele RC,Bivona TG

更新日期：2019-02-01 00:00:00

abstract：:The present study with N-methyl-N-nitrosourea and rat brain DNA was performed in order to study the distribution of alkylated products and the difference in the removal of these products from DNase I-sensitive and -resistant regions of DNA. Nuclei were isolated from N-[3H]methyl-N-nitrosourea-treated rats and incubate...

journal_title：Cancer research

authors： Cox R

更新日期：1979-07-01 00:00:00

abstract：:Hereditary ovarian cancers associated with germline mutations in either BRCA1 or BRCA2 were studied to determine whether somatic mutation of the P53 gene is required for BRCA-linked ovarian tumorigenesis and further, whether the spectrum of additional somatic molecular genetic alterations present in these tumors diffe...

journal_title：Cancer research

authors： Rhei E,Bogomolniy F,Federici MG,Maresco DL,Offit K,Robson ME,Saigo PE,Boyd J

更新日期：1998-08-01 00:00:00

abstract：:The comparative metabolism of the enantiomers of cyclo phosphamide and of the racemate has been studied in humans. Four patients were each given, sequentially, the racemate, the (+)-enantiomer, and its (-)-antipode. The plasma levels of parent drug and the urinary output (24 hr) of unchanged drug and of two enzymatica...

journal_title：Cancer research

authors： Jarman M,Milsted RA,Smyth JF,Kinas RW,Pankiewicz K,Stec WJ

更新日期：1979-07-01 00:00:00

abstract：:A recently developed non-ionic surfactant called Solutol HS 15 (poly-oxyethylene esters of 12-hydroxystearic acid), with low toxicity in vivo, was shown to reverse completely the multidrug resistance of KB 8-5 and KB 8-5-11 human epidermoid carcinoma cells in vitro but did not potentiate drug toxicity in drug-sensitiv...

journal_title：Cancer research

authors： Coon JS,Knudson W,Clodfelter K,Lu B,Weinstein RS

更新日期：1991-02-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) expression by human breast cancer has been shown to predict poor patient outcome, as has amplification of the c-erbB-2 proto-oncogene. We have developed a quantitative immunohistochemical method for measuring protein levels of both receptors and have applied this to a series of ...

journal_title：Cancer research

authors： Robertson KW,Reeves JR,Smith G,Keith WN,Ozanne BW,Cooke TG,Stanton PD

更新日期：1996-08-15 00:00:00

abstract：:The expression of genes involved in p53-mediated apoptosis was studied using cDNA microarray after treating isogenic cell lines with either ionizing radiation or doxorubicin. Most of the known p53 transcriptional activation target genes clustered in a functional category defined by early and p53-dependent induction, r...

journal_title：Cancer research

authors： Robles AI,Bemmels NA,Foraker AB,Harris CC

更新日期：2001-09-15 00:00:00

abstract：:The epidermal growth factor (EGF) receptor in two colon carcinoma lines and in one vulval carcinoma line tested contains carbohydrate determinants that are recognized by monoclonal antibodies to tumor-associated antigens. These antibodies are directed to sialylated Lea and to difucosylated structures of the Y type. Ce...

journal_title：Cancer research

authors： Basu A,Murthy U,Rodeck U,Herlyn M,Mattes L,Das M

更新日期：1987-05-15 00:00:00

abstract：:We demonstrate that a mouse-human chimeric anti-ganglioside GD2-interleukin (IL)-2 fusion protein (ch14.18-IL2) substantially amplifies tumor-protective immunity against murine melanoma induced by an autologous oral DNA vaccine containing the murine ubiquitin gene fused to murine melanoma peptide epitopes gp100(25-35)...

journal_title：Cancer research

authors： Niethammer AG,Xiang R,Ruehlmann JM,Lode HN,Dolman CS,Gillies SD,Reisfeld RA

更新日期：2001-08-15 00:00:00

abstract：:Skeletal muscle wasting is a devastating consequence of cancer that contributes to increased complications and poor survival, but is not well understood at the molecular level. Herein, we investigated the role of Myocilin (Myoc), a skeletal muscle hypertrophy-promoting protein that we showed is downregulated in multip...

journal_title：Cancer research

authors： Judge SM,Deyhle MR,Neyroud D,Nosacka RL,D'Lugos AC,Cameron ME,Vohra RS,Smuder AJ,Roberts BM,Callaway CS,Underwood PW,Chrzanowski SM,Batra A,Murphy ME,Heaven JD,Walter GA,Trevino JG,Judge AR

更新日期：2020-05-01 00:00:00

abstract：:In the last decade, large-scale genomic studies in patients with hematologic malignancies identified recurrent somatic alterations in epigenetic modifier genes. Among these, the de novo DNA methyltransferase DNMT3A has emerged as one of the most frequently mutated genes in adult myeloid as well as lymphoid malignancie...

journal_title：Cancer research

authors： Venugopal K,Feng Y,Shabashvili D,Guryanova OA

更新日期：2021-01-15 00:00:00

abstract：:HER-2/neu protooncogene amplification and protein expression were analyzed with slot blot and Western blot techniques, respectively, in more than 300 invasive primary breast tumors of all stages. Amplification (2- greater than 30 copies) was found in 17% of these tumors and high expression was seen in 19%. There was a...

journal_title：Cancer research

authors： Borg A,Tandon AK,Sigurdsson H,Clark GM,Fernö M,Fuqua SA,Killander D,McGuire WL

更新日期：1990-07-15 00:00:00

abstract：:Isozymes of carbamyl phosphate synthetase (CPS), CPS I, a mitochondrial enzyme found exclusively in liver and involved in urea synthesis, and of CPS II, a soluble cytoplasmic enzyme widely distributed in animal tissues, were assayed in rat liver and in a series of rat liver neoplasms ranging widely in growth rate and ...

journal_title：Cancer research

authors： Lawson D,Paik WK,Morris HP,Weinhouse S

更新日期：1975-01-01 00:00:00

abstract：:Shorter alleles of a polymorphic [CAG](n) repeat in exon 1 of the androgen receptor (AR) have been associated with increased risk of prostate cancer and decreased risk of breast cancer. We prospectively assessed the association between the [CAG](n) repeat polymorphism in the androgen receptor and breast cancer risk am...

journal_title：Cancer research

authors： Haiman CA,Brown M,Hankinson SE,Spiegelman D,Colditz GA,Willett WC,Kantoff PW,Hunter DJ

更新日期：2002-02-15 00:00:00

abstract：:The idea of using oncolytic viruses for the treatment of cancers was proposed a century ago. During the last two decades, viruses able to replicate specifically in cancer cells and to induce their lysis were identified and were genetically modified to improve their viro-oncolytic properties. More recently, a new appro...

journal_title：Cancer research

authors： Gillet L,Dewals B,Farnir F,de Leval L,Vanderplasschen A

更新日期：2005-10-15 00:00:00

abstract：:Isoprenoid inhibitors are being evaluated as agents for the treatment of cancer. Their antitumor activity is attributed to inhibition of post-translational modification of Ras, which is crucial for its translocation and attachment to the plasma membrane, and ultimate involvement in signal transduction. However, whethe...

journal_title：Cancer research

authors： Efuet ET,Keyomarsi K

更新日期：2006-01-15 00:00:00

abstract：:Orthotopic transplantation of human tumors in nude mice reproduces the pattern of local growth and distal dissemination. The aim of our study was to determine the pattern of genetic alterations in human carcinomas of the exocrine pancreas orthotopically implanted and perpetuated in nude mice. Eight of the sixteen orth...

journal_title：Cancer research

authors： Reyes G,Villanueva A,García C,Sancho FJ,Piulats J,Lluís F,Capellá G

更新日期：1996-12-15 00:00:00

abstract：:Although the cancer cell cytoskeleton is a clinically validated target, few new strategies have emerged for selectively targeting cell division by modulating the cytoskeletal structure, particularly ways that could avoid the cardiotoxic and neurotoxic effects of current agents such as taxanes. We address this gap by d...

journal_title：Cancer research

authors： Lash LL,Wallar BJ,Turner JD,Vroegop SM,Kilkuskie RE,Kitchen-Goosen SM,Xu HE,Alberts AS

更新日期：2013-11-15 00:00:00

abstract：:Rational in vivo application of monoclonal antibodies for diagnosis and therapy of cancer requires an understanding of both the global and microscopic pharmacology of macromolecular ligands. Here, we introduce a new mathematical model for antibody distribution into small, prevascular, densely packed nodules (represent...

journal_title：Cancer research

authors： van Osdol W,Fujimori K,Weinstein JN

更新日期：1991-09-15 00:00:00

abstract：:The recent identification of cancer stem cells (CSCs) in multiple human cancers provides a new inroad to understanding tumorigenesis at the cellular level. CSCs are defined by their characteristics of self-renewal, multipotentiality, and tumor initiation upon transplantation. By testing for these defining characterist...

journal_title：Cancer research

authors： Harris MA,Yang H,Low BE,Mukherjee J,Guha A,Bronson RT,Shultz LD,Israel MA,Yun K

更新日期：2008-12-15 00:00:00

abstract：:Antibody titer to Bacillus Calmette-Guérin (BCG) was determined by complement fixation in 111 normal volunteers and 83 melanoma patients. In 43 of these melanoma patients, sequential determination of antibody titer was made and correlated with clinical course. Low titers of antibody to BCG were found frequently in nor...

journal_title：Cancer research

authors： Wile AG,Sparks FC,Morton DL

更新日期：1977-07-01 00:00:00

abstract：:Integrins interact with extracellular matrix (ECM) and deliver intracellular signaling for cell proliferation, survival, and motility. During tumor metastasis, integrin-mediated cell adhesion to and migration on the ECM proteins are required for cancer cell survival and adaptation to the new microenvironment. Using st...

journal_title：Cancer research

authors： Chen Y,Lu B,Yang Q,Fearns C,Yates JR 3rd,Lee JD

更新日期：2009-04-15 00:00:00

abstract：:A vitamin E derivative, vitamin E succinate (VES; RRR-alpha-tocopheryl succinate), and a vitamin E analogue, 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid (alpha-TEA), induce human breast, prostate, colon, lung, cervical, and endometrial tumor cells in culture to undergo apoptosis but ...

journal_title：Cancer research

authors： Anderson K,Simmons-Menchaca M,Lawson KA,Atkinson J,Sanders BG,Kline K

更新日期：2004-06-15 00:00:00