Seizures due to maprotiline overdose.

Abstract:

:Maprotiline, a new tetracyclic antidepressant, has a pattern of toxicity that is different from that of tricyclics. Maprotiline overdosage appears more likely to cause seizures but less likely to cause the peripheral autonomic and cardiac manifestations seen with tricyclics. Two cases of maprotiline overdose resulting in seizures without significant anticholinergic or cardiotoxic effects are presented. Both patients were treated acutely with gastric emptying and were observed to have no further seizures during subsequent drug-free hospital and outpatient follow up. Physostigmine salicylate has been used as an antidote for the anticholinergic syndrome of tricyclic overdose, but probably offers less in maprotiline overdose. Careful observation for seizures appears to be warranted.

journal_name

Ann Emerg Med

authors

Northup L,Reed G,McAnalley B,Anderson RJ

doi

10.1016/s0196-0644(84)80016-5

subject

Has Abstract

pub_date

1984-06-01 00:00:00

pages

468-70

issue

6

eissn

0196-0644

issn

1097-6760

pii

S0196-0644(84)80016-5

journal_volume

13

pub_type

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