Electromagnetic breast imaging: results of a pilot study in women with abnormal mammograms.

Abstract:

PURPOSE:To prospectively assess quantitatively the inherent contrast of electromagnetic (EM) properties that can be imaged by using available technology in women with abnormal findings at conventional breast imaging who underwent subsequent biopsy. MATERIALS AND METHODS:The protocol was HIPAA compliant and approved by the institutional review board. All participants provided informed consent. Fifty-three women with normal (Breast Imaging Reporting and Data System [BI-RADS] category 1) and ninety-seven women with abnormal (BI-RADS category 4 or 5) screening mammograms were imaged with three EM imaging methods: electrical impedance spectroscopy (EIS), microwave imaging spectroscopy (MIS), and near-infrared spectral tomography (NIR). A region-of-interest (ROI) analysis was used to assess the EM image properties for comparison of findings with conventional image findings and correlation with specific pathologic parameters for women with abnormal findings. Statistical analyses were conducted. RESULTS:One hundred fifty participants (age range, 35-81 years) were included. EM image property contrast ratios of 150%-200% were found in breast abnormality ROIs relative to the ipsilateral breast background. Analysis of variance demonstrated significant differences in ROI image summaries of mammographically normal versus abnormal breasts for EIS, across diagnostic groups for NIR, and for MIS (analysis restricted to lesions larger than 1 cm(3)). Receiver operating curve (ROC) analysis of the EM properties for cancers among subjects with BI-RADS category 4 or 5, compared with the EM properties for the subjects with normal breasts (BI-RADS category 1), yielded areas under the ROC curve ranging from 0.67 to 0.81. Pathologic correlations with mean vessel density, mean vessel area, and epithelium-to-stroma ratio suggest a biological origin of the EM image properties associated with disease. CONCLUSION:Results from EM breast examinations provide statistical evidence of a mean increase in image contrast of 150%-200% between abnormal (benign and malignant) and normal breast tissue.

journal_name

Radiology

journal_title

Radiology

authors

Poplack SP,Tosteson TD,Wells WA,Pogue BW,Meaney PM,Hartov A,Kogel CA,Soho SK,Gibson JJ,Paulsen KD

doi

10.1148/radiol.2432060286

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

350-9

issue

2

eissn

0033-8419

issn

1527-1315

pii

2432060286

journal_volume

243

pub_type

杂志文章
  • Liposomal doxorubicin increases radiofrequency ablation-induced tumor destruction by increasing cellular oxidative and nitrative stress and accelerating apoptotic pathways.

    abstract:PURPOSE:To determine if oxidative and nitrative stress and/or apoptosis contribute to increased coagulation when combining radiofrequency (RF) ablation with liposomal doxorubicin. MATERIALS AND METHODS:Animal care committee approval was obtained. R3230 mammary adenocarcinomas in Fischer rats were treated with either R...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.09091196

    authors: Solazzo SA,Ahmed M,Schor-Bardach R,Yang W,Girnun GD,Rahmanuddin S,Levchenko T,Signoretti S,Spitz DR,Torchilin V,Goldberg SN

    更新日期:2010-04-01 00:00:00

  • Capsular transgression of prostatic carcinoma: evaluation with transrectal US with pathologic correlation.

    abstract::One hundred twenty-five patients with biopsy proved clinical stage A or B prostatic carcinoma were evaluated with biplane transrectal ultrasonography (US) prior to radical prostatectomy. Sonograms were evaluated for capsular transgression of the tumor into the posterior and posterolateral aspects of the glands as mani...

    journal_title:Radiology

    pub_type: 临床试验,杂志文章

    doi:10.1148/radiology.178.3.1994420

    authors: Hamper UM,Sheth S,Walsh PC,Holtz PM,Epstein JI

    更新日期:1991-03-01 00:00:00

  • The brain in children: is contrast enhancement really needed after obtaining normal unenhanced CT results?

    abstract:PURPOSE:To retrospectively determine and compare the sensitivity and specificity of unenhanced and contrast material-enhanced computed tomography (CT) (reference standard) in the diagnosis of brain abnormalities and to evaluate any change in diagnosis that resulted from the contrast-enhanced study. MATERIALS AND METHO...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2443051785

    authors: Branson HM,Doria AS,Moineddin R,Shroff MM

    更新日期:2007-09-01 00:00:00

  • MR imaging with surface coils.

    abstract::The use of specialized coils to improve signal-to-noise ratios in magnetic resonance (MR) imaging is an important innovation. The role of surface coils has not yet been well defined, but it seems likely that they will be routinely used for clinical imaging of the orbit, neck, and spine. Surface coils have important li...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.157.2.4048470

    authors: Ehman RL

    更新日期:1985-11-01 00:00:00

  • In vivo functional and anatomic imaging for assessment of in vivo gene transfer.

    abstract:PURPOSE:To assess whether a combination of in vivo anatomic and functional imaging can help quantify expression of somatostatin receptor type 2 (SSTR2)-based reporters after in vivo gene transfer. MATERIALS AND METHODS:All animal experiments were approved by an institutional animal care and use committee. Six nude mic...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2531081825

    authors: Singh SP,Yang D,Ravoori M,Han L,Kundra V

    更新日期:2009-09-01 00:00:00

  • Myocardial bridging: depiction rate and morphology at CT coronary angiography--comparison with conventional coronary angiography.

    abstract:PURPOSE:To prospectively assess the depiction rate and morphologic features of myocardial bridging (MB) of coronary arteries with 64-section computed tomographic (CT) coronary angiography in comparison to conventional coronary angiography. MATERIALS AND METHODS:Patients were simultaneously enrolled in a prospective st...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2463062071

    authors: Leschka S,Koepfli P,Husmann L,Plass A,Vachenauer R,Gaemperli O,Schepis T,Genoni M,Marincek B,Eberli FR,Kaufmann PA,Alkadhi H

    更新日期:2008-03-01 00:00:00

  • Immunoglobulin G4-related periaortitis and periarteritis: CT findings in 17 patients.

    abstract:PURPOSE:To retrospectively evaluate computed tomographic (CT) findings of immunoglobulin G4 (IgG4)-related disease involving the vascular system. MATERIALS AND METHODS:This study was approved by the institutional review board, and all patients included had consented to the use of their medical records for the purpose ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.11102250

    authors: Inoue D,Zen Y,Abo H,Gabata T,Demachi H,Yoshikawa J,Miyayama S,Nakanuma Y,Matsui O

    更新日期:2011-11-01 00:00:00

  • (99m)Tc sestamibi breast imaging for the examination of patients with dense and fatty breasts: multicenter study.

    abstract:PURPOSE:To evaluate the accuracy of scintimammography as an adjunct to physical examination and mammography in the detection of breast cancer in women with dense and fatty breasts. MATERIALS AND METHODS:A total of 558 women were prospectively enrolled from 42 centers in North America. Images were interpreted by reader...

    journal_title:Radiology

    pub_type: 杂志文章,多中心研究

    doi:10.1148/radiol.2221010237

    authors: Khalkhali I,Baum JK,Villanueva-Meyer J,Edell SL,Hanelin LG,Lugo CE,Taillefer R,Freeman LM,Neal CE,Scheff AM,Connolly JL,Schnitt SJ,Houlihan MJ,Sampalis JS,Haber SB

    更新日期:2002-01-01 00:00:00

  • Cranial bone marrow in children: assessment of normal development with MR imaging.

    abstract::Magnetic resonance images of cranial bone marrow in 238 patients (246 examinations) less than 25 years old were reviewed to establish normal age-related standards. Bone marrow in the clivus and calvaria had uniformly low signal intensity (grade 1) on T1-weighted images in most infants less than 1 year old. The number ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.171.1.2928520

    authors: Okada Y,Aoki S,Barkovich AJ,Nishimura K,Norman D,Kjos BO,Brasch RC

    更新日期:1989-04-01 00:00:00

  • Why women resist screening mammography: patient-related barriers.

    abstract::Mammography utilization remains below the level needed to achieve the National Cancer Institute's year-2000 goals for reducing breast cancer mortality by 50%. Previous research has identified both patient and physician barriers. The authors interviewed 600 randomly selected women who were offered a free mammographic e...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.172.1.2740510

    authors: Rimer BK,Keintz MK,Kessler HB,Engstrom PF,Rosan JR

    更新日期:1989-07-01 00:00:00

  • Craniosynostosis: diagnostic value of three-dimensional CT reconstruction.

    abstract::Three-dimensional computed tomography (CT) has an important role in determining the presence and extent of congenital and acquired craniofacial deformities. The authors compared the sensitivity and specificity of three-dimensional CT in the detection and characterization of craniosynostosis with that of planar CT and ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.173.3.2813770

    authors: Vannier MW,Hildebolt CF,Marsh JL,Pilgram TK,McAlister WH,Shackelford GD,Offutt CJ,Knapp RH

    更新日期:1989-12-01 00:00:00

  • Holistic component of image perception in mammogram interpretation: gaze-tracking study.

    abstract:PURPOSE:To test the hypothesis that rapid and accurate performance of the proficient observer in mammogram interpretation involves a shift in the mechanism of image perception from a relatively slow search-to-find mode to a relatively fast holistic mode. MATERIALS AND METHODS:This HIPAA-compliant study had institution...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2422051997

    authors: Kundel HL,Nodine CF,Conant EF,Weinstein SP

    更新日期:2007-02-01 00:00:00

  • Transhepatic portal venous embolization of varices: pros and cons.

    abstract::Transhepatic portal venous embolization does not reduce immediate or long-term mortality or the incidence of rebleeding in patients with acute hemorrhage from gastroesophageal varices. Since in addition the procedure is not without risk to the operator, who is exposed to a considerable amount of radiation, the author ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.148.2.6603000

    authors: Sos TA

    更新日期:1983-08-01 00:00:00

  • Neck-bridge device for endovascular treatment of wide-neck bifurcation aneurysms: initial experience.

    abstract:PURPOSE:To report the authors' initial experience in treating patients with wide-neck aneurysms with assistance from a recently developed neck-bridge device (TriSpan; Target Therapeutics/Boston Scientific, Fremont, Calif). MATERIALS AND METHODS:Twenty-five patients were examined. Aneurysms were most frequently at the ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2212010474

    authors: Raymond J,Guilbert F,Roy D

    更新日期:2001-11-01 00:00:00

  • Radiation therapy of microgliomas.

    abstract::Microglioma (reticulum-cell sarcoma) of the central nervous system is uncommon. The authors reviewed 12 biopsy-proved cases with clinical and radiographic evidence of involvement limited to the central nervous system which were seen between 1966 and 1980. The age range was 15-81 and there were 8 females and 4 males. N...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.149.2.6353480

    authors: Sagerman RH,Collier CH,King GA

    更新日期:1983-11-01 00:00:00

  • Prosthetic testicle: appearance at MR imaging.

    abstract::The appearance of testicular prostheses on magnetic resonance (MR) images was studied in six patients with seven silicone implants: two with a fluid consistency and five that were solid. On T1-weighted images, both types of prosthesis demonstrated homogeneous low signal intensity; on T2-weighted images, the fluid impl...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.173.2.2798890

    authors: Semelka R,Anderson M,Hricak H

    更新日期:1989-11-01 00:00:00

  • Inferior vena caval filter thrombi: evaluation with intravascular US.

    abstract::A 20-MHz intravascular ultrasound (US) transducer inside a percutaneously inserted catheter was used to evaluate inferior vena caval (IVC) filters for thrombi in vitro and in vivo. Six different IVC filters were studied with intravascular US in a saline-filled model. Each filter had a characteristic, recognizable US p...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.177.3.2243990

    authors: McCowan TC,Ferris EJ,Carver DK

    更新日期:1990-12-01 00:00:00

  • Melorheostosis with linear sclerodermatous skin changes.

    abstract::A case of melorheostosis with overlying linear skin changes is reported. The radiographic appearance is that of a linear hyperostosis which appears to flow along the cortex of the bone. This is believed to be the twelfth such case in the literature. ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/114.3.577

    authors: Soffa DJ,Sire DJ,Dodson JH

    更新日期:1975-03-01 00:00:00

  • Coronary MR angiography with steady-state free precession: individually adapted breath-hold technique versus free-breathing technique.

    abstract:PURPOSE:To compare image quality and coronary artery stenosis detection with breath-hold (BH) and free-breathing navigator-gated (NAV) coronary magnetic resonance (MR) angiography performed with the same imaging sequence (steady-state free precession) and identical spatial resolution in patients suspected of having cor...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2323031225

    authors: Jahnke C,Paetsch I,Schnackenburg B,Bornstedt A,Gebker R,Fleck E,Nagel E

    更新日期:2004-09-01 00:00:00

  • Postprandial splanchnic hemodynamic response in patients with cirrhosis of the liver: evaluation with "triple-vessel" duplex US.

    abstract:PURPOSE:To investigate the effect of a meal on splanchnic circulation in patients with cirrhosis of the liver. MATERIALS AND METHODS:Ten adult patients with cirrhosis and 10 adult control subjects (mean age, 54 years) underwent duplex ultrasonography. Flow volumes of the portal vein, superior mesenteric artery, spleni...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.201.3.8939220

    authors: Iwao T,Toyonaga A,Oho K,Sakai T,Tayama C,Masumoto H,Sato M,Nakahara K,Tanikawa K

    更新日期:1996-12-01 00:00:00

  • Evaluation of Low-Contrast Detectability of Iterative Reconstruction across Multiple Institutions, CT Scanner Manufacturers, and Radiation Exposure Levels.

    abstract:PURPOSE:To compare image resolution from iterative reconstruction with resolution from filtered back projection for low-contrast objects on phantom computed tomographic (CT) images across vendors and exposure levels. MATERIALS AND METHODS:Randomized repeat scans of an American College of Radiology CT accreditation pha...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2015141260

    authors: Saiprasad G,Filliben J,Peskin A,Siegel E,Chen J,Trimble C,Yang Z,Christianson O,Samei E,Krupinski E,Dima A

    更新日期:2015-10-01 00:00:00

  • Taste acuity, plasma zinc levels, and weight loss during radiotherapy: a study of relationships.

    abstract::Thirty-five patients who were to undergo radiotherapy and 13 normal subjects were evaluated with taste questionnaires, taste acuity tests, and plasma zinc analyses. The studies were repeated on the patients in the fifth week of radiotherapy. The mean taste thresholds for NaCl (salt), sucrose (sweet), HCl (sour), and u...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.144.1.7089250

    authors: Bolze MS,Fosmire GJ,Stryker JA,Chung CK,Flipse BG

    更新日期:1982-07-01 00:00:00

  • Evidence-based radiology: review and dissemination.

    abstract::Evidence-based radiology (EBR) is an important tool for the practice of radiology. The user of the EBR approach identifies evidence in a systematic fashion and then assimilates information through in-depth, explicit critical review of the best-designed and most recent literature on the subject in question. Clinical de...

    journal_title:Radiology

    pub_type: 杂志文章,评审

    doi:10.1148/radiol.2442051766

    authors: Medina LS,Blackmore CC

    更新日期:2007-08-01 00:00:00

  • Caudate lobe hepatocellular carcinoma treated with selective chemoembolization.

    abstract:PURPOSE:To analyze the clinical outcomes of chemoembolization for solitary caudate lobe hepatocellular carcinoma (HCC) found at initial presentation. MATERIALS AND METHODS:This retrospective study was approved by the institutional review board; the requirement for informed patient consent was waived. From July 1998 to...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.10100105

    authors: Kim HC,Chung JW,Jae HJ,Yoon JH,Lee JH,Kim YJ,Lee HS,Yoon CJ,Park JH

    更新日期:2010-10-01 00:00:00

  • The air-fluid level in cavitary pulmonary tuberculosis.

    abstract::Pulmonary tuberculosis has long been associated with the formation of cavities in the lung. Many reports in the literature indicate that the occurrence of air-fluid levels in tuberculosis is unusual. The authors present 18 cases of proved active cavitary tuberculosis where air-fluid levels occurred during the active p...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/127.2.315

    authors: Cohen JR,Amorosa JK,Smith PR

    更新日期:1978-05-01 00:00:00

  • Breast cancers: noninvasive method of preoperative localization with three-dimensional US and surface contour mapping.

    abstract::Formal ethical approval was granted by the local research ethics committee; all participants gave written consent. The purpose of the study was to prospectively evaluate the feasibility of a noninvasive method of breast tumor localization in 25 participants, based on the coregistration of three-dimensional (3D) ultras...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2452060906

    authors: Cash CJ,Coles CE,Treece GM,Purushotham AD,Britton P,Sinnatamby R,Gee AH,Prager RW

    更新日期:2007-11-01 00:00:00

  • Radiologic criteria of retropharyngeal lymph node metastasis in nasopharyngeal carcinoma treated with radiation therapy.

    abstract:PURPOSE:To determine the appropriate radiologic criteria of metastatic retropharyngeal lymph nodes (RLNs) in patients with nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS:After institutional review board approval and informed consent, 303 consecutive NPC patients treated with definitive radiation therapy were ex...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.10090289

    authors: Zhang GY,Liu LZ,Wei WH,Deng YM,Li YZ,Liu XW

    更新日期:2010-05-01 00:00:00

  • Alzheimer Disease and Mild Cognitive Impairment: Integrated Pulsed Arterial Spin-Labeling MRI and 18F-FDG PET.

    abstract::Purpose To compare PET/MR hypoperfusion and hypometabolism in patients with Alzheimer disease (AD) and mild cognitive impairment (MCI) compared with healthy control (HC) participants. Materials and Methods Maps of cerebral blood flow (CBF; pulsed arterial spin-labeling [ASL] MRI), glucose metabolism (fluorine 18 [18F]...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2018170575

    authors: Riederer I,Bohn KP,Preibisch C,Wiedemann E,Zimmer C,Alexopoulos P,Förster S

    更新日期:2018-07-01 00:00:00

  • Nuclear imaging, tomographic nuclear imaging, and gray scale ultrasound in the evaluation of the porta hepatis.

    abstract::Twenty-six patients with an eqivocal portal defect on conventional nuclear images were evaluated with a multiplane tomographic nuclear scanner and gray scale ultrasound. In most cases the correct determination (normal or abnormal) for an area of decreased uptake could be made from the multiplane tomographic scans. Whe...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/122.3.773

    authors: Sample WF,Gray RK,Poe ND,Graham LS,Bennett LR

    更新日期:1977-03-01 00:00:00

  • Imaging of carotid arteries in symptomatic patients: cost-effectiveness of diagnostic strategies.

    abstract:PURPOSE:To assess the cost-effectiveness of noninvasive imaging strategies in patients who have had a transient ischemic attack (TIA) or minor stroke and are suspected of having significant carotid artery stenosis. MATERIALS AND METHODS:From 1997 through 2000, 350 patients were included in a multicenter blinded consec...

    journal_title:Radiology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1148/radiol.2331030863

    authors: Buskens E,Nederkoorn PJ,Buijs-Van Der Woude T,Mali WP,Kappelle LJ,Eikelboom BC,Van Der Graaf Y,Hunink MG

    更新日期:2004-10-01 00:00:00