Abstract:
PURPOSE:To prospectively assess quantitatively the inherent contrast of electromagnetic (EM) properties that can be imaged by using available technology in women with abnormal findings at conventional breast imaging who underwent subsequent biopsy. MATERIALS AND METHODS:The protocol was HIPAA compliant and approved by the institutional review board. All participants provided informed consent. Fifty-three women with normal (Breast Imaging Reporting and Data System [BI-RADS] category 1) and ninety-seven women with abnormal (BI-RADS category 4 or 5) screening mammograms were imaged with three EM imaging methods: electrical impedance spectroscopy (EIS), microwave imaging spectroscopy (MIS), and near-infrared spectral tomography (NIR). A region-of-interest (ROI) analysis was used to assess the EM image properties for comparison of findings with conventional image findings and correlation with specific pathologic parameters for women with abnormal findings. Statistical analyses were conducted. RESULTS:One hundred fifty participants (age range, 35-81 years) were included. EM image property contrast ratios of 150%-200% were found in breast abnormality ROIs relative to the ipsilateral breast background. Analysis of variance demonstrated significant differences in ROI image summaries of mammographically normal versus abnormal breasts for EIS, across diagnostic groups for NIR, and for MIS (analysis restricted to lesions larger than 1 cm(3)). Receiver operating curve (ROC) analysis of the EM properties for cancers among subjects with BI-RADS category 4 or 5, compared with the EM properties for the subjects with normal breasts (BI-RADS category 1), yielded areas under the ROC curve ranging from 0.67 to 0.81. Pathologic correlations with mean vessel density, mean vessel area, and epithelium-to-stroma ratio suggest a biological origin of the EM image properties associated with disease. CONCLUSION:Results from EM breast examinations provide statistical evidence of a mean increase in image contrast of 150%-200% between abnormal (benign and malignant) and normal breast tissue.
journal_name
Radiologyjournal_title
Radiologyauthors
Poplack SP,Tosteson TD,Wells WA,Pogue BW,Meaney PM,Hartov A,Kogel CA,Soho SK,Gibson JJ,Paulsen KDdoi
10.1148/radiol.2432060286subject
Has Abstractpub_date
2007-05-01 00:00:00pages
350-9issue
2eissn
0033-8419issn
1527-1315pii
2432060286journal_volume
243pub_type
杂志文章相关文献
RADIOLOGY文献大全abstract:PURPOSE:To determine if oxidative and nitrative stress and/or apoptosis contribute to increased coagulation when combining radiofrequency (RF) ablation with liposomal doxorubicin. MATERIALS AND METHODS:Animal care committee approval was obtained. R3230 mammary adenocarcinomas in Fischer rats were treated with either R...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.09091196
更新日期:2010-04-01 00:00:00
abstract::One hundred twenty-five patients with biopsy proved clinical stage A or B prostatic carcinoma were evaluated with biplane transrectal ultrasonography (US) prior to radical prostatectomy. Sonograms were evaluated for capsular transgression of the tumor into the posterior and posterolateral aspects of the glands as mani...
journal_title:Radiology
pub_type: 临床试验,杂志文章
doi:10.1148/radiology.178.3.1994420
更新日期:1991-03-01 00:00:00
abstract:PURPOSE:To retrospectively determine and compare the sensitivity and specificity of unenhanced and contrast material-enhanced computed tomography (CT) (reference standard) in the diagnosis of brain abnormalities and to evaluate any change in diagnosis that resulted from the contrast-enhanced study. MATERIALS AND METHO...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2443051785
更新日期:2007-09-01 00:00:00
abstract::The use of specialized coils to improve signal-to-noise ratios in magnetic resonance (MR) imaging is an important innovation. The role of surface coils has not yet been well defined, but it seems likely that they will be routinely used for clinical imaging of the orbit, neck, and spine. Surface coils have important li...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.157.2.4048470
更新日期:1985-11-01 00:00:00
abstract:PURPOSE:To assess whether a combination of in vivo anatomic and functional imaging can help quantify expression of somatostatin receptor type 2 (SSTR2)-based reporters after in vivo gene transfer. MATERIALS AND METHODS:All animal experiments were approved by an institutional animal care and use committee. Six nude mic...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2531081825
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:To prospectively assess the depiction rate and morphologic features of myocardial bridging (MB) of coronary arteries with 64-section computed tomographic (CT) coronary angiography in comparison to conventional coronary angiography. MATERIALS AND METHODS:Patients were simultaneously enrolled in a prospective st...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2463062071
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:To retrospectively evaluate computed tomographic (CT) findings of immunoglobulin G4 (IgG4)-related disease involving the vascular system. MATERIALS AND METHODS:This study was approved by the institutional review board, and all patients included had consented to the use of their medical records for the purpose ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.11102250
更新日期:2011-11-01 00:00:00
abstract:PURPOSE:To evaluate the accuracy of scintimammography as an adjunct to physical examination and mammography in the detection of breast cancer in women with dense and fatty breasts. MATERIALS AND METHODS:A total of 558 women were prospectively enrolled from 42 centers in North America. Images were interpreted by reader...
journal_title:Radiology
pub_type: 杂志文章,多中心研究
doi:10.1148/radiol.2221010237
更新日期:2002-01-01 00:00:00
abstract::Magnetic resonance images of cranial bone marrow in 238 patients (246 examinations) less than 25 years old were reviewed to establish normal age-related standards. Bone marrow in the clivus and calvaria had uniformly low signal intensity (grade 1) on T1-weighted images in most infants less than 1 year old. The number ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.171.1.2928520
更新日期:1989-04-01 00:00:00
abstract::Mammography utilization remains below the level needed to achieve the National Cancer Institute's year-2000 goals for reducing breast cancer mortality by 50%. Previous research has identified both patient and physician barriers. The authors interviewed 600 randomly selected women who were offered a free mammographic e...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.172.1.2740510
更新日期:1989-07-01 00:00:00
abstract::Three-dimensional computed tomography (CT) has an important role in determining the presence and extent of congenital and acquired craniofacial deformities. The authors compared the sensitivity and specificity of three-dimensional CT in the detection and characterization of craniosynostosis with that of planar CT and ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.173.3.2813770
更新日期:1989-12-01 00:00:00
abstract:PURPOSE:To test the hypothesis that rapid and accurate performance of the proficient observer in mammogram interpretation involves a shift in the mechanism of image perception from a relatively slow search-to-find mode to a relatively fast holistic mode. MATERIALS AND METHODS:This HIPAA-compliant study had institution...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2422051997
更新日期:2007-02-01 00:00:00
abstract::Transhepatic portal venous embolization does not reduce immediate or long-term mortality or the incidence of rebleeding in patients with acute hemorrhage from gastroesophageal varices. Since in addition the procedure is not without risk to the operator, who is exposed to a considerable amount of radiation, the author ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.148.2.6603000
更新日期:1983-08-01 00:00:00
abstract:PURPOSE:To report the authors' initial experience in treating patients with wide-neck aneurysms with assistance from a recently developed neck-bridge device (TriSpan; Target Therapeutics/Boston Scientific, Fremont, Calif). MATERIALS AND METHODS:Twenty-five patients were examined. Aneurysms were most frequently at the ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2212010474
更新日期:2001-11-01 00:00:00
abstract::Microglioma (reticulum-cell sarcoma) of the central nervous system is uncommon. The authors reviewed 12 biopsy-proved cases with clinical and radiographic evidence of involvement limited to the central nervous system which were seen between 1966 and 1980. The age range was 15-81 and there were 8 females and 4 males. N...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.149.2.6353480
更新日期:1983-11-01 00:00:00
abstract::The appearance of testicular prostheses on magnetic resonance (MR) images was studied in six patients with seven silicone implants: two with a fluid consistency and five that were solid. On T1-weighted images, both types of prosthesis demonstrated homogeneous low signal intensity; on T2-weighted images, the fluid impl...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.173.2.2798890
更新日期:1989-11-01 00:00:00
abstract::A 20-MHz intravascular ultrasound (US) transducer inside a percutaneously inserted catheter was used to evaluate inferior vena caval (IVC) filters for thrombi in vitro and in vivo. Six different IVC filters were studied with intravascular US in a saline-filled model. Each filter had a characteristic, recognizable US p...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.177.3.2243990
更新日期:1990-12-01 00:00:00
abstract::A case of melorheostosis with overlying linear skin changes is reported. The radiographic appearance is that of a linear hyperostosis which appears to flow along the cortex of the bone. This is believed to be the twelfth such case in the literature. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/114.3.577
更新日期:1975-03-01 00:00:00
abstract:PURPOSE:To compare image quality and coronary artery stenosis detection with breath-hold (BH) and free-breathing navigator-gated (NAV) coronary magnetic resonance (MR) angiography performed with the same imaging sequence (steady-state free precession) and identical spatial resolution in patients suspected of having cor...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2323031225
更新日期:2004-09-01 00:00:00
abstract:PURPOSE:To investigate the effect of a meal on splanchnic circulation in patients with cirrhosis of the liver. MATERIALS AND METHODS:Ten adult patients with cirrhosis and 10 adult control subjects (mean age, 54 years) underwent duplex ultrasonography. Flow volumes of the portal vein, superior mesenteric artery, spleni...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.201.3.8939220
更新日期:1996-12-01 00:00:00
abstract:PURPOSE:To compare image resolution from iterative reconstruction with resolution from filtered back projection for low-contrast objects on phantom computed tomographic (CT) images across vendors and exposure levels. MATERIALS AND METHODS:Randomized repeat scans of an American College of Radiology CT accreditation pha...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2015141260
更新日期:2015-10-01 00:00:00
abstract::Thirty-five patients who were to undergo radiotherapy and 13 normal subjects were evaluated with taste questionnaires, taste acuity tests, and plasma zinc analyses. The studies were repeated on the patients in the fifth week of radiotherapy. The mean taste thresholds for NaCl (salt), sucrose (sweet), HCl (sour), and u...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.144.1.7089250
更新日期:1982-07-01 00:00:00
abstract::Evidence-based radiology (EBR) is an important tool for the practice of radiology. The user of the EBR approach identifies evidence in a systematic fashion and then assimilates information through in-depth, explicit critical review of the best-designed and most recent literature on the subject in question. Clinical de...
journal_title:Radiology
pub_type: 杂志文章,评审
doi:10.1148/radiol.2442051766
更新日期:2007-08-01 00:00:00
abstract:PURPOSE:To analyze the clinical outcomes of chemoembolization for solitary caudate lobe hepatocellular carcinoma (HCC) found at initial presentation. MATERIALS AND METHODS:This retrospective study was approved by the institutional review board; the requirement for informed patient consent was waived. From July 1998 to...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.10100105
更新日期:2010-10-01 00:00:00
abstract::Pulmonary tuberculosis has long been associated with the formation of cavities in the lung. Many reports in the literature indicate that the occurrence of air-fluid levels in tuberculosis is unusual. The authors present 18 cases of proved active cavitary tuberculosis where air-fluid levels occurred during the active p...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/127.2.315
更新日期:1978-05-01 00:00:00
abstract::Formal ethical approval was granted by the local research ethics committee; all participants gave written consent. The purpose of the study was to prospectively evaluate the feasibility of a noninvasive method of breast tumor localization in 25 participants, based on the coregistration of three-dimensional (3D) ultras...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2452060906
更新日期:2007-11-01 00:00:00
abstract:PURPOSE:To determine the appropriate radiologic criteria of metastatic retropharyngeal lymph nodes (RLNs) in patients with nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS:After institutional review board approval and informed consent, 303 consecutive NPC patients treated with definitive radiation therapy were ex...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.10090289
更新日期:2010-05-01 00:00:00
abstract::Purpose To compare PET/MR hypoperfusion and hypometabolism in patients with Alzheimer disease (AD) and mild cognitive impairment (MCI) compared with healthy control (HC) participants. Materials and Methods Maps of cerebral blood flow (CBF; pulsed arterial spin-labeling [ASL] MRI), glucose metabolism (fluorine 18 [18F]...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2018170575
更新日期:2018-07-01 00:00:00
abstract::Twenty-six patients with an eqivocal portal defect on conventional nuclear images were evaluated with a multiplane tomographic nuclear scanner and gray scale ultrasound. In most cases the correct determination (normal or abnormal) for an area of decreased uptake could be made from the multiplane tomographic scans. Whe...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/122.3.773
更新日期:1977-03-01 00:00:00
abstract:PURPOSE:To assess the cost-effectiveness of noninvasive imaging strategies in patients who have had a transient ischemic attack (TIA) or minor stroke and are suspected of having significant carotid artery stenosis. MATERIALS AND METHODS:From 1997 through 2000, 350 patients were included in a multicenter blinded consec...
journal_title:Radiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1148/radiol.2331030863
更新日期:2004-10-01 00:00:00