Tissue engineering: bridging the gap between replantation and composite tissue allografts.

Abstract:

:This article explores issues related to tissue engineering and composite tissue allografts that employ physiologic and anatomic autogenous replicates to restore tissue loss. Composite tissue allotransplantation has become a controversial option for reconstruction, most prominently for reconstruction involving the hand and, recently, the face. While the side-effect profile of systemic immunosuppression continues to improve, the long-term risks of immunosuppression leaves composite tissue allotransplantation a domain for cautious exploration. Meanwhile, tissue engineering could, conceivably, be the gap between replantation and composite tissue allografts. Whereas the perils of immunosuppression may limit the routine use of allografts, employing constructions made of the patient's own cells negates the need for any antirejection therapy.

journal_name

Clin Plast Surg

authors

Megee DM,Berry N,Russell RC,Neumeister MW

doi

10.1016/j.cps.2006.12.004

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

319-25, xi

issue

2

eissn

0094-1298

issn

1558-0504

pii

S0094-1298(06)00131-3

journal_volume

34

pub_type

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