Restoration and stimulation of the in vitro immune response of B cells to sheep erythrocytes by interleukins and muramyl dipeptide (MDP).

abstract：:The poly(ADP-ribose) polymerase inhibitor 3-aminobenzamide had dramatically different effects on X-ray-induced cytogenetic damage in human lymphocytes depending on the stage of the cell cycle in which cells were irradiated. 3-Aminobenzamide (0.08-3.00 mM) potentiated the frequency of chromosomal aberrations when lymph...

journal_title：Biochemical and biophysical research communications

authors： Wiencke JK,Morgan WF

更新日期：1987-02-27 00:00:00

abstract：:pNO40/PS1D, a novel nucleolar protein, has been characterized as a core protein of eukaryotic 60S ribosome and at least two splicing forms of pNO40 mRNAs with alternative starting sites have been identified. Through production of knockout (ko) mice with either exon 2 (△E2), exon 4 (△E4) or △E2+E4 targeted disruption w...

journal_title：Biochemical and biophysical research communications

authors： Lin YM,Wu CC,Chang YC,Wu CH,Ho HL,Hu JW,Chang RC,Wang CT,Ouyang P

更新日期：2016-01-22 00:00:00

abstract：:The recognition and removal of interstrand cross-links is perhaps the least understood of all repair pathways in eukaryotic cells. We have shown previously that uncoupling of cross-links occurs in mammalian cell extracts and have identified a number of factors that mediate this process. However, we have not observed c...

journal_title：Biochemical and biophysical research communications

authors： Lu X,Zhang N,Vasquez K,Barton M,Legerski R

更新日期：2005-10-14 00:00:00

abstract：:Specific receptors for murine TNF have been identified in homogenates of rodent brain. These receptors are saturable and bind TNF with sufficient affinity to ensure occupancy by cytokine elaborated during infection. 125I-mTNF was detected in four specific complexes of Mr 130,000, 90,000, 66,000 and 60,000 after affini...

journal_title：Biochemical and biophysical research communications

authors： Kinouchi K,Brown G,Pasternak G,Donner DB

更新日期：1991-12-31 00:00:00

abstract：:A type II DNA topoisomerase has been partially purified from calf thymus mitochondria by a combination of differential centrifugation and column chromatography. The mitochondrial enzyme was inhibited by amsacrine (m-AMSA) slightly at 0.5 microM, significantly at 5.0 microM, and completely at 50 microM. A similar profi...

journal_title：Biochemical and biophysical research communications

authors： Lin JH,Castora FJ

更新日期：1991-04-30 00:00:00

abstract：:Inactivated vaccines are widely used for prevention of viral disease. Both humoral and cellular immune responses have been shown to play important roles in the control and clearance of virus infections. CpG motif containing oligodeoxynucleotides (ODN) have recently gained considerable interest and been used as vaccine...

journal_title：Biochemical and biophysical research communications

authors： Liang H,Xiao X,Zhang X,Hu Q,Yang Y,Cen S,Deng X,Sheng W

更新日期：2019-04-02 00:00:00

abstract：:NDC1 is a transmembrane nucleoporin that is required for NPC assembly and nucleocytoplasmic transport. We show here that NDC1 directly interacts with the nucleoporin ALADIN, mutations of which are responsible for triple-A syndrome, and that this interaction is required for targeting of ALADIN to nuclear pore complexes...

journal_title：Biochemical and biophysical research communications

authors： Yamazumi Y,Kamiya A,Nishida A,Nishihara A,Iemura S,Natsume T,Akiyama T

更新日期：2009-11-06 00:00:00

abstract：:The effect of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one, a potent inhibitor of cholesterol synthesis with marked hypocholesterolemic activity, on the intestinal absorption of exogenous cholesterol has been studied in lymph-cannulated rats. Administration of the 15-ketosterol at a level of 0.05% in a rat chow diet for ...

journal_title：Biochemical and biophysical research communications

authors： Schroepfer GJ Jr,Christophe A,Needleman DH,Kisic A,Sherrill BC

更新日期：1987-08-14 00:00:00

abstract：:The mRNA for the novel aldehyde dehydrogenase 5 (ALDH5) gene was detected in HuH7 hepatoma cells. The cells also expressed cytosolic aldehyde dehydrogenase (ALDH1) mRNA, but no mitochondrial aldehyde dehydrogenase (ALDH2) mRNA. Extracts of the hepatoma cells contained an enzymatic activity with an isoelectric point si...

journal_title：Biochemical and biophysical research communications

authors： Stewart MJ,Malek K,Xiao Q,Dipple KM,Crabb DW

更新日期：1995-06-06 00:00:00

abstract：:Transforming growth factor beta 1 (TGF beta 1) has been reported to be secreted and to act within the somatic cells of the testis. We examined whether the TGF beta 1 expression is present at mRNA and protein levels in purified rat Sertoli cells (SC), purified pachytene spermatocytes (SPC), and early spermatids (SPT) c...

journal_title：Biochemical and biophysical research communications

authors： Avallet O,Gomez E,Vigier M,Jégou B,Saez JM

更新日期：1997-09-29 00:00:00

abstract：:alpha 2-Antiplasmin (AP) inhibits plasmin in a two-step reaction in which AP reversibly binds to lysine-binding sites of plasmin and, then, more slowly complexes covalently with the enzyme's active site. Here, we show that the C-terminal lysine residue of AP has a key role in binding of the inhibitor to plasmin. A syn...

journal_title：Biochemical and biophysical research communications

authors： Hortin GL,Gibson BL,Fok KF

更新日期：1988-09-15 00:00:00

abstract：:Pluripotent human embryonic stem cells (hESCs) have the distinguishing feature of innate capacity to allow indefinite self-renewal. This attribute continues until specific constraints or restrictions, such as DNA methylation, are imposed on the genome, usually accompanied by differentiation. With the aim of utilizing ...

journal_title：Biochemical and biophysical research communications

authors： Yeo S,Jeong S,Kim J,Han JS,Han YM,Kang YK

更新日期：2007-08-03 00:00:00

abstract：:The role of alcohol consumption and alcoholism as an addiction in regulating the chemistry of the brain and its physiology has gained a backlog of interest over the past few decades. Besides the notion that alcohol acts as a brain depressant, the molecular mechanisms and neuronal interactions are not well understood. ...

journal_title：Biochemical and biophysical research communications

authors： Haddad JJ

更新日期：2004-10-15 00:00:00

abstract：:By radiolabeling using NaIO4/[3H]KBH4, a new sialoglycoprotein with Mr of 19,000 was found in the secretion of rat seminal vesicle. It was shown to interact non-covalently with semen coagulum. It existed in three acidic forms with pI values of 4.1, 3.7 and 2.9 and possessed high contents of sialic acids and acidic ami...

journal_title：Biochemical and biophysical research communications

authors： Limpaseni T,Chulavatnatol M

更新日期：1986-04-29 00:00:00

abstract：:Whereas sitosterol and 24(28)-methylene cycloartanol were competitive inhibitors (with Ki = 26 microM and 14 microM, respectively), 24(R,S)-25-epiminolanosterol was found to be a potent non-competitive inhibitor (Ki = 3.0 nM) of the S-adenosyl-L-methionine-C-24 methyl transferase from sunflower embryos. Because the gr...

journal_title：Biochemical and biophysical research communications

authors： Nes WD,Janssen GG,Norton RA,Kalinowska M,Crumley FG,Tal B,Bergenstrahle A,Jonsson L

更新日期：1991-05-31 00:00:00

abstract：:Treatment of RGCs with insulin or C2 ceramide alone increased survival rate by 30%. Adding both insulin and C2 ceramide increased survival rate by 80%. Protein phosphatase 2A (PP2A) inhibitor okadaic acid (OA) eliminated the effect of C2 ceramide, but not that of insulin. Protein kinase inhibitor K252a decreased the e...

journal_title：Biochemical and biophysical research communications

authors： Ito M

更新日期：2003-02-07 00:00:00

abstract：:In the heart, insulin controls key functions such as metabolism, muscle contraction and cell death. However, all studies have been focused on insulin action during reperfusion. Here we explore the cardioprotective action of this hormone during ischemia. Rat hearts were perfused ex vivo with an ischemia/reperfusion Lan...

journal_title：Biochemical and biophysical research communications

authors： Díaz A,Humeres C,González V,Gómez MT,Montt N,Sanchez G,Chiong M,García L

更新日期：2015-11-13 00:00:00

abstract：:Lymphokine and hematopoietic growth factors control the differentiation and proliferation of diverse cell types by binding to specific cell-surface receptors. Strikingly, the recently elucidated sequences of the interleukin-6 and erythropoietin receptors, and the interleukin-2 receptor beta-chain (p75), display a sign...

journal_title：Biochemical and biophysical research communications

authors： Bazan JF

更新日期：1989-10-31 00:00:00

abstract：:The current utility of bioluminescence imaging is constrained by a low photon yield that limits temporal sensitivity. Here, we describe an imaging method that uses a chemiluminescent/fluorescent protein, ffLuc-cp156, which consists of a yellow variant of Aequorea GFP and firefly luciferase. We report an improvement in...

journal_title：Biochemical and biophysical research communications

authors： Hara-Miyauchi C,Tsuji O,Hanyu A,Okada S,Yasuda A,Fukano T,Akazawa C,Nakamura M,Imamura T,Matsuzaki Y,Okano HJ,Miyawaki A,Okano H

更新日期：2012-03-09 00:00:00

abstract：:Alveolar epithelial type I and type II cells (AEC I and II) are closely aligned in alveolar surface. There is much interest in the precise identification of AEC I and II in order to separate and evaluate functional and other properties of these two cells. This study aims to identify specific AEC I and AEC II cell mark...

journal_title：Biochemical and biophysical research communications

authors： Chen Z,Jin N,Narasaraju T,Chen J,McFarland LR,Scott M,Liu L

更新日期：2004-07-02 00:00:00

abstract：:Ras association domain family (RASSF) proteins are encoded by several tumor suppressor genes that are frequently silenced in human cancers. In this study, we investigated RASSF10 as a target of epigenetic inactivation and examined its functions as a tumor suppressor in gastric cancer. RASSF10 was silenced in six out o...

journal_title：Biochemical and biophysical research communications

authors： Wei Z,Chen X,Chen J,Wang W,Xu X,Cai Q

更新日期：2013-03-22 00:00:00

abstract：:Cardiac hypertrophy is a major predictor of heart failure and of morbidity and mortality in developed countries. Many hormones and growth factors induce cardiac hypertrophy via activation of members of the phospholipase C (PLC) family. The expression pattern of the PLCbeta isozyme subfamily was investigated in neonata...

journal_title：Biochemical and biophysical research communications

authors： Schnabel P,Mies F,Nohr T,Geisler M,Böhm M

更新日期：2000-08-18 00:00:00

abstract：:Autophagy is evolutionarily conservative in eukaryotic cells that engulf cellular long-lived proteins and organelles, and it degrades the contents through fusion with lysosomes, via which the cell acquires recycled building blocks for the synthesis of new molecules. In this study, we revealed that peiminine induces ce...

journal_title：Biochemical and biophysical research communications

authors： Lyu Q,Tou F,Su H,Wu X,Chen X,Zheng Z

更新日期：2015-06-19 00:00:00

abstract：:Mutant superoxide dismutase 1 (mSOD1) is often found as aggregates at the outer-membrane of mitochondria in motor neurons of various mouse models and familial amyotrophic lateral sclerosis (f-ALS) patients. It has been postulated that disruption of mitochondrial function by physical association of misfolded mSOD1 aggr...

journal_title：Biochemical and biophysical research communications

authors： Wei R,Bhattacharya A,Chintalaramulu N,Jernigan AL,Liu Y,Van Remmen H,Chaudhuri AR

更新日期：2012-01-27 00:00:00

abstract：:Salvianolic acid A (Sal A) is a polyphenol extracted from the root of the Salvia miltiorrhiza bunge. Hydrogen peroxide (H(2)O(2)) is a major reactive oxygen species (ROS), which has been implicated in stroke and other neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In this study, we ...

journal_title：Biochemical and biophysical research communications

authors： Zhang HA,Gao M,Zhang L,Zhao Y,Shi LL,Chen BN,Wang YH,Wang SB,Du GH

更新日期：2012-05-11 00:00:00

abstract：:VMA1 translational product undergoes excision of a 50-kDa intervening segment (VDE: VMA1-derived endonuclease) and religation of the flanking regions to create a 69-kDa catalytic subunit of vacuolar membrane H+-ATPase. VDEs conjugated with polypeptides at both N- and C-terminal ends were expressed in Escherichia coli ...

journal_title：Biochemical and biophysical research communications

authors： Kawasaki M,Makino S,Matsuzawa H,Satow Y,Ohya Y,Anraku Y

更新日期：1996-05-24 00:00:00

abstract：:We report high resolution images of RecA-double stranded (ds) DNA complexes obtained by atomic force microscopy (AFM). When a carbon nanotube (CNT) tip was used, AFM images visualized the 10-nm pitch of RecA-dsDNA complexes and RecA filaments as three-dimensional surface topography without reconstruction analysis. The...

journal_title：Biochemical and biophysical research communications

authors： Umemura K,Komatsu J,Uchihashi T,Choi N,Ikawa S,Nishinaka T,Shibata T,Nakayama Y,Katsura S,Mizuno A,Tokumoto H,Ishikawa M,Kuroda R

更新日期：2001-02-23 00:00:00

abstract：:The present study demonstrates that exposure of human thyroid slices to thyrotropin causes an increase in phospholipid metabolism as measured by an increased incorporation of myo-2-[3H]-inositol into phosphatidylinositol, the generation of InsP3 and formation of GInsP as well as metabolism of phosphatidylcholine and p...

journal_title：Biochemical and biophysical research communications

authors： Mosko P,Zarzycki W,Jaroszewicz L,Kinalska I

更新日期：1994-06-30 00:00:00

abstract：:Clostridium difficile toxin A (TcdA) is one of the main pathogenic factors released by C. difficile. Due to its potent cytotoxic and proinflammatory activities, we investigated the anti-tumor activity of TcdA. CT26 colorectal cancer cells were challenged with recombinant TcdA, and it was found that TcdA could induce a...

journal_title：Biochemical and biophysical research communications

authors： Tian Y,Huang T,Li G,Liu J,Wang X,Feng H,Wang J

更新日期：2012-05-25 00:00:00

abstract：:Embryo development proceeds under strict temporal control and an embryonic molecular clock (EC), evidenced by cyclic gene expression, is operating during somite formation and limb development, providing temporal information to precursor cells. In somite precursor cells, EC gene expression and periodicity depends on Re...

journal_title：Biochemical and biophysical research communications

authors： Sheeba CJ,Palmeirim I,Andrade RP

更新日期：2012-07-13 00:00:00