Abstract:
:The mechanism of the antiaggregating activity of flavonoids was studied in vitro. The activity of fifteen different compounds was tested on platelet aggregation and arachidonic acid metabolism. The effect of flavonoids on platelet adenosine 3',5'-cyclic monophosphate (cyclic AMP) levels under basal conditions, as well as after stimulation by prostacyclin (PGI2), was also measured. The glycons of flavonoids in general and the flavanone derivatives that we tested did not affect platelet function. On the other hand, flavone, chrysin , apigenin and phloretin inhibited platelet aggregation by depressing the cyclooxygenase pathway. In addition, flavone, chrysin and apigenin reduced the platelet cyclic AMP response to PGI2. This effect was probably mediated by an inhibition of adenylate cyclase. Myricetin and quercetin, however, increased the PGI2-stimulated rise of platelet cyclic AMP. Both of these flavonoids inhibited primarily lipoxygenase activity. Modification of platelet cyclic AMP metabolism through inhibition of phosphodiesterase activity was found to be the probable mechanism of their antiaggregating effect.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Landolfi R,Mower RL,Steiner Mdoi
10.1016/0006-2952(84)90423-4subject
Has Abstractpub_date
1984-05-01 00:00:00pages
1525-30issue
9eissn
0006-2952issn
1873-2968pii
0006-2952(84)90423-4journal_volume
33pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/0006-2952(87)90326-1
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更新日期:2006-11-30 00:00:00
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pub_type: 杂志文章
doi:10.1016/0006-2952(91)90620-k
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pub_type: 杂志文章,评审
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更新日期:2014-08-15 00:00:00
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pub_type: 杂志文章
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更新日期:1997-07-01 00:00:00
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journal_title:Biochemical pharmacology
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更新日期:2001-02-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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更新日期:2017-12-15 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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更新日期:1986-11-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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更新日期:2003-06-15 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/j.bcp.2005.07.031
更新日期:2005-11-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/j.bcp.2007.02.006
更新日期:2007-06-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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更新日期:1983-04-15 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/j.bcp.2014.09.007
更新日期:2014-12-01 00:00:00