Hyperviscosity caused by hyaluronic acid in serum in a case of Wilms' tumor.

Abstract:

:We describe the case of a three-year-old girl with Wilms' tumor, whose serum showed at least a fivefold increase in relative viscosity although concentrations of albumin and immunoglobulins were normal. An unusual electrophoretogram of serum protein prompted further investigation. The increased viscosity was caused by the presence of high concentrations of hyaluronic acid, a glycosaminoglycan normally not detectable in serum.

journal_name

Clin Chem

journal_title

Clinical chemistry

authors

Wu AH,Parker OS,Ford L

subject

Has Abstract

pub_date

1984-06-01 00:00:00

pages

914-6

issue

6

eissn

0009-9147

issn

1530-8561

journal_volume

30

pub_type

杂志文章
  • Effect of serum-clot contact time on clinical chemistry laboratory results.

    abstract::The effect of serum-clot contact time on laboratory results was studied by dividing each blood specimen into four blood collection tubes. The control sera were separated from the clot within 30 min of the collection. The other tubes were incubated at 32 degrees C, and the sera were separated at 3, 6, and 24 h. The ser...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Zhang DJ,Elswick RK,Miller WG,Bailey JL

    更新日期:1998-06-01 00:00:00

  • Immunological measurement of transferrin compared with chemical measurement of total iron-binding capacity.

    abstract::Because of uncertainty as to the molecular weight of transferrin, a previous comparison [Von der Heul et al., Clin. Chim. Acta 38, 347 (1972)] between transferrin content of serum and total iron-binding capacity cannot be definitive. We found a conversion factor for expressing the maximum amount of iron bound by 1 mg ...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Tsung SH,Rosenthal WA,Milewski KA

    更新日期:1975-07-01 00:00:00

  • Mass concentration and activity concentration of creatine kinase isoenzyme MB compared in serum after acute myocardial infarction.

    abstract::We compared three current methods (immunoinhibition, "Isomune-CK" immunoprecipitation, and the Tandem-E CKMB II immunoenzymometric assay) for determination of creatine kinase (CK; EC 2.7.3.2) isoenzyme MB in serum. Although results inter-correlated well, the immunoinhibition assay gave higher activity values. Atypical...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Delanghe JR,De Mol AM,De Buyzere ML,De Scheerder IK,Wieme RJ

    更新日期:1990-01-01 00:00:00

  • Role of nitric oxide in cardiovascular disease: focus on the endothelium.

    abstract::Nitric oxide is a soluble gas continuously synthesized by the endothelium. This substance has a wide range of biological properties that maintain vascular homeostasis, including modulation of vascular dilator tone, regulation of local cell growth, and protection of the vessel from injurious consequences of platelets a...

    journal_title:Clinical chemistry

    pub_type: 杂志文章,评审

    doi:

    authors: Cannon RO 3rd

    更新日期:1998-08-01 00:00:00

  • Description of a computer program to assess cancer antigen 15.3, carcinoembryonic antigen, and tissue polypeptide antigen information during monitoring of metastatic breast cancer.

    abstract::It is time-consuming to process and compare the clinical and marker information registered during monitoring of breast cancer patients. To facilitate the assessment, we developed a computer program for interpreting consecutive measurements. The intraindividual biological variation, the analytical precision profile, th...

    journal_title:Clinical chemistry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Sölétormos G,Schiøler V

    更新日期:2000-08-01 00:00:00

  • Identification of chromosomally integrated human herpesvirus 6 by droplet digital PCR.

    abstract:BACKGROUND:Human herpesvirus 6 (HHV-6) latently infects a majority of adults. In about 1% of the population HHV-6 exists in a chromosomally integrated form (ciHHV-6) that resides in every somatic and germ cell and can be transmitted through the germ line. Patients with ciHHV-6 have been misdiagnosed and unnecessarily t...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2013.217240

    authors: Sedlak RH,Cook L,Huang ML,Magaret A,Zerr DM,Boeckh M,Jerome KR

    更新日期:2014-05-01 00:00:00

  • Searching for new biomarkers of renal diseases through proteomics.

    abstract:BACKGROUND:Technological advances have resulted in a renaissance of proteomic studies directed at finding markers of disease progression, diagnosis, or responsiveness to therapy. Renal diseases are ideally suited for such research, given that urine is an easily accessible biofluid and its protein content is derived mai...

    journal_title:Clinical chemistry

    pub_type: 杂志文章,评审

    doi:10.1373/clinchem.2011.165969

    authors: Konvalinka A,Scholey JW,Diamandis EP

    更新日期:2012-02-01 00:00:00

  • Hyperamylasemia and ovarian carcinoma.

    abstract::We present a case of advanced ovarian carcinoma associated with high concentrations of serum and urine amylase. Biochemical analysis to elucidate the nature and origin of the hyperamylasemia identified seven amylase isoenzymes, of which five appeared to be distinct from normal salivary and pancreatic amylase. We discu...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Sandiford JA,Chiknas SG

    更新日期:1979-06-01 00:00:00

  • "Ultrasensitive" silver stains: their use exemplified in the study of normal human cerebrospinal fluid proteins separated by two-dimensional electrophoresis.

    abstract::We have developed a series of photochemical silver stains that are more than 100 times as sensitive as the Coomassie Blue stains. These stains facilitate the quantitative estimation of proteins in two-dimensional gel patterns. Recently, we discovered that by using light (photodevelopment) to catalyze the reduction of ...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Merril CR,Harrington MG

    更新日期:1984-12-01 00:00:00

  • Quality-control (QC) performance measures and the QC planning process.

    abstract::Numerous outcome measures can be used to characterize and compare the performance of alternative quality-control (QC) strategies. The performance measure traditionally used in the QC planning process is the probability of rejecting an analytical run when a critical out-of-control error condition exists. Another perfor...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Parvin CA

    更新日期:1997-04-01 00:00:00

  • A sensitive liquid-chromatographic method for determination of 3'-azido-3'-deoxythymidine (AZT) in plasma and urine.

    abstract::We describe a liquid-chromatographic assay for AZT in human plasma and urine. This assay involves the use of two internal standards, allowing reference of AZT peaks to the appropriate internal standard, the choice depending on the range of concentrations encountered. This method is isocratic, specific, sensitive enoug...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Hedaya MA,Sawchuk RJ

    更新日期:1988-08-01 00:00:00

  • Laboratory computing--process and information management supporting high-quality, cost-effective healthcare.

    abstract::One currently observes many healthcare institutions rushing to reengineer and install information systems with the expectation of achieving enhanced efficiency, competitiveness, and, it is hoped, higher patient satisfaction resulting from timely, high-quality care. Unfortunately, information system concepts, design, a...

    journal_title:Clinical chemistry

    pub_type: 杂志文章,评审

    doi:

    authors: Buffone GJ,Moreau DR

    更新日期:1995-09-01 00:00:00

  • Analysis of the physicochemical state of C-reactive protein in different preparations including 2 certified reference materials.

    abstract:BACKGROUND:Standardization of clinical measurements of C-reactive protein (CRP) is based on the availability of reference materials. The serum protein reference material ERM-DA470 was used as a calibrant for various commercially available immunoassays but has now been exhausted. The recently released ERM-DA470k/IFCC wa...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2010.147124

    authors: Rzychon M,Zegers I,Schimmel H

    更新日期:2010-09-01 00:00:00

  • Five creatine kinase isoenzymes in serum of a patient with severe heart disease.

    abstract::Abnormal creatine kinase (CK) isoenzyme patterns were observed in the serum of a 64-year-old woman with severe heart disease. Agarose electrophoresis revealed the presence of all the usual CK isoenzymes (MM, MB, and BB) plus an extra band between MM and MB. Total serum CK activity was within the normal range. Within 2...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Csako G,Papadopoulos NM,Jett GK,McIntosh CL

    更新日期:1982-10-01 00:00:00

  • Enzyme-linked immunosorbent assay for 17 alpha-hydroxyprogesterone in dried blood spotted on filter paper.

    abstract::In this rapid, cost-effective, enzyme-linked immunosorbent assay for 17 alpha-hydroxyprogesterone (17-OHP) eluted from dried blood spotted on filter paper, second antibody is coated onto the microwell plate and horseradish peroxidase (EC 1.11.1.7) is the label enzyme. Antiserum to 17-OHP was prepared by using 4-(2-car...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Maeda M,Arakawa H,Tsuji A,Yamagami Y,Isozaki A,Takahashi T,Haruki E

    更新日期:1987-06-01 00:00:00

  • Liquid-chromatographic measurement of taurine in cerebrospinal fluid of normal individuals and patients with meningitis.

    abstract::Taurine was measured in cerebrospinal fluid by reacting it with fluorescamine to form a fluorescent derivative, followed by separation on a reversed-phase column and fluorometric detection and evaluation. The assay is rapid (17 min) and sensitive to as little as 1 mumol/L. The mean value for 27 cerebrospinal fluid sam...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Shihabi ZK,White JP

    更新日期:1979-08-01 00:00:00

  • Turnover rate of skeletal alkaline phosphatase in humans.

    abstract::Two patients with Paget's disease of bone were subjected to plasmapheresis. Alkaline phosphatase activities of serum declined sharply, but returned to preplasmapheresis values within eight to 10 days. The biological half-life of circulating skeletal alkaline phosphatase, as calculated from these experiments, is betwee...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Posen S,Grunstein HS

    更新日期:1982-01-01 00:00:00

  • Quality assurance, accreditation, and certification: needs and possibilities.

    abstract::Demonstrable quality of laboratory services entails two parts. First, one needs a quality policy statement, identification of user needs, choice of measurement procedures, reference measurement system to provide traceability, control materials, and proficiency testing with materials having reference-measurement-assign...

    journal_title:Clinical chemistry

    pub_type: 杂志文章,评审

    doi:

    authors: Dybkaer R

    更新日期:1994-07-01 00:00:00

  • Diagnostic accuracy of pancreatic enzymes evaluated by use of multivariate data analysis.

    abstract::We analyzed pancreatic enzyme data from 508 patients with suspected pancreatitis by neural network analysis, by an Expert multirule generation protocol, and by receiver-operator characteristic (ROC) curve analysis of a single test result. Neural network analysis showed that use of lipase provided the best means for di...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Kazmierczak SC,Catrou PG,Van Lente F

    更新日期:1993-09-01 00:00:00

  • Screening with zinc protoporphyrin for iron deficiency in non-anemic female blood donors.

    abstract::Iron-depleted donors are at increased risk of developing anemia; if these donors could be identified by a screening test, iron supplementation or decreased donation frequency could be considered. Tests to determine serum ferritin, blood hemoglobin, and erythrocyte (Erc)-zinc protoporphyrin concentrations were examined...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Jensen BM,Sandø SH,Grandjean P,Wiggers P,Dalhøj J

    更新日期:1990-06-01 00:00:00

  • Multicenter harmonization of common enzyme results by fresh patient-pool sera.

    abstract::A region consisting of 19 clinical laboratories harmonized their calibration of seven common enzymes by using fresh patient-pool sera. One of the laboratories was chosen to act as Regional Reference Laboratory (RRL). This laboratory used internationally accepted (mostly IFCC) methods at 37 degrees C, with an intralabo...

    journal_title:Clinical chemistry

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Franck PF,Steen G,Lombarts AJ,Souverijn JH,van Wermeskerken RK

    更新日期:1998-03-01 00:00:00

  • Clinical and genetic correlates of growth differentiation factor 15 in the community.

    abstract:BACKGROUND:Growth differentiation factor 15 (GDF15), a stress-responsive cytokine produced in cardiovascular cells under conditions of inflammation and oxidative stress, is emerging as an important prognostic marker in individuals with and without existing cardiovascular disease (CVD). We therefore examined the clinica...

    journal_title:Clinical chemistry

    pub_type: 杂志文章,meta分析

    doi:10.1373/clinchem.2012.190322

    authors: Ho JE,Mahajan A,Chen MH,Larson MG,McCabe EL,Ghorbani A,Cheng S,Johnson AD,Lindgren CM,Kempf T,Lind L,Ingelsson E,Vasan RS,Januzzi J,Wollert KC,Morris AP,Wang TJ

    更新日期:2012-11-01 00:00:00

  • State-of-the-art of serum testosterone measurement by isotope dilution-liquid chromatography-tandem mass spectrometry.

    abstract:BACKGROUND:The recent interest of clinical laboratories in developing serum testosterone assays based on isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS) stems from the lack of accuracy of direct immunoassays. In this study, we assessed the accuracy and state of standardization (traceabilit...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2008.105841

    authors: Thienpont LM,Van Uytfanghe K,Blincko S,Ramsay CS,Xie H,Doss RC,Keevil BG,Owen LJ,Rockwood AL,Kushnir MM,Chun KY,Chandler DW,Field HP,Sluss PM

    更新日期:2008-08-01 00:00:00

  • Screening newborn blood spots for 22q11.2 deletion syndrome using multiplex droplet digital PCR.

    abstract:BACKGROUND:The diagnosis of 22q11 deletion syndrome (22q11DS) is often delayed or missed due to the wide spectrum of clinical involvement ranging from mild to severe, often life-threatening conditions. A delayed diagnosis can lead to life-long health issues that could be ameliorated with early intervention and treatmen...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2014.230086

    authors: Pretto D,Maar D,Yrigollen CM,Regan J,Tassone F

    更新日期:2015-01-01 00:00:00

  • Circulating human hepcidin-25 concentrations display a diurnal rhythm, increase with prolonged fasting, and are reduced by growth hormone administration.

    abstract:BACKGROUND:Hepcidin-25 reduces iron absorption by binding to the intestinal iron transporter ferroportin and causing its degradation. Currently, little is known about the basal regulation of circulating hepcidin-25. In addition, although erythropoietin administration has been reported to decrease the circulating hepcid...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2012.186866

    authors: Troutt JS,Rudling M,Persson L,Ståhle L,Angelin B,Butterfield AM,Schade AE,Cao G,Konrad RJ

    更新日期:2012-08-01 00:00:00

  • Gas-chromatographic determination of 5-fluorocytosine in human serum.

    abstract::We describe a sensitive and precise gas-chromatographic method, in which cytosine is used as the internal standard, for determination of an antifungal agent, 5-fluorocytosine, in serum. The trimethylsilyl derivative of this drug is well separated from the internal standard and from normal serum constituents. Amphoteri...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Harding SA,Johnson GF,Solomon HM

    更新日期:1976-06-01 00:00:00

  • Medicare's demonstration of competitive bidding for clinical laboratory services: what it means for clinical laboratories.

    abstract::The purpose of Medicare's Demonstration of Competitive Bidding for Clinical Laboratory Services is to determine whether competitive bidding can be used to provide quality laboratory services at prices below current Medicare reimbursement rates. Here, we present key features of the preliminary design for the demonstrat...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Hoerger TJ,Lindrooth RC,Eggleston JL

    更新日期:1998-08-01 00:00:00

  • Genetic variants in the fibroblast growth factor pathway as potential markers of ovarian cancer risk, therapeutic response, and clinical outcome.

    abstract:BACKGROUND:The fibroblast growth factor (FGF) and FGF receptor (FGFR) axis plays a critical role in tumorigenesis, but little is known of its influence in ovarian cancer. We sought to determine the association of genetic variants in the FGF pathway with risk, therapeutic response, and survival of patients with ovarian ...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2013.211490

    authors: Meng QH,Xu E,Hildebrandt MA,Liang D,Lu K,Ye Y,Wagar EA,Wu X

    更新日期:2014-01-01 00:00:00

  • Denaturing gradient-gel electrophoresis screening of familial defective apolipoprotein B-100 in a mixed Asian cohort: two cases of arginine3500-->tryptophan mutation associated with a unique haplotype.

    abstract::The Arg-to-Trp substitution at codon 3500 in the apolipoprotein (apo) B-100 gene is established as a cause of familial defective apo B-100 (FDB), a functional mutation, resulting in reduced LDL receptor binding and manifest hypercholesterolemia. In a search for similar mutations in 163 Malaysians, we screened the puta...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:

    authors: Choong ML,Koay ES,Khoo KL,Khaw MC,Sethi SK

    更新日期:1997-06-01 00:00:00

  • Noninvasive Detection of Cocaine and Heroin Use with Single Fingerprints: Determination of an Environmental Cutoff.

    abstract:BACKGROUND:Recent publications have explored the possibility of using fingerprints to confirm drug use, but none has yet dealt with environmental contamination from fingertips. Here we explored the possibility of establishing an environmental cutoff for drug testing from a single fingerprint. METHODS:Fingerprint sampl...

    journal_title:Clinical chemistry

    pub_type: 杂志文章

    doi:10.1373/clinchem.2017.281469

    authors: Ismail M,Stevenson D,Costa C,Webb R,de Puit M,Bailey M

    更新日期:2018-06-01 00:00:00