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Binding constants of isolated NGF-receptors from different species.

Abstract：

:It is known that NGF-responsive cells bind NGF at cell surface receptors in a specific and saturable fashion and there are two separate kinds of receptor-ligand binding interactions as judged by Rosenthal analyses. Following isolation of nerve growth factor receptors from embryonic chicken sensory ganglia, rat pheochromocytoma cells and human neuroblastoma cells, equilibrium binding studies were carried out and two different equilibrium binding constants similar to that described for whole cells were determined. This evidence is consistent with the hypothesis that there are two different receptors for NGF which have been conserved.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lyons CR,Stach RW,Perez-Polo JR

doi

10.1016/0006-291x(83)91013-6

subject

Has Abstract

pub_date

1983-08-30 00:00:00

pages

368-74

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(83)91013-6

journal_volume

115

pub_type

杂志文章

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